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Guo, WA

Amy Guo, Mercer Island, WA US

Patent application numberDescriptionPublished
20100226925Homogeneous Antibody Populations - The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.09-09-2010

Bei-Jing Guo, Seattle, WA US

Patent application numberDescriptionPublished
20100082372NETWORK-BASED HEALTHCARE DATA MANAGEMENT - A web- or network-based healthcare management tool is provided. The innovation provides for a browser-based version of a client that enables clinicians, from remote locations, to securely review patient data retrieved from a healthcare data store. Remote locations include, but are not limited to, from outside the hospital (e.g., at home) or from inside the hospital but in an office or lab that does not have intranet access to the healthcare data store.04-01-2010

Chenlei Guo, Redmond, WA US

Patent application numberDescriptionPublished
20120066204PROVIDING LIGHTWEIGHT MULTIDIMENSIONAL ONLINE DATA STORAGE FOR WEB SERVICE USAGE REPORTING - Distributed and local processes analyze usage data and transform it into objects including timestamps and dimensions. Objects include a position vector to represent dimension analysis and additional attributes associated with measurements of different types. The objects are stored in a multidimensional database indexed on the vector and timestamp attributes.03-15-2012

Di Guo, Redmond, WA US

Patent application numberDescriptionPublished
20110035506DISTRIBUTED WORKFLOW FRAMEWORK - Aspects of the subject matter described herein relate to workflows. In aspects, an activity of a workflow may request data and provide a logical handle. In response, distributed workflow components use the logical handle to determine whether the requested data is available locally or remotely. If the data is available remotely, the components may obtain the data for the requesting entity. In the process of obtaining the data, the data may be serialized and deserialized. After the data is available locally, it is provided to the requesting entity.02-10-2011
20110161391FEDERATED DISTRIBUTED WORKFLOW SCHEDULER - A computer may function as a broker that brokers execution of portions of a workflow. The broker computer may have a processor and memory configured to receive the workflow via a network. The workflow may have a corresponding SLA document that has rules governing how the workflow is to be executed. The broker computer may identify discretely executable sub-workflows of the workflow. The broker computer may also obtain information describing computing characteristics of each of a plurality of service providers (e.g., computation clusters, cloud services, etc.) connected with the broker computer via the network. The broker computer may select a set of the service providers by determining whether their respective computing characteristics satisfy the SLA. The broker computer may pass the discretely executable sub-workflows to the selected set of service providers. The workflow is thus executed, in distributed federated fashion, transparently to the user submitting the workflow.06-30-2011

Donghang Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090259757Securely Pushing Connection Settings to a Terminal Server Using Tickets - Systems and techniques for securely pushing connection settings to a terminal server using tickets are described. In one embodiment, a request is received at a first network component from a client for access to a second network component. A ticket associated with one or more connection settings is created and provided to the client. The ticket is provided by the client to the second network component. The ticket is provided from the second network component to the first network component, and the one or more connection settings associated with the ticket are received from the first network component back to the second network component. The one or more connection settings are enforced at the second network component.10-15-2009

Lin Guo, Seattle, WA US

Patent application numberDescriptionPublished
20090247605Treating diseases mediated by metalloprotease-shed proteins - This invention relates to the identification of membrane-associated proteins shed by metalloproteinases and in particular by TNF-alpha converting enzyme (TACE), to the use of such metalloproteinase-shed proteins in assays for TACE agonists and antagonists, and to the use of metalloproteinase agonists and antagonists, and particularly TACE agonists and antagonists, in the treatment of diseases mediated by certain shed proteins.10-01-2009

Lin Guo, Redmond, WA US

Patent application numberDescriptionPublished
20110295844ENHANCING FRESHNESS OF SEARCH RESULTS - Methods, systems, and computer-storage media for improving the freshness, or the apparent freshness, of search results are described. In an embodiment, the first portion of search results presented on a search results page are based on responsiveness to the search query and a second portion of results describe only recently published documents that are responsive to the search query. In an embodiment, a more recent version of the document, which is not directly used to determine responsiveness, is used to build the caption for a search result. Another way to make search results appear fresh is to include a publication time within the search result caption. In one embodiment, the publication time is generated by calculating a point in time between when a document is first added to a search index and the previous time the search engine visited the site where the document was found.12-01-2011

Michael Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090254978DELEGATED AUTHENTICATION FOR WEB SERVICES - Embodiments of the claimed subject matter provide a method and an apparatus for enabling delegated authentication for web services. Delegated authentication is provided without divulging the information the user requires to complete an authorization procedure of another web service or otherwise subjecting the user to unnecessary risk. Furthermore, delegated authentication is granted for a limited duration and access is subject to further limitations to prevent unnecessary intrusion to the user, the user's data, and the host web service.10-08-2009

Qun Guo, Redmond, WA US

Patent application numberDescriptionPublished
20090216777MULTIPHASE TOPOLOGY-WIDE CODE MODIFICATIONS FOR PEER-TO-PEER SYSTEMS - Systems and methods that supply changes on-the-fly and without breaking execution of codes for schema changes in a peer-to-peer environment. The modification component supplies changes to peers or nodes in a topology by initially identifying dependencies (e.g., multiple level) of that can be affected by the schema change, followed by performing the schema change to the codes or stored procedures. Accordingly, dependencies in entire system can be refreshed, wherein multiple levels of dependencies can exist.08-27-2009
20100125557ORIGINATION BASED CONFLICT DETECTION IN PEER-TO-PEER REPLICATION - Systems and methods that enable conflict detection in a peer-to-peer replication by embedding origination information in data records. A tracing component can track embedded information in form of peer ID and transaction ID, wherein conflicts can be detected by comparing a pre-version (prior to current version) of data on the source node—with—a current version of the data on the destination node.05-20-2010

Patent applications by Qun Guo, Redmond, WA US

Qun Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20100274768DE-DUPLICATION AND COMPLETENESS IN MULTI-LOG BASED REPLICATION - Aspects of the subject matter described herein relate to multi-log based replication. In aspects, database fragments are associated with different logs. Each change to a duplicated database record may be recorded in multiple logs. A history data structure is used to determine when duplication schemas are valid. A duplication schema indicates what database fragments duplicate one or more database records. For a particular time range, the duplication schema history is used to determine whether currently available logs include all changes. If multiple logs include the same change, one log may be selected to provide the change. Non-duplicative changes may be placed into a single data stream usable to update a remote database.10-28-2010
20110167038Dispatching Conflicting Data Changes - A method for distributing one or more conflicting data changes. The method includes extracting data changes from the source site log, and applying the data changes to the destination site. The method then includes identifying one or more constraints for each data change and generating a hash value for each identified constraint. The method then dispatches the data changes into a plurality of streams based on the hash values. The hash values are used to identify conflicting data changes and determine how the data changes should be sent through the plurality of streams such that data changes are applied in parallel in the plurality of streams without violating any causal consistency constraints. The method then includes committing data changes in the plurality of streams to the destination site in a single transaction, creating a consistent transactional view.07-07-2011
20110251997LOGICAL REPLICATION IN CLUSTERED DATABASE SYSTEM WITH ADAPTIVE CLONING - Architecture that addresses an end-to-end solution for logical transactional replication from a shared-nothing clustered database management system, which uses adaptive cloning for high availability. This can be time based using a global logical timestamp. The disclosed architecture, used for refreshing stale clones, does not preserve user transaction boundaries, which is a more complex situation than where the boundaries are preserved. In such a scenario it is probable that for a given data segment no clone of the segment may contain the complete user transaction history, and hence, the history has to be pieced together from the logs of multiple different clones. This is accomplished such that log harvesting is coordinated with the clone state transitions to ensure the correctness of logical replication.10-13-2011

Shelly Guo, Redmond, WA US

Patent application numberDescriptionPublished
20100100868INTERACTIVE DESIGN ENVIRONMENTS TO VISUALLY MODEL, DEBUG AND EXECUTE RESOURCE ORIENTED PROGRAMS. - In scenarios involving a data set accessible through a protocol, operations sets may be formulated for performing various operations on the data set, and may be expressed as resource scripts according to a scripting language. However, such resource scripts may be difficult to design due to the complicated aspects of the interaction, such as asynchrony, network transport, the syntax of the scripting language, and the details of the protocol. A design environment may be devised to facilitate designers in generating resource scripts, e.g., through the manipulation of visual elements. The design environment may abstract the lower-level working details of the resource scripts, and may allow designers to focus on the logical designing of the operations set. The design environment may then automatically generate the resource script from the operations set in accordance with the constraints of the script language and the protocol.04-22-2010

Shunri Guo, Sammamish, WA US

Patent application numberDescriptionPublished
20090006188ASSOCIATING AN ACTIVITY WITH AN ONLINE ADVERTISEMENT - The disclosed subject matter pertains to systems and/or methods that facilitate associating user activity, such as offline user activity, with an online advertisement. An ad link component can receive information associated with online activity and offline activity of a user, online advertisements, and other information, and can analyze such information. The online activity can include viewing, clicking on, pledging interest in, or obtaining a token related to, an online advertisement. The ad link component can employ ad link criteria to determine whether offline user activity, such as a purchase or other desired activity, can be associated with the online advertisement. If the ad link component determines the offline user activity is associated with the online advertisement, an incentive, which can be based on incentive criteria, can be awarded to the user. A distribution component can distribute the incentive to the account of the user.01-01-2009

Patent applications by Shunri Guo, Sammamish, WA US

Wei-Qiang Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090320114FEDERATED REALM DISCOVERY - A federated realm discovery system within a federation determines a “home” realm associated with a portion of the user's credentials before the user's secret information (such as a password) is passed to a non-home realm. A login user interface accepts a user identifier and, based on the user identifier, can use various methods to identify an account authority service within the federation that can authenticate the user. In one method, a realm list of the user device can be used to direct the login to the appropriate home realm of the user. In another method, an account authority service in a non-home realm can look up the user's home realm and provide realm information directing the user device to login at the home realm.12-24-2009
20090320116FEDERATED REALM DISCOVERY - A federated realm discovery system within a federation determines a “home” realm associated with a portion of the user's credentials before the user's secret information (such as a password) is passed to a non-home realm. A login user interface accepts a user identifier and, based on the user identifier, can use various methods to identify an account authority service within the federation that can authenticate the user. In one method, a realm list of the user device can be used to direct the login to the appropriate home realm of the user. In another method, an account authority service in a non-home realm can look up the user's home realm and provide realm information directing the user device to login at the home realm.12-24-2009

Weiqiang Michael Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20110214173PROTECTING ACCOUNT SECURITY SETTINGS USING STRONG PROOFS - One or more strong proofs are maintained as associated with an account of a user. In response to a request to change a security setting of the account, an attempt is made to confirm the request by using one of the one or more strong proofs to notify the user. The change is permitted if the request is confirmed via one or more of the strong proofs, and otherwise the change to the security setting of the account is kept unchanged.09-01-2011

Wei-Qiang Michael Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090300168DEVICE-SPECIFIC IDENTITY - A device identifier (ID) is used across enterprise boundaries. A user can use the device ID to publish a device for sharing with other remote users. The remote users can discover devices that are shared by other users based on device IDs, connect to a selected device, and then verify that they have connected to the correct device based on its device ID. An account authority service may be used to manage the publication and/or discovery of the shared devices and their device IDs.12-03-2009
20090300720CENTRALIZED ACCOUNT REPUTATION - A centralized account reputation system differentiates between illegitimate users and legitimate users using reputation scores associated with the users' online accounts. The system restricts the access of illegitimate users to certain network services while minimizing its negative effects on legitimate users. The system can manage the life cycle of an online account, considering data about the account that is obtained throughout the account network to compute the online account reputation score and allocating access to network services based on the online account reputation score. For example, a reputation score may be embedded in a security token that can be accessed by multiple services on the account network, so that each service can determine the appropriate level of access to be granted to the associated user account based on the reputation score. Various types of online account behavior over time can improve or diminish the online account's reputation.12-03-2009
20090300744TRUSTED DEVICE-SPECIFIC AUTHENTICATION - An authentication system combines device credential verification with user credential verification to provide a more robust authentication mechanism that is convenient to the user and effective across enterprise boundaries. In one implementation, user credential verification and device credential verification are combined to provide a convenient two-factor authentication. In this manner, an account authority service or other authentication provider verify both factors and provide a security token in accordance with the security policy of the account network resource the user is intending to access. The level of privilege granted by the target account network resource can vary depending on the number and type of factors verified by the account authority service.12-03-2009
20100088753IDENTITY AND AUTHENTICATION SYSTEM USING ALIASES - An identity and authentication platform utilizes a data model that enables multiple identities such as e-mail addresses, mobile phone numbers, nicknames, gaming IDs, and other user IDs to be utilized as aliases which are unique sub-identities of a main account name. A user may utilize the aliases supported by the platform to project multiple different on-line identities while using the authentication credentials of the main account. The platform is configured to expose the aliases to various client applications and Internet-accessible sites and services such as e-mail, instant messaging, media sharing, gaming and social networks, and the like, to enable the implementation of a variety of usage scenarios that employ aliases.04-08-2010
20100287019SERVER FARM MANAGEMENT - Techniques and systems are disclosed that can measure capacity of a server farm, and project capacity needs based on traffic and resources. Server farm system information is collected for managing the server farm by identifying a list of servers in the server farm. Performance metrics are collected from identified servers and stored in a collection database. The stored performance metrics are analyzed in accordance with a server farm management request.11-11-2010
20100299716Model Based Multi-Tier Authentication - Authentication is widely used to protect consumer data and computing services, such as email, document storage, and online banking. Current authentication models, such as those employed by online identity providers, may have limited options and configurations for authentication schemes. Accordingly, as provided herein, a model based authentication scheme may be configured based upon a policy and/or an authentication mechanism list. The policy may define the target resource, a user, a group the user belongs to, devices used to connect to the target resource, a service owning the target resource, etc. The authentication mechanism list may comprise predefined authentication mechanisms and/or user plug-in authentication mechanisms (e.g., user created authentication mechanism). Once the authentication scheme is configured, it may be enforced upon authentication requests from a user. Feedback may be provided to the user based upon patterns of usage of the target resource.11-25-2010
20110247055TRUSTED DEVICE-SPECIFIC AUTHENTICATION - An authentication system combines device credential verification with user credential verification to provide a more robust authentication mechanism that is convenient to the user and effective across enterprise boundaries. In one implementation, user credential verification and device credential verification are combined to provide a convenient two-factor authentication. In this manner, an account authority service or other authentication provider verify both factors and provide a security token in accordance with the security policy of the account network resource the user is intending to access. The level of privilege granted by the target account network resource can vary depending on the number and type of factors verified by the account authority service.10-06-2011

Patent applications by Wei-Qiang Michael Guo, Bellevue, WA US

Wei-Quiang Michael Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090187988CROSS-NETWORK REPUTATION FOR ONLINE SERVICES - A reputation server associates feedback from previous network transactions with an account of a user in a network. A reputation score for the user is calculated based on the feedback to indicate the probability the user will abuse the network. When an online service receives a request to perform a transaction from the user, the online service performs the transaction based on the user's reputation score. Additionally, a server generates a reputation packet including the reputation score for a user for use by an online service when the user requests the online service to perform a transaction. The online service may authenticate the reputation packet with the server and, if the reputation packet is authenticated, the online service performs the transaction based on the user's reputation score.07-23-2009
20090204808Session Key Security Protocol - Exchanging information in a multi-site authentication system. A network server receives, from an authentication server, a request by a client computing device for a service provided by the network server along with an authentication ticket. The authentication ticket includes: a session key encrypted by a public key associated with the network server, message content encrypted by the session key, and a signature for the encrypted session key and the encrypted message content. The signature includes address information of the network server. The network server identifies its own address information in the signature to validate the signature included in the authentication ticket and verifies the authentication ticket content based on the signature included in the authentication ticket. The network server decrypts the encrypted session key via a private key associated with the second network server and decrypts the encrypted message content via the decrypted session key.08-13-2009
20090260072IDENTITY OWNERSHIP MIGRATION - Systems, computer-implemented methods, and computer-readable media for establishing an online account with a resource provider are provided. An authentication token including identification of a user from an authentication server is received. The identification of the user from the authentication token is utilized to establish an online account for the user with the resource provider. Additional credentialing information from the user for the online account is received. The additional information received from the user is associated with the online account for the user with the resource provider.10-15-2009
20100042735CROSS-DOMAIN AUTHENTICATION - Providing services within a network of service providers sharing an authentication service and a set of business rules. A central server receives a first request from a first server to provide a first service to a user via a client without forcing the user to present credentials. In response to the received first request, the central server stores data identifying the first service on the client. The central server further receives a second request from a second server to provide a second service to the user via the client after the user presents the credentials to the second service. After receiving the second request and the presented credentials, the central server allows the user access to the second service. In response to allowing the user access to the second service, the central server further allows the user access to the first service as a result of the stored data.02-18-2010
20110138179Scalable Session Management - Scalable session management is achieved by generating a cookie that includes an encrypted session key and encrypted cookie data. The cookie data is encrypted using the session key. The session key is then signed and encrypted using one or more public/private key pairs. The encrypted session key can be decrypted and verified using the same private/public key pair(s). Once verified, the decrypted session key can then be used to decrypt and verify the encrypted cookie data. A first server having the private/public key pair(s) may generate the cookie using a randomly generated session key. A second server having the same private/public key pair(s) may decrypt and verify the cookie even if the session key is not initially installed on the second server. A session key cache may be used to provide session key lookup to save public/private key operations on the servers.06-09-2011
20110179469CROSS-DOMAIN AUTHENTICATION - Providing services within a network of service providers sharing an authentication service and a set of business rules. A central server receives a first request from a first server to provide a first service to a user via a client without forcing the user to present credentials. In response to the received first request, the central server stores data identifying the first service on the client. The central server further receives a second request from a second server to provide a second service to the user via the client after the user presents the credentials to the second service. After receiving the second request and the presented credentials, the central server allows the user access to the second service. In response to allowing the user access to the second service, the central server further allows the user access to the first service as a result of the stored data.07-21-2011
20110271329CROSS-NETWORK REPUTATION FOR ONLINE SERVICES - A reputation server associates feedback from previous network transactions with an account of a user in a network. A reputation score for the user is calculated based on the feedback to indicate the probability the user will abuse the network. When an online service receives a request to perform a transaction from the user, the online service performs the transaction based on the user's reputation score. Additionally, a server generates a reputation packet including the reputation score for a user for use by an online service when the user requests the online service to perform a transaction. The online service may authenticate the reputation packet with the server and, if the reputation packet is authenticated, the online service performs the transaction based on the user's reputation score.11-03-2011
20110314540PREVENTING ABUSE OF SERVICES THROUGH INFRASTRUCTURE INCOMPATIBILITY - Spammers, and other abusers of web services, may be deterred in their attempts to sign up for these services at large scale by making changes to the service registration procedure, where the changes are designed to break the spammer's infrastructure. In one example, a procedure to register for a web service involves presenting a Human Interaction Proof (HIP, or “captcha”) to the user, and gating access to the service upon receipt of a correct solution. If spammers use botnets and/or image capture techniques to initiate registration processes and to transport the HIPs to human or automated solvers, then the registration procedure can be changed in a way that is incompatible with capturing these images, or in a way that is incompatible with receiving HIP solutions from someplace other than the location at which registration was initiated.12-22-2011

Patent applications by Wei-Quiang Michael Guo, Bellevue, WA US

William Guo, Sammamish, WA US

Patent application numberDescriptionPublished
20100281436BINDING USERS TO A GESTURE BASED SYSTEM AND PROVIDING FEEDBACK TO THE USERS - Techniques for managing a set of states associated with a capture device are disclosed herein. The capture device may detect and bind to users, and may provide feedback about whether the capture device is bound to, or detecting a user. Techniques are also disclosed wherein virtual ports may be associated with users bound to a capture device and feedback about the state of virtual ports may be provided.11-04-2010

Xiaocong Guo, Woodinville, WA US

Patent application numberDescriptionPublished
20090034370Diagnostic ultrasound transducer - An ultrasound transducer includes an array of PZT elements mounted on a non-recessed distal surface of a backing block. Between each element and the backing block is a conductive region formed as a portion of a metallic layer sputtered onto the distal surface. Traces on a longitudinally extending circuit board—preferably, a substantially rigid printed circuit board, which may be embedded within the block—connect the conductive region, and thus the PZT element, with any conventional external ultrasound imaging system. A substantially “T” or “inverted-L” shaped electrode is thereby formed for each element, with no need for soldering. At least one longitudinally extending metallic member mounted on a respective lateral surface of the backing block forms a heat sink and a common electrical ground. A thermally and electrically conductive layer, such as of foil, transfers heat from at least one matching layer mounted on the elements to the metallic member.02-05-2009
20100327698DIAGNOSTIC ULTRASOUND TRANSDUCER - An ultrasound transducer includes an array of PZT elements mounted on a non-recessed distal surface of a backing block. Between each element and the backing block is a conductive region formed as a portion of a metallic layer sputtered onto the distal surface. Traces on a longitudinally extending circuit board—preferably, a substantially rigid printed circuit board, which may be embedded within the block—connect the conductive region, and thus the PZT element, with any conventional external ultrasound imaging system. A substantially “T” or “inverted-L” shaped electrode is thereby formed for each element, with no need for soldering. At least one longitudinally extending metallic member mounted on a respective lateral surface of the backing block forms a heat sink and a common electrical ground. A thermally and electrically conductive layer, such as of foil, transfers heat from at least one matching layer mounted on the elements to the metallic member.12-30-2010
20110088248DIAGNOSTIC ULTRASOUND TRANSDUCER - An ultrasound transducer includes an array of PZT elements mounted on a non-recessed distal surface of a backing block. Between each element and the backing block is a conductive region formed as a portion of a metallic layer sputtered onto the distal surface. Traces on a longitudinally extending circuit board—preferably, a substantially rigid printed circuit board, which may be embedded within the block—connect the conductive region, and thus the PZT element, with any conventional external ultrasound imaging system. A substantially “T” or “inverted-L” shaped electrode is thereby formed for each element, with no need for soldering. At least one longitudinally extending metallic member mounted on a respective lateral surface of the backing block forms a heat sink and a common electrical ground. A thermally and electrically conductive layer, such as of foil, transfers heat from at least one matching layer mounted on the elements to the metallic member.04-21-2011

Patent applications by Xiaocong Guo, Woodinville, WA US

Xiaotian Guo, Redmond, WA US

Patent application numberDescriptionPublished
20080293450Consumption of Items via a User Device - An item-providing system supplies items to a user device for consumption at the user device via communication infrastructure. In one illustrative implementation, the communication infrastructure may rely, in part, on wireless communication. The device may correspond to a book reader device or other type of device.11-27-2008

Xinxin Guo, Richland, WA US

Patent application numberDescriptionPublished
20110270452SCHEDULING AND MODELING THE OPERATION OF CONTROLLABLE AND NON-CONTROLLABLE ELECTRONIC DEVICES - Disclosed herein are representative embodiments of methods, apparatus, and systems for controlling and scheduling power distribution in a power network, such as household power network. One disclosed embodiment is a system comprising a central controller and a control device coupled to a household appliance. The central controller can comprise computing hardware coupled to a wireless transceiver. The central controller can be configured to generate and transmit control signals for controlling the operational state of the household appliance according to the schedule. Furthermore, the control device can be configured to receive the transmitted control signals from the central controller and to control the operational state of the household appliance in response to the control signals.11-03-2011

Zhen Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20090099035OLIGONUCLEOTIDE ARRAYS FOR HIGH RESOLUTION HLA TYPING - Arrays of HLA Class I oligonucleotide probes on a solid support are provided, wherein the probes are sufficient to represent at least 80% of the known polymorphisms in exons 2 and 3 of the HLA Class I locus.04-16-2009
20100167295METHODS FOR HAPLOTYPING GENOMIC DNA - The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed to specifically hybridize to each particular haplotype of an individual sample, e.g., oligonucleotides designed to specifically hybridize with each of the two HLA-B haplotypes, HLA-A, HLA-C, HLA-DR, HLA-DQ, and the like. The genomic DNA is contacted and hybridized to the arrayed oligonucleotides to form a genomic DNA/oligonucleotide complex. The excess genomic DNA is washed away and the haplotype separated genomic DNA is denatured from the oligonucleotide probe and collected. The method of the present invention allows for the separation of genomic DNA fragments of between approximately 2 to about 4 megabases (Mb). Separation of the haplotypes of large genomic DNA fragments allows for linkage analysis of other HLA alleles and polymorphisms, microsatellite, SNPs, and the like across a large span of the HLA region, including HLA-A, -B, -C, and HLA-DRB1 regions. This linkage analysis is particularly useful when HLA typing for an individual with limited family HLA typing available.07-01-2010

Patent applications by Zhen Guo, Bellevue, WA US

Zihong Guo, Bellevue, WA US

Patent application numberDescriptionPublished
20080269846DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT - Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.10-30-2008
20090036773METHODS AND APPARATUS FOR ENGAGEMENT AND COUPLING OF AN INTRACAVITORY IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND PROBE - A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.02-05-2009
20100213200Temperature-stabilized storage systems - A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.08-26-2010
20100274330DEVICE FOR TREATMENT OF BLOOD VESSELS USING LIGHT - Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.10-28-2010
20110077464MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME - A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.03-31-2011
20110155745Temperature-stabilized storage systems with flexible connectors - Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. The flexible connectors include a duct forming an elongated thermal pathway between the exterior of the container and the substantially thermally sealed storage region within the container. The flexible connectors include compression units mated to each end of the duct and a plurality of compression strands connected between the compression units.06-30-2011

Patent applications by Zihong Guo, Bellevue, WA US