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| 20080248533 | METHOD FOR IN VITRO MOLECULAR EVOLUTION OF PROTEIN FUNCTION - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of
| 10-09-2008 |
| 20090203572 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a first population of polynucleotide molecules and a second population of polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) digesting the first and second populations of polynucleotide molecules with a nuclease to generate polynucleotide fragments, (c) contacting said polynucleotide fragments generated from the plus strands with fragments generated from the minus strands and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having an altered amino acid sequence as compared to those encoded by the parent polynucleotides, wherein the degree of sequence variability in a selected region of the at least one polynucleotide molecule produced in step (d) is controlled by the addition of one or more oligonucleotides of predetermined variability, which oligonucleotides anneal to a sequence that lies between, but excludes, the 3′ or 5′ terminal nucleotide of the parent polynucleotide molecule. The invention also provides polynucleotides obtained by the method of the invention and polypeptides encoded by the same. | 08-13-2009 |
| 20090280526 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of
| 11-12-2009 |
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| 20100120684 | MUTANTS OF INTERLEUKIN- 1 RECEPTOR ANTAGONIST AND USES THEREOF - The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors. | 05-13-2010 |
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| 20080230691 | METHOD FOR OPERATING AN ION TRAP MASS SPECTROMETER SYSTEM - A method of operating a mass spectrometer system having an ion trap is provided. The method comprises encoding a selected characteristic in at least one of the first group of precursor ions and the first plurality of fragments, wherein the encoding operation is applied to at least one of the first group of precursor ions and the first plurality of fragments without being applied to other ions such that the first plurality of fragment ions has the first selected characteristic and the other ions lack the first selected characteristic. | 09-25-2008 |
| 20080272295 | MULTIPOLE MASS FILTER HAVING IMPROVED MASS RESOLUTION - A multipole mass filter having improved mass resolution. The multipole mass filer having a first electrode set coupled to at least a RF voltage source and a second electrode set interposed and parallel to the first electrode set. The second electrode set having a variable AC voltage coupled to two radially opposing electrodes of the second electrode set. | 11-06-2008 |
| 20100176291 | MASS SPECTROMETER - A mass analyzer system includes an ion inlet that receives a flow of ions, a multi-mode ion controller that controls some or all of the ions, and a multi-mode mass analyzer, in communication with the ion controller, that performs at least one of analyzing and controlling some or all of the ions. The system also includes a detector, in communication with the multi-mode mass analyzer, that detects some or all of the ions and a processor that controls the operation of at least one of the multi-mode ion controller and the multimode mass analyzer. | 07-15-2010 |
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| 20100105057 | HUMAN DIABETES SUSCEPTIBILITY TNFRSF10D GENE - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10D gene locus in a biological sample of said subject. | 04-29-2010 |
| 20100240539 | Human Autism Susceptibility Gene Encoding PRKCB1 and Uses Thereof - The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the PRKCB 1 gene on chromosome 16 and certain alleles thereof are related to susceptibility to autism and represent novel targets for therapeutic intervention. The present invention relates to particular mutations in the PRKCBI gene and expression products, as well as to diagnostic tools and kits based on these mutations. The invention can be used in the diagnosis of predisposition to, detection, prevention and/or treatment of Asperger syndrome, pervasive developmental disorder, childhood disintegrative disorder, mental retardation, anxiety, depression, attention deficit hyperactivity disorders, speech delay or language impairment, epilepsy, metabolic disorder, immune disorder, bipolar disease and other psychiatric and neurological diseases. | 09-23-2010 |
| 20100285459 | Human Diabetes Susceptibility TNFRSF10A gene - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10A gene locus in a biological sample of said subject. | 11-11-2010 |
| 20110003287 | HUMAN DIABETES SUSCEPTIBILITY TNFRSF10C GENE - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10C gene locus in a biological sample of said subject. | 01-06-2011 |
| 20110086777 | METHOD FOR AUTISM PREDICTION - The present invention relates to a method for evaluating the level of risk for a subject to develop autism, or an autism spectrum disorder, which method comprises determining the number of risk alleles in autism-associated gene loci in a sample of a subject, wherein the more risk alleles are detected within said gene loci combined, the more increased is the risk of developing autism or an autism-spectrum disorder. | 04-14-2011 |
| 20110091899 | COMBINATION OF RISK ALLELES ASSOCIATED WITH AUTISM - The present invention relates to a method of detecting the presence of or predisposition to autism, or to an autism spectrum disorder, the method comprising detecting the presence of an alteration in the gene loci PITX1, ATP2B2, SLC25A12 and EN2 in a sample from said subject. More particularly, the presence of specific single nucleotide polymorphisms (SNPs) within these genes correlates to a substantially increased risk to develop autism. | 04-21-2011 |
| 20110129820 | HUMAN DIABETES SUSCEPTIBILITY TNFRSF10B GENE - The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10B gene locus in a biological sample of said subject. | 06-02-2011 |
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| 20080243086 | BLOOD EXPOSURE PREVENTION IN VASCULAR ACCESS DEVICES - An apparatus for preventing blood exposure or contamination upon withdrawal of a hypodermic needle is provided. The apparatus may include a needle having a tip and a shield configured to at least partially entrap the needle tip upon withdrawal of the needle. The apparatus may further include a blood stabilizing material disposed such that upon withdrawal of the needle the blood stabilizing material is disposed in operative association with the needle tip such that blood carried by the needle is prevented from escaping the apparatus. In some exemplary implementations, the blood stabilizing material may be disposed on one or more surfaces of the shield. The shield of the hypodermic needle may include protective device and/or a housing for shielding the needle tip upon withdrawal. The housing may be adapted to at least partially cover the needle tip upon withdrawal of the needle. In some implementations, the housing may be adapted to allow the protective device to shield the needle before the needle is completely withdrawn. | 10-02-2008 |
| 20080243092 | BLOOD EXPOSURE PREVENTION IN VASCULAR ACCESS DEVICES - An extravascular system includes a catheter assembly, a needle assembly, and a hemostatic adapter. The catheter assembly defines a lumen extending from an opening at a distal end thereof to a catheter hub at a proximal end thereof. The needle assembly includes a needle hub disposed at a proximal end of a needle disposed within the lumen defined by the catheter assembly. The needle has a needle tip extending from the opening of the catheter assembly. The hemostatic adapter defines a passage and is adapted to be operatively associated with the needle assembly and the catheter assembly. The hemostatic adapter further includes at least one liquid-reactive material adapted to at least substantially seal the passage upon contact with one or more liquids. The liquid-reactive material is selected and configured to morph upon contact with liquids to provide a mechanical barrier to prevent blood flow. A fluid may be injected into the lumen and/or passage by way of an optional port to provide a fluidic barrier in addition to the mechanical barrier. | 10-02-2008 |
| 20090182280 | REDUCING WITHDRAWAL FORCE IN A SAFETY IV CATHETER - An extravascular system for accessing the vasculature of a patient may include a catheter adapter, a needle, and/or a needle tip shield assembly. The needle tip shield assembly may have a needle cap, and the needle cap may have a needle shield and at least one low friction surface. The needle may be disposed within the catheter assembly and the needle tip shield assembly. The low friction surface may reside between the needle shield and the needle. The at least one low friction surface may reside on the needle, on the V-clip, and/or on a structure located between the needle and the V-clip. | 07-16-2009 |
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| 20100099799 | PROCESS FOR THE PRODUCTION OF A SUPERABSORBENT POLYMER - The present invention relates to a process for the production of a superabsorbent polymer comprising preparing an aqueous mixture of monomers selected to provide after polymerization a superabsorbent polymer; feeding said monomer mixture to a reactor; subjecting the aqueous monomer mixture in the reactor to free-radical polymerization to obtain a superabsorbent polymer gel; removing the superabsorbent polymer from the reactor; and working-up the superabsorbent polymer removed from the reactor to obtain a final product, whereby a basic aqueous medium comprising carbonate and/or hydrogen carbonate is fed to the superabsorbent polymer gel. | 04-22-2010 |
| 20100105808 | CONTINUOUS PROCESS FOR THE PRODUCTION OF A SUPERABSORBENT POLYMER - The present invention relates to a continuous process for the production of a superabsorbent polymer comprising providing an acidic liquid aqueous monomer mixture containing dissolved oxygen; continuously feeding the aqueous monomer mixture to a reactor; introducing a source of carbonate or hydrogen carbonate into the aqueous monomer mixture prior to entry into the reactor thereby forming a gas phase comprising carbon dioxide and at least a part of the dissolved oxygen, the gas phase being dispersed in the liquid phase; subjecting the gas/liquid mixture to at least partial phase separation immediately prior to or after entry into the reactor and at least partially removing the separated gaseous phase; subjecting the liquid phase in the reactor to free-radical polymerization to obtain the superabsorbent polymer, and continuously removing the superabsorbent polymer from the reactor. | 04-29-2010 |
| 20100105809 | PROCESS FOR THE PRODUCTION OF A SUPERABSORBENT POLYMER - The present invention relates to a process for the production of a superabsorbent polymer comprising preparing an aqueous mixture of monomers selected to provide after polymerization a superabsorbent polymer; feeding said monomer mixture to a reactor; subjecting the aqueous monomer mixture in the reactor to free-radical polymerization to obtain a superabsorbent polymer gel; removing the superabsorbent polymer gel from the reactor; and drying the superabsorbent polymer gel. Where at least one off-gas stream removed from any stage of the process is subjected to scrubbing with a basic aqueous solution prior to venting to obtain an aqueous scrubber solution that is at least partially recycled to any of the above steps of the process. | 04-29-2010 |
| 20110245436 | PROCESS FOR THE PRODUCTION OF A SUPERABSORBENT POLYMER - The present invention relates to process for the preparation of a superabsorbent polymer comprising the steps of a) subjecting an aqueous monomer mixture containing at least one α,β-ethylenically unsaturated monomer; at least one monomer bearing at least two α,β-ethylenically unsaturated groups; iron ions in an amount of 0.1 to 3 wppm based on the total weight of the aqueous monomer mixture; and at least one chelating agent in an amount to provide a mol ratio of chelating agent to iron ion of 0.8 to 4.0 to free radical polymerization in an reactor to obtain a super-absorbent polymer; and b) recovering the superabsorbent polymer, whereby if the process is continuous and is run in an agitated reactor the upper limit of the mol ratio of chelating agent to iron ion is 4.0 for a throughput of total reaction mixture through the reactor of at most 1.3 kg/h per liter reactor volume. | 10-06-2011 |
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| 20090102743 | Antenna Tower Structure With Installation Shaft - An antenna tower structure comprising an essentially vertical elongated tower body with an internal installation shaft provided therein. One or more radio base stations are arranged in the installation shaft in the vicinity of one or more associated antennas at the top of the tower body. The installation shaft is formed to allow personnel access to the radio base station. There is also provided an elevator arrangement for an antenna tower structure. | 04-23-2009 |
| 20100315309 | TUBULAR TELECOM TOWER - The present invention aims to provide a hollow antenna tower structure for use in a wireless communications network. The tower comprises tubular tower sections made of concrete, and having a generally hollowed cross section. A movable base station unit, having at least one antenna and at least one micro wave link, is being disposed inside the tubular tower. The whole base station unit is movable up and down inside the tower by the aid of an elevator system. The tower further comprises at least one entrance into the tower and a climbing facility and/or a second elevator system, inside the tower, giving access to the base station unit. | 12-16-2010 |
| 20100327488 | Method of Making Hollow Concrete Elements - A method of making an open ended hollow concrete element includes arranging a mold about a substantially horizontal roller shaft, the mold having a sleeve-shaped mold wall defining the outer peripheral shape of the concrete element and first and second end rims, each with an inner periphery smaller than the inner periphery of the mold wall at the respective end and defining the end surfaces of the concrete element. The mold is rotatably supported by the roller shaft by abutment at the inner peripheries of the first and second end rims so that the roller shaft upon rotation defines the inner peripheral shape of the concrete elements. The method further includes rotating the shaft to rotate the mold; feeding curable concrete to the rotating mold; stopping the rotation of the mold; and removing the cured concrete element from the mold. The inner perimeter of the mold wall defines an exterior shape of the concrete element that varies along and/or radially to the direction of the rotational axis. There is further provided an arrangement for making such concrete elements. | 12-30-2010 |
