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György
Gyorgy Andor, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100197666 | (THIO) -CARBAMOYL-CYCLOHEXANE DERIVATIVES AND METHOD FOR TREATING SCHIZOPHRENIA - The present invention relates to use of (thio)-carbamoyl-cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment of schizophrenia. Furthermore, the present invention relates to the treatment of schizophrenia through the administration of (thio)-carbamoyl cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof. | 08-05-2010 |
| 20100197704 | PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING ACUTE MANIA - The present invention relates to use of (thio)-carbamoyl-cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment of acute mania. Furthermore, the present invention relates to the treatment of acute mania through the administration of (thio)-carbamoyl cyclohexane derivatives, particularly trans-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexylamine and pharmaceutically acceptable salts thereof. | 08-05-2010 |
Gyorgy Bekes, Szeged HU
| Patent application number | Description | Published |
|---|---|---|
| 20090097726 | SYSTEMS, METHODS AND APPARATUS AUTOMATIC SEGMENTATION OF LIVER IN MULTIPHASE CONTRAST-ENHANCED MEDICAL IMAGES - Systems, method and apparatus in which some embodiments of automatic segmentation of a liver parenchyma from multiphase contrast-enhanced computed-tomography images includes analyzing an intensity change in the images belonging to the different phases in order to determine the region-of-interest of the liver, thereafter segmenting starting from the region-of-interest and incorporating anatomical information to prevent oversegmentation, and thereafter combining the information of all available images. | 04-16-2009 |
Gyorgy Bolgar, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090255599 | Insertion piece to a single-grip mixing faucet - The invention relates to an insertion piece to a single-grip mixing faucet developed as a control unit with a ceramic insertion, and on its one side it is connected to a footing, on its other side to a driving arm, the control unit itself, the cartridge, comprises a fixed stationary inlet disc and a moving control disc arranged one above the other to form together a plane sealing. The other side of the inlet disc is coupled to a footing, whereas the control disc on its side opposite to the inlet disc is in a forced connection with a ceramic moving element, which, in turn, is in connection with the driving arm. On the footing, a warm water inlet, a cold water inlet and an outlet are situated. | 10-15-2009 |
| 20100006169 | Insertion to a single-grip, rotation-operated mixing faucet - The invention relates to a single-grip, rotational mixing faucet insertion piece developed as a control unit with ceramic insertion, which is connected in its one face to a base, on its other face to an operation arm. The control unit, the so-called cartridge comprises a fixed stationary inlet disc and an adjustable control disc placed one above the other forming thereby a plane seal. The other face of the inlet disc is connected to the base, whereas the side of the control disc opposite to the inlet disc is connected to the operating arm. The base contains an inlet for the hot water, and an inlet for the cold water and an outlet. | 01-14-2010 |
| 20110146821 | INSERTION FOR SINGLE-GRIP MIXING FAUCET WITH INCREASED COMFORT ANGLE - The invention relates to single-grip mixing faucet comprising a control unit with ceramic insertion piece, so-called cartridge, one side of the cartridge is connected to a footing, the other side to an operating arm, the cartridge comprising a fixed, stationary inlet disc one side of which is connected to one side of a movable control disc and the two discs forming together a plane sealing, and forming a mixing space at the same time the opposite side of the inlet disc is in connection with the footing, whereas at the opposite side of the control disc is in driving connection with a ceramic disc mover, which, in turn, is connected to the operating arm, further on the footing cold water inlet and hot water inlet and an outlet for water flowing out are arranged. | 06-23-2011 |
Gyorgy Bozoki, Plano, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20120124462 | Web Application Optimization - A method of optimizing a web page includes selecting an original web application code. A server-side executable associated with the original web application code is identified, and an object used in the server-side executable is identified. An evaluation is made of how the server-side executable uses the object. Then a determination is made as to whether substitute instructions, which provide functionality similar to that of the object, provides all of the functionality of the object that is used by the server-side executable. If so, then the original web application code is modified to use the substitute instructions. | 05-17-2012 |
| 20120124488 | Network Client Optimization - A method of rendering an optimized web page or other resource includes requesting a resource and receiving a response including a user interface control declaration and a data array containing properties for the user interface control. The data array is parsed to produce a first property value, and a property of the user interface control is modified to correspond to the first property value. Alternatively, the response may not include a user interface control declaration, but a user interface control may be instantiated having a property that corresponds to the first property value. The property value may have been determined dynamically based at least in part on information provided with the request. | 05-17-2012 |
| 20120124555 | Optimization of Compiled Control Objects - A method of optimizing a compiled control, for example a user interface control, includes generating a source code document including a test instruction statement that accesses an element of the control. The source code is then compiled, and one or more matched instructions in the compiled document are identified that correspond to the test instruction statement. A pattern is then formed using the one or more matched instructions. | 05-17-2012 |
Gyorgy Csako, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090011974 | Scavenger Receptor B1 (Cla-1) Targeting for the Treatment of Infection, Sepsis and Inflammation - This invention relates to methods and compositions for the treatment of sepsis, inflammation or infection. In particular, the invention concerns the use of molecule(s) that target SR-BI, which is also referred to as CLA-1 (SR-BI/CLA-1), to treat sepsis, bacterial and viral infections, and inflammatory diseases. SRB I/CLA- | 01-08-2009 |
Gyorgy Csapo, Boszormenyi HU
| Patent application number | Description | Published |
|---|---|---|
| 20090057217 | Apparatus for contaminant recovery - A contaminant recovery apparatus may have a sprayer attached to a front portion of the apparatus and operative to delivery droplets of molten wax to oil spilled in water or on ground. The apparatus may further comprise a take up system which picks up wax after it has solidified and absorbed the oil. The take up system may be attached to the rearward portion of the apparatus. The apparatus may also have a separation system which separates the wax and the oil. The reclaimed wax can be reused to pick up more spilled oil. The reclaimed oil may be refined for fuel. | 03-05-2009 |
Gyorgy Csatadi, Nagykovacs HU
| Patent application number | Description | Published |
|---|---|---|
| 20090164881 | Scan-to-Redact Searchable Documents - An automatic scan-to-redacted electronic document is described. A user input is received which identifies a scanned document. Then the scanned document is automatically processed to produce a corresponding redacted document which having searchable document text and a document image. The searchable document text includes coded redaction text satisfying defined redaction parameters. The document image includes redacted image areas corresponding to redacted elements. | 06-25-2009 |
Gyorgy Csefan, Gyula HU
| Patent application number | Description | Published |
|---|---|---|
| 20120129505 | GENERATING RELATIONAL INDICATORS BASED ON ANALYSIS OF TELECOMMUNICATIONS EVENTS - A system for generating a relational indicator based on analysis of at least one telecommunications event between a first party and a second party, comprises: a relation management engine which is configured to process first content characteristics extracted from a plurality of telecommunications events to produce a first relation parameter and to process second content characteristics extracted from the plurality of telecommunications events to produce a second relation parameter; a terminal device configured to use the first and second relation parameters to generate the relational indicator. | 05-24-2012 |
Gyorgy Ferenczy, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20080287434 | New amino-alkyl-amide derivatives as CCR3 receptor ligands - The invention relates to a compound of the general formula (I), | 11-20-2008 |
| 20080293745 | New amino-alkyl-amide derivatives as CCR3 receptor ligands - The invention relates to a compound of the general formula (I), | 11-27-2008 |
Gyorgy Gajari, Pilisvorosvar HU
| Patent application number | Description | Published |
|---|---|---|
| 20110011165 | METHOD FOR PLANNING ROAD ASPHALTS - The subject of the present invention is a new method for designing road asphalts, comprising:—the determination of the optimal bitumen content with compacting experiments using samples made of asphalt mixtures; the optimal bitumen content being the one at which the receptive void volume has a minimum value, depending on the bitumen content; that is, where the compactness of the sample is the highest, and by changing the mass rates in the asphalt mixture, the bitumen content is set to the optimal bitumen content at most. The optimal bitumen content provides the possibility to aim for reaching the highest compactness, i.e. the smallest possible void volume which provides the most favorable fatigue and solidity characteristics. | 01-20-2011 |
Gyorgy Galik, Albertirsa HU
| Patent application number | Description | Published |
|---|---|---|
| 20080200668 | Industrial Process for the Preparation of 17-Hydroxy-6Beta, 7Beta; 15Beta, 16Beta-Bismethylene-3-Oxo-17Alpha-Pregn-4-Ene-21-Carboxylic Acid Y-Lactone and Key Intermediates for this Process - The invention relates to an industrial process for the preparation of 17-hydroxy-6β,7β;15β,16β-bismethylene-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone of formula (I), and to the key-intermediates for this process. | 08-21-2008 |
Gyorgy Hasko, Scotch Plains, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090041751 | Sepsis Prevention Through Adenosine Receptor Modulation - Methods for treating sepsis or septic shock in a patient comprising administering to said patient a therapeutically effective amount of a composition containing an adenosine A | 02-12-2009 |
Gyorgy Krasznay, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090137563 | PROCESS FOR THE PREPARTION OF OLANZAPINE - The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno [2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound. | 05-28-2009 |
Gyorgy Lipovszki, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100116734 | BIOLOGICAL WASTEWATER TREATMENT APPARATUS AND METHODS USING MOVING BELT CONTRACTOR - A compact biological treatment assembly, apparatus and methods are disclosed, the apparatus including a movable belt biological contactor having selected microbial cultures established thereon. The apparatus further includes a tank having a volume for receipt of wastewater to be treated, first and second drums positioned at the tank each connected to an end of the belt contactor, and a motor or motors together with a controller for rotating the drums cooperatively to move the belt contactor between the drums thereby coiling and uncoiling the belt contactor on the drums. | 05-13-2010 |
| 20110257788 | Mobile station and methods for diagnosing and modeling site specific full-scale effluent treatment facility requirements - A mobile station and methods are disclosed for diagnosing and modeling site specific effluent treatment facility requirements to arrive at a treatment regimen and/or proposed commercial plant model idealized for the particular water/site requirements. The station includes a mobile platform having power intake, effluent intake and fluid outflow facilities and first and second suites of selectably actuatable effluent pre-treatment apparatus. An effluent polishing treatment array is housed at the station and includes at least one of nanofiltration, reverse osmosis and ion-exchange stages. A suite of selectively actuatable post-treatment apparatus is housed at the station. Controls are connected at the station for process control, monitoring and data accumulation. A plurality of improved water treatment technologies is also disclosed. The modeling methods include steps for analyzing raw effluent to be treated, providing a field of raw effluent condition entry values and a field of treated effluent condition goals entry values, and utilizing said fields to determine an initial treatment model including a selection of, and use parameters for, treatment technologies from the plurality of down-scaled treatment technologies at the facility, the model dynamically and continuously modifiable during treatment modeling. | 10-20-2011 |
Gyorgy Lipovszki, Verbena HU
| Patent application number | Description | Published |
|---|---|---|
| 20090032446 | Mobile station and methods for diagnosing and modeling site specific effluent treatment facility requirements - A mobile station and methods are disclosed for diagnosing and modeling site specific effluent treatment facility requirements to arrive at a treatment regimen and/or proposed commercial plant model idealized for the particular water/site requirements. The station includes a mobile platform having power intake, effluent intake and fluid outflow facilities and first and second suites of selectably actuatable effluent pre-treatment apparatus. An effluent polishing treatment array is housed at the station and includes at least one of nanofiltration, reverse osmosis and ion-exchange stages. A suite of selectively actuatable post-treatment apparatus are housed at the station. Controls are connected at the station for process control, monitoring and data accumulation. A plurality of improved water treatment technologies are also disclosed. | 02-05-2009 |
Gyorgy Lipusz, Bekes HU
| Patent application number | Description | Published |
|---|---|---|
| 20100083627 | HARVESTER ADAPTER WITH STALK SHREDDER FOR HARVESTING GRAIN CROPS, PARTICULARLY SUNFLOWER - The invention relates to a harvester adapter with stalk shredder for harvesting grain crops, particularly sunflower, comprising a frame structure attached to a combine harvester, and at least two crop gathering units having a snout, where the crop gathering units are secured to the frame structure. Neighbouring crop gathering units are arranged such that a channel with an open leading end is formed between them, with a stalk gathering unit being disposed in driving connection with a harvesting mechanism on at least one side of the channels. The adapter has a collecting auger disposed rearward from the harvesting mechanism and at least one stalk shredder unit attached to the frame structure. The speed of the stalk gathering unit ( | 04-08-2010 |
Gyorgy Lustyik, Pecs HU
| Patent application number | Description | Published |
|---|---|---|
| 20080293585 | 5'/3' Ratioing Procedure for Detection of Gene Rearrangements - The present invention relates to methods and kits useful for the detection of gene rearrangements and the diagnosis of a propensity to develop a disease condition caused by the gene rearrangements, wherein two PCR products are prepared from the 5′ side and from the 3′ side of a putative breakpoint of the gene of interest, and the ratio of the two products are measured. | 11-27-2008 |
Gyorgy Marko-Varga, Lund SE
| Patent application number | Description | Published |
|---|---|---|
| 20080227117 | Peptides as Biomarkers of Copd - The present invention relates to the identification of biomarkers for the disease condition COPD. The uses of such biomarkers in diagnosis and therapy and a novel method for their identification is are also described. | 09-18-2008 |
| 20100203565 | Peptide Fingerprint from the Degradation of Elastin by HNE - Methods for producing and using protein/peptide fingerprints, derived from elastin degraded by the enzyme human Neutrophil Elastase (HNE), allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive Pulmonary Disease (COPD). | 08-12-2010 |
Gyorgy Medgyesi, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20080247516 | Cable Guiding for a Ceiling Support of an X-Ray Device - The invention relates to a ceiling support system for a movable component ( | 10-09-2008 |
| 20090154653 | DRIVE UNIT FOR X-RAY SYSTEM - The invention relates to a drive unit ( | 06-18-2009 |
Gyorgy Morovjan, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090111829 | Aripiprazole Salts - The present invention provides for new salts of aripiprazole of the general formula (II) formed with dibasic organic acids, camphorsulfonic acid, phosphoric acid, and processes for their preparation. Further objects of the present invention are pharmaceutical compositions containing said new aripiprazole salts. Aripiprazole salts according to present invention can be prepared by the reaction of aripiprazole base and suitable acid compounds in a molar ratio 0.5-3 based on the molar amount of aripiprazole in a suitable organic solvent. | 04-30-2009 |
Gyorgy Ordody, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100031196 | METHOD AND APPARATUS FOR SELECTING AND HIGHLIGHTING OBJECTS IN A CLIENT BROWSER - A computer implemented method, apparatus, article of manufacture and storage medium, provide the ability to select and highlight objects. A rendered image (containing one or more rendered objects) is displayed in a client browser on a client computer. A run length encoded (RLE) selection buffer is received, from a server across a network, into the client browser. The selection buffer provides a mapping of each pixel from the rendered image to rendered objects. User input is accepted that identifies a location of a cursor with respect to the rendered image. A determination is made, on the client computer, regarding which of the rendered objects has been selected based on the user input and the RLE selection buffer. The selected rendered object is then displayed in a visually distinguishable manner. | 02-04-2010 |
Gyorgy Petrovics, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080269157 | Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations - Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate cancer. Compositions comprising these isoforms provide therapeutic benefit and can be used in methods of detecting, diagnosing, prognosing, and treating prostate cancer. These compositions provide biomarkers for detecting the expression of combinations of the PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG genes. | 10-30-2008 |
| 20090170075 | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer - The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene. | 07-02-2009 |
| 20100144832 | Prostate Cancer-Specific Alternations in ERG Gene Expression and Detection and Treatment Methods Based on Those Alterations - The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG. | 06-10-2010 |
Gyorgy Posfai, Szeged HU
| Patent application number | Description | Published |
|---|---|---|
| 20090075333 | Reduced Genome E. Coli - Reduced genome strains of | 03-19-2009 |
Gyorgy Ruzsics, Hogyesz HU
| Patent application number | Description | Published |
|---|---|---|
| 20090215855 | New Crystalline Atorvastatin Hemicalcium Salt Polymorph Form - The present invention relates to a new crystalline polymorph B-52 form of atorvastatin hemicalcium salt [A[(3R,5R)-7-[3-phenyl-4-[(phenyl carbamoyl]-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-1-yl]-3,5-dihydroxy-heptanoic acid calcium salt (2:1)], medicinal preparations containing the new polymorph form, process for the preparation thereof and the use of the new polymorph form for the preparation of medicinal products. | 08-27-2009 |
Gyorgy Stampf, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090253712 | AQUEOUS SOLVENT SYSTEM FOR SOLUBILIZATION OF AZOLE COMPOUNDS - A pharmaceutical composition includes: | 10-08-2009 |
Gyorgy Vamosi, Debrecen HU
| Patent application number | Description | Published |
|---|---|---|
| 20090180966 | Cancer cell diagnosis by targeting delivery of nanodevices - Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line. | 07-16-2009 |
Gyorgy Vukics, Urhajos HU
| Patent application number | Description | Published |
|---|---|---|
| 20090153016 | COLORED FLUORESCENT LAMP - A colored fluorescent lamp is provided. The lamp comprises an envelope having an inner surface, means for providing discharge within the envelope, a discharge gas fill inside the envelope, a phosphor coating adjacent to the inner surface of the envelope, and at least a barrier coating between the inner surface of the envelope and the phosphor coating. The barrier coating comprises a blend of alumina and at least one coloring pigment. | 06-18-2009 |
Gyorgy Wolfner, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20080279151 | METHOD AND DEVICE FOR PROCESSING DATA AND COMMUNICATION SYSTEM COMPRISING SUCH DEVICE - A method and a device for processing data are provided, the device includes a first network element sends a message to a second network element thereby informing the second network element about a change of attachment of a third network element. | 11-13-2008 |
| 20090303924 | PACKET DATA NETWORK SELECTION - According to an example embodiment, a method may include sending, by a mobile station in a wireless network, a dynamic service addition (DSA) message to a base station, the DSA message identifying a packet data network (PDN) by access point name (APN). The method may further include exchanging data with the indicated packet data network via the base station. | 12-10-2009 |
György Báthori, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100021927 | CHOLESTEROL LOADED INSECT CELL MEMBRANES AS TEST SYSTEMS FOR ABC TRANSPORTER PROTEINS - The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane. | 01-28-2010 |
György Clememtis, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090306117 | ROSUVASTATIN ZINC SALT - The present invention is related to rosuvastatin zinc salt of the Formula (I), process for preparation thereof and medicinal products containing said salt. Rosuvastatin zinc salt according to the present invention is prepared by reacting rosuvastatin with a zinc alcoholate, zinc enolate or an inorganic or organic zinc salt and isolating the thus obtained rosuvastatin zinc salt (2:1). | 12-10-2009 |
György Dormán, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100267711 | METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF - A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). | 10-21-2010 |
György Juhász, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100296096 | IMAGING OPTICAL INSPECTION DEVICE WITH A PINHOLE CAMERA - The invention relates to an imaging optical inspection setup for inspecting a sample ( | 11-25-2010 |
György Kaszás, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100065202 | Procedure of Manufacturing a Neutron-Guiding Flat Surface - The subject of the invention is a procedure for manufacturing a neutron-guiding flat surface of low waviness in the course of which a thin plate coated by a material suitable for neutron reflection, advantageously of multilayered structure, is glued onto a significantly thicker carrier surface. The procedure is characterised by placing the thin neutron-reflecting plate onto a base surface of low flatness, typically of the order of magnitude of 10 | 03-18-2010 |
György Kéri, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20080207677 | Napthyridine Compounds As Rock Inhibitors - The present invention relates to compounds having a naphthyridine scaffold, and stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these naphthyridine derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said naphthyridine compounds have been identified as inhibitors of the protein kinase ROCK2, also known as Rho-kinase, and are useful for the treatment of cancers (tumor growth and metastases), erectile dysfunction, cardiovascular diseases, hypertension, angina pectoris, cerebral ischaemia, cerebral vasospasm, myocardial ischaemia, coronary vasospasm, heart failure, myocardial hypertrophy, atherosclerosis, restenosis, spinal cord injuries, neuronal degeneration, thrombotic disorders, asthma, glaucoma, inflammation, anti-viral diseases (e.g. HIV), and osteoporosis. | 08-28-2008 |
| 20080214583 | 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent - The invention relates to new 7H-pyrrolo[2,3-d]pyrimidine derivatives, as well as their therapeutically acceptable salts, pharmaceutical preparations containing them and process for producing the active agent. The pharmaceutical preparation is adventageously antiphlogistic and analgetic one, a preparation reducing neuropathic hyperalgesia and rheumatic arthritis, a preparation for hindering destruction of bones chondrus, being applicable for treatment of other diseases, which may be connected with other inflammatory processes e.g. asthma, eczema or psoriasis. | 09-04-2008 |
| 20090018149 | 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections - Described are 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of mycobacteria-induced infections and opportunistic infections, as well as compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene derivative and/or pharmaceutically acceptable salts thereof. Furthermore, the present application refers to the use of mycobacterial protein serine/threonine kinases for developing methods for detection and determination of these kinases for recognising and monitoring diseases and for controlling therapy of diseases. | 01-15-2009 |
| 20090298842 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor - Described herein is the discovery that certain mycobacterial serine/threonine protein kinases, particularly protein kinase G (PknG), are effective therapeutic targets for the treatment of mycobacterial infections. Furthermore, the present application refers to the use of mycobacterial serine/threonine protein kinases for developing methods for detection and determination of these kinases for recognizing and monitoring diseases and for controlling therapy of diseases. Additionally disclosed are novel 4,5,6,7-tetrahydrobenzo[b]thiophene compounds, benzo(g)quinoxaline compounds, and pharmaceutically acceptable salts thereof, and methods of using such compounds and salts thereof for the prophylaxis and/or treatment of virally and/or bacterially induced infections, particularly mycobacteria-induced infections, including opportunistic infections, as well as pharmaceutical compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene compound and/or benzo(g)quinoxaline compound and/or pharmaceutically acceptable salts thereof in a pharmaceutically acceptable carrier. | 12-03-2009 |
György KeserÜ, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090312299 | Isolated Isomers of Norelgestromin and Methods of Making and Using the Same - The invention is directed to a process of preparing substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions. | 12-17-2009 |
György Krasznai, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090215757 | Process for Preparation of High-Purity Meloxicam and Meloxicam Potassium Salt - The invention provides a process for the preparation of high purity meloxicam of the Formula (II). The meloxicam raw product is reacted with the solution of potassium hydroxide or potassium carbonate, whereby high purity meloxicam potassium salt monohydrate is produced. Said salt is subsequently treated with mineral or organic acid to yield high-purity meloxicam. | 08-27-2009 |
György Panyi, Debrecen HU
| Patent application number | Description | Published |
|---|---|---|
| 20110059064 | Vm23 and Vm24, two scorpion peptides that block human T-lymphocyte potassium channels (sub-type Kv1.3) w/High Selectivity and Decrease the in vivo DTH-responses in Rats - Potassium channels Kv1.3 are known to be implicated in immunological diseases and graft rejections. Disclosed are peptides capable of blocking with high affinity and specificity potassium channels Kv1.3, their pharmaceutical compositions, and methods for their use to block Kv1.3 potassium channels, to treat various immunological conditions and to diagnostic applications. Methods for their chemical synthesis and correct folding are also disclosed. Exemplary peptides correspond to protein components (Vm23 and Vm24) isolated from the venom of the Mexican scorpion | 03-10-2011 |
György Rabloczky, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20100048627 | SYNERGISTIC PHARMACEUTICAL COMBINATION FOR THE PREVENTION OR TREATMENT OF DIABETES - The invention refers to a synergistic pharmaceutical combination which comprises (a) a first pharmaceutical composition containing an antidiabetic or anti-hyperlipidemic active agent and one or more conventional carrier(s), and (b) a second pharmaceutical composition containing a hydroximic acid derivative of the formula I and one or more conventional carrier(s). The pharmaceutical combination is suitable for the prevention or treatment of, among others, diabetes mellitus. | 02-25-2010 |
György Visky, Budapest HU
| Patent application number | Description | Published |
|---|---|---|
| 20090187032 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17alpha-ACETOXY-11beta-[4-(N,N-DIMETHYL-AMINO)-PHENYL]-19-NORPREGNA-4,9-D- IENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS - The present invention relates to a new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. | 07-23-2009 |
| 20100137622 | INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-- DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS - The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones. The process has the following steps: i) formation of an epoxide; ii) addition of hydrogen cyanide; iii) silylation of a hydroxyl group; iv) reaction with 4-(dimethylamino)-phenyl magnesium bromide Grignard reagent in the presence of CuCl (Teutsch reaction); v) silylation of a hydroxyl group with trimethyl chlorosilane; vi) reaction with diisobutyl aluminum hydride and after addition of acid to the reaction mixture; vii) methoxy-methylation with methoxy-methyl Grignard reagent formed in situ, while hydrolyzing the trimethylsilyl protective groups; viii) oxidation of a hydroxyl group with dicyclohexyl carbodiimide in the presence of dimethyl sulfoxide and a strong organic acid (Swern oxidation), and in given case after purification by chromatography; ix) acetylation of a hydroxyl group with acetic anhydride in the presence of perchloric acid, and in given case, purification by chromatography. The invention also relates to new intermediates of the process. | 06-03-2010 |