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Guilhot
Christophe Guilhot, Castelnaurou FR
| Patent application number | Description | Published |
|---|---|---|
| 20100267112 | USE OF PKS 13 PROTEIN CODING FOR CONDENSASE OF MYCOLIC ACIDS OF MYCOBACTERIA AND RELATED STRAINS AS AN ANTIBIOTICS TARGET - The invention relates to a novel enzyme involved in the biosynthesis of mycolic acids and to the use thereof for the screening of antibiotics, especially antimycobacterials. The invention more particularly relates to the Pks13 protein which catalyzes Claisen condensation or malonic condensation in mycolates between an acyl-CoA molecule or an acyl-AMP molecule and an acylmalonyl-CoA molecule to form an intermediate β-cEto acyl or β-cEto ester. | 10-21-2010 |
Christophe Guilhot, Castelmaurou FR
| Patent application number | Description | Published |
|---|---|---|
| 20090170142 | USE OF 4'-PHOSPHOPANTETHEINYL TRANSFERASE AS A TARGET FOR IDENTIFYING ANTIBIOTIC MOLECULES - The present invention pertains to the use of a PptT protein, as a target for screening compounds for identifying those having an antibiotic activity, especially against a pathogenic bacterium containing mycolic acids. The invention also concerns an in vitro screening process for identifying compounds having an antibiotic activity, by measuring the activity of a PptT protein in the presence or absence of said compounds. | 07-02-2009 |
Florence Guilhot, Saint Julien En Genevois FR
| Patent application number | Description | Published |
|---|---|---|
| 20110002936 | Anti-IL-6/IL-6R Antibodies and Methods of Use Thereof - This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic. | 01-06-2011 |
Florence Guilhot, St. Julien En Genevois FR
| Patent application number | Description | Published |
|---|---|---|
| 20120020981 | Anti-IL6/IL-6R Antibodies and Methods of Use Thereof - This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic. | 01-26-2012 |