Patent application number | Description | Published |
20100209991 | IONIC LIQUIDS DERIVED FROM FUNCTIONALIZED ANIONIC SURFACTANTS - A novel class of ionic liquids and methods for their preparation are disclosed. Specifically, these novel ionic liquids can be derived from anionic surfactants, such as alkyl aryl sulfonates, and mid-chain branched derivatives of alkyl sulfates, alkyl alkoxy sulfates, and alkyl aryl sulfonates. In addition, novel ionic liquids can be derived from other anionic surfactants, such as methyl ester sulfonates (MES), alkyl glycerol ether sulfonates, and alpha olefin sulfonates. Anions may be paired with a variety of cations to achieve various advantageous properties. The present invention also relates to compositions containing these novel ionic liquids and method of using the same. | 08-19-2010 |
20110152566 | Process for Conducting an Organic Reaction in Ionic Liquids - The present disclosure describes processes for producing cyclohexenes using Lewis acidic ionic liquids comprising the steps of providing to a reactor an α,β-unsaturated carbonyl dienophile, providing to the reactor a 1,3-diene, providing a Lewis acidic ionic liquid to the reactor; and reacting the α,β-unsaturated carbonyl dienophile with 1,3-diene to form a substituted cyclohexene product. The α,β-unsaturated carbonyl dienophile can be mesityl oxide, the 1,3-diene can be piperylene; and the Lewis acidic ionic liquid can be AlCl | 06-23-2011 |
20110152575 | Processes for Epimerizing Cyclohexenyl Ketones with Subsequent Aldol Condensation to Produce Fragrance Compounds - The present disclosure describes processes for the epimerization of a cyclohexene comprising the steps of providing to a reactor a first isomer of a 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone compound according to Formula I | 06-23-2011 |
Patent application number | Description | Published |
20130065949 | MICRORNA MIRNA-31 AS A THERAPEUTIC APPROACH FOR THE TREATMENT OF CANCER - The present invention generally concerns methods and compositions for treating and/or preventing cancer with microRNAs. In specific embodiments, the present invention encompasses a particular microRNA, microRNA-31, as useful in cancer therapy and/or prevention. Specific cancers may be treated, including at least ovarian, prostate, urothelial, osteosarcoma, and glioblastoma. | 03-14-2013 |
20130177624 | MIRNA EXPRESSION IN ALLERGIC DISEASE - Disclosed are methods for detecting an allergic lung disease that involve assessing the level of one or more microRNAs (miRNAs) in a biological sample, wherein the level of the one or more miRNAs in the biological sample compared to a reference level of the one or more miRNAs is indicative of allergic lung disease. Also disclosed are methods for the treatment or prevention of inflammatory or allergic lung disease that involve administration of a let-7 miRNA inhibitor as set forth herein, as well as biochips and kits that can be applied in the methods of the present invention. | 07-11-2013 |
20150159159 | MICRORNAs SENSITIZE CANCERS TO THERAPY - The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including sensitization to cancer therapy or prevention of a cancer to become sensitized to a cancer therapy. In specific embodiments, the microRNAs include miR-520a (including at least miR-520a-3p and miR-520-5p), miR-520g, miR-520h, and functional variants thereof. In some embodiments, the cancer is ovarian cancer, and in particular embodiments, the cancer therapy is platinum-based chemotherapy. | 06-11-2015 |
Patent application number | Description | Published |
20120029062 | Interior functionalized hyperbranched dendron-conjugated nanoparticles and uses thereof - Provided herein are nanoparticle platforms and combinatorial drug delivery vehicles comprising gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment. | 02-02-2012 |
20120251619 | MicroRNA-29a,b,c as a Tumor Suppressor and Sensitizing Agent for Chemotherapy - The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA 29 or an agent that mimics the effects of microRNA 29. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA 29 or an agent that enhances the expression of microRNA 29. | 10-04-2012 |
20120269883 | MicroRNA-140-5P as a Tumor Suppressor and Sensitizing Agent for Chemotherapy - The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p. | 10-25-2012 |
20130089597 | MicroRNA-130a,b as a Tumor Suppressor and Sensitizing Agent for Chemotherapy - The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-130 or an agent that mimics the effects of microRNA-130. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-130 or an agent that enhances the expression of microRNA-130. | 04-11-2013 |
20140128451 | Compositions and Methods for Delivery of MicroRNA to Cells - Provided herein are gold nanoparticles mediated non-viral delivery of miRNAs, siRNAs, genes and drugs. Nanoparticle platforms and combinatorial drug delivery vehicles comprises gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Successful manipulation of the degree of PEGylation and the amount of gold nanoparticles in a polyelectrolyte complex to evaluate the best formulation for highest payload delivery of chemically unmodified miRNA duplexes and stemloops is presented. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment. | 05-08-2014 |
Patent application number | Description | Published |
20100238034 | SYSTEM FOR RAPID DETECTION OF DROWSINESS IN A MACHINE OPERATOR - The present invention discloses a system and a process for rapidly detecting drowsiness in a individual operating a machine. The system can capture a plurality of facial images of the individual and compare one or more facial parameters from the images to a plurality of stored high priority sleepiness facial actions that are in a prioritized action database. Based on the comparison, a current level of sleepiness can be determined for the individual and an actuator can be actuated in order to alert the individual and possibly any other individuals that may be in the vicinity. | 09-23-2010 |
20100322507 | SYSTEM AND METHOD FOR DETECTING DROWSY FACIAL EXPRESSIONS OF VEHICLE DRIVERS UNDER CHANGING ILLUMINATION CONDITIONS - The present invention includes a method of detecting drowsy facial expressions of vehicle drivers under changing illumination conditions. The method includes capturing an image of a person's face using an image sensor, detecting a face region of the image using a pattern classification algorithm, and performing, using an active appearance model algorithm, local pattern matching to identify a plurality of landmark points on the face region of the image. The method also includes generating a 3D face model with facial muscles of the face region, determining photometric flows from the 3D face model using an extract photometric flow module, determining geometric flows from the 3D face model using a compute geometric flow module, determining a noise component generated by varying illuminations by comparing the geometric flows to the photometric flows, and removing the noise component by subtracting two photometric flows. | 12-23-2010 |
20120083942 | METHOD AND SYSTEM FOR RISK PREDICTION FOR A SUPPORT ACTUATION SYSTEM - The present invention relates to a method and system for risk prediction for a support actuation system. The present invention includes a support actuation system for an automobile having a support actuation module and/or a risk prediction system. The risk prediction system includes a sensor, a processor, and/or a memory. The sensor detects images corresponding to identity data, environment data, event data, and/or behavior data, which are stored in the memory. The memory also stores a database including identities of users, environment risk values, event risk values, and/or behavior risk values. Using the identity data, the environment data, the event data, and/or the behavior data, the processor determines the environment risk value, the event risk value, the behavior risk value, and/or the total risk value for a user. When the total risk value is above a predetermined risk threshold, the support actuation module performs support actuation. | 04-05-2012 |
20140125474 | ADAPTIVE ACTUATOR INTERFACE FOR ACTIVE DRIVER WARNING - A method, system, device and computer readable medium for adaptively warning a driver includes detecting a behavior of the driver, the behavior including engagement in a secondary activity, which is an activity other than driving a vehicle. Based on the detected behavior, a level of engagement in the secondary activity is estimated, and, based on the estimated level of engagement in the secondary activity, the driver's level of perception of an external hazard is determined. A warning alert for the driver, when the level of perception is below a threshold is actuated. A reaction of the driver to the actuated warning alert is determined. Based on the reaction of the driver to the actuated warning alert, the warning alert is adjusted, and the warning alert is terminated when the level of perception becomes above the threshold because of the reaction of the driver to the actuated warning alert. | 05-08-2014 |
20140210978 | METHOD AND APPARATUS FOR EARLY DETECTION OF DYNAMIC ATTENTIVE STATES FOR PROVIDING AN INATTENTIVE WARNING - A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency. | 07-31-2014 |
20140340228 | METHOD AND APPARATUS FOR EARLY DETECTION OF DYNAMIC ATTENTIVE STATES FOR PROVIDING AN INATTENTIVE WARNING - A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency. | 11-20-2014 |
20150077272 | INTERACTIVE VEHICLE WINDOW DISPLAY SYSTEM WITH PERSONAL CONVENIENCE REMINDERS - A system for a vehicle that provides personal convenience reminders to a user of a vehicle. The system accesses an off board system such as a personal electronic device of the user to display the personal convenience reminders. The system can also access various off board applications in response to the personal electronic device of the user to further refine the personal convenience reminders in response to a user selection. | 03-19-2015 |