Patent application number | Description | Published |
20100138268 | PROGRESS MANAGEMENT PLATFORM - A device receives milestone information and dependency information associated with a project, generates a milestone flow chart based on the milestone information and the dependency information, and represents one or more milestones, in the milestone flow chart, with one or more nodes. The device also represents one or more dependencies among the one or more milestones with one or more directed arcs provided between corresponding nodes of the one or more nodes, and calculates a critical path associated with the one or more milestones. The device further represents the critical path with bolded directed arcs provided between corresponding nodes of the one or more nodes, and provides the milestone flow chart, including the representations of the one or more milestones, the one or more dependencies, and the critical path, for display. | 06-03-2010 |
20150189495 | PROVIDING DEVICE-TO-DEVICE CONNECTIVITY BY DETERMINING COMMUNICATION PREFERENCES IN REAL-TIME - A device may determine a condition for providing customer information to a mobile device. The device may detect the mobile device, and may request, from the mobile device and based on detecting the mobile device, information that identifies a user communication preference associated with providing the customer information to the mobile device. The device may receive, from the mobile device and based on the request, the information that identifies the user communication preference. The device may determine whether the customer information is to be provided to the mobile device based on the user communication preference and the condition, and may selectively provide the customer information and an instruction to the mobile device based on determining whether the customer information is to be provided to the mobile device. The instruction may cause the mobile device to relay the customer information to a network storage device. | 07-02-2015 |
Patent application number | Description | Published |
20090213816 | Timeslot Sharing Protocol for Wireless Communication Networks - A method for transmitting information in a communication network of multiple nodes, in which information transmission is partitioned into successive superframes, and in which each superframe is partitioned into a beacon period followed by a data period, which may consist of a contention free period (CFP), and each beacon period and CFP of the data period is partitioned into timeslots. The method includes allocating to at least a first node of the multiple nodes a designated timeslot in which to transmit data in at least one of a plurality of superframes, and allocating to at least a second node of the multiple nodes the same designated timeslot in which to transmit information during at least one subsequent superframe. | 08-27-2009 |
20100182982 | Method for Broadcasting Alert Message in Mobile Multi-Hop Networks Using Inferred Distance Prioritization - A method and system broadcasts an alert packet in a wireless multi-hop network of nodes. An event is sensed in a source node of the network, and an alert packet is broadcast in response to sensing the event. The alert packet is received in a set of candidate nodes within a broadcast range of the source node. Each candidate node infers a distance between the candidate node and the source node based on a receive power of the received alert packet, and determines a priority for rebroadcasting the alert packet, wherein the priority is based on the distance to minimizing a probability of collisions while rebroadcasting the alert packet and extend a range of the rebroadcasting. | 07-22-2010 |
20100208690 | Fast Handover Protocols for Wimax Networks - A method performs handover of a mobile station (MS from a current base station (BSC) connected to a target base station (BST) via a backbone in a Worldwide interoperability for Microwave Access (WiMAX) mobile communication network. The MS, before handover, transmits a Connection Identifier Request (CID-REQ) to the BST via the BSC, and receiving a Connection Identifier Response (CID-RSP) from the BST via the BSC. The MS, before handover, transmits a Subscriber Station (SS) Basic Capability Request (SBC-REQ), and receives a SS Basic Capability Response (SBC-RSP) from the BST via the BSC. Then, the MS transmits a Ranging Request (RNG-REQ) to the BST, and receives a Ranging Response (RNG-RSP) from the BST. During the handover, the MS transmits a Registration Request (REG-REQ) to the BST, and receives a Registration Response from the BST to establish the connection between the MS and the BST. | 08-19-2010 |
20110128849 | Signaling for Safety Message Transmission in Vehicular Communication Networks - Messages are broadcast in a vehicular environment using a network of nodes. Each node includes a transceiver and a processor arranged in a vehicle. A bandwidth of the network is partitioned into a set of channels including a control channel (CCH) and multiple service channel (SCH). Time is partitioned into alternating control channel intervals (CCHI) and service channel intervals (SCHI). A particular node transmits an attention signal indicating intent to access a particular channel to transmit a high priority safety message, wherein the network is designed according to a standard for a vehicular environment. The node then waits a random length backoff time and transmits the high priority safety message related to the vehicular environment after the random length backoff time. | 06-02-2011 |
20110128902 | Broadcasting Messages in Multi-Channel Vehicular Networks - Message are broadcast in a vehicular environment using a network of nodes, wherein each node includes a transceiver and a processor arranged in a vehicle, and a bandwidth of the network is partitioned into a control channel (CCH) and multiple service channel (SCH). Time is partitioned into alternating control channel intervals (CCHI) and service channel intervals (SCHI). A source node detects an event and broadcasts a message related to the event. The message specifies current channels and next channels used by the source node to broadcast the message. The message is received in a set of relay nodes. Then, each relay node that receives the message rebroadcasts the message during the SCHI on the CCH or any other channels not specified in the message. | 06-02-2011 |
20110164556 | Wireless Star Networks with Dual Adaptive Central Nodes - A wireless network with a star topology has a first and second central node. The first central node starts up first and initiates the network. The second central node starts up second and synchronizes to the first central node, and wherein one node is in active mode and the other node is in standby mode, and a set of leaf nodes configured to communicate only with the active node. | 07-07-2011 |
20120129458 | Wireless Communication Network for Transportation Safety Systems - In a network for a safety system in a transportation system, the transportation system includes a shaft and a car arranged in the shaft. A first wall node is at a first end of the shaft and a second wall node is at a second end of the shaft to communicate safety messages with the car. Each wall node includes at least one wireless transceiver connected to one or more antennas. Each car in the shaft includes at least two wireless transceiver connected to one or more antennas, wherein the first transceiver of the car uses a first frequency and the second transceiver of the car uses a second frequency to communicate each safety messages in duplicate. A wired backbone connects the set of wall nodes to a controller of the safety system of the transportation system. | 05-24-2012 |
Patent application number | Description | Published |
20110176416 | Method for Discovering Multiple Routes in Sensor Networks - Multiple routes from a data source node to multiple data destination nodes in a large scale multi-hop mesh network are discovered. Nodes discover multiple routes to two destinations in an initial discovery phase that includes only two network-wide flooding of packets. The method can also work with one destination. The method can be extended to include more destinations with a proportional increase in the communication overhead. After the completion of the discovery phase, nodes can communicate or forward their own or received data by using any of the available routes. | 07-21-2011 |
20120147864 | Synchronous Data Transmission in Hybrid Communication Networks for Transportation Safety Systems - A hybrid communication network for a transportation safety system includes a wired network including a set of fixed nodes. Each fixed node includes a wired interface for connecting the fixed node to the wired network and at least one wireless interface. The set of fixed nodes further includes a head node at a first end of the wired network connected to a controller, a terminal node at a second end of the wired network, and a set of relay nodes arranged between the head node and the terminal node. A wireless network includes a set of mobile nodes and a set of fixed nodes connected to the wired network. Each mobile node includes at least one of the wireless interfaces, and each mobile node is arranged in a moveable car. | 06-14-2012 |
20120147879 | Method for Scheduling Data Transmission in Hybrid Communication Networks for Transportation Safety Systems - A hybrid communication network for a transportation safety system includes a fixed wired nodes and mobile wireless nodes. Because the wired nodes operate independently packets transmitted by the wired nodes to the wireless nodes need to be synchronized. A downlink travel time for downlink packets traveling from a controller to the wireless nodes is determined. Then, the controller schedules downlink data intervals (DDI) based on the downlink travel time; and transmits downlink packets to the wireless nodes during the DDI, such that a latency requirement of the transportation safety system is satisfied. | 06-14-2012 |
20120163486 | Method of Selecting Antennas in a Wireless Communicating Network for High Reliability and Low Latency - A network includes a transmitter and a receiver, wherein the transmitter includes a set of transmit antennas and the receiver includes a set of receive antennas. The transmitter duplicates a packet as copies of the packet, and selects subsets of the set of transmit antennas independent of channel characteristics between the subsets of transmit antennas and the set of receive antennas, wherein combinations of the antennas in the subsets of the transmit antennas are different. The receiver selects subsets of the set of receive antennas independent of channel characteristics between the subsets of receive antennas and the set of transmit antennas, wherein combinations of the antennas in the subsets of the receive antennas are different. The selected subsets are used to transmit the packet, and retransmit the packet in case of a failure in a previous transmission. | 06-28-2012 |
20120327792 | Method for Discovering and Maintaining Routes in Smart Meter Networks - A set of routes are discovered in a network including concentrators, smart meters and an imaginary node. Each concentrator node, a source, broadcasts a route request (RREQ) packet to the imaginary destination node. Intermediate nodes store a route as a node list (NL) in the RREQ packet and as a route table (RT) in the node. Then, each smart meter node can select a primary route and a secondary route from the smart meter node to any concentrator from the route table. | 12-27-2012 |
20130119770 | Network Architectures for Distributed Resource Management in Electric Power Systems - A network for managing distributed resources (DRs) is connected to an electric power system (EPS). The network includes a set of controllers, and multiple sets of the DRs, wherein each controller is connected to one of the sets of the DRs by a personal area network (PAN). A management system connects the EPS and the set of controllers by a wide area network (WAN). The EPS generates commands for selected DRs to take actions, the commands are routed to the selected DRs via the WAN and PANs. | 05-16-2013 |
20130158903 | Method and System for Detecting Transients in Power Grids - Conditions in a power grid are detected by sampling a voltage in the grid. A normal condition hypothesis is modeled as a sinusoid, and a transient condition hypothesis is modeled as a sum of damped sinusoids. The samples are used to construct probability density function. A likelihood ratio based on the pdf and the hypotheses is compared to a threshold to determine whether the condition is normal or transient. | 06-20-2013 |
20130208583 | Avoiding Broken Links in Smart Meter Networks for Loop-Free Routing of Packets - Broken links in a sensor network are avoided by representing the network as a DODAG. A rank associated with each node defines a position of each node relative to other nodes, and the rank is in a form of a proper fraction, and the rank of each node never increases to enable loop-free routing. | 08-15-2013 |
20130223334 | Channel Scan for Smart Meter Networks to Determine Operating Channels - An operation channel in a multi-hop network is determined. The network uses a set of channels, and one of the nodes is a network management node. The operation channel is selected in the network management node. Then, the network management node broadcasts a channel information packet including the operation channel using all channels. The channel information packet is received in each of other nodes, either directly from the network management node or from an intermediate node that received and rebroadcasted the channel information packet. Lastly, the operation channel in each node is set according to the channel information packet until the network is formed. | 08-29-2013 |
20130262648 | Location Based Data Delivery Schedulers - Packets are transmitted by a server to mobile nodes in a coverage area of a wireless network using a coverage and reliability map, which indicates qualities and reliabilities of links between the server and the nodes. When a new packet is received in the server, the server transmits the packet if a current load of the packets including the new packet is less than a peak load constraint. Otherwise, the new packet is delayed for one time slot. Packets are transmitted according to associated priorities. | 10-03-2013 |
20140204759 | Load Balanced Routing for Low Power and Lossy Networks - A node includes a receiver for receiving a first packet from a first node at a first time and a second packet from a second node at a second time, a processor for determining the first time and the second time and for comparing the first time with the second time to produce a ratio of workloads of the first node and the second node, and a transmitter for transmitting packets to the first and the second nodes based on the ratio. | 07-24-2014 |
20140244187 | Method for Detecting Islanding with Periodically Transmitted Sequence of Unsynchronized Signals - Conditions in a power grid are detected by sampling a voltage in the grid. A normal condition hypothesis is modeled as a sinusoid, and a transient condition hypothesis is modeled as a sum of damped sinusoids. The samples are used to construct a probability density function. A likelihood ratio based on the pdf and the hypotheses is compared to a threshold to determine whether the condition is normal or transient. | 08-28-2014 |
20140304383 | Method for Clustering Devices in Machine-to-Machine Networks to Minimize Collisions - Nodes in a network are clustered by first determining, in each node, a cluster head capability (CHC). The CHC is broadcasting, directly or indirectly, until all nodes have received the CHCs. Each node nominates, one or more candidate cluster heads based on the CHCs, and then, in each node, at least one cluster head is selected from the candidate cluster head nodes based on maximal CHCs. | 10-09-2014 |
20150085668 | Discovering Stable Routes in Wireless Networks - A method discovers routes for forwarding packets from source nodes (sources) to sink nodes (sinks) in a wireless network, wherein some neighboring sources act as relay nodes. Each source measures a rate of receiving control messages from each neighboring node. Then, the data packets are forwarded from a particular source to the sink via the neighboring nodes having a lowest rate. | 03-26-2015 |
20150085696 | Method for Discovering Neighboring Nodes in Wireless Networks - A method discovers neighboring nodes in a wireless network of nodes. The nodes include a set of concentrators acting as IPv6 routers and a set of sensor nodes acting as IPv6 hosts. The sensor nodes can also act as relay nodes. In each node, a 64-bit interface ID is configured using a 48-bit MAC address. In each node, a unique IPv6 link-local address is configured using the 64-bit interface ID. In each node, the neighboring nodes are discovered by transmitting unsolicited Neighbor Advertisement (NA) messages. A Router Advertisement (RA) messages is distributed from the concentrators to the sensor nodes meters by using the relay nodes. In each node, a unique IPv6 address is configured and registered at the concentrators by using the relay nodes. | 03-26-2015 |
20150156736 | Passive Synchronization in Wireless Networks - A method for synchronizing a node to a data sink determines a first time of receiving by the node a packet transmitted by a neighboring node and a second time of receiving by the data sink or a synchronized neighboring node the packet transmitted by the neighboring node. The node is synchronized to the data sink based on the difference between the first time and the second time. | 06-04-2015 |
20150156738 | Synchronized Multi-Sink Routing for Wireless Networks - A method transmitting packets in a wireless network including a node, a first data sink and a second data sink is disclosed. The method performs a synchronization of the node with the first data sink and the second data sink and transmits first data packets from the node to the first data sink at a first allocated time synchronized with the first data sink. Next, the method transmits second data packets from the node to the second data sink at a second allocated time synchronized with the second data sink. The first and the second data packets are transmitted without updating the synchronization. | 06-04-2015 |
Patent application number | Description | Published |
20080249239 | Process for improving water-whitening resistance of pressure sensitive adhesives - Pressure sensitive adhesive compositions having enhanced resistance to water-whitening comprising an aqueous emulsion polymer are disclosed. The polymer comprises the polymerization reaction product of a polymerizable aqueous emulsion comprising: (i) at least one hydrophobic alkyl acrylate or alkyl methacrylate ester of an alcohol, (ii) at least about 1 wt. % of at least one hydrophilic monomer, (iii) at least about 5 wt. % of at least one partially hydrophilic alkyl acrylate or alkyl methacrylate ester of an alcohol, and (iv) a water-soluble or water-dispersible polymerizable surfactant selected from compounds having a terminal allyl amine moiety, substituted phenyl compounds having at least one alkenyl substituent, polyoxyalkylene-1-(allyloxymethyl) alkyl ether sulfate salts, or mixtures thereof, and the average particle size of the polymer is less than or equal to 200 nm. Also disclosed are processes for preparing same. | 10-09-2008 |
20090299004 | Pressure Sensitive Adhesives - PSAs having high shear stability are disclosed. The PSAs are obtained from an aqueous dispersion comprising an effective amount of surfactant mixture comprising at least one ionic surfactant comprising a plurality, preferably at least three, aromatic rings, at least one electronegative substituent selected from a mono valent oxy substituted sulfo anion, and/or a mono valent oxy substituted phospho anion, and optionally at least one substituent comprising one or more repeating alkoxy units (e.g. Soprophor 4D 384 and/or DPOS-45), and at least one non-ionic surfactant (e.g. Abex 2535) and a monomer composition comprising: at least one hydrophobic monomer (Component I), at least one hydrophilic monomer (Component II) at least one partially hydrophilic monomer (Component III). The dispersion forms PSAs which are sufficiently stable under high shear to be curtain coatable. | 12-03-2009 |
20100016493 | Pressure Sensitive Adhesives - PSAs having enhanced resistance to water-whitening and high shear stability are disclosed. The PSAs are obtained from an aqueous dispersion comprising an effective amount of surfactant mixture comprising at least one ionic surfactant comprising a plurality, preferably at least three, aromatic rings, at least one electronegative substituent selected from a mono valent oxy substituted sulfo anion, and/or a mono valent oxy substituted phospho anion, and at least one substituent comprising one or more repeating alkoxy units (e.g. Soprophor 4D 384), and at least one non-ionic surfactant (e.g. Abex 2535) and a further non aromatic ionic surfactant (e.g. Aerosol OT 75); and a monomer composition comprising: at least one hydrophobic monomer (Component I), at least one hydrophilic monomer (Component II) at least one partially hydrophilic monomer (Component III) and optionally at least one a ureido monomer (e.g. Norsocryl 102) (Component IV). The dispersion has an average particle size of from about 100 nm to about 400 nm and a pH of from about 5.5 to about 9.0. The latex forms PSAs which have good water whitening resistance and is sufficiently stable under high shear to be curtain coatable. | 01-21-2010 |
20100081764 | AQUEOUS POLYMER DISPERSION AND PROCESS - There is described a multi step process for preparing an aqueous dispersion of heterogeneous polymer particles by mini-emulsion polymerisation, the process comprising the steps of (I) (a) forming a mixture comprising: (i) water; (ii) at least one stabiliser (such as a surfactant and a hydrophobic co-stabiliser); (iii) at least one tackifier (such as polyterpenes, rosin resins and/or hydrocarbon resins); (iv) at least one α,β-ethylenically unsaturated monomer; (b) applying high shear to the mixture from step (a) to form an essentially stable mini-emulsion comprising an aqueous continuous phase and dispersed therein stabilised droplets of average diameter from about 10 to about 1000 nm, (c) polymerising the monomer(s) within the droplets in the presence of a free radical initiator; (d) adding further monomer to the dispersed phase to form a dispersion; then: (II) using the dispersion from step (I) as a seed to form a dispersion of heterogeneous polymer particles in a subsequent emulsion polymerisation. The resultant tackified PSAs may have a core shell structure and are stable under high shear. | 04-01-2010 |
20100093930 | Polymer Composition and Process - There is described a multi step mini-emulsion process for preparing a hybrid acrylic/polyurethane pressure sensitive adhesive (PSA) of very high shear strength, good peel strength and/or also high moisture vapor transmission rate, the process comprising the steps of: a) forming a first aqueous mixture comprising a hydrophilic stabilizer; b) forming separately a second oil mixture comprising: i) at least one vinyl functional polyurethane (optionally prepared from an isocyanate functional monomer; at least one monol and/or at least one α,β-ethylenically unsaturated monomer ii) optionally at least one hydrocarbon polymer (such as polystyrene); and iii) at least one α,β-ethylenically unsaturated monomer (such as (meth)acrylate or acids thereof; and/or iv) option-=ally at least one hydrophobic stabilizer; where components (ii), (iii) and/or (iv) may optionally be the same; c) mixing the aqueous and oil mixtures together to form a pre-(macro) emulsion; d) generating a stable mini-emulsion there-from optionally by applying high shear to form an aqueous continuous phase and stabilized oil droplets of average diameter from about 10 to about 1000 nm, and e) polymerizing the polymer precursor(s) within the droplets, optionally in the presence of a free radical initiator; to obtain a polymer latex. | 04-15-2010 |
Patent application number | Description | Published |
20140213738 | POLY(ESTER AMIDE)S AND POLY(ESTER ETHER AMIDE)S WITH ALIPHATIC POLYESTERS, METHOD OF MAKING SAME, AND USES THEREOF - Polymers and copolymers having one or more aliphatic polyester groups or blocks. For example, the aliphatic polyester groups or blocks can be derived from a caprolactone such as, for example, ε-caprolactone. The polymers and copolymers can have desirable properties such as, for example, improved solubility and improved thermal properties. | 07-31-2014 |
20140275325 | Compositions and Devices of Poly-4-Hydroxybutyrate - Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues. | 09-18-2014 |
20140277572 | Ultrafine Electrospun Fibers of Poly-4-Hydroxybutyrate and Copolymers Thereof - Methods to produce structures containing ultrafine fibers with average diameters from 10 nm to 10 μm and more preferably from 50 nm to 5 μm, have been developed. These methods produce ultrafine fibers without substantial loss of the polymer's weight average molecular weight. The ultrafine electrospun fibers have an unexpectedly higher degree of molecular orientation, and higher melt temperature than fibers derived by dry spinning. In the preferred embodiment, the polymer comprises 4-hydroxybutyrate. The ultrafine fibers are preferably derived by electrospinning. A solution of the polymer is dissolved in a solvent, pumped through a spinneret, subjected to an electric field, and ultrafine fibers with a high degree of molecular orientation are collected. These structures of ultrafine fibers can be used for a variety of purposes including fabrication of medical devices. | 09-18-2014 |
Patent application number | Description | Published |
20110015367 | UNSATURATED POLY(ESTER-AMIDE) AND POLY(ETHER ESTER AMIDE) BIOMATERIALS - Functionalized poly(ester-amides) and poly(ether ester amides) polymers having the structural formula: | 01-20-2011 |
20120150285 | MEDICAL DEVICES CONTAINING DRY SPUN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS - Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices. | 06-14-2012 |
20130085185 | CONTROLLED HYDROLYSIS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS - Methods for making P4HB polymers and copolymers thereof that are useful for preparing controlled release systems, medical devices and as intermediates in chemical synthesis, have been developed. These methods avoid the use of organic solvents, and basic conditions that can cause transesterification reactions with polymer terminal end groups or elimination reactions. A preferred embodiment is a method for producing polymers of P4HB with weight average molecular weight less than 250,000, and more preferably, less than 100,000, and a Pd of less than 3, which are useful in controlled release. A particularly preferred embodiment utilizes aqueous acetic acid to hydrolyze pellets of P4HB polymers and copolymers while in suspension. | 04-04-2013 |
Patent application number | Description | Published |
20090142806 | INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR - The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling. | 06-04-2009 |
20100075329 | METHODS FOR PREDICTING PRODUCTION OF ACTIVATING SIGNALS BY CROSS-LINKED BINDING PROTEINS - The present invention provides human binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL21R), and uses therefore. The invention further provides methods to predict whether the binding proteins of the invention may take on agonistic activities in vivo and produce a cytokine storm. In addition, the invention provides methods for determining whether an anti-IL21R binding protein is a neutralizing anti-IL21R binding protein, based on the identification of several IL21-responsive genes. The binding proteins can act as, e.g., antagonists of IL21R activity, thereby modulating immune responses in general, and those mediated by IL21R in particular. | 03-25-2010 |
20110033451 | INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR - The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling. | 02-10-2011 |