Hajduch
Jaroslav Hajduch, Bytca SK
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20090053354 | VENTING VALVE TO BE USED IN VENTING BORES OF VULCANIZATION MOLDS - Vent valve for venting bores of vulcanization moulds, especially for the tread profile area, consisting of a valve sleeve ( | 02-26-2009 |
20100166900 | VENTING VALVE TO BE USED IN VENTING BORES OF VULCANIZATION MOLDS - Vent valve for venting bores of vulcanization moulds, especially for the tread profile area, consisting of a valve sleeve, in which a valve insert and a wound spring are movably located, wherein the valve insert consists of a valve shank, which is at one end equipped with a disk and at the other end with a conical surface changing into backwards oriented conical end, and the movement of the valve insert is controlled by a delimiter of opening the valve. Inner surface of the valve sleeve is in its part located further away from disk provided with conical surface, oriented away from the disk, and the delimiter of opening the valve is formed by two mutually cooperating conical surfaces or parts of conical surfaces, wherein the conical surface formed at the end of the valve shank of the valve insert is oriented against the conical surface or part of conical surface of the valve sleeve. | 07-01-2010 |
Marian Hajduch, Moravsky Beroun CZ
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20090318719 | METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN - The invention relates to a method of preparation and isolation of betulin diacetate from birch bark from paper mills and its optional processing to betulin, wherein the birch bark is ground, mixed with two- to twenty-fold excess volume of water and is stirred so that all birch bark is dipped, then the fraction of the birch bark which floats on the surface is collected, said collected fraction is dried at the temperature in the range of from 50 to 85° C. and the betulin contained in the dried birch bark is then subjected to an acetylation reaction, after the acetylation the birch bark is dried at the temperature of from 50 to 100° C. and the formed betulin diacetate is then isolated from the birch bark by supercritical extraction of the birch bark with carbon dioxide at the pressure of 28-35 MPa and the temperature of from 50 to 100° C. and subsequently, the supercritical extract is recrystallized for direct use or for further processing. The further processing can be basic hydrolysis of the re-crystallized betulin diacetate to betulin. | 12-24-2009 |
20090325919 | METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION - The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. | 12-31-2009 |
20110014637 | Method For Determining The Sensitivity Of Patients Suffering From A Cancer Disease To Biological Therapy - The invention relates to a method for determining the sensitivity of patients suffering from a cancer disease towards targeted biological therapy based on the inhibition of signaling pathways of the members of HER family (e.g., HER-1, HER-2, HER-3 and HER-4) by determining the expression of the biomarker S6 kinase or its post-translationally modified form or of the biomarkers of the activation of S6 kinase or their post-translationally modified forms in the tumor. | 01-20-2011 |
20110218167 | Triterpenoid 2-deoxy Glycosides, Method of Preparation Thereof and Use Thereof as Medicaments - The invention describes novel triterpenoid 2-deoxy glycosides of general formula I, wherein at least one of the substituents X | 09-08-2011 |
20140336073 | METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS - A method for determining the sensitivity and/or resistance of a patient suffering from a cancer disease to Aurora kinase inhibitor therapy, which comprises determining in vitro in the cancer cells or body fluids taken from the patient the expression of at least one gene selected from a particular group and/or determining in vitro in the cancer cells or body fluids taken from the patient the level of at least one protein selected from a particular group. | 11-13-2014 |
Marian Hajduch, Olomouc CZ
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20100022587 | DERIVATIVES OF 2-PHENYL-3-HYDROXYQUINOLINE-4(1H)-ONE AND METHODS OF THEIR PREPARATION AND UTILIZATION - Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one of the general formula (II), where X represents a nitro group, amino group, and Y represents an atom of halogen, oxygen or sulphur substituted by C | 01-28-2010 |
Marian Hajduch, Moravsky Beraun CZ
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20140303390 | CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION - Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases. | 10-09-2014 |
Michael P. Hajduch, Munster, IN US
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20130160246 | Cable Tray Mount - The present invention is directed towards a cable tie mount. The cable tie mount includes a body and a mount. The mount includes a top, a bottom, sides, and a channel therethrough. The body has a base member with a mounting hole and a receiving member with a locking hole. The receiving member extends at an angle from the base member. The mount is installed on the receiving member of the body such that the receiving member is positioned within the channel of the mount. | 06-27-2013 |