Patent application number | Description | Published |
20110145692 | Method for Tracking Annotations with Associated Actions - A method for tracking annotations on a document is contemplated. A first annotation defined by a plurality of first annotation attributes is received. Thereafter, a primary visual representation of the first annotation is generated according to the first annotation attributes. The method continues with associating an action identifier with the first annotation as an action link. A thumbnail representation of the first annotation is generated in a toolbox window. A second annotation defined by a plurality of second annotation attributes and associated with the action identifier derived from the action link for the first annotation is linkable to the document in response to a selection input of the thumbnail representation of the first annotation. | 06-16-2011 |
20110302506 | Method for Multi-User Collaboration on Visual Content Based Upon the Exchange of Session Data Objects Including New Parameters - A method and system for coordinating visual content collaboration is disclosed. A collaboration session is first established from a server with a plurality of participant nodes. The visual content is transmitted to each of the participant nodes. A session data object is received by the collaboration server from a first one of the participant nodes, and may include view parameters specific to the display of the visual content thereon. A session record entry is generated from the received session data object, and is then transmitted from the collaboration server to one or more of the participant nodes. The view parameters are then applied to the receiving participant nodes. | 12-08-2011 |
20120198331 | METHOD FOR ALIGNING A MODIFIED DOCUMENT AND AN ORIGINAL DOCUMENT FOR COMPARISON AND DIFFERENCE HIGHLIGHTING - A method for aligning a modified document and an original document is provided according to an aspect of the present invention. The method includes a step of receiving a first bitmap representative of the modified document, including a first anchor. Additionally, a second bitmap representative of the original document including a second anchor is received. The method also includes the step of deriving a set of first vertex coordinates of the first anchor, and a set of second vertex coordinates of the second anchor. The method further includes the step of transforming the first bitmap to a common reference based upon the first set of vertex coordinates, and the step of transforming the second bitmap to the common reference based upon the second set of vertex coordinates. | 08-02-2012 |
20120299944 | METHOD FOR EMPHASIZING DIFFERENCES IN GRAPHICAL APPEARANCE BETWEEN AN ORIGINAL DOCUMENT AND A MODIFIED DOCUMENT WITH ANNOTATIONS INCLUDING OUTER AND INNER BOUNDARIES - A method for emphasizing differences in graphical appearances between an original document and a modified document is provided in accordance with an aspect of the present invention. The method includes the step of receiving a first bitmap of the modified document, and a second bitmap of the original document. The method includes deriving a set of difference points based upon a comparison of the first bitmap and the second bitmap. The method includes a step of superposing a spatial index onto the set of difference points, and generating polygon vertices from a plurality of adjacent elements of index. Each of the elements has a predetermined density of difference points. The method concludes with generating an annotation from the polygon vertices. | 11-29-2012 |
20130249906 | METHOD FOR INDICATING ANNOTATIONS ASSOCIATED WITH A PARTICULAR DISPLAY VIEW OF A THREE-DIMENSIONAL MODEL INDEPENDENT OF ANY DISPLAY VIEW - An annotation method for a three-dimensional model is disclosed. A first set of data representative of a three-dimensional model is stored in a computer memory. A second set of data representative of an annotation is also stored in the computer memory. The annotation is associated with a first spatial location on the three-dimensional model and a first display view. The three-dimensional model and a first graphical representation of the annotation is displayed according to the first display view, with the annotation being positioned as specified by the associated first spatial location. The displaying of the three-dimensional model is modified to a second display view different from the first display view. The annotation is removed from the display window, and an annotation indicator associated with the annotation is displayed. The annotation indicator is visible independent of any display view of the three-dimensional model. | 09-26-2013 |
20140215322 | METHOD FOR MANAGING AND SELECTIVELY ARRANGING SETS OF MULTIPLE DOCUMENTS AND PAGES WITHIN DOCUMENTS - A method of computerized presentation of a plurality documents is disclosed. There is at least one original document with at least one original document page, and an addendum document with at least one addendum document page. A first selection of the at least one original document is received. There is a page sequencing array defined by an arrangement of each original document. A second selection of the addendum document is received. Each of the at least one addendum document page is correlated to an original document page. A document set is generated, using the first selection and the second selection. For each addendum document in the document set, a priority identifier is determined. A document set view is generated from the document set with the original document pages and the addendum document pages, and is defined by an ordered page selection according to the page sequencing array. | 07-31-2014 |
Patent application number | Description | Published |
20080262747 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 10-23-2008 |
20090186349 | DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS - The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays. | 07-23-2009 |
20100137166 | INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 06-03-2010 |
20100138162 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD USING A SUBSET OF SITES OF A SUBSTRATE - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 06-03-2010 |
20110009278 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 01-13-2011 |
20110009296 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 01-13-2011 |
20120129716 | USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS - The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. | 05-24-2012 |
20120202704 | MULTI-SAMPLE INDEXING FOR MULTIPLEX GENOTYPING - A method for determining the presence of multiple nucleotide sequences of interest in multiple samples while preserving the identity of each sample, by contacting the samples with a plurality of probe sets. The probes are designed to indicate the presence of the sequences of interest and the identity of the sample containing the sequence of interest in complex mixtures. Applications of the method include genotyping, expression analysis, and identification of individual species in complex samples. Kits of probe sets for use in the methods are also provided. | 08-09-2012 |
20120208705 | LINKING SEQUENCE READS USING PAIRED CODE TAGS - Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids. | 08-16-2012 |
20120208724 | LINKING SEQUENCE READS USING PAIRED CODE TAGS - Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target nucleic acids. | 08-16-2012 |
20120316086 | PATTERNED FLOW-CELLS USEFUL FOR NUCLEIC ACID ANALYSIS - Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces. | 12-13-2012 |
20130288931 | INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate. | 10-31-2013 |
20130316917 | SELECTIVE ENRICHMENT OF NUCLEIC ACIDS - Methods for the selective enrichment of nucleic acids. | 11-28-2013 |
20130331288 | DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS - The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays. | 12-12-2013 |
20130338042 | KINETIC EXCLUSION AMPLIFICATION OF NUCLEIC ACID LIBRARIES - A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated. | 12-19-2013 |
20130345067 | USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS - The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. | 12-26-2013 |
20140315729 | DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS - The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs). Similarly, the invention finds use in the detection and quantification of a nucleic acid target using a variety of amplification techniques, including both signal amplification and target amplification. The methods and compositions of the invention can be used in nucleic acid sequencing reactions as well. All applications can include the use of adapter sequences to allow for universal arrays. | 10-23-2014 |
20140329723 | PATTERNED FLOW-CELLS USEFUL FOR NUCLEIC ACID ANALYSIS - Provided is a surface having metal regions and an interstitial region having a composition that differs from the metal regions, wherein a continuous gel layer coats the surface across the metal regions and the interstitial regions. Nucleic acids or other analytes can be attached to the continuous gel layer such that a greater amount is attached over the metal regions than over the interstitial region. Also provided are methods for making such surfaces. Methods are also provided for making an array of nucleic acids or other analytes using such surfaces. | 11-06-2014 |
20140364323 | MULTI-SAMPLE INDEXING FOR MULTIPLEX GENOTYPING - A method for determining the presence of multiple nucleotide sequences of interest in multiple samples while preserving the identity of each sample, by contacting the samples with a plurality of probe sets. The probes are designed to indicate the presence of the sequences of interest and the identity of the sample containing the sequence of interest in complex mixtures. Applications of the method include genotyping, expression analysis, and identification of individual species in complex samples. Kits of probe sets for use in the methods are also provided. | 12-11-2014 |
20150024965 | USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS - The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes. | 01-22-2015 |
20150072871 | NUCLEIC ACID SEQUENCING SYSTEM AND METHOD - A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected. | 03-12-2015 |
20150080230 | KINETIC EXCLUSION AMPLIFICATION OF NUCLEIC ACID LIBRARIES - A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated. | 03-19-2015 |
Patent application number | Description | Published |
20080242560 | METHODS FOR GENERATING AMPLIFIED NUCLEIC ACID ARRAYS - The present invention relates to methods for generating an array of amplified nucleic acid sequences. The methods can utilize amplicons that form nucleic acid balls that can be arrayed on a solid support. The invention additionally provides methods for obtaining targeted nucleic acid sequences. | 10-02-2008 |
20130116153 | MICROARRAY FABRICATION SYSTEM AND METHOD - A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites. | 05-09-2013 |
20140200158 | MICROARRAY FABRICATION SYSTEM AND METHOD - A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites. | 07-17-2014 |
20140274746 | SUPER RESOLUTION IMAGING - A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad. | 09-18-2014 |
20140274747 | SUPER RESOLUTION IMAGING - A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad. | 09-18-2014 |