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| 20090074828 | POLY(AMINO ACID) TARGETING MOIETIES - The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries. | 03-19-2009 |
| 20100203142 | AMPHIPHILIC COMPOUND ASSISTED NANOPARTICLES FOR TARGETED DELIVERY - The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries. | 08-12-2010 |
| 20100323199 | POLYMERS FOR FUNCTIONAL PARTICLES - The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like. | 12-23-2010 |
| 20110027172 | DRUG DELIVERY SYSTEM FOR PHARMACEUTICALS AND RADIATION - The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo. | 02-03-2011 |
| 20110300219 | NANOSTRUCTURES FOR DRUG DELIVERY - The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor. | 12-08-2011 |
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| 20110038530 | ENHANCED OBJECT RECONSTRUCTION - Processing images includes projecting an infra-red pattern onto a three-dimensional object and producing a first image, a second image, and a third image of the three-dimensional object while the pattern is projected on the three-dimensional object. The first image and the second image include the three-dimensional object and the pattern. The first image and the second image are produced by capturing at a first camera and a second camera, respectively, light filtered through an infra-red filter. The third image includes the three-dimensional object but not the pattern. Processing the images also includes establishing a first-pair correspondence between a portion of pixels in the first image and a portion of pixels in the second image. Processing the images further includes constructing, based on the first-pair correspondence and the third image, a two-dimensional image that depicts a three-dimensional construction of the three-dimensional object. | 02-17-2011 |
| 20110262032 | ENHANCED OBJECT RECONSTRUCTION - Processing images includes projecting an infra-red pattern onto a three-dimensional object and producing a first image, a second image, and a third image of the three-dimensional object while the pattern is projected on the three-dimensional object. The first image and the second image include the three-dimensional object and the pattern. The first image and the second image are produced by capturing at a first camera and a second camera, respectively, light filtered through an infra-red filter. The third image includes the three-dimensional object but not the pattern. Processing the images also includes establishing a first-pair correspondence between a portion of pixels in the first image and a portion of pixels in the second image. Processing the images further includes constructing, based on the first-pair correspondence and the third image, a two-dimensional image that depicts a three-dimensional construction of the three-dimensional object. | 10-27-2011 |
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| 20080199071 | CREATING 3D IMAGES OF OBJECTS BY ILLUMINATING WITH INFRARED PATTERNS - According to a general aspect, processing images includes projecting an infra-red pattern onto a three-dimensional object and producing a first image, a second image, and a third image of the three-dimensional object while the pattern is projected on the three-dimensional object. The first image and the second image include the three-dimensional object and the pattern. The first image and the second image are produced by capturing at a first camera and a second camera, respectively, light filtered through an infra-red filter. The third image includes the three-dimensional object but not the pattern. Processing the images also includes establishing a first-pair correspondence between a portion of pixels in the first image and a portion of pixels in the second image. Processing the images further includes constructing, based on the first-pair correspondence and the third image, a two-dimensional image that depicts a three-dimensional construction of the three-dimensional object. | 08-21-2008 |
| 20090003686 | ENHANCED OBJECT RECONSTRUCTION - Processing images includes projecting an infra-red pattern onto a three-dimensional object and producing a first image, a second image, and a third image of the three-dimensional object while the pattern is projected on the three-dimensional object. The first image and the second image include the three-dimensional object and the pattern. The first image and the second image are produced by capturing at a first camera and a second camera, respectively, light filtered through an infra-red filter. The third image includes the three-dimensional object but not the pattern. Processing the images also includes establishing a first-pair correspondence between a portion of pixels in the first image and a portion of pixels in the second image. Processing the images further includes constructing, based on the first-pair correspondence and the third image, a two-dimensional image that depicts a three-dimensional construction of the three-dimensional object. | 01-01-2009 |
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| 20100228122 | MICROBUBBLE MEDICAL DEVICES - Method and medical devices for generating and stabilizing micro- or nano-bubbles, and systems and methods for therapeutic applications using the bubbles, are provided. The micro-bubbles may be used to enhance therapeutic benefits such as ultrasound-guided precision drug delivery and real-time verification, acoustic activation of large tumour masses, enhanced acoustic activation through longer retention of therapeutic agents at the point of interest, enhancement of high intensity focused ultrasound treatments, light activation of photodynamic drugs at a depth within a patient using extracorporeal light sources, probes, or sonoluminescence, and initiation of time reversal acoustics focused ultrasound to permit highly localized treatment. | 09-09-2010 |
| 20110167864 | AMMONIA REFRIGERATION SYSTEM - In accordance with the present disclosure there is provided an efficient refrigeration system for cooling an environment using ammonia and sodium thiocyanate using a low grade heat source. The refrigeration system comprises a condenser for condensing vaporous ammonia to liquid ammonia coupled to an evaporator. The condenser condenses the ammonia vapour using a heat exchanger. The evaporator evaporates liquid ammonia to vaporous ammonia by absorbing heat from the cooling environment. An absorber absorbs the vaporous ammonia into an ammonia sodium thiocyanate solution and adsorbs vaporous ammonia on to sodium thiocyanate salts. The absorber is coupled to a regenerator through a solution pump for pumping ammonia sodium thiocyanate solution with dissolved ammonia from the absorber to the regenerator. The regenerator regenerates ammonia vapour from the pumped solution and supplies the regenerated ammonia vapour to the condenser and the concentrated solution back to the absorber. | 07-14-2011 |
| 20110314844 | METHOD AND APPARATUS FOR WASTE HEAT RECOVERY AND ABSORPTION GASES USED AS WORKING FLUID THEREIN - A method provides for waste heat power generation or heat recovery and for a driving power with an absorption process using low grade heat sources. An apparatus also provides for such waste heat recovery in absorption process and to the used vapor-salt working fluid. A low temperature heat source is used as a heating working medium to heat in a regenerator by heat exchange the absorption liquid working fluid from the absorber and consisting of a salt absorbent and ammonia or carbon dioxide as an absorbed agent to form the absorbent and the superheated high pressure absorbed agent. The superheated and vaporized absorbed agent enters into a turbine to provide energy and generate power via turbine expansion step. After heat release, the resultant low pressure absorbed agent is discharged from the turbine and returns to the absorption step and contacts with the absorbent from the regeneration step to form the absorption liquid which can enter into the next thermodynamic cycle process. | 12-29-2011 |
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| 20080208560 | System and method of interlocking to protect software - mediated program and device behaviors - A method for rendering software resistant to reverse engineering. Replace at least one first constant (mathematical expression, etc.) in a computational expression with a second mixed mathematical and bitwise-Boolean expression, the first constant being simpler than the second expression and the second expression being based on the value or the variables found in the first constant (or expression). Evaluation of the second mixed mathematical and bitwise-Boolean expression produces a value preserving the value of the first constant, either: with the original value of the first constant or the original value of the result of the first expression, in which case the second mixed mathematical and bitwise-Boolean expression is obtained from the first constant by converting the first constant by mathematical identities; or, in an encoded form, as a new value, which can be converted back to the original value of the first constant by applying an information-preserving decoding function, in which case the second mixed mathematical and bitwise-Boolean expression is obtained from the first constant by modifying the first constant by a combination of conversion according to mathematical identities and transformation according to an information preserving encoding function. | 08-28-2008 |
| 20080216051 | System and method of interlocking to protect software-mediated program and device behaviours - Methods and devices for thwarting code and control flow based attacks on software. The source code of a subject piece of software is automatically divided into basic blocks of logic. Selected basic blocks are amended so that their outputs are extended. Similarly, other basic blocks are amended such that their inputs are correspondingly extended. The amendments increase or create dependencies between basic blocks such that tampering with one basic block's code causes other basic blocks to malfunction when executed. | 09-04-2008 |
| 20120192283 | Interlocked Binary Protection Using Whitebox Cryptography - A system and method for transforming a software application comprising binary code and optionally associated data, from an original form to a more secure form. The method includes performing a combination of binary transmutations to the application, and interlocking the transmutations by generating and placing interdependencies between the transmutations, wherein a transmutation is an irreversible change to the application. Different types of the transmutations are applied at varied granularities of the application. The transmutations are applied to the application code and the implanted code as well. The result is a transformed software application which is semantically equivalent to the original software application but is resistant to static and/or dynamic attacks. | 07-26-2012 |
| 20120246487 | System and Method to Protect Java Bytecode Code Against Static And Dynamic Attacks Within Hostile Execution Environments - A method and system that provides secure modules that can address Java platform weaknesses and protect Java bytecode during execution time. The secure modules are implemented in C/C++ as an example. Because implementation of the security modules is made in C/C++, this enables use of security technology that secures C/C++ software code. | 09-27-2012 |
