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Guo, NC
Hongtao Guo, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110190386 | Aptamer Inhibitors of Osteopontin and Methods of Use Thereof - The present invention polynucleotide aptamers that selectively bind to and inhibit the function of osteopontin, pharmaceutical compositions comprising the same, and methods of use for diagnostics and treatment of diseases and disorders associated with osteopontin. | 08-04-2011 |
Jian Guo, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110071086 | COMPOSITIONS FOR TISSUE REPAIR/REGENERATION - The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium. | 03-24-2011 |
Jihui Guo, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120035318 | POLYURETHANE DISPERSION, METHOD OF PRODUCING THE SAME, COATED ARTICLES, AND METHOD FOR COATING ARTICLES - The instant invention is a polyurethane dispersion, method of producing the same, coated articles, and method for coating articles. The polyurethane dispersion according to the present inventions includes (a) one or more polyurethane units derived from one or more prepolymers wherein the one or more prepolymers comprise the reaction product of a mixture dissolved in dipropylene glycol dimethyl ether in the presence of one or more first surfactants with one or more isocyanates, wherein the mixture comprises one or more natural oil based polyols, and one or more adipate polyols, and optionally one or more short diols; and (b) water. | 02-09-2012 |
Lining Guo, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110300571 | Determination of the Liver Toxicity of an Agent - The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant. | 12-08-2011 |
Lining Guo, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110030099 | PLANTS AND MODULATORS FOR IMPROVED DROUGHT TOLERANCE - Methods of conferring increased drought tolerance to a plant by reducing or inhibiting ammonia accumulation, and plants produced thereby. | 02-03-2011 |
Lining Guo, Chapell Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090203612 | XENORHABDUS TC PROTEINS AND GENES FOR PEST CONTROL - The subject invention relates to novel | 08-13-2009 |
Rong Guo, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090181116 | AXMI-031, AXMI-039, AXMI-040 AND AXMI-049, A FAMILY OF NOVEL DELTA-ENDOTOXIN GENES AND METHODS FOR THEIR USE - Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 8, 10, 12, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, or 38, or the nucleotide sequence set forth in SEQ ID NO:1, 3, 5, 7, 9, 11, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, or 37, as well as variants and fragments thereof. | 07-16-2009 |
Rong Guo, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100162439 | PESTICIDAL GENES FROM BREVIBACILLUS AND METHODS FOR THEIR USE - Compositions and methods for conferring insecticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for a | 06-24-2010 |
| 20110023184 | AXMI-205 PESTICIDAL GENE AND METHODS FOR ITS USE - Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof. | 01-27-2011 |
| 20110030096 | AXMI-192 Family of Pesticidal Genes and Methods for Their Use - Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:28-62, or the nucleotide sequence set forth in SEQ ID NO:1-27, as well as variants and fragments thereof. | 02-03-2011 |
| 20110263488 | FAMILY OF PESTICIDAL PROTEINS AND METHODS FOR THEIR USE - Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 4, 6, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37 or 61, the nucleotide sequence set forth in SEQ ID NO:1, 3, 5, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 60, or the nucleotide sequence deposited in a bacterial host as Accession No. NRRL B-30961, B-30955, B-30956, B-30957, B-30958, B-30942, B-30939, B-30941, B-50047, B-30959, B-30960, B-30943, or B-50048, as well as variants and fragments thereof. | 10-27-2011 |
Xiaochuan Guo, High Point, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100152170 | Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors - The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention. | 06-17-2010 |
Xiao-Chuan Guo, High Point, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20120088778 | AZOLE DERIVATIVES AND FUSED BICYCLIC AZOLE DERIVATIVES AS THERAPEUTIC AGENTS - This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis. | 04-12-2012 |