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Hajduch
Jaroslav Hajduch, Bytca SK
| Patent application number | Description | Published |
|---|---|---|
| 20090053354 | VENTING VALVE TO BE USED IN VENTING BORES OF VULCANIZATION MOLDS - Vent valve for venting bores of vulcanization moulds, especially for the tread profile area, consisting of a valve sleeve ( | 02-26-2009 |
| 20100166900 | VENTING VALVE TO BE USED IN VENTING BORES OF VULCANIZATION MOLDS - Vent valve for venting bores of vulcanization moulds, especially for the tread profile area, consisting of a valve sleeve, in which a valve insert and a wound spring are movably located, wherein the valve insert consists of a valve shank, which is at one end equipped with a disk and at the other end with a conical surface changing into backwards oriented conical end, and the movement of the valve insert is controlled by a delimiter of opening the valve. Inner surface of the valve sleeve is in its part located further away from disk provided with conical surface, oriented away from the disk, and the delimiter of opening the valve is formed by two mutually cooperating conical surfaces or parts of conical surfaces, wherein the conical surface formed at the end of the valve shank of the valve insert is oriented against the conical surface or part of conical surface of the valve sleeve. | 07-01-2010 |
Marian Hajduch, Moravsky Beroun CZ
| Patent application number | Description | Published |
|---|---|---|
| 20090318719 | METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN - The invention relates to a method of preparation and isolation of betulin diacetate from birch bark from paper mills and its optional processing to betulin, wherein the birch bark is ground, mixed with two- to twenty-fold excess volume of water and is stirred so that all birch bark is dipped, then the fraction of the birch bark which floats on the surface is collected, said collected fraction is dried at the temperature in the range of from 50 to 85° C. and the betulin contained in the dried birch bark is then subjected to an acetylation reaction, after the acetylation the birch bark is dried at the temperature of from 50 to 100° C. and the formed betulin diacetate is then isolated from the birch bark by supercritical extraction of the birch bark with carbon dioxide at the pressure of 28-35 MPa and the temperature of from 50 to 100° C. and subsequently, the supercritical extract is recrystallized for direct use or for further processing. The further processing can be basic hydrolysis of the re-crystallized betulin diacetate to betulin. | 12-24-2009 |
| 20090325919 | METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION - The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. | 12-31-2009 |
| 20110014637 | Method For Determining The Sensitivity Of Patients Suffering From A Cancer Disease To Biological Therapy - The invention relates to a method for determining the sensitivity of patients suffering from a cancer disease towards targeted biological therapy based on the inhibition of signaling pathways of the members of HER family (e.g., HER-1, HER-2, HER-3 and HER-4) by determining the expression of the biomarker S6 kinase or its post-translationally modified form or of the biomarkers of the activation of S6 kinase or their post-translationally modified forms in the tumor. | 01-20-2011 |
Marian Hajduch, Olomouc CZ
| Patent application number | Description | Published |
|---|---|---|
| 20100022587 | DERIVATIVES OF 2-PHENYL-3-HYDROXYQUINOLINE-4(1H)-ONE AND METHODS OF THEIR PREPARATION AND UTILIZATION - Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one of the general formula (II), where X represents a nitro group, amino group, and Y represents an atom of halogen, oxygen or sulphur substituted by C | 01-28-2010 |