| Patent application number | Description | Published |
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| 20080206804 | ARRANGEMENTS AND METHODS FOR MULTIDIMENSIONAL MULTIPLEXED LUMINESCENCE IMAGING AND DIAGNOSIS - Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the sample and second data associated with second luminescent characteristics of at least one second molecule of the sample can be obtained based on the unpartitioned electro-magnetic radiation. At least two of the photo-luminescent properties of the sample may be measured simultaneously as a function of the first and second data. Further, the information regarding the molecules of the sample may be determined as a function of the photo-luminescent properties. | 08-28-2008 |
| 20080232410 | METHODS, ARRANGEMENTS AND APPARATUS FOR UTILIZING A WAVELENGTH-SWEPT LASER USING ANGULAR SCANNING AND DISPERSION PROCEDURES - Exemplary systems and methods for filtering an electromagnetic radiation can be provided. For example, at least one first arrangement can be provided which is capable of receiving at least one first electro-magnetic radiation and forwarding at least one second electro-magnetic radiation at different angles with respect to a direction of incidence of the first electro-magnetic radiation. At least one second wavelength dispersion arrangement can be provided which is configured to receive the second electro-magnetic radiation, forward at least one third electro-magnetic radiation to the first arrangement and further receive at least one fourth electro-magnetic radiation. The third electro-magnetic radiation can be based on the second electro-magnetic radiation, and the fourth electro-magnetic radiation can be based on the third electro-magnetic radiation. For example, the second arrangement can be configured to forward the second electro-magnetic radiation at different angles with respect to a direction of incidence of the at least one particular electro-magnetic radiation. Exemplary embodiments of methods can be provided to implement such exemplary techniques. | 09-25-2008 |
| 20080234567 | APPARATUS AND METHOD FOR PROVIDING A NONINVASIVE DIAGNOSIS OF INTERNAL BLEEDING - Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data. | 09-25-2008 |
| 20080234586 | SYSTEM AND METHOD FOR PROVIDING NONINVASIVE DIAGNOSIS OF COMPARTMENT SYNDROME USING EXEMPLARY LASER SPECKLE IMAGING PROCEDURE - Exemplary systems and methods can be provided for providing information associated with tissue. For example, it is possible to illuminate the tissue with at least one electromagnetic radiation which is a coherent light and/or a partially coherent light. The electromagnetic radiation reflected from the tissue can be received and speckle patterns may be formed associated with the electromagnetic radiation. In addition, changes can be analyzed in the speckle patterns at time intervals sufficient to measure motion of or within a fascial compartment of the tissue. For example, it is also possible that the electromagnetic radiation is an interfered radiation from a sample and a reference. Further, the speckle patterns can be measured at different depths within the sample by moving the reference. | 09-25-2008 |
| 20080262314 | APPARATUS AND METHODS FOR MEASURING VIBRATIONS USING SPECTRALLY-ENCODED ENDOSCOPY - An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electromagnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electromagnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electromagnetic radiation electromagnetic radiation being returned from the sample and at least one fourth electromagnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion. | 10-23-2008 |
| 20080262359 | SYSTEM AND METHOD PROVIDING INTRACORONARY LASER SPECKLE IMAGING FOR THE DETECTION OF VULNERABLE PLAQUE - Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween. | 10-23-2008 |
| 20080287808 | APPARATUS, PROBE AND METHOD FOR PROVIDING DEPTH ASSESSMENT IN AN ANATOMICAL STRUCTURE - Apparatus and method can be provided for obtaining information regarding at least one portion of an anatomical structure. For example, using at least one first arrangement, it is possible to forward at least one first electromagnetic radiation to the at least one portion. In addition, using at least one second arrangement, it is possible to detect at least one second electromagnetic radiation from the sample, the second electromagnetic radiation being related to the first electromagnetic radiation. The second arrangement can be used to obtain data associated with the second electromagnetic radiation at a plurality of integration times. Further, with at least one third arrangement, it is possible to determine at least one motion characteristic as a function of depth within the portion using the second electromagnetic radiation. The motion characteristic can be determined by obtaining data associated with the second electromagnetic radiation. The data can be speckle data detected by the second arrangement. In addition, using the third arrangement, it is possible to determine optical properties of the portion based on the data. Furthermore, with a fourth arrangement, it is possible to receive the first electromagnetic radiation and generate a plurality of third electromagnetic radiations to irradiate multiple points on the portion. The second arrangement can be used to detect the second electromagnetic radiation from the sample based on the third electromagnetic radiations, and the third arrangement can also be used to determine a plurality of motion characteristics as a function of depth for a plurality of location of the at least one portion as a function of the second electromagnetic radiation. | 11-20-2008 |
| 20080297806 | APPARATUS AND METHOD FOR CONTROLLING RANGING DEPTH IN OPTICAL FREQUENCY DOMAIN IMAGING - Exemplary embodiments of an apparatus are provided. For example, the exemplary apparatus can include at least one first arrangement providing at least one first electro-magnetic radiation to a sample, at least one second electro-magnetic radiation to a first reference and at least one third electro-magnetic radiation to a second reference. A frequency of radiation provided by the first arrangement generally varies over time. The exemplary apparatus may also include at least one second arrangement which is configured to detect a first interference between at least one fourth electro-magnetic radiation associated with the first electro-magnetic radiation and at least one fifth electro-magnetic radiation associated with the second radiation. The second arrangement is also configured to detect a second interference between at least one sixth electro-magnetic radiation associated with the first electro-magnetic radiation and at least one seventh electro-magnetic radiation associated with the third radiation. | 12-04-2008 |
| 20090003765 | IMAGING SYSTEM AND RELATED TECHNIQUES - A method and apparatus for imaging using a double-clad fiber is described. | 01-01-2009 |
| 20090003789 | IMAGING SYSTEM AND RELATED TECHNIQUES - A method and apparatus for imaging using a double-clad fiber is described. | 01-01-2009 |
| 20090022463 | IMAGING SYSTEM AND RELATED TECHNIQUES - A method and apparatus for imaging using a double-clad fiber is described. | 01-22-2009 |
| 20090027689 | METHOD AND APPARATUS FOR PERFORMING OPTICAL IMAGING USING FREQUENCY-DOMAIN INTERFEROMETRY - An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond. | 01-29-2009 |
| 20090036770 | METHOD AND APPARATUS FOR DETERMINATION OF ATHEROSCLEROTIC PLAQUE TYPE BY MEASUREMENT OF TISSUE OPTICAL PROPERTIES - Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content. | 02-05-2009 |
| 20090036782 | SYSTEMS AND METHODS FOR PROVIDING BEAM SCAN PATTERNS FOR HIGH SPEED DOPPLER OPTICAL FREQUENCY DOMAIN IMAGING - An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points. | 02-05-2009 |
| 20090043192 | METHOD AND APPARATUS FOR DETERMINATION OF ATHEROSCLEROTIC PLAQUE TYPE BY MEASUREMENT OF TISSUE OPTICAL PROPERTIES - Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content. | 02-12-2009 |
| 20090073439 | APPARATUS, COMPUTER-ACCESSIBLE MEDIUM AND METHOD FOR MEASURING CHEMICAL AND/OR MOLECULAR COMPOSITIONS OF CORONARY ATHEROSCLEROTIC PLAQUES IN ANATOMICAL STRUCTURES - Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation. | 03-19-2009 |
| 20090131801 | SYSTEMS AND PROCESSES FOR OPTICAL IMAGING OF LUMINAL ANATOMIC STRUCTURES - Exemplary embodiments of an apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the exemplary apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion. A second arrangement may be provided that can at least partially enclose the first arrangement. At least one third arrangement may be provided which is configured to be actuated so as to expand, at least in part, beyond a periphery of the second arrangement. Such exemplary third arrangement can be structured to facilitate a fluid flow and/or a gas flow therethrough. Further, a fourth arrangement may be provided which can be structured to (i) actuate a particular number of the third arrangement and/or (ii) adjust a distance between at least two outer portions of the third arrangement. According to one exemplary embodiment, the third arrangement can be a plurality of the third arrangements. | 05-21-2009 |
| 20100094576 | APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS - Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system. | 04-15-2010 |
| 20100110414 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRACKING VESSEL MOTION DURING THREE-DIMENSIONAL CORONARY ARTERY MICROSCOPY - Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes. | 05-06-2010 |
| 20100150422 | Systems and Methods for Extending Imaging Depth Range of Optical Coherence Tomography Through Optical Sub-Sampling - Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements. | 06-17-2010 |
| 20100157309 | SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING - Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations. | 06-24-2010 |
| 20100165335 | SYSTEMS AND METHODS FOR RECEIVING AND/OR ANALYZING INFORMATION ASSOCIATED WITH ELECTRO-MAGNETIC RADIATION - According to an exemplary embodiment, a system can be provided which can have at least one fiber arrangement and at least one receiving arrangement. The fiber arrangement may have optical transmitting characteristics, and may be configured to transmit there through at least one electromagnetic radiation and forward the at least one electromagnetic radiation to at least one sample. At least one portion of the fiber arrangement may be composed of or can include therein sapphire, diamond, clear graphite, Chalcogenide, borosilicate, zirconium fluoride, silver halide, a liquid core light guide, a gas core light guide, a hollow core waveguide, and/or a solid core photonic crystal fiber. The receiving arrangement may be configured to receive the electromagnetic radiation that is filtered and received from the sample. According to another exemplary embodiment, a method can be provided for obtaining information associated with the sample. For example, at least one first electromagnetic radiation can be forwarded to the sample via at least one optical fiber. At least one first characteristic of at least one portion of the optical fiber can be controlled so as to modify at least one second characteristic of at least one second electromagnetic radiation generated within the optical fiber. The second electromagnetic radiation can be associated with the first electromagnetic radiation. | 07-01-2010 |
| 20100254415 | APPARATUS AND METHOD FOR UTILIZATION OF A HIGH-SPEED OPTICAL WAVELENGTH TUNING SOURCE - Exemplary embodiments of apparatus, source arrangement and method for, e.g., providing high-speed wavelength tuning can be provided. According to one exemplary embodiment, at least one arrangement can be provided which is configured to emit an electromagnetic radiation that (i) has a spectrum whose mean frequency changes at an absolute rate that is greater than about 6000 (or 2000) terahertz per millisecond, (ii) whose mean frequency changes over a range that is greater than about 10 terahertz, and/or (iii) has an instantaneous line width that is less than about 15 gigahertz. According to another exemplary embodiment, at least one arrangement can be provided configured to, periodically and as a function of time, select at least one first electro-magnetic radiation based on a mean frequency of the at least one first electro-magnetic radiation, with the periodic selection being performed at a first characteristic period. The mean frequency can vary linearly over time, wherein the apparatus can emit at least one second electromagnetic radiation that has a spectrum whose mean frequency changes periodically as a function of time with a second characteristic period. Further, the first characteristic period can be greater than the second characteristic period. | 10-07-2010 |
| 20100309477 | METHOD AND APPARATUS FOR PERFORMING OPTICAL IMAGING USING FREQUENCY-DOMAIN INTERFEROMETRY - An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond. | 12-09-2010 |
| 20110058178 | ARRANGEMENTS AND METHODS FOR PROVIDING MULTIMODALITY MICROSCOPIC IMAGING OF ONE OR MORE BIOLOGICAL STRUCTURES - Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality. | 03-10-2011 |
| 20110092823 | System and Method for Identifying Tissue Using Low-Coherence Interferometry - An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered. | 04-21-2011 |
| 20110137140 | Apparatus, Systems and Methods for Measuring Flow and Pressure within a Vessel - Exemplary embodiments of apparatus, system and method can be provided to measure a flow of fluid within an anatomical structure. For example, it is possible to use at least one first probe arrangement structured to be insertable into a vessel and configured to direct at least one radiation to at least one portion of the anatomical structure. Further, it is possible to provide at least one second arrangement which configured to detect an interference between a first radiation provided from the fluid via the probe arrangement and second a second radiation provided from a reference path as a function of wavelength thereof. Further, at least one third arrangement can be provided which is configured to determine at least one characteristic of the fluid as a function of the interference. | 06-09-2011 |
| 20110137178 | Devices and methods for imaging particular cells including eosinophils - An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation. | 06-09-2011 |
| 20110144504 | METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING - Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam. | 06-16-2011 |
| 20110149296 | METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING - Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data. | 06-23-2011 |
