Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Guild, US
Braydon C. Guild, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090081642 | Novel apoptosis gene EI24, compositions, and methods of use - Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced in a p53-dependent manner by ionizing irradiation of primary murine thymocytes. The invention is thus directed to an isolated EI24 protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the EI24 protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect EI24 in biological specimens, including, for example, human tissue samples. The present invention is further directed to methods of treating degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death. The present invention is further directed to methods for diagnosing degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death, as well as methods for monitoring the progress of such degenerative disorders. | 03-26-2009 |
Braydon Charles Guild, Concord, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090175875 | Molecules and Methods for Modulating Complement Component - Compositions that bind to C3b epitopes and methods of using the compositions are described herein. | 07-09-2009 |
| 20100034809 | Compositions and Methods for Antibodies Targeting Complement Protein C5 - The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. | 02-11-2010 |
| 20100291106 | COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING COMPLEMENT PROTEIN C3B - The present invention relates to antibodies and antigen binding fragments thereof that bind to both human and cynomolgus complement protein C3b, as well as compositions and methods of use thereof. | 11-18-2010 |
Braydon Charles Guild, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100166748 | C5 Antigens and Uses Thereof - The present invention pertains to the use of a complement inhibitor in methods of treatment of ocular disorders and the use of a complement inhibitor in the manufacture of a medicament in the treatment of an ocular disorder. | 07-01-2010 |
Jeffrey M. Guild, Torrance, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110001658 | SYSTEM AND METHOD FOR PRECISION GEOLOCATION UTILIZING MULTIPLE SENSING MODALITIES - A system and method for determining the geolocation of a signal emitter moving at an unknown velocity by combining signal data of a target detection platform (e.g., a radar system) and signal data collected by two or more moving signal collection platforms (e.g., RF signal receivers). In one embodiment, the target detection platform determines tentative location and velocity of the signal emitter, and the signal collection platforms are configured to perform TDOA and/or FDOA analysis of the collected signal data corresponding to a signal of the signal emitter. In one embodiment, solutions provided from the TDOA and/or FDOA analysis are unbiased by using the tentative velocity of the signal emitter, and the geolocation of the signal emitter is determined by matching the TDOA/FDOA solutions and the detected tentative location. | 01-06-2011 |
John A. Guild, Edgewater, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110010226 | MARKETING MODEL DETERMINATION SYSTEM - A system includes a variable determination module determining a variable operable to be used for the final model and also determining a modification to the at least one variable. An assumption determination module determines an assumption operable to be used for the final model. The assumption includes a transformation for the variable describing how the variable impacts the marketing objective or how the variable impacts another variable operable to be used in the final model. The assumption module also determines a modification to the assumption. A model generator generates a candidate model using the variable and the assumption, and generates a new candidate model using the modified assumption, the new variable or the modification to the variable. The candidate model or the new candidate model is operable to be selected as the final model based on at least one of a statistical measure and an indication of relevance for the variable in the candidate model and the new candidate model. | 01-13-2011 |
| 20110054860 | ADAPTIVE ANALYTICS MULTIDIMENSIONAL PROCESSING SYSTEM - A system includes a multidimensional data processing system storing meta data identifying a plurality of variables, a plurality of dimensions for each variable describing attributes of the variable, and a plurality of levels in each dimension. The meta data also identifies a hierarchy of the dimensions and levels for each variable. The multidimensional data processing system is configured to use the meta data to perform multidimensional queries to retrieve data for one or more of the variables from data storage. The system also includes a variable determination module determining at least one variable of the plurality variables operable to be used to generate a model, and a model generator receiving the data from the multidimensional data processing system and generating a model using the data. | 03-03-2011 |
Randall J. Guild, Okemos, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110000756 | BI-DIRECTIONAL IMPACT ABSORPTION DEVICE FOR A CLUTCH REACTION PLATE - A clutch reaction plate includes an annular device having a plurality of radially configured, alternating inwardly-oriented splines and keys, the splines and keys configured to meshingly engage a coaxial correspondingly-splined second device inserted therein. Selected ones of the splines include a bi-directional impact absorption device configured to engage selected ones of the splines of the inserted second device when a torque load is applied in one of a first rotational direction and a second, opposing rotational direction. The remaining splines engage the remaining splines of the inserted second device when the applied torque load exceeds a reaction force of the bi-directional impact absorption device. | 01-06-2011 |