Patent application number | Description | Published |
20120168671 | VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION - Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described. | 07-05-2012 |
20120267585 | VOLUME-LABELED NANOPARTICLES AND METHODS OF PREPARATION - Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described. | 10-25-2012 |
20130115413 | FABRICATION AND USE OF ELEVATED OPTICAL NANOANTENNAS - A nanostructure including a pair of pointed metallic tips in proximity to each other. The pair of pointed metallic tips protrudes from a planar top surface of a substrate by a pair of pillar structures. The pair of pointed metallic tips can enhance optical scattering of materials placed therebetween through plasmonic electromagnetic field effects induced by the proximity of the pair of pointed metallic tips. Perturbation or interference from the substrate can be minimized through the increased distance from the substrate. The pair of pointed metallic tips can be formed by patterning a pair of adhesion material portions on a substrate, by vertically and laterally recessing regions that are not covered by the adhesion material portions, and by depositing a metal on the pair of adhesion material portions. | 05-09-2013 |
Patent application number | Description | Published |
20110236371 | Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain. | 09-29-2011 |
20130177576 | Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain. | 07-11-2013 |
20150018281 | Compositions and Methods for Uncoupling TrkB Receptor from PLC gamma 1 for the Treatment of Epilepsy and Anxiety-Like Disorder - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides that when administered disrupt the physical interaction of TrkB with its signaling effector, phospholipase Cγ1 (PLCγ1). The invention further provides method of treatment comprising administering phosphopeptides that uncouple TrkB from PLCγ1 in order to prevent and/or ameliorate nervous system disorders such as epilepsy, anxiety, and seizures. | 01-15-2015 |
Patent application number | Description | Published |
20100274176 | WOUND CARE SYSTEM AND BACTERICIDAL METHODS AND DEVICES - A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO | 10-28-2010 |
20120237762 | DEVICE CONSTRUCTS AND METHODS OF COATING LUMINESCENT PHOSPHORS FOR DISPLAY AND LIGHTING APPLICATIONS - A device construct for lighting and display applications is fabricated from a substrate, a deposited phosphor layer over the substrate, and a layer of thermal and electrically-conductive luminescent material over the deposited layer. The layer of thermal and electrically-conductive luminescent material is a thin film that conforms to the morphology of the phosphor layer. The device is fabricated by providing a substrate, depositing a thin layer of phosphor powder on the substrate by any technique, and coating the phosphor layer with a layer of thermal and electrically-conductive luminescent material by atomic layer deposition. | 09-20-2012 |
20130189345 | WOUND CARE SYSTEM AND BACTERIDICAL METHODS AND DEVICES - A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO | 07-25-2013 |
Patent application number | Description | Published |
20120034410 | MULTIPLE WALLED NESTED COAXIAL NANOSTRUCTURES - Multiple walled nested coaxial nanostructures, methods for making multiple walled nested coaxial nanostructures, and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200. | 02-09-2012 |
20120080313 | ELECTROOSMOTIC DEVICES - Electroosmotic (EO) devices are provided which are not subject to mechanical wear and tear and with no moving parts, and having improved flow rates and electrical properties. Atomic layer deposition can be used to prepare three electrical terminal active zeta potential modulated EO devices from porous membranes. First, second, and further thin layers of materials can be formed with the pores. Thus, embedded electrodes can be formed along the length of the pores. The zeta potential in the pores can be modified by use of a voltage potential applied the embedded electrode, thereby achieving active control of surface zeta potential within the pores and active control of flow through the pores. | 04-05-2012 |
Patent application number | Description | Published |
20120173027 | Method and Apparatus for Pump Control Using Varying Equivalent System Characteristic Curve, AKA an Adaptive Control Curve - The present invention provides, e.g., apparatus comprising at least one processor; at least one memory including computer program code; the at least one memory and computer program code being configured, with at least one processor, to cause the apparatus at least to: respond to signaling containing information about an instant pressure and a flow rate of fluid being pumped in a pumping system, and obtain an adaptive control curve based at least partly on the instant pressure and flow rate using an adaptive moving average filter. The adaptive moving average filter may be based at least partly on a system flow equation: SAMA | 07-05-2012 |
20120197555 | ULTRASONIC WATER LEVEL GAUGE AND CONTROL DEVICE - Apparatus, including an ultrasonic liquid level gauge and control system, includes a gauge configured to be coupled on the outside of a device, having a boiler or hot water tank, having liquid contained therein. The gauge is also configured to receive and contain a small part of the liquid of the device; and an ultrasonic transducing and signal processing arrangement configured to: reflect an ultrasonic pulse off a liquid surface of the small part of the liquid of the device contained in the gauge, and determine the level of liquid in the device based at least partly on a time of flight analysis related to the ultrasonic pulse reflected off the liquid surface of the small part of the liquid of the device contained in the gauge. | 08-02-2012 |
20140005841 | DYNAMIC LINEAR CONTROL METHODS AND APPARATUS FOR VARIABLE SPEED PUMP CONTROL | 01-02-2014 |
20140249682 | 3-D Sensorless Conversion Method and Apparatus for Pump Differential Pressure and Flow - The present invention provides apparatus featuring a signal processor or processing module that may be configured at least to: receive signaling containing information about calibrated motor speed and power data for a hydronic pumping system; and determine system pumping flow rate and pressure associated with an equivalent hydronic system characteristic variable, based at least partly on the signaling received. The signal processor or processing module may be configured to provide corresponding signaling containing information about the system pumping flow rate and pressure determined. The corresponding signaling may contain information used to control the hydronic pumping system. | 09-04-2014 |
20140288716 | MIXED THEORETICAL AND DISCRETE SENSORLESS CONVERTER FOR PUMP DIFFERENTIAL PRESSURE AND FLOW MONITORING - The present invention provides apparatus featuring a signal processor or processing module that may be configured at least to: process signaling containing information about an equilibrium point of pump differential pressure and system pressure formulated in a hydronic domain by utilizing pump and system characteristic curve equations so as to yield system pressure and flow rate at any particular load and time in a pump hydronic system, including using a multi-dimensional sensorless conversion technique; and determine equivalent hydronic system characteristics associated with the pump differential pressure and flow rate to their corresponding motor power and speed reconstructed and remapped by using a discrete numerical approach, based at least partly on the signaling received. The signal processor or processing module may provide corresponding signaling containing information about the system pumping flow rate and pressure determined. | 09-25-2014 |
20150032271 | Sensorless Adaptive Pump Control with Self-Calibration Apparatus for Hydronic Pumping System - The present invention provides apparatus that features a signal processor or processing module configured to receive signaling containing information about an adaptive or self-calibrating set point control curve and a varying equivalent system characteristic curve based at least partly on an instant pump pressure and a flow rate using an adaptive moving average filter, and equivalent hydronic system characteristics associated with the instant pump pressure and the flow rate to corresponding motor power and speed reconstructed and remapped using a discrete numerical approach; and determine an adaptive pressure set point, based at least partly on the signaling received. | 01-29-2015 |
Patent application number | Description | Published |
20090043051 | Modified vinylamine-containing polymers as additives in papermaking - Vinylamine-containing polymers are disclosed where the amine groups are substituted with (1) cationic functional groups, (2) anionic functional groups, (3) hydrophobic functional groups, (4) hydrophilic functional groups, (5) functional groups that impart amphoteric characteristics to the polymers, or (6) combinations thereof. Also disclosed are processes for preparing such polymers, as well as compositions comprising such polymers. Among other applications, these polymers can be used in papermaking applications as dry strength additives, wet strength additives, retention aids, drainage aids, and pitch and stickies control agents. | 02-12-2009 |
20090098387 | Diluents for crosslinker-containing adhesive compositions - The disclosure relates to an adhesive composition for bonding lignocellulosic substrates. The adhesive composition contains a crosslinker and a non-urea diluent where the non-urea diluent is present in an amount from about 0.01 to about 75 weight % based on the total wet weight of the composition and where the crosslinker contains essentially no formaldehyde. Also disclosed is the adhesive further containing. an aqueous mixture of a protein source. The disclosure also relates to a process for making lignocellulosic composites utilizing the disclosed adhesive composition and to the lignocellulosic composites made using the disclosed process. | 04-16-2009 |
20100147476 | Hydrophobically Modified Poly(aminoamides) - Disclosed herein are hydrophobically-modified poly(aminoamides) useful as fixative detackifiers for stickies and pitch control in papermaking processes. These polymers are prepared via modification of amine-containing water-soluble poly(aminoamides) with reactive functional group-containing hydrophobic compounds. In particular, poly(aminoamides) may be modified, under appropriate reaction conditions, with long chain alkyl glycidyl ether, AKD (alkyl ketene dimer), ASA (alkyl succinyl anhydride), or Quab (3-chloro-2-hydroxypropyl-N,N,N-dimethylalkyl ammonium chloride). These novel polymers are effective in inhibiting deposition of organic contaminants in pulp and papermaking systems. | 06-17-2010 |
20100193148 | Quaternary Vinylamine-Containing Polymers as Additives in Papermaking - Vinylamine-containing polymers are disclosed where the amine groups are substituted with cationic functional groups. Processes for preparing such polymers, as well as compositions comprising such polymers are also disclosed. Among other applications, these polymers can be used in papermaking applications as dry strength additives, wet strength additives, retention aids, drainage aids, and pitch and stickies control agents. | 08-05-2010 |
20110247775 | Stable and Aqueous Compositions of Polyvinylamines with Cationic Starch, and Utility for Papermaking - A stable aqueous composition comprising polyvinylamine and liquid cationic starch in a ratio of from 90 to 55 parts of polyvinylamine on active basis to 10 to 45 parts of liquid cationic starch on active basis is disclosed. The composition can be used in papermaking as a strength or as a drainage aid. | 10-13-2011 |
20120264888 | Process To Produce An Acylated Vinylamine-Containing Polymer And Its Application As A Papermaking Additive - A process for producing an acylated vinylamine-containing polymer is disclosed. The acylated vinylamine-containing polymer is produced by reacting a vinylamine-containing polymer with at least one acylating agent. | 10-18-2012 |
20130224482 | DILUENTS FOR CROSSLINKER-CONTAINING ADHESIVE COMPOSITIONS - The disclosure relates to an adhesive composition for bonding lignocellulosic substrates. The adhesive composition contains a crosslinker and a non-urea diluent where the non-urea diluent is present in an amount from about 0.01 to about 75 weight % based on the total wet weight of the composition and where the crosslinker contains essentially no formaldehyde and contains no urea. Also disclosed is the adhesive further containing an aqueous mixture of a protein source. The disclosure also relates to a process for making lignocellulosic composites utilizing the disclosed adhesive composition and to the lignocellulosic composites made using the disclosed process. | 08-29-2013 |
20140174685 | CELLULASE COMPOSITION CONTAINING CELLULASE AND PAPERMAKING POLYMERS FOR PAPER DRY STRENGTH APPLICATION - Disclosed herein are cellulase compositions useful as papermaking performance additives for improving paper dry strength of a paper product and reducing refining energy in papermaking processes, and improving paper production. These cellulase compositions are formulated using cellulase, papermaking contaminant control polymers, protein stabilizers and cellulase enhancers. These cellulase compositions measure higher in endo-cellulase activity with better stability than conventional cellulase, and have shown differentiating performance in improving paper dry strength properties versus cellulase alone. | 06-26-2014 |
Patent application number | Description | Published |
20110249933 | OPTICAL INTERCONNECT SYSTEMS AND METHODS - Optical interconnect systems and methods are disclosed. An optical interconnect system includes a substrate, an optical waveguide, and first and second modulators. The optical waveguide has a first waveguide portion extending to a first coupling structure, a second waveguide portion extending from the first coupling structure to a second coupling structure, and a third waveguide portion extending from the second coupling structure. The first modulator is positioned adjacent the first coupling structure, and the second modulator is positioned adjacent the second coupling structure. The optical interconnect method includes modulating light with a first modulator to produce one-time modulated light, and modulating the one-time modulated light with a second modulator to produce two-time modulated light. | 10-13-2011 |
20110297229 | INTEGRATED CONCENTRATING PHOTOVOLTAICS - Optical sheets, light collection and conversion systems and methods of forming optical sheets are provided. An optical sheet includes a light guide layer having at least one light guide and a light concentrator layer adjacent to the light guide layer for concentrating incident light. Each light guide has a substantially uniform thickness with respect to a propagation direction of light through the light guide and includes a plurality of input-coupling elements and at least one output-coupling element. The light concentrator layer includes a plurality of concentrator elements optically coupled to the plurality of input-coupling elements of the respective light guide. Each light guide is configured to combine the concentrated light from the respective plurality of concentrator elements and to guide the combined light to the at least one output-coupling element. | 12-08-2011 |
20120106890 | SYSTEM AND METHOD FOR MODULATOR-BASED OPTICAL INTERCONNECTIONS - Systems and methods for modulator-based optical interconnections are disclosed. An optical interconnect system comprises a substrate, a wave path, a coupling structure, and a modulator. The wave path may be a waveguide disposed on the substrate. The coupling structure is coupled to the substrate and disposed within the wave path. The modulator is positioned between the substrate and the coupling structure. An optical interconnect method comprises the steps of transmitting light through a wave path, redirecting the light onto a modulator with a coupling structure, modulating the light from the coupling structure with the modulator; and redirecting modulated light from the modulator into the wave path with the coupling structure. | 05-03-2012 |
20120114281 | SYSTEM AND METHOD FOR FREE-SPACE OPTICAL INTERCONNECTIONS - Optical interconnect systems and methods are disclosed. An optical interconnect system includes a substrate, a first waveguide, and a free-space coupling structure. The first waveguide is disposed on the substrate. The free-space coupling structure is adjacent the first waveguide. The free-space coupling structure redirects light propagating through the first waveguide in a first direction out of the first waveguide in a second direction different from the first direction. An optical interconnect method comprises transmitting light through a first waveguide in a first direction; and redirecting the light out of the first waveguide in a second direction different from the first direction with a free-space coupling structure disposed in the first waveguide. | 05-10-2012 |
20130104981 | SYSTEMS AND METHODS FOR OPTICAL TRACKING | 05-02-2013 |
20140130855 | DISPERSIVE OPTICAL SYSTEMS AND METHODS AND RELATED ELECTRICITY GENERATION SYSTEMS AND METHODS - Dispersive optical systems and methods are disclosed, as well as energy generation systems utilizing such systems in combination with photovoltaic cells. A dispersive optical system includes an optical element, a layer of high-dispersion microprisms, and a layer of low-dispersion microprisms. The optical element is configured to focus a light beam. The layer of high-dispersion microprisms is configured to refract the light beam. The layer of low-dispersion microprisms is configured to refract the light beam. The dispersive optical system is configured to optically concentrate and disperse input light incident thereupon into an output comprising a plurality of bands of light each having a different wavelength. A method of optical dispersion includes focusing a light beam with an optical element, refracting the light beam with a layer of high-dispersion microprisms, and refracting the light beam with a layer of low-dispersion microprisms. | 05-15-2014 |
Patent application number | Description | Published |
20130008801 | METHODS AND COMPOSITIONS FOR APPLICATIONS RELATED TO MICROBIOLOGICALLY INFLUENCED CORROSION - Methods and compositions for applications related to the microbiologically influenced corrosion (MIC) are provided. MIC is becoming increasingly important, especially to the oil and gas industry due to water flooding practice and aging pipelines. The lack of understanding of the fundamental mechanisms in MIC have greatly hindered the development of reliable prediction and new mitigation methods. This disclosure demonstrates how a biocatalytic cathodic sulfate reduction (BCSR) theory, together with bioenergetics, electrochemical kinetics, and mass transfer, can be used with regard to MIC. The discovery of MIC promoters (that are electron mediators) allows for a new detection tool for more accurate assessment of MIC pitting, and potential new mitigation methods that targets the promoters or microorganisms that secrete these promoters. An MFC device to detect the presence of MIC promoters is provided. When accelerated MIC pitting is desired, such as destruction of undersea munitions or accelerated MIC lab tests, MIC promoters can be added. | 01-10-2013 |
20140048424 | METHODS AND DEVICES FOR THE DETECTION OF BIOFILMS - Methods and devices for the detection of corrosive biofilms and microbiologically influenced (MIC) corrosion rates are based upon the electrogenicity of the biofilms. The device may comprise a passive sensor having at least one first electrode, at least one second electrode, and an external circuit for electrically connecting the first electrode to the second electrode. At least one of the first electrode and the second electrode is capable of being at least partially coated by a biofilm. A sustainable electrical characteristic, such as voltage and current, generated when the first electrode and the second electrode are electrically connected and exposed to at least one medium indicates that the biofilm partially coating at least one of the first electrode and the second electrode is electrogenic, and thus corrosive. Special electrode and sensor designs are needed for the implementation of online and offline biofilm sensors. | 02-20-2014 |
20140194335 | COMPOSITIONS AND METHODS FOR TREATING BIOFILMS - Compositions and methods for treating biofilm formation and growth on a substrate are provided. The composition comprises 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The method comprises contacting the substrate with 1 ppb to 1,000 ppm of at least one D-amino acid and 1 ppm to 60,000 ppm of at least one biocide. The compositions and methods are effective for preventing, reducing or eliminating biofilm formation or biofilm growth or both, as well as eradicating established, recalcitrant biofilms, particularly biofilms comprising sulfate reducing bacteria that are known to cause microbiologically influenced corrosion, biofouling, or both. | 07-10-2014 |
Patent application number | Description | Published |
20090018562 | Percutaneous catheter directed intravascular occlusion devices - The present invention provides an improved vascular occlusion device having improved flexibility and retention of the type fabricated from braided tubular metal fabric having an expanded preset configuration and an elongated collapsed reduced diameter configuration for delivery through a catheter to a treatment site and shaped to create an occlusion of an abnormal opening in a body organ or vessel, the woven metal fabric having a memory property whereby the medical device tends to return to said expanded preset configuration when unconstrained. The device further including at least one disk portion adjacent a body cylindrical portion formed from the fabric and having a transition diameter between the disk and cylindrical portion, significantly smaller than the diameter of the disk and the diameter of the cylindrical portion. | 01-15-2009 |
20090209855 | MEDICAL DEVICES FOR TREATING A TARGET SITE AND ASSOCIATED METHOD - Embodiments of the present invention provide devices and methods for treating various target sites, such as vascular abnormalities. For example, a medical device according to one embodiment includes at least one layer of a fabric of braided strands having proximal and distal ends and a central axis extending therebetween. The medical device has an expanded configuration a generally frustroconical shaped portion at each end. The medical device is configured to be constrained to a reduced configuration for delivery through a diagnostic catheter and to at least partially return, when unconstrained, towards the expanded configuration. | 08-20-2009 |
20090210048 | STENT/STENT GRAFT FOR REINFORCEMENT OF VASCULAR ABNORMALITIES AND ASSOCIATED METHOD - A stent/stent graft for reinforcement of vascular abnormalities and an associated method are provided. According to on embodiment, the stent/stent graft includes a flexible tubular structure comprising proximal and distal ends and having a heat set configuration. The tubular structure is configured to engage a lumen upstream and downstream of a vascular abnormality, such as an aneurysm, and a portion between the proximal and distal ends of the tubular structure is configured to engage the aneurysm. | 08-20-2009 |
20130012979 | MULTI-LAYER BRAIDED STRUCTURES FOR OCCLUDING VASCULAR DEFECTS AND FOR OCCLUDING FLUID FLOW THROUGH PORTIONS OF THE VASCULATURE OF THE BODY - A collapsible medical device and associated methods of occluding an abnormal opening in, for example, a body organ, wherein the medical device is shaped from plural layers of a heat-treatable metal fabric. Each of the fabric layers is formed from a plurality of metal strands and the assembly is heat-treated within a mold in order to substantially set a desired shape of the device. By incorporating plural layers in the thus-formed medical device, the ability of the device to rapidly occlude an abnormal opening in a body organ is significantly improved. | 01-10-2013 |
Patent application number | Description | Published |
20080200945 | DEVICE FOR OCCLUDING VASCULAR DEFECTS - Embodiments of the present invention provide devices and methods for treating abnormalities. For example, a device according to one embodiment includes a plurality of planes of occlusion, at least one plane of occlusion comprising a plurality of layers of occlusive material. The device is configured to at least partially occlude an abnormality. | 08-21-2008 |
20090171386 | PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICES - Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage. | 07-02-2009 |
20090187214 | PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICE - Embodiments of the present invention provide medical devices and methods for occluding a target site are provided. For example, the medical device may include a tubular member having proximal and distal ends and at least one plane of occlusion. The at least one plane of occlusion may be configured to substantially occlude the patent ductus arteriosus in less than about 1 minute. In addition or alternatively, the tubular member may consist of a single layer of material and be configured to be constrained within a catheter having an outer diameter of less than about 4 French for percutaneous delivery to the patent ductus arteriosus. | 07-23-2009 |
20110307000 | PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICES - The present invention provides an improved vascular occlusion device having improved flexibility and retention of the type fabricated from braided tubular metal fabric having an expanded preset configuration and an elongated collapsed reduced diameter configuration for delivery through a catheter to a treatment site and shaped to create an occlusion of an abnormal opening in a body organ or vessel, the woven metal fabric having a memory property whereby the medical device tends to return to said expanded preset configuration when unconstrained. The device further including at least one disk portion adjacent a body cylindrical portion formed from the fabric and having a transition diameter between the disk and cylindrical portion, significantly smaller than the diameter of the disk and the diameter of the cylindrical portion. | 12-15-2011 |
20130218189 | PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICES - The present invention provides an improved vascular occlusion device having improved flexibility and retention of the type fabricated from braided tubular metal fabric having an expanded preset configuration and an elongated collapsed reduced diameter configuration for delivery through a catheter to a treatment site and shaped to create an occlusion of an abnormal opening in a body organ or vessel, the woven metal fabric having a memory property whereby the medical device tends to return to said expanded preset configuration when unconstrained. The device further including at least one disk portion adjacent a body cylindrical portion formed from the fabric and having a transition diameter between the disk and cylindrical portion, significantly smaller than the diameter of the disk and the diameter of the cylindrical portion. | 08-22-2013 |
20140135828 | PERCUTANEOUS CATHETER DIRECTED INTRAVASCULAR OCCLUSION DEVICE - Embodiments of the present invention provide medical devices and methods for occluding a target site are provided. For example, the medical device may include a tubular member having proximal and distal ends and at least one plane of occlusion. The at least one plane of occlusion may be configured to substantially occlude the patent ductus arteriosus in less than about 1 minute. In addition or alternatively, the tubular member may consist of a single layer of material and be configured to be constrained within a catheter having an outer diameter of less than about 4 French for percutaneous delivery to the patent ductus arteriosus. | 05-15-2014 |
Patent application number | Description | Published |
20100184989 | De Novo Synthesis of Conjugates - The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path. | 07-22-2010 |
20100298296 | Oligomer-Tricyclic Conjugates - The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer. | 11-25-2010 |
20110269677 | Oligomer-Protease Inhibitor Conjugates - The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer. | 11-03-2011 |
20120046279 | Oligomer-Phenothiazine Conjugates - The invention relates to (among other things) oligomer-phenothiazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated phenothiazine compounds. | 02-23-2012 |
Patent application number | Description | Published |
20090280065 | Uses and Compositions for Treatment of Psoriasis - The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject. | 11-12-2009 |
20110206680 | METHODS FOR TREATING PSORIASIS - The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. | 08-25-2011 |
20120189637 | METHODS FOR TREATING PSORIASIS - The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. | 07-26-2012 |
20140079714 | METHODS FOR TREATING PSORIASIS - The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23. | 03-20-2014 |
20150050216 | Uses and Compositions for Treatment of Psoriasis - The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject. | 02-19-2015 |
Patent application number | Description | Published |
20100166630 | REACTIVE CHEMICAL CONTAINMENT SYSTEM - A small scale, but effective, reactive chemical containment system includes apparatus and methods for reaction of process gases exhausted from reaction furnaces with a reactant gas in a non-combustible manner to produce and contain particulate or powder byproducts, thereby removing the process gas from the exhaust gas flow. The apparatus provides process gas inlet, treatment reactive gas diffusion, process gas and treatment reactive gas pre-mixing, primary containment, secondary containment, and outlet zones. | 07-01-2010 |
20120061369 | MULTIPLE HEATER CONTROL SYSTEM WITH EXPANDABLE MODULAR FUNCTIONALITY - A multiple heater control system includes cables, connectors, and junction boxes for user-friendly daisy chain connections of heater controllers and heaters in various configurations or combinations of individually controlled heater series and/or master and slave heater series. The heater controllers include process control of AC power to the heaters and upper-limit safety shutoff that is substantially independent from the process control. The heater controllers also have variable levels of control, adjustment, display, and communications functionality in a base module that is expandable to various levels with expansion modules that are attachable to and detachable from the base module. Connector, cable, and junction configurations, adapters, and latch features enhance user friendliness. | 03-15-2012 |
20120153193 | TWO-STAGE, SLOW-START VALVE APPARATUS AND METHOD - A two-stage, slow-start valve includes a minor valve assembly inside a major valve closure member of a major valve closure assembly so that fluid can flow through the valve at a higher rate by opening the major valve assembly or at a lower rate by opening the minor valve assembly while the major valve closure assembly is closed in order to allow fluid to flow in an alternate flow path through the major valve closure member. The example minor valve closure assembly has a minor valve closure member that is actuated to open by a minor valve piston on which minor valve actuating fluid is applied to the minor piston via a diaphragm seal positioned between the minor piston and the minor valve actuating fluid. Both the major valve closure assembly and the minor valve closure assembly can be pneumatically actuated to open. | 06-21-2012 |
20130146225 | GAS INJECTOR APPARATUS FOR PLASMA APPLICATOR - A plasma chamber for use with a reactive gas source that includes a first conduit comprising a wall, an inlet, an outlet, an inner and outer surface, and a plurality of openings through the wall, the inlet receives a first gas for generating a reactive gas in the first conduit with a plasma formed in the first conduit. The plasma chamber also includes a second conduit that includes a wall, an inlet, and an inner surface. The first conduit is disposed in the second conduit defining a channel between the outer surface of the first conduit and the inner surface of the second conduit. A second gas provided to the inlet of the second conduit flows along the channel and through the plurality of openings of the wall of the first conduit into the first conduit to surround the reactive gas and plasma in the first conduit. | 06-13-2013 |
20140109973 | CORROSION AND DEPOSITION PROTECTED VALVE APPARATUS AND METHOD - An expandable and contractible shield around a bellows in a valve protects the bellows from corrosive gases and solid particles in the valve chamber. In a manifold valve assembly with multiple outlet ports and multiple valves in a common valve chamber, a respective expandable and contractible shield around each respective bellows of each respective valve in the assembly separates each bellows from corrosive gases and solid particles in the common valve chamber regardless of whether one or all of the valves in the assembly is opened or closed. | 04-24-2014 |
20140130876 | METHOD OF TWO-STAGE FLOW CONTROL - A valve has a major valve closure member with a valve stem for opening and closing a major port in a valve chamber. An alternate flow path extends through the major valve closing member. Flow is controlled through the alternate flow path by directing a minor valve actuating fluid through the valve stem to apply pressure on a minor valve piston in the major valve closure member to move a minor valve closure member in the major valve closure member between a closed mode in which the minor valve closure member closes the alternate flow path and an opened mode in which the minor valve closure member opens the alternate flow path. The minor valve actuating fluid is sealed from the alternate flow path by a flexible diaphragm positioned between the minor valve actuating fluid and the minor valve piston, so the pressure of the minor valve actuating fluid is applied to the minor valve piston via the flexible diaphragm. | 05-15-2014 |