Guenther, US
Adam Guenther, Webb City, MO US
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20110277408 | ROOFING PRODUCT - A starter block and a shingle are utilized to form courses that may be positioned in overlapping fashion on a roof to form a roofing covering system. The particular design of the starter block and shingle result in a roofing product that provides increased durability over previous designs. The starter block may be formed with top and bottom surfaces, opposite side surfaces with tapering heights, and a front surface having a greater height than a back surface of the starter block. When the starter block is coupled to a roof deck, a semi-rigid shingle having a generally planar bottom surface may be placed upon the starter block so that a portion of the shingle extends off of the starter block over the back surface thereof and onto the roof deck to facilitate contact between the shingle and the roof deck at a location more proximal to the starter block back surface than if the same back surface had the same height as the front surface. Additionally, the semi-rigid shingle may have an exposed portion and a headlap portion, with the exposed portion extending from a forward shingle edge to the headlap portion and the headlap portion extending from a back shingle edge to the exposed portion. The exposed portion has a central region with a generally uniform thickness moving in the longitudinal direction. Unlike the exposed portion, the headlap portion has a taper in average thickness moving in the longitudinal direction. The taper extends for at least a substantial part of the headlap portion. | 11-17-2011 |
20120117908 | ROOFING PRODUCT - A method for covering and protecting a pitched roof deck having an eave including a starter block having unitary construction and a first course of semi-rigid shingles. The starter block has a generally rectangular shape and is tapered wherein the front surface has a greater height than the back surface. The starter block used in the starter course of a roofing project to facilitate the positioning the shingles upon a hip roof without causing said the shingles to bend. In one embodiment, the starter block and shingles are formed from a composite material, such as a combination of at least a polymer component and a filler component. The at least one course of shingles are positioned to lie flat on and at least partially overlap the course of starter blocks with the shingles extending back to the upper surface of the roof without substantially bending. | 05-17-2012 |
Brett Guenther, Cary, NC US
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20140052386 | Systems and Methods for Handheld Raman Spectroscopy - A fiber optic input receives light reflected from an unknown compound. An input mask encodes the light received with a one-dimensional input code. A spectral imaging subsystem images the input coded mask and disperses the image. An output mask receives the dispersed image on a row and, at each time step of a plurality of time steps, changes the code of the row to further encode the image. An illumination subsystem collects the additionally encoded light from the row at each time step. A point detector receives the collected light from the illumination subsystem and converts it to an electrical signal at each time step. A memory stores the electrical signal at each time step. A processor calculates a spectral signature for the unknown compound from the electrical signals stored, the one-dimensional input code, and the different additional one-dimensional codes applied. | 02-20-2014 |
Bryan Guenther, Tucson, AZ US
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20160123719 | AUTOMATED RE-FOCUSING OF INTERFEROMETRIC REFERENCE MIRROR - A reference surface is used to develop an empirical plot between a parameter of interest, such as roughness or modulation, and the position of the reference mirror in an interferometer by repeating measurements of the reference surface at different positions of the reference mirror so as to identify the in-focus position of the reference mirror. Serial quality-control measurements of samples of interest are carried out with the reference mirror in such in-focus position until a predetermined quality-control event triggers an automated system re-calibration by re-measuring the reference surface and, if the result does not correspond to the in-focus position of the reference mirror according to the plot, by finding a new in-focus position for the reference mirror using the same plot or, alternatively, a new similarly produced plot. Sample measurements are then resumed with the mirror placed at that new position. | 05-05-2016 |
Christopher G. Guenther, Tempe, AZ US
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20110025541 | UNFOLDING VCO-BASED QUANTIZATION CIRCUIT - Apparatus and methods are provided for a voltage-controlled oscillator (VCO) quantization circuit. A quantization circuit comprises an input node for an input signal, a VCO quantizer coupled to the input node, and an output generation module coupled to the VCO quantizer. The VCO quantizer is configured to generate a digital code that is representative of the input signal, wherein the digital code has a first code range. The output generation module generates a digital output value based on the digital code, wherein the digital output value has a second code range being greater than the first code range. | 02-03-2011 |
Christopher Palmer Guenther, Morgantown, WV US
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20110060563 | Carbonaceous Chemistry for Continuum Modeling - A system and method of calculating fuel gasifier reactions is disclosed. The method and system model combustion/gasification within a gasifier by using an Eulerian-Eulerian flow field. The flow field is updated as the combustion/gasification progresses to account for the use of fuel as well as other reactions, mass transferred, and heat that occur within the gasifier during the combustion/gasification reactions. | 03-10-2011 |
David Guenther, Los Alamos, NM US
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20150372374 | SPACE VEHICLE ELECTROMECHANICAL SYSTEM AND HELICAL ANTENNA WINDING FIXTURE - A space vehicle electromechanical system may employ an architecture that enables convenient and practical testing, reset, and retesting of solar panel and antenna deployment on the ground. A helical antenna winding fixture may facilitate winding and binding of the helical antenna. | 12-24-2015 |
David C. Guenther, Los Alamos, NM US
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20100091134 | HADAMARD MULTIMODE OPTICAL IMAGING TRANSCEIVER - Disclosed is a method and system for simultaneously acquiring and producing results for multiple image modes using a common sensor without optical filtering, scanning, or other moving parts. The system and method utilize the Walsh-Hadamard correlation detection process (e.g., functions/matrix) to provide an all-binary structure that permits seamless bridging between analog and digital domains. An embodiment may capture an incoming optical signal at an optical aperture, convert the optical signal to an electrical signal, pass the electrical signal through a Low-Noise Amplifier (LNA) to create an LNA signal, pass the LNA signal through one or more correlators where each correlator has a corresponding Walsh-Hadamard (WH) binary basis function, calculate a correlation output coefficient for each correlator as a function of the corresponding WH binary basis function in accordance with Walsh-Hadamard mathematical principles, digitize each of the correlation output coefficient by passing each correlation output coefficient through an Analog-to-Digital Converter (ADC), and performing image mode processing on the digitized correlation output coefficients as desired to produce one or more image modes. Some, but not all, potential image modes include: multi-channel access, temporal, range, three-dimensional, and synthetic aperture. | 04-15-2010 |
20120236905 | REMOTE DETECTION OF ELECTRONIC DEVICES - An apparatus and method for detecting solid-state electronic devices are described. Non-linear junction detection techniques are combined with spread-spectrum encoding and cross correlation to increase the range and sensitivity of the non-linear junction detection and to permit the determination of the distances of the detected electronics. Nonlinear elements are detected by transmitting a signal at a chosen frequency and detecting higher harmonic signals that are returned from responding devices. | 09-20-2012 |
Delmar Guenther, Dallas, TX US
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20140202925 | METHOD AND APPARATUS FOR MAKING HYBRID CRUDE OILS AND FUELS - A simplified process is provided for creating hybrid crude oils and hybrid crude fractions with characteristics superior to the original. The process uniquely combines gases with crude oil or crude fractions in an effervescent turbulent manner at low temperatures and pressures and without the further aid of catalysts. The process breaks large chain hydrocarbons into smaller chain hydrocarbons, molecularly combines carbon, hydrogen, and/or hydrocarbon molecules from the gases with and into hydrocarbon molecules of the crude or crude fraction, and separates contaminants and impurities. | 07-24-2014 |
20150152342 | METHOD AND APPARATUS FOR MAKING HYBRID CRUDE OILS AND FUELS - A simplified process is provided for creating hybrid crude oils and hybrid crude fractions with characteristics superior to the original. The process uniquely combines gases with crude oil or crude fractions in an effervescent turbulent manner at low temperatures and pressures and without the further aid of catalysts. The process breaks large chain hydrocarbons into smaller chain hydrocarbons, molecularly combines carbon, hydrogen, and/or hydrocarbon molecules from the gases with and into hydrocarbon molecules of the crude or crude fraction, and separates contaminants and impurities. | 06-04-2015 |
Derek Guenther, St. Paul, MN US
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20150177306 | Validation of Capacitor Bank Operation - A system for validating an operation of a capacitor bank is disclosed. The system can include a first capacitor of the capacitor bank electrically coupled to a first power line. The system can also include a first sensor operatively coupled to the first power line, where the first sensor is configured to measure a first representation of power flowing through the first power line. The system can further include a local control system communicably coupled to the first sensor, where the local control system receives the first representation of the power flowing through the first power line from the first sensor, where the local control system validates the operation of the first capacitor based on the first representation. | 06-25-2015 |
Donald Guenther, Brookville, OH US
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20140170215 | ORALLY DISINTEGRATING TABLETS AND METHODS OF MANUFACTURE - A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules. | 06-19-2014 |
20150283085 | ORALLY DISINTEGRATING TABLETS AND METHODS OF MANUFACTURE - A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drag, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules. | 10-08-2015 |
Douglas G. Guenther, Wheaton, IL US
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20080287230 | Game ball cover with improved stripes and/or logos - An inflatable game ball including a carcass, a cover and at least one thin member. The cover has inner and outer surfaces. The inner surface of the cover is coupled to the carcass. At least one recess is formed into the outer surface of the cover. At least one thin member is coupled to the cover at the at least one recess. The member substantially fills the recess. The member has inner and outer portions. The outer portion is formed of a highly grippable material. | 11-20-2008 |
20110118062 | AMERICAN-STYLE FOOTBALL INCLUDING IMPROVED BLADDER CONSTRUCTION FOR MOUNTING OF ELECTRONICS - An American style football including an inflatable bladder, a cover surrounding the bladder, and an electronic circuit. The bladder includes first and second side walls defining an expandable cavity and a cross-member configured to extend through the expandable cavity. The side walls and cross-member are coupled together to form a bladder seam. The electronic circuit is coupled to the cross-member and produces a signal to enable the position and movement of the football to be monitored during use. | 05-19-2011 |
20110118064 | AMERICAN-STYLE FOOTBALL INCLUDING ELECTRONICS COUPLED TO THE BLADDER - An American style football including an inflatable bladder, a cover surrounding the bladder, a lacing coupled to the at least one cover panel, and an electronic circuit. The electronic circuit is coupled to the bladder. The electronic circuit includes at least one sensor and the electronic circuit being configured to produce a signal to enable the position and movement of the football to be monitored during use. | 05-19-2011 |
20110118065 | AMERICAN-STYLE FOOTBALL INCLUDING ELECTRONICS - An American style football including an inflatable bladder, at least two cover panels surrounding the bladder, a lacing coupled to the at least one cover panel, and an electronic circuit. Each of the cover panels includes an outermost layer and a lining. The electronic circuit is coupled to at least one of the cover panels. The electronic circuit includes at least one sensor. The electronic circuit is configured to produce a signal to enable the position and movement of the football to be monitored during use. | 05-19-2011 |
20130231206 | GAME BALL COVER WITH IMPROVED STRIPES - An American football is configured for direct contact with a user's hands and includes first and second transversely extending stripes and a plurality of cover panels. The cover panels have an outer surface formed of a first material. One of the cover panels is formed of first, second and third sub-panels. One of the side edges of the first and second stripes is fixedly coupled to one of the first and second sub-panels, respectively, and the other of the side edges of the first and second stripes is fixedly coupled to one of the second and third sub-panels, respectively. The stripes having an outer surface formed of a second material. The second material has a static coefficient of friction that is greater than the static coefficient of friction of the first material when measured in accordance with the standard test method for static coefficient of friction of ASTM D1894-01. | 09-05-2013 |
20150343273 | AMERICAN-STYLE FOOTBALL INCLUDING ELECTRONICS - An American style football including an inflatable prolate spheroidal shaped bladder, a lining positioned over the bladder, a cover assembly, a lacing, and an electronic circuit positioned between the lining and the cover assembly and generally aligned with the lacing. The cover assembly includes at least first, second, third and fourth cover panels collectively positioned over the bladder and the lining. The lacing is coupled to the first and fourth cover panels. The electronic circuit includes at least one sensor and the electronic circuit is configured to produce a signal to enable at least one characteristic of the football to be monitored during use. | 12-03-2015 |
Drake Guenther, Charlottesville, VA US
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20150038844 | Portable Ultrasound System Comprising Ultrasound Front-End Directly Connected to a Mobile Device - A portable ultrasound imaging system includes a mobile computing device; a detachable front end component configured for attachment to and communication with the mobile computing device, and configured to transmit and receive ultrasound signals; and programming, when installed on the mobile computing device, being executable by the mobile computing device to cause the mobile computing device to send signals to the front end component causing the front end component to transmit the ultrasound signals, and to receive signals from the front end component resulting from the front end component receiving the receive ultrasound signals, and process the receive signal and display an ultrasound image resulting from the processing. The front end component is configured to be directly joined with the mobile computing device and directly connected, without the use of an external wire or cable. | 02-05-2015 |
Drake A. Guenther, Dublin, OH US
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20140348442 | IMAGING OR COMMUNICATIONS SYSTEM UTILIZING MULTISAMPLE APODIZATION AND METHOD - Methods, systems and system components for optimizing contrast resolution of an imaging or sensing system utilizing multiple channels of broadband data associated with an array of transducers. Channels of data are filtered by passing the channels of data through finite impulse response (FIR) filters on each channel. The filters each have multiple taps having tap weights pre-calculated as a function of distance of the array from an object that energy is being transmitted to or reflected from. The weights are pre-computed through a deterministic equation based on an a priori system model. | 11-27-2014 |
Drake A. Guenther, Annapolis, MD US
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20090299184 | IMAGING OR COMMUNICATIONS SYSTEM UTILIZING MULTISAMPLE APODIZATION AND METHOD - Methods systems and system components for optimizing contrast resolution of an imaging or sensing system utilizing multiple channels of broadband data associated with an array of transducers. Channels or data are filtered by passing the channels of data through finite impulse response (FIR) filters on each channel. The filters each have multiple taps having tap weights pre-calculated as a function of distance of the array from an object that energy is being transmitted to or reflected from. The weights are pre-computed through a deterministic equation based on an a priori system model. | 12-03-2009 |
Gary D. Guenther, Clarendon Hills, IL US
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20130307512 | SYSTEMS FOR INDIRECT AVERAGE CURRENT MEASUREMENT - One example of the invention relates to a power system. The power system can include a switching power converter configured to convert an input voltage to an output voltage for providing power at an output thereof to which a load is connectable. A measurement system can include measurement circuitry configured to measure an average of an accessible current in the power converter during both continuous and discontinuous modes of operation and derive an average measurement of another current in the power converter based on timing control signals used to control operation of the power converter. | 11-21-2013 |
Gary David Guenther, Warrenville, IL US
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20100161256 | Circuit and Method of Output Power Detection for a Converter Circuit - A circuit and method of determining the power output for a converter circuit includes determining a time averaged voltage from a rectified voltage of a winding of the transformer and multiplying the time averaged voltage by a constant determined at least in part by an average current of a winding of the transformer. By one approach, a rectified voltage from a primary side of the transformer is time averaged using a filter circuit. The current can be known or preset or controlled by the converter circuit such that the time averaged voltage reading, assuming a constant current, can be compared to a preset voltage such that the voltage reading approximates a power reading for the transformer. By another approach, the time averaged voltage is multiplied by the current to obtain a power output reading. | 06-24-2010 |
20120153920 | SYSTEMS FOR INDIRECT AVERAGE CURRENT MEASUREMENT - One example of the invention relates to a power system. The power system can include a power converter configured to convert an input voltage to an output voltage for providing power at an output thereof to which a load is connectable. A measurement system can include measurement circuitry configured to measure an average of an accessible current in the power converter and derive an average measurement of another current in the power converter based on timing control signals used to control operation of the power converter. | 06-21-2012 |
Gerhard Guenther, Seabrook, TX US
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20080269441 | Polymerization process providing polyethylene of enhanced optical properties - A process for the polymerization of ethylene to provide an ethylene polymer of reduced Yellowness Index. A feed stream, comprising an inert hydrocarbon diluent containing ethylene in a minor amount, is supplied to a polymerization reactor. A chromium-based polymerization catalyst and a triethylboron co-catalyst are incorporated into the feed stream within the reactor. The polymerization catalyst will normally be used in an amount within the range of 0.008-0.1 wt. % of the diluent in the feed stream and the triethylboron co-catalyst is incorporated in an amount within the range of 0.1-50 ppm of the diluent. The polymer fluff from the reactor is heated to a temperature sufficient to melt the fluff which is then extruded to produce a polymer product. The Yellowness Index after high temperature aging is at least 5% less than the corresponding Yellowness Index of a corresponding polymer product produced without the triethylboron co-catalyst. | 10-30-2008 |
20090035545 | POLYETHYLENE FILMS WITH IMPROVED BUBBLE STABILITY - This invention relates to high density polyethylene blown films having good barrier properties and improved processing characteristics. The method incorporates the use of peroxide which results in improved bubble stability without sacrifice in barrier properties. The polyethylenes have a density greater than about 0.950 g/cc, are relatively narrow in molecular weight distribution MWD (in the range of from about 2.0 to about 6.5), and are of medium molecular weight. In an embodiment, the films also have a rheological breadth parameter, a, that has been reduced by at least about 5%, but not more than 45%, by addition of a peroxide to the polyethylene. The addition of peroxide improves processability without sacrificing strength and barrier properties such as oxygen transmission rate. | 02-05-2009 |
20140138870 | Polyethylene Useful For Producing Film and Molded Articles In A Process Which Uses Solid State Stretching - Applicants have discovered that certain polyethylene (PE) homopolymers or copolymers of ethylene and C | 05-22-2014 |
Gerhard Guenther, Kemah, TX US
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20080275197 | Bimodal Polyethylene Resins That Have High Stiffness and High ESCR - A bimodal polyethylene having a high density ranging from about 0.955 to about 0.959 g/cc, an improved environmental stress cracking resistance (ESCR) of from about 400 to about 2500 hours, and an improved 0.4% flexural modulus of from about 180,000 to about 260,000 psi (1,200 MPa to about 1,800 MPa) may be formed using a Ziegler-Natta polymerization catalyst using two reactors in series. The bimodal polyethylene may have a high load melt index (HLMI) of from about 2 and about 30 dg/min and may be optionally made with a small amount of alpha-olefinic comonomer in the second reactor. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 11-06-2008 |
20100129579 | Rapid Crack Properties in High Performance Pipe - Pipe articles and methods of forming the same are described herein. The pipe articles generally include a bimodal polyethylene including a greater amount of high molecular weight fraction than low molecular weight fraction and wherein the pipe article exhibits a critical temperature of less than about 0° C. at 5 bar. | 05-27-2010 |
20100159173 | Polyethylene Polymerization Processes - Polymer articles and processes of forming the same are described herein. The processes generally include providing a bimodal ethylene based polymer, blending the bimodal ethylene based polymer with a nucleator to form modified polyethylene and forming the modified polyethylene into a polymer article, wherein the polymer article is selected from pipe articles and blown films. | 06-24-2010 |
20100267909 | Bimodal Pipe Resin and Products Made Therefrom - Disclosed is a bimodal Ziegler-Natta catalyzed polyethylene, having a density of from 0.930 g/cc to 0.960 g/cc, and a molecular weight distribution of from 10 to 25, wherein an article formed therefrom has a PENT of at least 1500. Also disclosed is a method of preparing a tubular article including obtaining a bimodal polyethylene having a density of from 0.930 g/cc to 0.960 g/cc and a molecular weight distribution of from 10 to 25, and processing the polyethylene under conditions where a specific energy input (SEI) is less than 300 kW·h/ton, and wherein the article has a PENT of at least 1500. Further disclosed is a method for controlling the degradation of polyethylene including polymerizing ethylene monomer, recovering polyethylene, extruding the polyethylene, and controlling the degradation of polyethylene by measuring the SEI to the extruder and adjusting throughput and/or gear suction pressure keep SEI less than 300 kW·h/ton, and forming an article. | 10-21-2010 |
20110174413 | Modification of Polyethylene Pipe to Improve Sag Resistance - Methods of forming pipe articles and pipe articles are described herein. The methods generally include providing a bimodal ethylene based polymer, blending the bimodal ethylene based polymer with up to about 50 ppm peroxide to form modified polyethylene and forming the modified polyethylene into a pipe. | 07-21-2011 |
Gerhard Guenther, Houston, TX US
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20120091621 | BIMODAL PIPE RESIN AND PRODUCTS MADE THEREFROM - Disclosed is a bimodal Ziegler-Natta catalyzed polyethylene, having a density of from 0.930 glee to 0.960 glee, and a molecular weight distribution of from 10 to 25, wherein an article formed therefrom has a PENT of at least 1500. Also disclosed is a method of preparing a tubular article including obtaining a bimodal polyethylene having a density of from 0.930 glee to 0.960 Wee and a molecular weight distribution of from 10 to 25, and processing the polyethylene under conditions where a specific energy input (SET) is less than 300 kW.h/ton, and wherein the article has a PENT of at least 1500. Further disclosed is a method for controlling the degradation of polyethylene including polymerizing ethylene monomer, recovering polyethylene, extruding the polyethylene, and controlling the degradation of polyethylene by measuring the SEI to the extruder and adjusting throughput and/or gear suction pressure keep SEI less than 300 kW.h/ton, and forming an article. | 04-19-2012 |
Gerhard K. Guenther, Seabrook, TX US
Gernot E. Guenther, Endicott, NY US
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20080243462 | INSTRUCTION ENCODING IN A HARDWARE SIMULATION ACCELERATOR - A hardware simulation accelerator to simulate logic designs, a method to encode instructions for use in the hardware simulation accelerator, and a computer program product having code of the method by which the hardware simulation accelerator can read encoded instructions to simulate the logic design, and computer program product of the encoded instructions to simulate a logic design in a hardware accelerator. Each instruction has one of a plurality of opcodes, the opcodes select which of the hardware resources of the hardware simulation accelerator will implement and use the values set forth in other programmable bits of the encoded instruction. The encoded instruction may be a routing and/or a gate evaluation instruction. | 10-02-2008 |
20080270748 | HARDWARE SIMULATION ACCELERATOR DESIGN AND METHOD THAT EXPLOITS A PARALLEL STRUCTURE OF USER MODELS TO SUPPORT A LARGER USER MODEL SIZE - A system and method for design verification and, more particularly, a hardware simulation accelerator design and method that exploits a parallel structure of user models to support a large user model size. The method includes a computer including N number of logic evaluation units (LEUs) that share a common pool of instruction memory (IM). The computer infrastructure is operable to: partition a number of parallel operations in a netlist; and send a same instruction stream of the partitioned number of parallel operations to N number of LEUs from a single IM. The system is a hardware simulation accelerator having a computer infrastructure operable to provide a stream of instructions to multiple LEUs from a single IM. The multiple LEUs are clustered together with multiple IMs such that each LEU is configured to use instructions from any of the multiple IMs thereby allowing a same instruction stream to drive the multiple LEUs. | 10-30-2008 |
Godehard Guenther, Reno, NV US
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20140064541 | Wrist Band and Other Portable Loudspeakers and Electronic Apparatus Utilizing Same - The invention provides in some aspects a loudspeaker, for example, configured in a band-like shape and suitable, for example, for wearing as a wristband, armband, legband or the like. A related aspect of the invention is to provide such a wearable loudspeaker comprising a band-shaped enclosure, a driver that is mounted in the enclosure, and an active diaphragm that is coupled to the driver to generate sound waves directed outwardly from the enclosure (referred to below as “outwardly directed waves,” “outward waves” and, more often, by analogy to a conventional, non-wearable loudspeaker “frontward-directed sound waves” or, more simply, “front waves”) and backward-directed sound waves (“back waves”) directed inwardly into the enclosure (referred to below as “inwardly directed waves,” “inward waves” and, more often, by analogy to a conventional loudspeaker “backward-directed waves” or, more simply, “back waves”). A reflective member, which is also disposed within the enclosure and/or on an inner surface of a wall thereof, reflects one or more components of the back wave. | 03-06-2014 |
Godehard A. Guenther, Concord, MA US
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20080247582 | Loudspeaker and Systems - The invention provides, in one aspect, a loudspeaker that has electrodynamically-driven piston mounted in one external wall and that has movable panels in one or more other external walls. Those panels are air-coupled to the piston, e.g., via air within the enclosure, such that vibrational motion of the piston causes the vibration of the panels, thereby, improving the overall air coupling of the piston to the external environment, e.g., the listening room. Further aspects of the invention provide an improved driver for use, e.g., in the aforementioned loudspeaker. The driver comprises a three-part piston having first and second diaphragms coupled back-to-back with one another and having a voice coil face-mounted (or front-mounted) within the second diaphragm. | 10-09-2008 |
20080292117 | LOUDSPEAKER AND ELECTRONIC DEVICES INCORPORATING SAME - The invention provides, in some aspects, electronic devices with improved radiators (or “passive drivers”) comprising an elastomerically mounted mass in order to improve sound reproduction fidelity. The mass comprises a component of the device not normally used for such purpose—e.g., a battery—thereby, permitting size reductions while, at the same time, enhancing audio fidelity | 11-27-2008 |
20090161902 | LOUDSPEAKERS, SYSTEMS AND COMPONENTS THEREOF - Improved loudspeakers, systems and components are adapted to interconnect with many forms of communication media. In one embodiment, a speaker is mountable within a receptacle. The speaker includes a magnetic driver and a diaphragm mounted to a frame. The frame includes a mounting member extending from a surface of the frame behind the flange plane. The mounting member is engagable in a notch formed in the receptacle for securing the speaker within the receptacle. In another embodiment, a low-profile loudspeaker has a front-mounted magnetic driver disposed within a cone-shaped acoustic diaphragm. The magnetic driver includes a first rare earth magnet centrally disposed within an electromagnetic shielding material. In another embodiment, a low-profile, two-way loudspeaker includes a cone-shaped diaphragm and a dome-shaped (tweeter) diaphragm. A front-mounted magnetic driver comprises first and second rare earth magnets each centrally disposed within electromagnetic shielding material. The driver and cone-shaped diaphragm are mounted to a speaker frame. The tweeter diaphragm is mounted onto the driver coaxially and substantially coplanar with a forward edge of the cone-shaped diaphragm. | 06-25-2009 |
20090304222 | LOW COST MOTOR DESIGN FOR RARE-EARTH-MAGNET LOUDSPEAKERS - A loudspeaker magnetic motor utilizes a voice coil with two or more wire coils that are connected in parallel and that are layered on top of one another. The motor utilizes, as a magnetic field source, a permanent magnet and, more particularly, a permanent magnet that includes a rare earth metal such as a neodymium boron iron magnet. | 12-10-2009 |
20100254564 | LOUDSPEAKERS AND SYSTEMS - The invention provides, in one aspect, a loudspeaker that has electrodynamically-driven piston mounted in one external wall and that has movable panels in one or more other external walls. Those panels are air-coupled to the piston, e.g., via air within the enclosure, such that vibrational motion of the piston causes the vibration of the panels, thereby, improving the overall air coupling of the piston to the external environment, e.g., the listening room. Further aspects of the invention provide an improved driver for use, e.g, in the aforementioned loudspeaker. The driver comprises a three-part piston having first and second diaphragms coupled back-to-back with one another and having a voice coil face-mounted (or front-mounted) within the second diaphragm. | 10-07-2010 |
20120328133 | LOUDSPEAKER AND ELECTRONIC DEVICES INCORPORATING SAME - The invention provides, in some aspects, electronic devices with improved radiators (or “passive drivers”) comprising an elastomerically mounted mass in order to improve sound reproduction fidelity. The mass comprises a component of the device not normally used for such purpose—e.g., a battery—thereby, permitting size reductions while, at the same time, enhancing audio fidelity | 12-27-2012 |
20130170689 | Ultra-Low Profile Loudspeakers - The invention provides in some aspects a loudspeaker comprising an enclosure, a driver that is mounted in the enclosure, and an active diaphragm that is coupled to the driver to generate frontward-directed sound waves (“front waves”) directed outwardly from the enclosure and backward-directed sound waves (“back waves”) directed inwardly into the enclosure. A foam member, disposed within the enclosure and/or on an inner surface of a wall thereof, attenuates components of the back wave as a function of frequency, e.g., in the manner of a low-pass filter. The foam member comprises a foam of rigid material, namely, by way of example, a foam of metal, ceramic, carbon, silicon, glass, and/or epoxy. | 07-04-2013 |
20150256923 | LOUDSPEAKER AND ELECTRONIC DEVICES INCORPORATING SAME - The invention provides, in some aspects, electronic devices with improved radiators (or “passive drivers”) comprising an elastomerically mounted mass in order to improve sound reproduction fidelity. The mass comprises a component of the device not normally used for such purpose—e.g., a battery'thereby, permitting size reductions while, at the same time, enhancing audio fidelity | 09-10-2015 |
Godehard A. Guenther, Reno, NV US
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20130329935 | LOUDSPEAKERS AND SYSTEMS - The invention provides, in one aspect, a loudspeaker that has electrodynamically-driven piston mounted in one external wall and that has movable panels in one or more other external walls. Those panels are air-coupled to the piston, e.g., via air within the enclosure, such that vibrational motion of the piston causes the vibration of the panels, thereby, improving the overall air coupling of the piston to the external environment, e.g., the listening room. Further aspects of the invention provide an improved driver for use, e.g, in the aforementioned loudspeaker. The driver comprises a three-part piston having first and second diaphragms coupled back-to-back with one another and having a voice coil face-mounted (or front-mounted) within the second diaphragm. | 12-12-2013 |
20140044302 | LOW COST MOTOR DESIGN FOR RARE-EARTH-MAGNET LOUDSPEAKERS - A loudspeaker magnetic motor utilizes a voice coil with two or more wire coils that are connected in parallel and that are layered on top of one another. The motor utilizes, as a magnetic field source, a permanent magnet and, more particularly, a permanent magnet that includes a rare earth metal such as a neodymium boron iron magnet. | 02-13-2014 |
20140334657 | PORTABLE LOUDSPEAKERS AND CONVERTIBLE PERSONAL AUDIO HEADPHONE/LOUDSPEAKERS - The invention provides, in some aspects, an audio headphone suitable for conversion to a loudspeaker. The device includes one or more earcups, each having a concavity that includes first and second volumetric regions and a wall that seals the regions from one another. The first volumetric region defines a space that receives a pinnea when the headphone is worn by a user, and the second volumetric region has one or more active drivers (a/k/a “speakers”). The wall includes one or more active diaphragms of those one or more active drivers. Those diaphragms generate front waves directed into the first volumetric region and back waves directed (back) into the second volumetric region. A passive radiator that is elastically mounted in the wall passes to the first volume from the second volume at least a portion of back waves generated by one or more of the active diaphragms. The invention provides, in other aspects, portable loudspeakers constructed in a manner of the earcups described above. | 11-13-2014 |
20150222983 | ULTRA-LOW PROFILE LOUDSPEAKERS - The invention provides in some aspects a loudspeaker comprising an enclosure, a driver that is mounted in the enclosure, and an active diaphragm that is coupled to the driver to generate frontward-directed sound waves (“front waves”) directed outwardly from the enclosure and backward-directed sound waves (“back waves”) directed inwardly into the enclosure. A foam member, disposed within the enclosure and/or on an inner surface of a wall thereof, attenuates components of the back wave as a function of frequency, e.g., in the manner of a low-pass filter. The foam member comprises a foam of rigid material, namely, by way of example, a foam of metal, ceramic, carbon, silicon, glass, and/or epoxy. It (the foam member) may be disposed adjacent the reflective member and, indeed, together those members may comprise one or more walls of the enclosure, e.g., with the reflective member forming an outer surface of the wall(s) and with the foam member forming an inner surface. A reflective member, which is also disposed any of within the enclosure or on an inner surface of a wall thereof, reflects one or more components of the back wave that have passed through the foam member and that have not been eliminated thereby. | 08-06-2015 |
20150260392 | LIGHTBULB LOUDSPEAKER - The foregoing are among the objects attained by the invention, which provides in some aspects a loudspeaker adapted for mounting in a lightbulb socket. The loudspeaker has a body that can, for example, be shaped like a lightbulb and that has a concavity that includes a first volumetric region. A wall that is disposed within the body and that at least partially defines that region includes one or more active diaphragms. The diaphragms generate (i) front waves directed from the first volumetric region to at least one of an environment and a second volumetric region, if any, defined within the concavity, and (ii) back waves directed into the volumetric region. A passive radiator that is elastically mounted in the wall passes from the volumetric region at least a portion of back waves generated by one or more of the active diaphragms. | 09-17-2015 |
Grant B. Guenther, San Diego, CA US
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20130011398 | Serpin Fusion Polypeptides and Methods of Use Thereof - This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. | 01-10-2013 |
20130011399 | WAP Domain Fusion Polypeptides and Methods of Use Thereof - This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a WAP domain-containing polypeptide, a second polypeptide, and a third polypeptide. The second and/or third polypeptides of the fusion proteins of the invention are an Fc polypeptide; an albumin polypeptide; a cytokine targeting polypeptide; or a serpin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. | 01-10-2013 |
Grant B. Guenther, La Jolla, CA US
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20150147324 | WAP DOMAIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF - This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a WAP domain-containing polypeptide a second polypeptide, and a third polypeptide. The second and/or third polypeptides of the fusion proteins of the invention are a Fe polypeptide; an albumin polypeptide; a cytokine targeting polypeptide; or a serpin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. | 05-28-2015 |
20150147325 | SERPIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF - This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules. | 05-28-2015 |
Harald R. Guenther, Schnecksville, PA US
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20140072002 | Method and System for Operating Semiconductor Optical Amplifiers - Disclosed are systems and methods for using a semiconductor optical amplifier (SOA) as an optical modulator for pulsed signals. In accordance with the principles of the invention, the SOA can be biased with a negative voltage to suppress transmission and improve modulator extinction and biased with a positive pulsed signal with sufficient amplitude to forward bias the amplifier (SOA), both transmitting the carrier and increasing its amplitude by means of a gain provided by the SOA under forward biased conditions. In addition, the forward bias voltage may be selected to compensate for losses within the SOA. | 03-13-2014 |
20140072004 | Wavelength-Stabilized Diode Laser - A hybrid external cavity laser (HECL) system comprises a diode laser, collection and collimation optics, and a volume Bragg grating, emits radiation at a single wavelength with a short-term wavelength stability in the order of at least one part in a billion The wavelength stability is achieved by use of a thermal management system, comprising inner and outer housings, each containing a temperature sensor, and electronic circuitry that monitors the temperatures and controls both the laser diode current and a thermoelectric cooler based on temperatures determined from said temperature sensors. The laser system is packaged in a compact enclosure that minimizes waste heat, facilitating use in applications that have heretofore employed stable, single-frequency lasers, including He—Ne lasers. | 03-13-2014 |
Harald R. Guenther, Schnecksvile, PA US
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20150131686 | Wavelength Stabilized Diode Laser - A hybrid external cavity laser and a method for configuring the laser having a stabilized wavelength is disclosed. The laser comprises a semiconductor gain section and a volume Bragg grating, wherein a laser emission from the semiconductor gain section is based on a combination of a reflectivity of a front facet of the semiconductor gain section and a reflectivity of the volume Bragg grating and the reflectivity of the semiconductor gain section and the volume Bragg grating are insufficient by themselves to support the laser emission. The hybrid cavity laser further comprises an etalon that provides further wavelength stability. | 05-14-2015 |
20150131690 | Wavelength Stabilized Diode Laser - A hybrid external cavity laser and a method for configuring the laser having a stabilized wavelength is disclosed. The laser comprises a semiconductor gain section and a volume Bragg grating, wherein a laser emission from the semiconductor gain section is based on a combination of a reflectivity of a front facet of the semiconductor gain section and a reflectivity of the volume Bragg grating and the reflectivity of the semiconductor gain section and the volume Bragg grating are insufficient by themselves to support the laser emission. The hybrid cavity laser further comprises an etalon that provides further wavelength stability. | 05-14-2015 |
20150346102 | Compact Raman Probe Integrated with Wavelength Stabilized Diode Laser Source - A compact Raman probe integrated with a wavelength-stabilized laser source is disclosed. The output beam of the laser source has an elongated cross-section that is focused onto a target of interest. Raman and Rayleigh scattered light is collected, collimated, and filtered by free-space optics to form a beam that is coupled to the input of a multimode optical fiber having an elongated core that is aligned to edge slits of an optical spectrometer. | 12-03-2015 |
Henry Guenther, Elm Grove, WI US
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20140116522 | FLUID CONDUIT ARRANGEMENT - A fluid conduit arrangement includes a reservoir containing a pressurized gas therein. An outer rigid conduit in communication with the reservoir contains a first working fluid under pressure from the pressurized gas within a dosed system defined by the reservoir and the outer rigid conduit. An inner flexible conduit is provided for conducting a second working fluid therethrough upon application of a supply pressure. The inner flexible conduit is disposed within the outer rigid conduit, and is subjected to the pressurized first working fluid in surrounding relationship therewith. Relative differences between the pressurized first working fluid and the second working fluid enable the inner flexible conduit to either expand and permit free flow of the second working fluid therethrough, or collapse and evacuate flow of the second working fluid therefrom. | 05-01-2014 |
Jason Guenther, Bellevue, CA US
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20080221998 | PARTICIPANT INTERACTION WITH ENTERTAINMENT IN REAL AND VIRTUAL ENVIRONMENTS - A system of interaction between an electronic theme park experience and live theme park interaction and activity earns rewards. The interaction permits for rewards earned in the electronic theme park experience to be redeemed in the live theme park experience and vice versa. The electronic theme park and live activity are interactive in real or delayed time through an Internet connection. Activities on one or both of the live and electronic formats are designed to drive increased player visiting of the live and/or electronic versions. The Virtual Magic Kingdom in some embodiments includes a virtual version of one or more of theme parks such as the “Magic Kingdom” portion of Disney, Inc.'s theme parks. | 09-11-2008 |
Jerry Norman Guenther, Verona, WI US
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20130129331 | PORTABLE THAWING UNIT - A portable thawing unit for heating animal fluids and cells (stored in straws) includes a main casing for holding water therein. A lower body secured to the main casing includes a battery pack and plug for recharging the battery pack. An upper body secured to the main casing allows at least one straw to enter the main casing for immersion in the heated water. A heating element and thermistor heat the water in the main casing to a desired temperature. A straw rack unit having at least one straw shaft holds straws and allows them to be lowered and raised. A motor powered by the batter pack runs a propeller that helps mix the water. The thawing unit does not allow straws in the main casing to contact each other, allowing, for example, 95 to 98.6 degrees Fahrenheit water to better contact the straws and heat them more efficiently. | 05-23-2013 |
John Guenther, Chicago, IL US
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20140367292 | TRASH CART SMART LID - A trash cart lid comprising a body including four edges, wherein the four edges define a perimeter of the body; and at least one flange connected to the body, wherein the flange shares at least a portion of an edge of the body; wherein each flange includes an advertising receiving space. In addition, the lid may provide one or more modules that communicate information about the status of the smart lid and user interactions with the trash cart to a remote server. | 12-18-2014 |
20150262247 | CURBSIDE CART DIRECT MARKETING SYSTEMS AND METHODS - A marketing system including an ad receiving item including a first ad receiving space associated with a unique identifier, a database including a plurality of unique identifiers each associated with an address and a demographic trait information, a controller, and a memory including instructions that cause the controller to receive a plurality of ads, populate the first ad receiving space with a first selected ad associated with targeting information that matches the demographic trait information of the first ad receiving space, upon user interaction with the call-to-action token of the first selected ad, receive user interaction information including user demographic information, update the demographic trait information associated with the unique identifier to include the user demographic information, and populate a second ad receiving space with a second selected ad from the plurality of ads, wherein the second selected ad is associated with targeting information that matches the user demographic information. | 09-17-2015 |
John H. Guenther, Merrill, WI US
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20160031921 | OXYGEN ASSISTED ORGANOSOLV PROCESS, SYSTEM AND METHOD FOR DELIGNIFICATION OF LIGNOCELLULOSIC MATERIALS AND LIGNIN RECOVERY - An oxygen assisted Organosolv process for a more efficient delignification and producing bio-products by decomposing lignocellulosic materials comprises providing a lignin solvent with water, an acid, an oxidant and one or more lignin dissolving chemicals. The process also includes placing biomass in contact with oxidant, acid, water, the lignin solvent in any order or combined to form a recyclable solvent, and recycling at least a portion of the recyclable solvent by circulating the recyclable solvent back into contact with the biomass. The circulating of the recyclable solvent occurs for a period of time, during which, acid and oxidant may be added if necessary as they may be consumed by the process, after which, the process then includes separating material such as chemicals and lignin from the recyclable solvent. The chemicals can be recycled as new lignin dissolving solvent or sold, while lignin can be used as natural and renewable colorant for polymers such as poly lactic acid, or mixed with other polymers as an additive and extruded or injected to consumable polymeric parts, or can be used and the natural source of renewable aromatics. Application of an oxidant will help the overall fractionation process by changing the chemical characteristics of the lignin and therefore allows more lignin to be removed from biomass. At the end, the lignin is separated from the lignin dissolving solvent by a separation process to also reclaim the lignin dissolving solvent for the next fractionation process. | 02-04-2016 |
Karl W. Guenther, Palm Harbor, FL US
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20140046249 | DUAL PUMP ARTHROSCOPIC IRRIGATION/ASPIRATION SYSTEM WITH OUTFLOW CONTROL - A dual pump irrigation/aspiration pump system capable of operating in a plurality of different modes suitable for a variety of different endoscopic surgical procedures. The system monitors actual or calculated intra-articular pressure and adjusts flow to maintain surgeon requested pressure at the surgical site while controlling outflow. The irrigation/aspiration pump system has an inflow pump and tubing dedicated to communicating fluid to the surgical work site and an outflow pump and tubing dedicated to removing fluid from the work site at a controlled rate. The system further has different size inflow and outflow pumps and tubing cassettes, means for altering the outflow fluid flow rate to accommodate a surgical tool and a means for declogging the surgical tool in the event of blockage. In a preferred embodiment a pressure control system provides inferred pressure information representative of the pressure at the work site. | 02-13-2014 |
Keith E. Guenther, Milan, MI US
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20140313703 | LED LIGHTING MODULE HAVING BATTERY POWER AND PHOTOVOLTAIC CHARGING - A lighting module ( | 10-23-2014 |
Kenneth W. Guenther, Portland, OR US
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20140272807 | INTERACTIVE SYSTEM AND METHOD FOR SHOOTING AND TARGET TRACKING FOR SELF-IMPROVEMENT AND TRAINING - A device configured to track and capture the movement data of a target as well as shooting and firearm movement activity of a hunter includes a housing, a camera, sensors, a processor, a memory, and a battery. The camera is disposed in close proximity to the housing to capture the movement of a target. One or more sensors are disposed in the housing and interfaced with the processor to capture the velocity and orientation of a gun. A trigger activation sensor is also in communication with the processor. The memory stores camera activity, trigger activity, sensor activities, and also stores an alarm setting on the device. The processor activates the alarm setting when predefined criteria are met. Radar can be incorporated to determine the distance of the target from the user. GPS can also be included to provide precise location and time information. | 09-18-2014 |
Mark Guenther US
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20110252864 | Emissions Test System And Method - An emission test system may include at least one controller configured to determine, directly or indirectly, a quantity of diluted exhaust sample in a container at the completion of an emissions test, and to cause additional diluent gas to be added to the container based on the determined quantity. | 10-20-2011 |
Mark Guenther, Novi, MI US
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20120304737 | Emissions Test System And Method - An emission test system may include at least one controller configured to determine, directly or indirectly, a quantity of diluted exhaust sample in a container at the completion of an emissions test, and to cause additional diluent gas to be added to the container based on the determined quantity. | 12-06-2012 |
Mark L. Guenther, Portland, OR US
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20090207886 | Apparatus and method for synthesizing and generating an SSC modulated signal - A system and method for synthesizing and generating the SSC modulated signal with precision and in a controlled manner is provided. In one embodiment the system may be integrated in an arbitrary waveform generator. | 08-20-2009 |
20110119688 | Method and System to Measure and Represent the Measured Value of a Limit in Terms of Another Measurement in a Signal Measurement System - Embodiments of the invention provide a system and method to measure and represent the measured value of a limit in terms of another measurement, such as clock values or cycles of the system. The system can include, for example, a test and measurement instrument such as an oscilloscope. In another embodiment of the present invention, slew rate de-rated values may be automatically determined through the use of configurable lookup tables. | 05-19-2011 |
20110292987 | METHOD FOR DECOMPOSING AND ANALYZING JITTER USING SPECTRAL ANALYSIS AND TIME-DOMAIN PROBABILITY DENSITY - A method for analyzing jitter using a test and measurement instrument includes obtaining a collection of time interval error (TIE) values corresponding to composite jitter of a waveform, optionally decomposing the composite jitter into jitter components that are correlated to the data pattern and components that are uncorrelated to the data pattern, and using a spectral approach to decompose the jitter components into jitter components that are recognizable as deterministic and jitter components that are unrecognizable as deterministic. Thereafter, the jitter components analyzed in the frequency domain are converted back to the time domain, and subtracted from the composite jitter, thereby isolating uncorrelated residual jitter. The uncorrelated residual jitter is decomposed into bounded uncorrelated jitter and random jitter, for example, by integrating a probability density (PDF) function of the residual jitter and analyzing the resulting cumulative distribution function (CDF) curve in Q-space. | 12-01-2011 |
20160036568 | METHOD FOR PERFORMING JOINT JITTER AND AMPLITUDE NOISE ANALYSIS ON A REAL TIME OSCILLOSCOPE - A method for determining jitter and noise of an input signal. The method includes acquiring one or more uncorrelated waveform records by an acquisition unit of a test and measurement instrument, determining a correlated waveform from the acquired waveform(s), dividing the correlated waveform into unit intervals, dividing an uncorrelated waveform into unit intervals, measuring a timing displacement (t | 02-04-2016 |
Matthew Guenther, Cambridge, MA US
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20090221428 | Methods of Genome-Wide Location Analysis in Stem Cells - The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that apply to stem cells such as but not limited to; embryonic stem cells and adult stem cells. The invention also provides methods of identifying agents which modulate differentiation of stem cells. The invention also provides methods of defining the differentiation potential of a cell and of designing array oligonucleotides. | 09-03-2009 |
Matthew G. Guenther, Boston, MA US
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20160032387 | METHODS AND SYSTEMS FOR EVALUATING GENES - Aspects and embodiments disclosed herein are directed to providing methods and systems for evaluating target genes and/or associated super enhancers and or super-enhance components. In some embodiments, the method includes selecting a gene associated with a super-enhancer, to provide a selected gene, evaluating the selected gene for contribution to a cell state, e.g., a state characterized by a disease or disorder (a disease/disorder state), and responsive to the evaluation, classifying the selected gene and/or associated super-enhancer. | 02-04-2016 |
Morgan P. Guenther, Sausalito, CA US
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20120297490 | MEDIA CONTENT DEVICE, SYSTEM AND METHOD - Media content is provided using metric-apportioning. In accordance with one or more embodiments, remote-user interface circuits are authenticated and remote access is provided to different sets of media content via the interface. For each authenticated interface and a time-based period during which the interface accesses the media content, time-stamped usage data that characterizes use of the media content at the interface is communicated therewith. A usage metric characterizing usage of the media content is apportioned based upon the time-stamped usage data and stored weighting factor data for the media content. | 11-22-2012 |
20150200819 | MEDIA CONTENT DEVICE, SYSTEM AND METHOD - Media content is provided using metric-apportioning. In accordance with one or more embodiments, remote-user interface circuits are authenticated and remote access is provided to different sets of media content via the interface. For each authenticated interface and a time-based period during which the interface accesses the media content, time-stamped usage data that characterizes use of the media content at the interface is communicated therewith. A usage metric characterizing usage of the media content is apportioned based upon the time-stamped usage data and stored weighting factor data for the media content. | 07-16-2015 |
Nicholas A. Guenther, Imperial, MO US
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20090265118 | METHODS AND SYSTEMS FOR PROVIDING UNANTICIPATED DEMAND PREDICTIONS FOR MAINTENANCE - A method for predicting a probability of failure for a component of a platform at a specified time is described. The method includes collecting historical maintenance data relating to the component, selecting, utilizing the collected historical maintenance data, a lifetime distribution model that best fits the historical maintenance data, estimating upcoming component failures using the selected lifetime distribution model, and applying maintenance schedule dates for the platform to the upcoming component failures to determine a likelihood of failure of the component on one of the scheduled maintenance dates. | 10-22-2009 |
Quentin Paul Guenther, Winston-Salem, NC US
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20140096781 | ELECTRONIC SMOKING ARTICLE AND ASSOCIATED METHOD - Smoking articles, and methods for forming such smoking articles, such as an electronic smoking article, are provided. An exemplary smoking article comprises a control body portion having a control body engagement end, and having a first control component therein. A cartridge body portion includes a cartridge body engagement end configured to removably engage the control body engagement end of the control body portion. The cartridge body portion further includes a consumable arrangement comprising at least an aerosol precursor composition and at least one heating element operably engaged therewith, and a second control component. At least the consumable arrangement is configured to be in communication with the first control component upon engagement between the cartridge body and control body portions. | 04-10-2014 |
20140261408 | CARTRIDGE FOR AN AEROSOL DELIVERY DEVICE AND METHOD FOR ASSEMBLING A CARTRIDGE FOR A SMOKING ARTICLE - The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided. | 09-18-2014 |
Rebecca Lynn Rezac Guenther, Lonsdale, MN US
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20090088428 | CYCLOHEXYLIMIDIAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: (I) having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity. | 04-02-2009 |
R.h. Guenther, Cary, NC US
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20120015020 | BIODEGRADABLE DRUG OR OTHER ACTIVE DELIVERY SYSTEM - A nonwoven fabric has been developed as a delivery system for drugs or other actives which includes biodegradable and biocompatible fibers with plant virus nanoparticles. The plant virus nanoparticles are pre-loaded with one or more actives. | 01-19-2012 |
Richard Guenther, Cary, NC US
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20120039799 | VIRAL NANOPARTICLE CELL-TARGETED DELIVERY PLATFORM - This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble. | 02-16-2012 |
20150033418 | NANOTECHNOLOGY SYSTEM FOR AGRICULTURAL APPLICATIONS - A first aspect of the invention is an agricultural composition comprising nanoparticles, an agrochemical active ingredient in the nanoparticles, and optionally (but in some embodiments preferably) a carrier for the nanoparticles. In some embodiments, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids. In some embodiments, the carrier comprises an inert or biodegradable carrier (e.g., a solid carrier) to which the nanoparticles are bound or in which the nanoparticles are suspended. In some embodiments, the carrier comprises inert or biodegradable polymer fibers. | 01-29-2015 |
Richard H. Guenther, Cary, NC US
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20080199870 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided. | 08-21-2008 |
20100069260 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided. | 03-18-2010 |
20100291032 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule. | 11-18-2010 |
20110033850 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule. | 02-10-2011 |
20110229920 | SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS - Methods of inhibiting | 09-22-2011 |
20110306509 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF PROTEIN SYNTHESIS - Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided. | 12-15-2011 |
20130071353 | Antiviral Compounds and Methods of Use Thereof - Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed. | 03-21-2013 |
20140121124 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule. | 05-01-2014 |
20140163037 | SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS - Methods of inhibiting | 06-12-2014 |
20150359786 | ANTIVIRAL COMPOUNDS AND METHODS OF USE THEREOF - Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed. | 12-17-2015 |
Rodney S. Guenther, Houston, TX US
Patent application number | Description | Published |
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20120046868 | DOWNHOLE CLOSED-LOOP GEOSTEERING METHODOLOGY - A closed-loop method for geosteering includes acquiring logging while drilling data and processing the logging while drilling data downhole while drilling to obtain a geosteering correction (a correction to the drilling direction based upon the LWD measurements). The geosteering correction is further processed downhole to obtain new steering tool settings which are then applied to the steering tool to change the direction of drilling. These steps are typically repeated numerous times without the need for uphole processing or surface intervention. | 02-23-2012 |
Rolf Guenther, Monte Sereno, CA US
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20100080957 | Surface Coating - A corrosion barrier is provided, disposed on a substrate. The corrosion barrier includes a vapor corrosion inhibitor (VCI) material and an anti-wetting barrier having a nano-particle composite structure. | 04-01-2010 |
Rolf A. Guenther, Monte Sereno, CA US
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20080271309 | HEATED SUBSTRATE SUPPORT AND METHOD OF FABRICATING SAME - A method and apparatus for forming a substrate support is provided herein. In one embodiment, the substrate support includes a body having a support surface and at least one groove. A heater element clad with a malleable heat sink is disposed in the groove. Substantially no air is trapped between the clad heater element and the groove. An insert is disposed in the groove above the heater. The insert substantially completely covers and contacts the clad heater element and the sides of the groove. A cap is disposed in the groove above the insert. The cap covers and contacts the insert and has an upper surface disposed substantially flush with the support surface. | 11-06-2008 |
Ross Guenther, Nevada City, CA US
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20100104381 | HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic elevation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments. | 04-29-2010 |
20100117273 | PROCESS FOR HOT-FORGING SYNTHETIC CERAMIC - The embodiments of the invention are directed to a synthetic ceramic comprising pyroxene-containing crystalline phase, a clast, and a glass phase, wherein at least a portion of the synthetic ceramic is plastically deformable in a certain temperature range. Other embodiments of the invention relate to a method of making a synthetic ceramic, comprising heating a green ceramic material to 900-1400° C., to a temperature sufficient to initiate partial melting of at least a portion of the green ceramic material, transferring the heated green ceramic material to a press, pressing the heated green ceramic material in a die at 1,000 to 10,000 psi, and transferring the heated, pressed green ceramic material to a furnace for cooling to form the synthetic ceramic. | 05-13-2010 |
Ross Guenther, Penn Valley, CA US
Patent application number | Description | Published |
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20100273630 | SYNTHESIZED HYBRID ROCK COMPOSITION, METHOD, AND ARTICLE FORMED BY THE METHOD - The invention relates to synthetic hybrid rock compositions, articles of manufacture and related processes employing mineral waste starting materials such as mine tailings, mine development rock, ash, slag, quarry fines, and slimes, to produce valuable articles of manufacture and products, which are characterized by superior physical and structural characteristics, including low porosity, low absorption, increased strength and durability, and retained plasticity. The resulting materials are compositionally and chemically distinct from conventional synthetic rock materials as demonstrated by scanning electron microprobe analysis, and are useful in a wide variety of applications, particularly with respect to commercial and residential construction. | 10-28-2010 |
20100303560 | HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic transportation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate and lower object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments. | 12-02-2010 |
20120093591 | HYDRAULIC ELEVATION APPARATUS AND METHOD - The hydraulic transportation apparatus and method of the present invention incorporate a multiple chamber framework internally disposed preferably within at least one single shaft structure, which facilitates movement of object transport containers within the multiple chamber framework. Preferably, fluid elevation is employed to elevate and lower object transport containers and their contents within the multiple chamber framework. Each single shaft structure may be constructed from an existing rehabilitated shaft, or a newly drilled shaft. The present invention may be utilized in vertical or incline lifting environments, and an auxiliary hoist chamber may be incorporated into the multiple chamber framework for use as an alternative to, or in conjunction with, elevating objects by employing fluid elevation. The present invention may be employed in a variety of heavy lifting scenarios, including underground mining or in above ground lifting environments. | 04-19-2012 |
20120235320 | SYNTHESIZED HYBRID ROCK COMPOSITION, METHOD, AND ARTICLE FORMED BY THE METHOD - The invention relates to synthetic hybrid rock compositions, articles of manufacture and related processes employing mineral waste starting materials such as mine tailings, mine development rock, ash, slag, quarry fines, and slimes, to produce valuable articles of manufacture and products, which are characterized by superior physical and structural characteristics, including low porosity, low absorption, increased strength and durability, and retained plasticity. The resulting materials are compositionally and chemically distinct from conventional synthetic rock materials as demonstrated by scanning electron microprobe analysis, and are useful in a wide variety of applications, particularly with respect to commercial and residential construction. | 09-20-2012 |
Sven Guenther, Blacksburg, VA US
Patent application number | Description | Published |
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20080260691 | Prodrugs of Ribavirin with Improved Hepatic Delivery - The present invention relates ribavirin delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to ribavarin and methods for administering conjugated ribavirin compositions. | 10-23-2008 |
Sven Guenther, Coralville, IA US
Patent application number | Description | Published |
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20110002990 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROCODONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 01-06-2011 |
20110002991 | PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF - The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 01-06-2011 |
20110183963 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology. | 07-28-2011 |
20110223207 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided. | 09-15-2011 |
20120142719 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 06-07-2012 |
20120142720 | Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof - The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 06-07-2012 |
20120276168 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized bu chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology. | 11-01-2012 |
20130045247 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided. | 02-21-2013 |
20130150395 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 06-13-2013 |
20130158007 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided. | 06-20-2013 |
20130245265 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 09-19-2013 |
20130252994 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 09-26-2013 |
20130259909 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 10-03-2013 |
20140243291 | METHYLPHENIDATE-OXOACID CONJUGATES, PROCESSES OF MAKING AND USING THE SAME - The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof. | 08-28-2014 |
20140287050 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology. | 09-25-2014 |
20140330021 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 11-06-2014 |
20150044261 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same - The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided. | 02-12-2015 |
20150050339 | Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Method of Making and Use Thereof - The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 02-19-2015 |
20150065536 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Uses Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 03-05-2015 |
20150087667 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | 03-26-2015 |
20150266911 | Methylphenidate-Prodrugs, Processes of Making and Using the Same - The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof. | 09-24-2015 |
20150335759 | Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs, Methods of Making and Use Thereof - The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid withdrawal. The presently described methods are carried out by comprising administering to the patient a pharmaceutically effective amount of a composition comprising acetaminophen and benzoate-hydrocodone hydrochloride. The composition has reduced side effects when compared with unconjugated hydrocodone. | 11-26-2015 |
Tim Guenther, Vinton, IA US
Patent application number | Description | Published |
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20100025445 | THREE PIECE LIFTING DEVICE - A three piece lifting system for lifting loads such as furniture during a move. The system has a first elongated strap that has a plurality of loops at its first and second ends that receive second and third elongated straps. The second and third elongated straps each have shoulder loops that go on the shoulders of workers such that when assembled the first elongated strap engages the load so that the workers are enabled to lift the load off the ground. | 02-04-2010 |