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Gruber, US
Andras Gruber, Portland, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20080219998 | Anti-Thrombotic Agents - The present invention embodies: methods; compounds, their pharmaceutically acceptable analogs, isomer, salts, hydrates, solvates and prodrug derivatives, and pharmaceutically acceptable compositions thereof that have particular biological properties; devices; diagnostic and other assays; and the uses of such methods, compounds, devices and assays. Common throughout these embodiments is specific selective reduction of intravascular thromboplastin antecedent activity, which results in a safe antithrombotic effect. A particularly prominent application or the invention relates to diagnosis and treatment of patients which have, or are at risk of, developing thrombosis, thrombotic injury, or vaso-occlusive diseases, such as myocardial infarction, stroke, restenosis after angioplasty, thrombotic diseases, etc. Another particularly prominent feature of the present invention is its high level of hemostatic safety at optimal efficacy. Also, the present invention is compatible for use in combination with other traditional therapeutic agent such as another antithrombotic, antiplatelet, thrombolytic, or anticoagulant agents. | 09-11-2008 |
| 20100158890 | USE OF THROMBIN MUTANTS TO INHIBIT THE ANTICOAGULATION EFFECT OF THROMBIN INHIBITORS - The present invention provides methods for inhibiting the anticoagulation effect of a thrombin inhibitor in a patient in need thereof comprising administration of a therapeutically effective amount of a variant prothrombin or thrombin that is capable of binding the thrombin inhibitor and that has reduced procoagulant activity. Variant prothrombins or thrombins of use in the methods of the present invention include thrombin mutants W215A, W215A/E217A, or variants thereof in which the amino acids at positions 215 and/or 217 are alanine. Methods are also provided in which the thrombin mutants are administered with an additional active agent, particularly hemostatic agents such as activated factor VII or activated prothrombin complex concentrate. In one embodiment of the invention, the methods are useful in the treatment of patients in which a direct thrombin inhibitor has been administered, particularly argatroban. The present invention further provides a method for quantifying the concentration of an anticoagulant in the plasma or whole blood of a patient using a variant prothrombin or thrombin titration assay. | 06-24-2010 |
| 20100184672 | PROTEIN C FOR USE IN MAINTAINING HEMOSTASIS - It is disclosed herein that protein C functions as a hemostatic agent. Thus, provided is a method of preventing, treating or ameliorating abnormal bleeding in a subject, comprising administering to the subject a protein C polypeptide or polynucleotide. Abnormal bleeding can result from a bleeding disorder, such as hemophilia or a platelet disorder, or from a bleeding episode, such as from a traumatic injury. | 07-22-2010 |
| 20110020349 | ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction. Methods for making an anti-factor XI monoclonal antibody, or epitope-binding fragments, variants, or derivatives thereof, are also provided. | 01-27-2011 |
| 20110250207 | ANTI-FXI ANTIBODIES AND METHODS OF USE - Disclosed herein are monoclonal antibodies specific for factor XI (fXI) that prevent activation of fXI by factor XIIa (fXIIa). The monoclonal antibodies are universal fXI antibodies, capable of binding all mammalian species tested. The anti-fXI monoclonal antibodies prolong clotting time in mammalian plasmas. Moreover, administration of the fXI monoclonal antibodies disclosed herein results in inhibition of thrombosis without altering hemostasis in animal models of thrombosis. Thus, provided herein are monoclonal antibodies specific for fXI that block activation of fXI by fXIIa, compositions and immunoconjugates comprising such antibodies and their methods of use. | 10-13-2011 |
Charles J. Gruber, Monument, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20110026406 | APPARATUS AND METHODS FOR CAPTURING DATA PACKETS FROM A NETWORK - In one embodiment, data packets are captured from a network using a physical, network-connectable data capture probe. As the data packets are captured, the data packets are time-stamped with time-of-capture time-stamps. The time-stamped data packets are then stored; and in parallel, the time-stamped data packets are forwarded to at least one consumer in real-time. | 02-03-2011 |
Christian E. Gruber, Frederick, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080227107 | COMPOSITIONS AND METHODS FOR LABELING OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics. | 09-18-2008 |
| 20080287321 | cDNA synthesis improvements - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 11-20-2008 |
| 20090176242 | COMPOSITIONS AND METHODS FOR LABELING OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics. | 07-09-2009 |
| 20100093989 | Methods For Production And Purification Of Nucleic Acid Molecules - The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), which may be single- or double-stranded. Additionally, the invention concerns selection and isolation of particular nucleic acid molecules of interest from a sample which may contain a population of molecules. Specifically, the invention concerns affinity-labeled primer-adapter molecules which allow improved isolation and production of such nucleic acid molecules, increasing both product recovery and speed of isolation. | 04-15-2010 |
| 20100168408 | COMPOSITIONS AND METHODS FOR LABELING OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for to fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics. | 07-01-2010 |
| 20100317063 | COMPOSITIONS FOR IMPROVED cDNA SYNTHESIS - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 12-16-2010 |
| 20110151521 | cDNA SYNTHESIS IMPROVEMENTS - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 06-23-2011 |
Christopher Gruber, Cincinnati, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20110033313 | Air Flow Control Apparatus - An apparatus includes a valve housing having an inlet port, a first chamber with a first outlet port, and a second chamber with a second outlet port. A first valve opens between the inlet port and the first chamber under a first level of pneumatic pressure at the inlet port. A second valve opens between the first chamber and the second chamber under a second, greater level of pneumatic pressure in the first chamber. A third valve opens between the second chamber and the first chamber under a third level of pneumatic pressure in the second chamber, with the third level being less than the first level. | 02-10-2011 |
Dale F. Gruber, Leesburg, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20110183375 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS - The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-described compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens. | 07-28-2011 |
David Cammiade Gruber, Cincinnati, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090191310 | Method for Reducing Acrylamide in Foods, Foods Having Reduced Levels of Acrylamide and Article of Commerce - A method for the reduction of acrylamide in food products, food products having reduced levels of acrylamide, and an article of commerce. In one aspect, the method comprises reducing the level of asparagine in a food material before final heating (e.g., cooking). In another aspect, the method comprises adding to a food material an enzyme capable of hydrolyzing the amide group of free asparagine. In yet another aspect, an article of commerce communicates to the consumer that a food product has reduced or low levels of acrylamide or asparagine. | 07-30-2009 |
Diane K. Gruber, Las Vegas, NV US
| Patent application number | Description | Published |
|---|---|---|
| 20110266745 | MULTI-DIRECTION SLOT MACHINE PAY LINES - Slot machines utilize one or more pay lines on which a combination of symbols are lined up to determine whether a particular pay line wagered is a winner according to a pay table that shows winning combinations with associated pays. Players are able to place wagers or bets of varying amounts on the pay lines and the machine pays out based on the amount wagered and the number of winning pay line combinations displayed. The present invention enhances game play by offering players the opportunity to choose whether to wager on a pay line that runs right-to-left or left-to-right without changing the probabilities of winning. Or, alternatively, of offering the player the option to wager on pay lines that run in both directions with a weighting of the win probabilities. | 11-03-2011 |
Erick L. Gruber, Rubicon, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20090000282 | PERFORMANCE EXHAUST SYSTEM - An exhaust system for a motorcycle engine including a header having an upstream end adjacent a combustion chamber of the engine and having a downstream end opposite the upstream end. The exhaust system includes a catalytic converter positioned downstream of the combustion chamber and configured to improve the emissions quality of exhaust gases discharged from the combustion chamber. The exhaust system further includes a perforated section at least partially defining an exhaust passageway, the perforated section disposed adjacent the downstream end of the header. A resonator chamber is in fluid communication with the perforated section. The resonator chamber is configured to allow expansion of the exhaust gases in the exhaust passageway through the perforated section. | 01-01-2009 |
| 20090000862 | MOTORCYCLE EXHAUST SYSTEM - An exhaust system for a motorcycle engine includes a muffler assembly. The muffler assembly includes a downstream attenuation portion adapted to be positioned substantially rearward of the motorcycle engine and having a first height, an upstream portion adapted to be positioned substantially forward of the motorcycle engine and having a second height, and an intermediate attenuation portion between the upstream portion and the downstream attenuation portion. The intermediate attenuation portion is adapted to be positioned substantially below the motorcycle engine and has a third height less than half the first height. In some embodiments, a motorcycle is provided, in which the motorcycle engine is positioned substantially within a recess of the muffler assembly to a depth greater than the third height. | 01-01-2009 |
Gerald W. Gruber, Englewood, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100286013 | Chemical wipes - Wipes treated with organometallic compounds used in combination with organic acids in kit form, particularly organophosphorus acid, are disclosed. The kits can be used to treat various surfaces to alter the physical properties of the surfaces. | 11-11-2010 |
Herbert Gruber, Rochester Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20080252092 | Swing and fold down tailgate actioning mechanism - The present invention is a swing and fold down tailgate mechanism which includes an inner panel, a first handle supported by the inner panel operably associated with a first latch and a second latch, a second handle supported by the inner panel operably associated with the first handle and a third latch. The present invention also includes a hinge member operably associated with the first handle and the second handle for providing hinged support of the tailgate such that the tailgate pivots in a drop down direction and alternatively in a swing open direction. When the first handle is actuated, the first and second latch will release and the second handle will be deactivated, allowing the tailgate to pivot using the third latch and hinge. When the second handle is actuated, the second and latch will release and the first handle will be deactivated, allowing the tailgate to pivot about the first latch and hinge. | 10-16-2008 |
James V. Gruber, Washington, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100143451 | Composition for Improving Skin Condition and Appearance - Disclosed is a cosmetic composition comprising prenylated isoflavonoid and a carrier, wherein the prenylated isoflavonoid is from about 0.0000001% to about 10%, preferably from 0.00001% to 1%, most preferably from 0.01% to 1%, by weight, based on the total weight of the composition. The active agent prenylated isoflavonoid induces a statistically significant upregulation of collagen 1A1 and elastin genes in normal human dermal fibroblasts. The composition is effective to stimulate the production of collagen and elastin and improve the appearance and condition of the skin. | 06-10-2010 |
| 20110091406 | COMPOSITION AND METHOD FOR PROTECTING LABILE ACTIVE COMPONENTS DURING HIGH TEMPERATURE DRYING - A composition and method for protecting personal care components, advantageously labile active personal care components, from decomposition during high temperature drying, employing water-soluble hydrolyzed polysaccharide encapsulants. Also disclosed is an additive for a personal care composition comprising a personal care component that is at least partially encapsulated within a hydrolyzed polysaccharide encapsulant. Also disclosed is a method for protecting a composition containing labile biologically active particles which comprises encapsulating at least a portion of the biologically active particles within hydrolyzed polysaccharide particles, thereby protecting said portion of said biologically active particles. | 04-21-2011 |
James V. Gruber, Somerville, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110286992 | PERSONAL CARE COMPOSITION CONTAINING LEGHEMOGLOBIN - A personal care composition comprising leghemoglobin and at least one preservative selected from the group consisting of alcohols, glycols, parabens, hydantoins, quaternary nitrogen-containing compounds, isothiazolinones, aldehyde-releasing agents, and halogenated compounds. Preferably, the leghemoglobin is a nitrogen fixation root nodule extract providing a leghemoglobin concentration in the composition of between 0.0001% and about 10% based upon the total weight of the composition. Also disclosed is a method for preparing the personal care composition. | 11-24-2011 |
James Vincent Gruber, Washington, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100021532 | Personal care composition containing yeast/polyphenol ferment extract - Disclosed is a yeast/polyphenol ferment extract, and a personal care composition including the yeast/polyphenol ferment extract. Also disclosed is a method for preparing and using the yeast/polyphenol extract and the personal care composition. | 01-28-2010 |
| 20110052676 | Composition For Delaying Cellular Senescence - Disclosed herein is a composition for delaying cellular senescence comprising from about 0.01 wt % to about 5 wt % of Hexapeptide-11(Phe-Val-Ala-Pro-Phe-Pro), based on the total weight of the composition, and a dermatologically-acceptable carrier for the peptide selected from the group consisting of water, oil, alcohol, silicone, and combinations thereof. | 03-03-2011 |
Jennifer Gruber, Stillwater, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20080271813 | Funnel With Shut Off Valve - A funnel with a shut-off valve terminates the flow of fluid from a reservoir to a spout passageway upon activation of the shut-off valve. The flow of fluid is terminated when a float contacts a seal mounted within the spout passageway. An upper magnet is mounted above the seal and a lower magnet is attached to the float, a portion of which extends over the lower magnet. In the open position, the force provided between the magnets serves to provide lift to the float. When the fluid level in the container rises, additional lift is provided until the lower magnet comes sufficiently within the range of the upper magnet causing the lower magnet to be drawn to the upper magnet. The force between the magnets is sufficient to provide compression of the seal by the float. A ball joint is provided between a control rod and the float to correct misalignment between the float and the seal. A significant portion of the float extends beyond the lower end of the spout passageway to reduce the influence of forces on the float. In addition, flanges are provided at the lower end of the float to direct fluid away from the float preventing premature closing of the valve. | 11-06-2008 |
Joe Gruber, West Chester, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100192150 | EXCLUSIVE ACCESS FOR SECURE AUDIO PROGRAM - Executing a monitor on a platform, the monitor capable of providing exclusive, secure access to an audio I/O device of the platform, executing a first partition on the platform, providing an audio device model in the first partition by directly mapping the audio I/O device from the monitor to the first partition for applications executing in the first partition, and providing exclusive, secure access to the audio I/O device to a program performing an audio function in a secure mode in the first partition. | 07-29-2010 |
Joe R. Gruber, West Chester, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20080240403 | DUAL MODE NETWORK TELEPHONY GATEWAY - A system and method for routing and interacting with a dual mode network telephony environment are disclosed. In one embodiment, the system includes an external analog telephony line, a DSL modem, an analog telephony bridge controller, one or more additional analog telephony lines, and a communication center computer. The system routes analog and Voice-over-Internet Protocol calls between the analog telephony lines and the communication center computer. Furthermore, the communication center computer performs operations on calls inbound to the environment and calls outbound from the environment. | 10-02-2008 |
Karl F. Gruber, Tempe, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20100181239 | Integrated High Throughput System for the Analysis of Biomolecules - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 07-22-2010 |
| 20110192778 | INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 08-11-2011 |
Karl L. Gruber, Port Ludlow, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110181172 | Fold and Spiral CFL Bulb Safety Cups, Diffusion Covers and Shade Assemblies - Screw-on or slip-on covers, in the form of transparent or translucent plastic sleeves for CFLs functioning as diffusers and cups for handling bulbs during installation, removal and as a safety receptacle for mercury-contaminated broken bulbs. The covers have interior surfaces contoured to the various sizes of CFL tube configurations, spiral or axially folded tubes, so that they are securely retained when screwed or slipped onto the tubes. The inventive covers may be used in any orientation, open end up, down or horizontal, so that they are equally useful for upright CFLs in lamps, horizontally oriented CFLs screwed into wall sockets, or downwardly oriented or angled CFLs screwed into horizontal or sloped ceiling fixtures. The inventive covers function as light diffusers and hide the tubes in more pleasing external shapes. Attractive sleeve colors, designs and surface textures are disclosed. Shades and shade frames may be secured to the inventive CFL covers. | 07-28-2011 |
Max L. Gruber, Lake Worth, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100192944 | SOLAR WATER HEATER AND DISTILLER - A water heating/distillation chamber with multiple lenses arranged on its external walls such that direct sunlight from any direction is input into the chamber to heat the chamber contents. An input line provides water when necessary, and an output condensing structure channels water vapor out of the device for condensation into distilled water. Alternatively, a supply of hot water can be output from the chamber after heating. Alternatively, steam can be generated which can be used as an energy source for turbines. The chamber can be fabricated from glass, or any other material suitable for creating a greenhouse effect inside the chamber. The device can be applied to a wide spectrum of uses, from large scale commercial activity to small applications such as camping equipment. | 08-05-2010 |
Pat Gruber, Longmont, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20080230954 | Injection Stretch Blow Molded Polylactide Bottle and Process For Making Same - An injection stretch blow molding process for making containers from a polylactic acid resin. In one aspect the process comprises molding the polylactic acid resin into a perform, applying heat to the perform, stretching and blowing the perform in axial and radial dimensions in order to form a preliminary molded container, conditioning the molded container pursuant to a first conditioning method, conditioning the molded container pursuant to a second conditioning method, and stretching and blowing the molded container in order to form a final molded container. Relatively rigid bottles constructed in accordance with one or more processes disclosed herein are also contemplated. | 09-25-2008 |
Patrick R. Gruber, Longmont, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090171129 | RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS - This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs. | 07-02-2009 |
| 20090215137 | METHODS FOR THE ECONOMICAL PRODUCTION OF BIOFUEL PRECURSOR THAT IS ALSO A BIOFUEL FROM BIOMASS - Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor. | 08-27-2009 |
| 20090246842 | ENGINEERED MICROORGANISMS FOR PRODUCING PROPANOL - Methods and compositions for the production of bio-based material precursors are provided. | 10-01-2009 |
| 20090299109 | Renewable Compositions - The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions. | 12-03-2009 |
Paul Gruber, Kirkland, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090136285 | Structural Arrangement for a Fluid-Dispensing Power Toothbrush - The fluid-dispensing power toothbrush includes a selected toothbrush architecture, generally, a handle portion, a head portion which is removable from the handle portion and a fluid-dispensing system which is removable with the head portion. The fluid-dispensing portion includes a pump and a fluid reservoir, with the reservoir being removable from the pump. The entire reservoir extends down along an exterior surface of the handle, below the lower edge of the head portion. A cover member overlies and mates with the handle, covering the reservoir when the cover member is in a closed position. | 05-28-2009 |
Robert V. Gruber, Dallas, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110162563 | SNAP-TOGETHER PALLET - A pallet for use with a fork lift includes a top deck, a mid-top member and a base. The top deck has a plurality of ribs extending downwardly and a plurality of column-receiving recesses formed on the underside thereof. The base includes a plurality of columns projecting substantially vertically and received within the recesses of the top deck. Snap-tabs secure the columns to the deck. A generally planar mid-top member is secured to the plurality of ribs on the deck and has a plurality of openings into which are received the plurality of columns. The mid-top member is sandwiched between the ribs of the top deck and shoulders formed on the outer periphery of the columns. | 07-07-2011 |
Stephen B. Gruber, Ann Arbor, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090092987 | Polymorphic Nucleic Acids Associated With Colorectal Cancer And Uses Thereof - The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to colorectal cancer and related conditions. In particular, the present invention provides genetic variations in or associated with one or more of the STK38L, GPR45, TGFBRAP1, PADI3, IBRDC1, and/or GRK5 genes as being associated with such conditions. | 04-09-2009 |
| 20100280056 | IDENTIFICATION OF SUBJECTS LIKELY TO BENEFIT FROM STATIN THERAPY - Methods are provided herein to determine if a subject is a candidate for treatment with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The method includes determining the presence of at least one polymorphism in the HMGCR gene in a sample from a subject. The presence of at least one polymorphism indicates that the subject is a candidate for treatment with a statin, for example to decrease risk of or treat cancer, cardiovascular disease, diabetes, obesity, inflammatory disease, or auto-immune disease. | 11-04-2010 |
Stephen Joseph Gruber, Cincinnati, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100126018 | METHOD OF MANUFACTURING A VANE WITH REDUCED STRESS - A method of manufacturing an airfoil assembly is described, the method comprising the steps of supplying an airfoil and a band, creating a support aperture in the band capable of receiving a portion of the airfoil, creating a slot in the band for reducing stress in the airfoil, and bonding the airfoil with the band. | 05-27-2010 |
| 20100129210 | VANE WITH REDUCED STRESS - An airfoil assembly is described comprising an airfoil, a band coupled to the airfoil for providing at least a portion of support for the airfoil in the airfoil assembly and a slot capable reducing stress in the airfoil wherein the slot is located in the band near a portion of the airfoil. A compression system is described comprising a stator assembly comprising a plurality of arcuate vane sectors arranged circumferentially around a longitudinal axis, each vane sector comprising an airfoil, an arcuate inner band and an arcuate outer band coupled to the airfoil, and a slot capable of reducing stress in the airfoil, the slot being located in the vane sector near a portion of the airfoil. | 05-27-2010 |
Thomas Gruber, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110062192 | Spout for Flexible Fluid Reservoirs - A spout, particularly for flexible fluid reservoirs having opposing film panels, which minimizes stresses and abrasion resulting from manufacture and/or use of such reservoirs as well as enhances the strength of the weld/bond between the films and the spout. Spouts according to the invention include a generally cylindrical neck portion and a pair of opposed, generally triangular portions extending laterally there from that form a spout-film interface. This interface may be smooth and/or define depressions or holes to increase bond integrity. Spout embodiments of the invention also may include at least one, and preferably four, stress delocalizing feature(s) (“SDF”) to disperse material stress from edges of the spout-film interface that might form during use of the spout. Exemplary SDFs include flexible appendages, preferably at the apex of the triangular portions or at neck portions that form a portion of the spout-weld interfaces, which depend beyond the spout weld interface and into the reservoir. | 03-17-2011 |