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Haigis
Marcia Haigis, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110287026 | SIRT4 AND USES THEREOF - Provided herein are SIRT4 compositions and methods of use thereof. The invention provides functional information for use in the identification and design of compounds that modulate SIRT4 enzyme activity (e.g., inhibition of fatty acid oxidation, ADP ribosylation, and/or downregulation of glutamate dehydrogenase), and to the compounds identified by such methods and the research, diagnostic and therapeutic uses of such compounds. | 11-24-2011 |
Marcia C. Haigis, Stoneham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110098190 | SIRT4 ACTIVITIES - Methods of screening for compounds that modulate the expression or activity of Sirt4 are provided. Also provided are methods of modulating insulin secretion, treating metabolic disorders, and treating neurodegenerative disorders by modulating the expression or activity of Sirt4. | 04-28-2011 |
Robert Haigis, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100133118 | ELECTROCHEMICAL METHODS OF DETECTING NUCLEIC ACID HYBRIDIZATION - In accordance with the present invention, there are provided systems for detecting hybridization of nucleic acids using electrochemical methods having improved sensitivity. Such systems include an electrode having a variably charged oligonucleotide probe and a redox probe. In some embodiments, the systems may further include a binding nexus having an immobilized reporter oligonucleotide probe, which hybridizes to a target nucleic acid sequence. The reporter oligonucleotide probe may be naturally charged, uncharged, or either partially negatively or positively charged. Further provided are methods for detecting the presence of a nucleic acid sequence of interest in a sample. | 06-03-2010 |
Wolfgang Haigis, Wurzburg DE
| Patent application number | Description | Published |
|---|---|---|
| 20080231809 | Method for Measuring Intraocular Lens - The invention relates to a method for measuring an optimally adapted intraocular lens for patients having a refractively modified cornea. The inventive method includes the following steps: determining the formula-specific corneal refractive powers before the refractive intervention; determining the formula-specific corneal refractive powers after the refractive intervention, and; putting the formula-specific corneal refractive powers before and after the refractive intervention into the respective IOL formula. | 09-25-2008 |