Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Guido Grandi, Siena IT

Guido Grandi, Siena IT

Patent application numberDescriptionPublished
20090117113Immunogenic And Therapeutic Compositions For Streptococcus Pyogenes - Group A streptococcal (GAS) antigens useful for providing immunity against 05-07-2009
20090162392MUTANT FORMS OF STREPTOLYSIN O - Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against 06-25-2009
20090317420Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae - The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B 12-24-2009
20100015168IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE - The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein.01-21-2010
20100015212IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS - Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.01-21-2010
20100056447IMMUNIZATION AGAINST CHLAMYDIA PNEUMONIAE - The published genomic sequence of 03-04-2010
20100105865Nucleic acids and proteins from streptococcus groups a & b - The invention provides proteins from group B 04-29-2010
20100136041COMBINATION GAS VACCINES AND THERAPEUTICS - Compositions useful for reducing the risk of, preventing, and/or treating 06-03-2010
20100150943IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA - The invention relates to the identification of a new adhesin islands within the genomes of several Gram positive 06-17-2010
20100158935MUTANT FORMS OF STREPTOLYSIN O - Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against 06-24-2010
20100215683PROTECTIVE ANTIGENS FOR GROUP B STREPTOCOCCUS HYPERVIRULENT STRAINS - The invention provides protective antigens for Group B streptococcus hypervirulent strains. The fragments are useful in vaccine compositions to induce protection against 08-26-2010
20100272725Neisserial antigens - The invention provides proteins from 10-28-2010
20110110857MUTANT FORMS OF CHLAMYDIA HTRA - An immunogenic 05-12-2011
20110110967GAS57 MUTANT ANTIGENS AND GAS57 ANTIBODIES - The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against 05-12-2011
20110158977Immunogenic compositions for Chlamydia trachomatis - The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the 06-30-2011

Patent applications by Guido Grandi, Siena IT