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Guckian, US
Kevin Guckian, Marlborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080234271 | Arylphenylamino- and Arylphenylether-Sulfide Derivatives, Useful For the Treatment of Inflammatory and Immune Diseases, and Pharmaceutical Compositions Containing Them - The present invention relates in part to compounds of formulas (I) and (III): and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject. | 09-25-2008 |
| 20100035918 | Imidazolone Compounds and Methods of Making and Using the Same - In one aspect, the invention features a compound of the general Formula (I). Compounds of Formula (I) possess high affinity for Alk 5 and/or AIk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. | 02-11-2010 |
| 20100056505 | Substituted Pyrazalones - The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable. | 03-04-2010 |
| 20100144730 | PYRIDINONYL PDK1 INHIBITORS - The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same. | 06-10-2010 |
| 20100240617 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 09-23-2010 |
| 20110152260 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase - The present invention relates to modulators of IRAK kinases of formula (I) and provides compositions comprising such modulators, as well as methods therewith for treating IRAK-mediated or IRAK-associated conditions or diseases. | 06-23-2011 |
Kevin M. Guckian, Marlborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100160258 | Bicyclic aryl sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 06-24-2010 |
| 20100160357 | Heterobicyclic sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors. | 06-24-2010 |
Paul Guckian, La Jolla, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090318103 | EMBEDDED MODULE RECEIVER NOISE PROFILING - A self-test prediction system predicts the impact that a host device has on an embedded wireless device's receiver performance by recording the wireless device's received power. No carrier or pilot signal is necessary to predict the impact. The wireless device's embedded receiver monitors its own received power (e.g., RSSI) from any type of radiated noise from the host device. For receivers that do not provide RSS referenced to absolute power, an external reference tone can be used in order to scale the measured receiver carrier to noise or signal to noise data to an absolute power. The increase in measured received power on the wireless device's receiver correlates to the impact the host device will have on the embedded wireless device's receiver sensitivity performance, providing a faster approach with less external equipment than current approaches that use external equipment to simulate the wireless device's forward link signal. | 12-24-2009 |
Paul Guckian, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120021707 | APPARATUS AND METHOD FOR ADJUSTMENT OF TRANSMITTER POWER IN A SYSTEM - Certain aspects of the present disclosure propose methods for determining power level of one or more transmitters based on a power level of a primary transmitter when the transmitters are located in close proximity of each other. The power levels may be determined such that a combined power of all the transmitters is compliant with regulatory radio frequency (RF) safety requirements. For certain aspects, power level of the lower priority transmitters may be determined utilizing one or more look-up tables. For another aspect, power level of the lower priority transmitters may be calculated using an algorithm based on the power level of the priority transmitter. In aspects, the power level of lower priority transmitters and the time duration for which the transmitters are active may be selected dynamically so that the time averaged power of the transmitters for a defined period of time falls below the RF exposure limit. | 01-26-2012 |