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Guan, MA
Bing Guan, Needham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090005359 | Heterocyclic Compounds Useful as RAF Kinase Inhibitors - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 01-01-2009 |
| 20090036419 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 02-05-2009 |
| 20090275556 | Aryl sulfonamides useful as inhibitors of chemokine receptor activity - The present invention provides compounds of general formula I: | 11-05-2009 |
| 20120040951 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 02-16-2012 |
Chudi Guan, Wenham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100173364 | Repair of Nucleic Acids for Improved Amplification - Methods and compositions are provided for repairing a polynucleotide so that it can be copied with improved fidelity and/o yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a DNA ligase and an effective amount of at least one endonuclease as well as a cofactor selected from NAD | 07-08-2010 |
| 20110065182 | Modified DNA Cleavage and Methods for Use - Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme cleavage activity compared to the unmodified enzyme. Activities associated with the modified DNA cleaving enzyme that can be modulated in different reaction conditions include at least one of: (a) non-sequence specific nicking activity; (b) cleaving the second strand of a duplex DNA at a preexisting nick site to produce a linear duplex with a single strand overhang; (c) non-sequence specific DNA cleavage; (d) cleaving DNA flanking a mismatch; and (e) cleavage at a cruciform structure in a DNA duplex. | 03-17-2011 |
| 20110201056 | Repair of Nucleic Acids for Improved Amplification - Methods and compositions are provided for repairing a polynucleotide so that it can be synthesized efficiently with improved fidelity and yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected from NAD+ or ATP and incubating the polynucleotide with the reaction mixture in the absence of Endonuclease VI. | 08-18-2011 |
| 20110256593 | Generation of Random Double-Strand Breaks in DNA Using Enzymes - An enzyme preparation is described that includes a non-specific nuclease and a T7 Endo I mutant in a unit ratio of less than 1:200. This enzyme preparation may be used to generate double-stranded DNA fragments of a size suitable for DNA sequencing. The ends of the fragments can be readily modified as necessary to ligate adaptors or individual nucleotides to one strand of the double-stranded DNA fragments. | 10-20-2011 |
Huiping Guan, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080287475 | 4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer - This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer. | 11-20-2008 |
| 20100160325 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER - This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer. | 06-24-2010 |
| 20100204231 | AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer. | 08-12-2010 |
| 20120071480 | 4-(3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER - This invention relates to novel compounds having the formula (I): | 03-22-2012 |
Ji-Song Guan, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110224303 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS - The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof. | 09-15-2011 |
Rui Guan, Framingham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120068657 | ELECTRIC MACHINE SYSTEM INCLUDING AN ELECTRIC MACHINE HAVING SWITCHED STATOR WINDINGS - An electric machine system includes an electric motor. The electric motor includes a stator having a plurality of windings that define a number of phases. A plurality of switch members are operatively coupled to the plurality of windings. The plurality of switch members are no more than one less than three times the number of phases. A controller is operatively coupled to the plurality of switch members. The controller selectively changes a state of the plurality of switch members to establish one of a first electrical connection configuration of the plurality of windings and a second electrical connection configuration of the plurality of windings. | 03-22-2012 |
Shengxi Guan, Stoneham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110151450 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 06-23-2011 |
Shengxi Guan, Ipswich, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
Yousheng Guan, North Billerica, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090130097 | Quinazolinone Compounds and Methods of Use Thereof - The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention | 05-21-2009 |