Gutke
Hans-Jurgen Gutke, Stuttgart DE
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20090093014 | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof - This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker. | 04-09-2009 |
20110028417 | Macrocyclic Compounds and Methods of Use Thereof - The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds. | 02-03-2011 |
Hans-Jürgen Gutke, München DE
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20090221697 | MACROLIDE CONJUGATES OF PYRROLIZINE AND INDOLIZINE COMPOUNDS AS INHIBITORS OF 5-LIPOOXYGENASE AND CYCLOOXYGENASE - The present invention relates to macrolide conjugates of pyrrolizine and indolizine derivatives with macrocyclic antibiotics and derivatives thereof. The macrolide conjugates are potent inhibitors of 5-lipoxygenase and cyclooxygenase and are therefore suitable to treat disorders of the rheumatic type and to prevent allergically induced diseases. The macrolide conjugates have significantly enhanced potency and efficacy. | 09-03-2009 |
Hans-Jürgen Gutke, München DE
Patent application number | Description | Published |
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20090221697 | MACROLIDE CONJUGATES OF PYRROLIZINE AND INDOLIZINE COMPOUNDS AS INHIBITORS OF 5-LIPOOXYGENASE AND CYCLOOXYGENASE - The present invention relates to macrolide conjugates of pyrrolizine and indolizine derivatives with macrocyclic antibiotics and derivatives thereof. The macrolide conjugates are potent inhibitors of 5-lipoxygenase and cyclooxygenase and are therefore suitable to treat disorders of the rheumatic type and to prevent allergically induced diseases. The macrolide conjugates have significantly enhanced potency and efficacy. | 09-03-2009 |
Katarina Gutke, Fjaras SE
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20100032117 | Process for the production of cellulosic product - The present invention relates to a process for the production of a cellulosic product which comprises providing an aqueous thick suspension containing cellulosic fibers having a fiber concentration of at least about 2% by weight; adding to the thick suspension an aluminum compound, alkaline earth metal salt and acid; diluting the obtained thick suspension to form a thin suspension; adding to the thin suspension one or more drainage and retention aids; and dewatering the obtained thin suspension. The invention further relates to a process for the production of a cellulosic product which comprises providing an aqueous thick suspension containing cellulosic fibers having a fiber concentration of at least about 2% by weight and an alkaline earth metal ion concentration of at least about 100 mg/l; adding to the thick suspension an aluminum compound and optionally an acid to obtain a pH of from about 4 to about 5.5; diluting the obtained thick suspension to form a thin suspension; adding to the thin suspension one or more drainage and retention aids; and dewatering the obtained thin suspension. The invention also relates to an aqueous composition comprising a mixture of an aluminum compound, alkaline earth metal salt and acid and the use of the composition. | 02-11-2010 |
Kathryn Gutke, Salt Lake City, UT US
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20110142945 | Hydrophobic Active Agent Compositions and Related Methods - Compositions and methods for providing hydrophobic active agents in a bioavailable form are disclosed and described. In one aspect of the invention, pharmaceutical composition containing a testosterone ester is provided. The composition includes a testosterone ester in both dissolved form and as undissolved particles and the dissolved form comprises at least 35 wt % of the testosterone ester present in the composition. The composition further includes a solubilizer and a stabilizer. | 06-16-2011 |