Patent application number | Description | Published |
20080279698 | CONTROLLED MAGNETOHYDRODYNAMIC FLUIDIC NETWORKS AND STIRRERS - The present invention relates to controlled, magnetohydrodynamically-driven, fluidic networks containing a plurality of individually controlled branches. The branches consist of conduits equipped with pairs of electrodes that are controlled by electrode controllers. In operation, the network is placed within a magnetic field and potentials or currents are applied across electrode pairs within the various branches of the network in specifically determined magnitudes and polarities for specifically determined time intervals in accordance with an activation sequence that may be determined by an algorithm. Placed within a temperature gradient, at least a part of the network can act as a thermal cycler for use in biological interactions that employ temperature variations. The invention also relates to magnetohydrodynamic stirrers comprising a conduit or cavity having at least two electrodes disposed in such an orientation that, upon the application of a potential or current across the electrode pair within a magnetic field, secondary flows such as chaotic advection is generated. | 11-13-2008 |
20080280285 | Systems and Methods For Testing using Microfluidic Chips - Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods. | 11-13-2008 |
20090186357 | Integrated PCR Reactor for Cell Lysis, Nucleic Acid Isolation and Purification, and Nucleic Acid Amplication Related Applications - Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis. | 07-23-2009 |
20100035349 | Biodetection Cassette with Automated Actuator - Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes. | 02-11-2010 |
20100304986 | MECHANICALLY ACTUATED DIAGNOSTIC DEVICE - Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system. | 12-02-2010 |
20110027913 | MULTIPLEXED NANOSCALE ELECTROCHEMICAL SENSORS FOR MULTI-ANALYTE DETECTION - Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices. | 02-03-2011 |
20110125050 | Multiple-Electrode and Metal-Coated Probes - Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided. | 05-26-2011 |
20120245042 | DEBUBBLER FOR MICROFLUIDIC SYSTEMS - Provided are robust, passive, membrane-based debubblers that are readily incorporated into microfluidic devices for rapid degassing. Also provided are methods of degassing fluid disposed within fluidic systems. | 09-27-2012 |
20120282644 | MULTIPLE-ELECTRODE AND METAL-COATED PROBES - Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided. | 11-08-2012 |
20120298883 | Flow Cells for Electron Microscope Imaging With Multiple Flow Streams - Provided are flow cell devices—referred to as nanoaquariums—that are microfabricated devices featuring a sample chamber having a controllable height in the range of nanometers to micrometers. The cells are sealed so as to withstand the vacuum environment of an electron microscope without fluid loss. The cells allow for the concurrent flow of multiple sample streams and may be equipped with electrodes, heaters, and thermistors for measurement and other analysis devices. | 11-29-2012 |
20120315638 | Moisture-Activated Self-Heating Analysis Device - Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate. | 12-13-2012 |
20130037423 | Multi-Point Cellular Analysis - Provided are devices and methods for performing multi-point analysis on biological materials, such as cells. In one embodiment, the devices simultaneously collect information related to a characteristic of a cell membrane and a characteristic of the interior of the cell. | 02-14-2013 |
20140023520 | Controlled Magnetohydrodynamic Fluidic Networks and Stirrers - The present invention relates to controlled, magnetohydrodynamically-driven, fluidic networks containing a plurality of individually controlled branches. The branches consist of conduits equipped with pairs of electrodes that are controlled by electrode controllers. In operation, the network is placed within a magnetic field and potentials or currents are applied across electrode pairs within the various branches of the network in specifically determined magnitudes and polarities for specifically determined time intervals in accordance with an activation sequence that may be determined by an algorithm. Placed within a temperature gradient, at least a part of the network can act as a thermal cycler for use in biological interactions that employ temperature variations. The invention also relates to magnetohydrodynamic stirrers comprising a conduit or cavity having at least two electrodes disposed in such an orientation that, upon the application of a potential or current across the electrode pair within a magnetic field, secondary flows such as chaotic advection is generated. | 01-23-2014 |
20140162244 | ISOTHERMAL NUCLEIC ACID AMPLIFICATION REACTOR WITH INTEGRATED SOLID STATE MEMBRANE - Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids. | 06-12-2014 |