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Guenther, US

Adam Guenther, Webb City, MO US

Patent application numberDescriptionPublished
20110277408ROOFING PRODUCT - A starter block and a shingle are utilized to form courses that may be positioned in overlapping fashion on a roof to form a roofing covering system. The particular design of the starter block and shingle result in a roofing product that provides increased durability over previous designs. The starter block may be formed with top and bottom surfaces, opposite side surfaces with tapering heights, and a front surface having a greater height than a back surface of the starter block. When the starter block is coupled to a roof deck, a semi-rigid shingle having a generally planar bottom surface may be placed upon the starter block so that a portion of the shingle extends off of the starter block over the back surface thereof and onto the roof deck to facilitate contact between the shingle and the roof deck at a location more proximal to the starter block back surface than if the same back surface had the same height as the front surface. Additionally, the semi-rigid shingle may have an exposed portion and a headlap portion, with the exposed portion extending from a forward shingle edge to the headlap portion and the headlap portion extending from a back shingle edge to the exposed portion. The exposed portion has a central region with a generally uniform thickness moving in the longitudinal direction. Unlike the exposed portion, the headlap portion has a taper in average thickness moving in the longitudinal direction. The taper extends for at least a substantial part of the headlap portion.11-17-2011

Christopher G. Guenther, Tempe, AZ US

Patent application numberDescriptionPublished
20110025541UNFOLDING VCO-BASED QUANTIZATION CIRCUIT - Apparatus and methods are provided for a voltage-controlled oscillator (VCO) quantization circuit. A quantization circuit comprises an input node for an input signal, a VCO quantizer coupled to the input node, and an output generation module coupled to the VCO quantizer. The VCO quantizer is configured to generate a digital code that is representative of the input signal, wherein the digital code has a first code range. The output generation module generates a digital output value based on the digital code, wherein the digital output value has a second code range being greater than the first code range.02-03-2011

Christopher Palmer Guenther, Morgantown, WV US

Patent application numberDescriptionPublished
20110060563Carbonaceous Chemistry for Continuum Modeling - A system and method of calculating fuel gasifier reactions is disclosed. The method and system model combustion/gasification within a gasifier by using an Eulerian-Eulerian flow field. The flow field is updated as the combustion/gasification progresses to account for the use of fuel as well as other reactions, mass transferred, and heat that occur within the gasifier during the combustion/gasification reactions.03-10-2011

David C. Guenther, Los Alamos, NM US

Patent application numberDescriptionPublished
20100091134HADAMARD MULTIMODE OPTICAL IMAGING TRANSCEIVER - Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture.04-15-2010

Douglas G. Guenther, Wheaton, IL US

Patent application numberDescriptionPublished
20080287230Game ball cover with improved stripes and/or logos - An inflatable game ball including a carcass, a cover and at least one thin member. The cover has inner and outer surfaces. The inner surface of the cover is coupled to the carcass. At least one recess is formed into the outer surface of the cover. At least one thin member is coupled to the cover at the at least one recess. The member substantially fills the recess. The member has inner and outer portions. The outer portion is formed of a highly grippable material.11-20-2008
20110118062AMERICAN-STYLE FOOTBALL INCLUDING IMPROVED BLADDER CONSTRUCTION FOR MOUNTING OF ELECTRONICS - An American style football including an inflatable bladder, a cover surrounding the bladder, and an electronic circuit. The bladder includes first and second side walls defining an expandable cavity and a cross-member configured to extend through the expandable cavity. The side walls and cross-member are coupled together to form a bladder seam. The electronic circuit is coupled to the cross-member and produces a signal to enable the position and movement of the football to be monitored during use.05-19-2011
20110118064AMERICAN-STYLE FOOTBALL INCLUDING ELECTRONICS COUPLED TO THE BLADDER - An American style football including an inflatable bladder, a cover surrounding the bladder, a lacing coupled to the at least one cover panel, and an electronic circuit. The electronic circuit is coupled to the bladder. The electronic circuit includes at least one sensor and the electronic circuit being configured to produce a signal to enable the position and movement of the football to be monitored during use.05-19-2011
20110118065AMERICAN-STYLE FOOTBALL INCLUDING ELECTRONICS - An American style football including an inflatable bladder, at least two cover panels surrounding the bladder, a lacing coupled to the at least one cover panel, and an electronic circuit. Each of the cover panels includes an outermost layer and a lining. The electronic circuit is coupled to at least one of the cover panels. The electronic circuit includes at least one sensor. The electronic circuit is configured to produce a signal to enable the position and movement of the football to be monitored during use.05-19-2011

Patent applications by Douglas G. Guenther, Wheaton, IL US

Drake A. Guenther, Annapolis, MD US

Patent application numberDescriptionPublished
20090299184IMAGING OR COMMUNICATIONS SYSTEM UTILIZING MULTISAMPLE APODIZATION AND METHOD - Methods systems and system components for optimizing contrast resolution of an imaging or sensing system utilizing multiple channels of broadband data associated with an array of transducers. Channels or data are filtered by passing the channels of data through finite impulse response (FIR) filters on each channel. The filters each have multiple taps having tap weights pre-calculated as a function of distance of the array from an object that energy is being transmitted to or reflected from. The weights are pre-computed through a deterministic equation based on an a priori system model.12-03-2009

Gary David Guenther, Warrenville, IL US

Patent application numberDescriptionPublished
20100161256Circuit and Method of Output Power Detection for a Converter Circuit - A circuit and method of determining the power output for a converter circuit includes determining a time averaged voltage from a rectified voltage of a winding of the transformer and multiplying the time averaged voltage by a constant determined at least in part by an average current of a winding of the transformer. By one approach, a rectified voltage from a primary side of the transformer is time averaged using a filter circuit. The current can be known or preset or controlled by the converter circuit such that the time averaged voltage reading, assuming a constant current, can be compared to a preset voltage such that the voltage reading approximates a power reading for the transformer. By another approach, the time averaged voltage is multiplied by the current to obtain a power output reading.06-24-2010

Gerhard Guenther, Houston, TX US

Patent application numberDescriptionPublished
20120091621BIMODAL PIPE RESIN AND PRODUCTS MADE THEREFROM - Disclosed is a bimodal Ziegler-Natta catalyzed polyethylene, having a density of from 0.930 glee to 0.960 glee, and a molecular weight distribution of from 10 to 25, wherein an article formed therefrom has a PENT of at least 1500. Also disclosed is a method of preparing a tubular article including obtaining a bimodal polyethylene having a density of from 0.930 glee to 0.960 Wee and a molecular weight distribution of from 10 to 25, and processing the polyethylene under conditions where a specific energy input (SET) is less than 300 kW.h/ton, and wherein the article has a PENT of at least 1500. Further disclosed is a method for controlling the degradation of polyethylene including polymerizing ethylene monomer, recovering polyethylene, extruding the polyethylene, and controlling the degradation of polyethylene by measuring the SEI to the extruder and adjusting throughput and/or gear suction pressure keep SEI less than 300 kW.h/ton, and forming an article.04-19-2012

Gerhard Guenther, Kemah, TX US

Patent application numberDescriptionPublished
20080275197Bimodal Polyethylene Resins That Have High Stiffness and High ESCR - A bimodal polyethylene having a high density ranging from about 0.955 to about 0.959 g/cc, an improved environmental stress cracking resistance (ESCR) of from about 400 to about 2500 hours, and an improved 0.4% flexural modulus of from about 180,000 to about 260,000 psi (1,200 MPa to about 1,800 MPa) may be formed using a Ziegler-Natta polymerization catalyst using two reactors in series. The bimodal polyethylene may have a high load melt index (HLMI) of from about 2 and about 30 dg/min and may be optionally made with a small amount of alpha-olefinic comonomer in the second reactor. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.11-06-2008
20100129579Rapid Crack Properties in High Performance Pipe - Pipe articles and methods of forming the same are described herein. The pipe articles generally include a bimodal polyethylene including a greater amount of high molecular weight fraction than low molecular weight fraction and wherein the pipe article exhibits a critical temperature of less than about 0° C. at 5 bar.05-27-2010
20100159173Polyethylene Polymerization Processes - Polymer articles and processes of forming the same are described herein. The processes generally include providing a bimodal ethylene based polymer, blending the bimodal ethylene based polymer with a nucleator to form modified polyethylene and forming the modified polyethylene into a polymer article, wherein the polymer article is selected from pipe articles and blown films.06-24-2010
20100267909Bimodal Pipe Resin and Products Made Therefrom - Disclosed is a bimodal Ziegler-Natta catalyzed polyethylene, having a density of from 0.930 g/cc to 0.960 g/cc, and a molecular weight distribution of from 10 to 25, wherein an article formed therefrom has a PENT of at least 1500. Also disclosed is a method of preparing a tubular article including obtaining a bimodal polyethylene having a density of from 0.930 g/cc to 0.960 g/cc and a molecular weight distribution of from 10 to 25, and processing the polyethylene under conditions where a specific energy input (SEI) is less than 300 kW·h/ton, and wherein the article has a PENT of at least 1500. Further disclosed is a method for controlling the degradation of polyethylene including polymerizing ethylene monomer, recovering polyethylene, extruding the polyethylene, and controlling the degradation of polyethylene by measuring the SEI to the extruder and adjusting throughput and/or gear suction pressure keep SEI less than 300 kW·h/ton, and forming an article.10-21-2010
20110174413Modification of Polyethylene Pipe to Improve Sag Resistance - Methods of forming pipe articles and pipe articles are described herein. The methods generally include providing a bimodal ethylene based polymer, blending the bimodal ethylene based polymer with up to about 50 ppm peroxide to form modified polyethylene and forming the modified polyethylene into a pipe.07-21-2011

Patent applications by Gerhard Guenther, Kemah, TX US

Gerhard Guenther, Seabrook, TX US

Patent application numberDescriptionPublished
20080269441Polymerization process providing polyethylene of enhanced optical properties - A process for the polymerization of ethylene to provide an ethylene polymer of reduced Yellowness Index. A feed stream, comprising an inert hydrocarbon diluent containing ethylene in a minor amount, is supplied to a polymerization reactor. A chromium-based polymerization catalyst and a triethylboron co-catalyst are incorporated into the feed stream within the reactor. The polymerization catalyst will normally be used in an amount within the range of 0.008-0.1 wt. % of the diluent in the feed stream and the triethylboron co-catalyst is incorporated in an amount within the range of 0.1-50 ppm of the diluent. The polymer fluff from the reactor is heated to a temperature sufficient to melt the fluff which is then extruded to produce a polymer product. The Yellowness Index after high temperature aging is at least 5% less than the corresponding Yellowness Index of a corresponding polymer product produced without the triethylboron co-catalyst.10-30-2008
20090035545POLYETHYLENE FILMS WITH IMPROVED BUBBLE STABILITY - This invention relates to high density polyethylene blown films having good barrier properties and improved processing characteristics. The method incorporates the use of peroxide which results in improved bubble stability without sacrifice in barrier properties. The polyethylenes have a density greater than about 0.950 g/cc, are relatively narrow in molecular weight distribution MWD (in the range of from about 2.0 to about 6.5), and are of medium molecular weight. In an embodiment, the films also have a rheological breadth parameter, a, that has been reduced by at least about 5%, but not more than 45%, by addition of a peroxide to the polyethylene. The addition of peroxide improves processability without sacrificing strength and barrier properties such as oxygen transmission rate.02-05-2009

Patent applications by Gerhard Guenther, Seabrook, TX US

Gerhard K. Guenther, Seabrook, TX US

Gernot E. Guenther, Endicott, NY US

Patent application numberDescriptionPublished
20080243462INSTRUCTION ENCODING IN A HARDWARE SIMULATION ACCELERATOR - A hardware simulation accelerator to simulate logic designs, a method to encode instructions for use in the hardware simulation accelerator, and a computer program product having code of the method by which the hardware simulation accelerator can read encoded instructions to simulate the logic design, and computer program product of the encoded instructions to simulate a logic design in a hardware accelerator. Each instruction has one of a plurality of opcodes, the opcodes select which of the hardware resources of the hardware simulation accelerator will implement and use the values set forth in other programmable bits of the encoded instruction. The encoded instruction may be a routing and/or a gate evaluation instruction.10-02-2008
20080270748HARDWARE SIMULATION ACCELERATOR DESIGN AND METHOD THAT EXPLOITS A PARALLEL STRUCTURE OF USER MODELS TO SUPPORT A LARGER USER MODEL SIZE - A system and method for design verification and, more particularly, a hardware simulation accelerator design and method that exploits a parallel structure of user models to support a large user model size. The method includes a computer including N number of logic evaluation units (LEUs) that share a common pool of instruction memory (IM). The computer infrastructure is operable to: partition a number of parallel operations in a netlist; and send a same instruction stream of the partitioned number of parallel operations to N number of LEUs from a single IM. The system is a hardware simulation accelerator having a computer infrastructure operable to provide a stream of instructions to multiple LEUs from a single IM. The multiple LEUs are clustered together with multiple IMs such that each LEU is configured to use instructions from any of the multiple IMs thereby allowing a same instruction stream to drive the multiple LEUs.10-30-2008

Patent applications by Gernot E. Guenther, Endicott, NY US

Godehard A. Guenther, Concord, MA US

Patent application numberDescriptionPublished
20080247582Loudspeaker and Systems - The invention provides, in one aspect, a loudspeaker that has electrodynamically-driven piston mounted in one external wall and that has movable panels in one or more other external walls. Those panels are air-coupled to the piston, e.g., via air within the enclosure, such that vibrational motion of the piston causes the vibration of the panels, thereby, improving the overall air coupling of the piston to the external environment, e.g., the listening room. Further aspects of the invention provide an improved driver for use, e.g., in the aforementioned loudspeaker. The driver comprises a three-part piston having first and second diaphragms coupled back-to-back with one another and having a voice coil face-mounted (or front-mounted) within the second diaphragm.10-09-2008
20080292117LOUDSPEAKER AND ELECTRONIC DEVICES INCORPORATING SAME - The invention provides, in some aspects, electronic devices with improved radiators (or “passive drivers”) comprising an elastomerically mounted mass in order to improve sound reproduction fidelity. The mass comprises a component of the device not normally used for such purpose—e.g., a battery—thereby, permitting size reductions while, at the same time, enhancing audio fidelity11-27-2008
20090161902LOUDSPEAKERS, SYSTEMS AND COMPONENTS THEREOF - Improved loudspeakers, systems and components are adapted to interconnect with many forms of communication media. In one embodiment, a speaker is mountable within a receptacle. The speaker includes a magnetic driver and a diaphragm mounted to a frame. The frame includes a mounting member extending from a surface of the frame behind the flange plane. The mounting member is engagable in a notch formed in the receptacle for securing the speaker within the receptacle. In another embodiment, a low-profile loudspeaker has a front-mounted magnetic driver disposed within a cone-shaped acoustic diaphragm. The magnetic driver includes a first rare earth magnet centrally disposed within an electromagnetic shielding material. In another embodiment, a low-profile, two-way loudspeaker includes a cone-shaped diaphragm and a dome-shaped (tweeter) diaphragm. A front-mounted magnetic driver comprises first and second rare earth magnets each centrally disposed within electromagnetic shielding material. The driver and cone-shaped diaphragm are mounted to a speaker frame. The tweeter diaphragm is mounted onto the driver coaxially and substantially coplanar with a forward edge of the cone-shaped diaphragm.06-25-2009
20090304222LOW COST MOTOR DESIGN FOR RARE-EARTH-MAGNET LOUDSPEAKERS - A loudspeaker magnetic motor utilizes a voice coil with two or more wire coils that are connected in parallel and that are layered on top of one another. The motor utilizes, as a magnetic field source, a permanent magnet and, more particularly, a permanent magnet that includes a rare earth metal such as a neodymium boron iron magnet.12-10-2009
20100254564LOUDSPEAKERS AND SYSTEMS - The invention provides, in one aspect, a loudspeaker that has electrodynamically-driven piston mounted in one external wall and that has movable panels in one or more other external walls. Those panels are air-coupled to the piston, e.g., via air within the enclosure, such that vibrational motion of the piston causes the vibration of the panels, thereby, improving the overall air coupling of the piston to the external environment, e.g., the listening room. Further aspects of the invention provide an improved driver for use, e.g, in the aforementioned loudspeaker. The driver comprises a three-part piston having first and second diaphragms coupled back-to-back with one another and having a voice coil face-mounted (or front-mounted) within the second diaphragm.10-07-2010

Patent applications by Godehard A. Guenther, Concord, MA US

Jason Guenther, Bellevue, CA US

Patent application numberDescriptionPublished
20080221998PARTICIPANT INTERACTION WITH ENTERTAINMENT IN REAL AND VIRTUAL ENVIRONMENTS - A system of interaction between an electronic theme park experience and live theme park interaction and activity earns rewards. The interaction permits for rewards earned in the electronic theme park experience to be redeemed in the live theme park experience and vice versa. The electronic theme park and live activity are interactive in real or delayed time through an Internet connection. Activities on one or both of the live and electronic formats are designed to drive increased player visiting of the live and/or electronic versions. The Virtual Magic Kingdom in some embodiments includes a virtual version of one or more of theme parks such as the “Magic Kingdom” portion of Disney, Inc.'s theme parks.09-11-2008

Mark Guenther US

Patent application numberDescriptionPublished
20110252864Emissions Test System And Method - An emission test system may include at least one controller configured to determine, directly or indirectly, a quantity of diluted exhaust sample in a container at the completion of an emissions test, and to cause additional diluent gas to be added to the container based on the determined quantity.10-20-2011

Mark L. Guenther, Portland, OR US

Patent application numberDescriptionPublished
20090207886Apparatus and method for synthesizing and generating an SSC modulated signal - A system and method for synthesizing and generating the SSC modulated signal with precision and in a controlled manner is provided. In one embodiment the system may be integrated in an arbitrary waveform generator.08-20-2009
20110119688Method and System to Measure and Represent the Measured Value of a Limit in Terms of Another Measurement in a Signal Measurement System - Embodiments of the invention provide a system and method to measure and represent the measured value of a limit in terms of another measurement, such as clock values or cycles of the system. The system can include, for example, a test and measurement instrument such as an oscilloscope. In another embodiment of the present invention, slew rate de-rated values may be automatically determined through the use of configurable lookup tables.05-19-2011
20110292987METHOD FOR DECOMPOSING AND ANALYZING JITTER USING SPECTRAL ANALYSIS AND TIME-DOMAIN PROBABILITY DENSITY - A method for analyzing jitter using a test and measurement instrument includes obtaining a collection of time interval error (TIE) values corresponding to composite jitter of a waveform, optionally decomposing the composite jitter into jitter components that are correlated to the data pattern and components that are uncorrelated to the data pattern, and using a spectral approach to decompose the jitter components into jitter components that are recognizable as deterministic and jitter components that are unrecognizable as deterministic. Thereafter, the jitter components analyzed in the frequency domain are converted back to the time domain, and subtracted from the composite jitter, thereby isolating uncorrelated residual jitter. The uncorrelated residual jitter is decomposed into bounded uncorrelated jitter and random jitter, for example, by integrating a probability density (PDF) function of the residual jitter and analyzing the resulting cumulative distribution function (CDF) curve in Q-space.12-01-2011

Patent applications by Mark L. Guenther, Portland, OR US

Matthew Guenther, Cambridge, MA US

Patent application numberDescriptionPublished
20090221428Methods of Genome-Wide Location Analysis in Stem Cells - The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that apply to stem cells such as but not limited to; embryonic stem cells and adult stem cells. The invention also provides methods of identifying agents which modulate differentiation of stem cells. The invention also provides methods of defining the differentiation potential of a cell and of designing array oligonucleotides.09-03-2009

Nicholas A. Guenther, Imperial, MO US

Patent application numberDescriptionPublished
20090265118METHODS AND SYSTEMS FOR PROVIDING UNANTICIPATED DEMAND PREDICTIONS FOR MAINTENANCE - A method for predicting a probability of failure for a component of a platform at a specified time is described. The method includes collecting historical maintenance data relating to the component, selecting, utilizing the collected historical maintenance data, a lifetime distribution model that best fits the historical maintenance data, estimating upcoming component failures using the selected lifetime distribution model, and applying maintenance schedule dates for the platform to the upcoming component failures to determine a likelihood of failure of the component on one of the scheduled maintenance dates.10-22-2009

Rebecca Lynn Rezac Guenther, Lonsdale, MN US

Patent application numberDescriptionPublished
20090088428CYCLOHEXYLIMIDIAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: (I) having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.04-02-2009

R.h. Guenther, Cary, NC US

Patent application numberDescriptionPublished
20120015020BIODEGRADABLE DRUG OR OTHER ACTIVE DELIVERY SYSTEM - A nonwoven fabric has been developed as a delivery system for drugs or other actives which includes biodegradable and biocompatible fibers with plant virus nanoparticles. The plant virus nanoparticles are pre-loaded with one or more actives.01-19-2012

Richard Guenther, Cary, NC US

Patent application numberDescriptionPublished
20120039799VIRAL NANOPARTICLE CELL-TARGETED DELIVERY PLATFORM - This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.02-16-2012

Richard H. Guenther, Cary, NC US

Patent application numberDescriptionPublished
20080199870COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.08-21-2008
20100069260COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.03-18-2010
20100291032COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.11-18-2010
20110033850COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.02-10-2011
20110229920SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS - Methods of inhibiting 09-22-2011
20110306509COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided.12-15-2011

Patent applications by Richard H. Guenther, Cary, NC US

Rodney S. Guenther, Houston, TX US

Patent application numberDescriptionPublished
20120046868DOWNHOLE CLOSED-LOOP GEOSTEERING METHODOLOGY - A closed-loop method for geosteering includes acquiring logging while drilling data and processing the logging while drilling data downhole while drilling to obtain a geosteering correction (a correction to the drilling direction based upon the LWD measurements). The geosteering correction is further processed downhole to obtain new steering tool settings which are then applied to the steering tool to change the direction of drilling. These steps are typically repeated numerous times without the need for uphole processing or surface intervention.02-23-2012

Rolf Guenther, Monte Sereno, CA US

Patent application numberDescriptionPublished
20100080957Surface Coating - A corrosion barrier is provided, disposed on a substrate. The corrosion barrier includes a vapor corrosion inhibitor (VCI) material and an anti-wetting barrier having a nano-particle composite structure.04-01-2010

Rolf A. Guenther, Monte Sereno, CA US

Patent application numberDescriptionPublished
20080271309HEATED SUBSTRATE SUPPORT AND METHOD OF FABRICATING SAME - A method and apparatus for forming a substrate support is provided herein. In one embodiment, the substrate support includes a body having a support surface and at least one groove. A heater element clad with a malleable heat sink is disposed in the groove. Substantially no air is trapped between the clad heater element and the groove. An insert is disposed in the groove above the heater. The insert substantially completely covers and contacts the clad heater element and the sides of the groove. A cap is disposed in the groove above the insert. The cap covers and contacts the insert and has an upper surface disposed substantially flush with the support surface.11-06-2008

Patent applications by Rolf A. Guenther, Monte Sereno, CA US

Ross Guenther, Penn Valley, CA US

Patent application numberDescriptionPublished
20100273630SYNTHESIZED HYBRID ROCK COMPOSITION, METHOD, AND ARTICLE FORMED BY THE METHOD - The invention relates to synthetic hybrid rock compositions, articles of manufacture and related processes employing mineral waste starting materials such as mine tailings, mine development rock, ash, slag, quarry fines, and slimes, to produce valuable articles of manufacture and products, which are characterized by superior physical and structural characteristics, including low porosity, low absorption, increased strength and durability, and retained plasticity. The resulting materials are compositionally and chemically distinct from conventional synthetic rock materials as demonstrated by scanning electron microprobe analysis, and are useful in a wide variety of applications, particularly with respect to commercial and residential construction.10-28-2010
20100303560HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic transportation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate and lower object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments.12-02-2010
20120093591HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic transportation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate and lower object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments.04-19-2012

Ross Guenther, Nevada City, CA US

Patent application numberDescriptionPublished
20100104381HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic elevation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments.04-29-2010
20100117273PROCESS FOR HOT-FORGING SYNTHETIC CERAMIC - The embodiments of the invention are directed to a synthetic ceramic comprising pyroxene-containing crystalline phase, a clast, and a glass phase, wherein at least a portion of the synthetic ceramic is plastically deformable in a certain temperature range. Other embodiments of the invention relate to a method of making a synthetic ceramic, comprising heating a green ceramic material to 900-1400° C., to a temperature sufficient to initiate partial melting of at least a portion of the green ceramic material, transferring the heated green ceramic material to a press, pressing the heated green ceramic material in a die at 1,000 to 10,000 psi, and transferring the heated, pressed green ceramic material to a furnace for cooling to form the synthetic ceramic.05-13-2010

Sven Guenther, Blacksburg, VA US

Patent application numberDescriptionPublished
20080260691Prodrugs of Ribavirin with Improved Hepatic Delivery - The present invention relates ribavirin delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to ribavarin and methods for administering conjugated ribavirin compositions.10-23-2008

Patent applications by Sven Guenther, Blacksburg, VA US

Sven Guenther, Coralville, IA US

Patent application numberDescriptionPublished
20110002990BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.01-06-2011
20110002991PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF - The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.01-06-2011
20110183963Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.07-28-2011
20110223207Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.09-15-2011

Tim Guenther, Vinton, IA US

Patent application numberDescriptionPublished
20100025445THREE PIECE LIFTING DEVICE - A three piece lifting system for lifting loads such as furniture during a move. The system has a first elongated strap that has a plurality of loops at its first and second ends that receive second and third elongated straps. The second and third elongated straps each have shoulder loops that go on the shoulders of workers such that when assembled the first elongated strap engages the load so that the workers are enabled to lift the load off the ground.02-04-2010