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Grogan, US
Jane Grogan, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090258013 | NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES - The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases. | 10-15-2009 |
| 20110263451 | BIOLOGICAL MARKERS PREDICTIVE OF RHEUMATOID ARTHRITIS RESPONSE TO LYMPHOTOXIN ANTAGONISTS - The present invention relates to a soluble lymphotoxin (solLT) and methods of using the solLT as a biomarker in the treatment of autoimmune disease. More particularly, the present invention relates to soluble lymphotoxin alpha-beta (solLTαβ) and methods of using this solLTαβ as a biomarker in the treatment of rheumatoid arthritis (RA). | 10-27-2011 |
Jane L. Grogan, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090285830 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 11-19-2009 |
| 20110150865 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 06-23-2011 |
| 20110208673 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 08-25-2011 |
Joseph Grogan, Port Washington, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100137884 | METHOD AND DEVICE FOR THE CONTROLLED DELIVERY AND PLACEMENT OF SECURING ELEMENTS IN A BODY | 06-03-2010 |
Joseph Grogan, San Antonio, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20080243321 | Event sensor - An automatic timing measurement system that provides a measure of time of passage of a watercraft through a prescribed course. Algorithms based on inertial or other estimates augmented by GPS speed/position measurements are used to track position of a watercraft. Said position estimates are used to allow the locations of prescribed courses to be mapped and memorized. Algorithms are then used to allow the apparatus to automatically detect passage of a watercraft through mapped courses for the purpose of measuring and reporting time of passage of said watercraft past key points in said course, and for modifying the behavior of the speed control portion of the apparatus if necessary at certain points in the mapped course. A measure of accuracy of driver steering can be provided along with the ability to automatically steer the watercraft through the course if “steer-by-wire” mechanism is available. GPS speed control is augmented with a secondary velocity measurement device that measures speed over water resulting in an optional user selectable real-time compensation for water current. Furthermore, GPS is used as the key input to produce boat speed-based pull-up profiles. | 10-02-2008 |
| 20090209152 | WATERCRAFT SPEED CONTROL DEVICE - An automatic speed control system that provides desired watercraft velocity over land. The coupled algorithms correct engine speed and torque using inertia based measurements, GPS, and tachometer measurements, and the corrections are augmented and enhanced by velocity/speed and torque/speed relationships that are dynamically and adaptively programmed with real-time data collected during replicated operations of the watercraft in specified conditions. | 08-20-2009 |
| 20090209153 | WATERCRAFT SPEED CONTROL DEVICE - An automatic speed control system that provides desired watercraft velocity over land. The coupled algorithms correct engine speed and torque using inertia based measurements, GPS, and tachometer measurements, and the corrections are augmented and enhanced by velocity/speed and torque/speed relationships that are dynamically and adaptively programmed with real-time data collected during replicated operations of the watercraft in specified conditions. | 08-20-2009 |
Michael Grogan, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093719 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: | 04-15-2010 |
| 20100324037 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: | 12-23-2010 |
| 20110172422 | Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds - The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds. | 07-14-2011 |
Michael L. Grogan, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120088738 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 04-12-2012 |
Ronald Grogan, Spokane, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090038650 | Compositions and substrate cleaning methods - Compositions are provided that can include a fatty acid ester such as canolates, and essential oils such as borneol. Example compositions can include a canolate and lime oil. Methods for cleaning substrates are also provided that can include exposing the substrate to a mixture including a fatty acid ester and an essential oil. Methods for dissolving a primarily organic substance are also provided that can include exposing the substance to a mixture including a fatty acid ester and an essential oil. Particular methods are provided for cleaning painting equipment that can include exposing the painting equipment to a composition comprising a fatty acid ester and an essential oil. | 02-12-2009 |
| 20090269499 | Mixtures, Compositions, and Methods of Using and Preparing Same - Mixtures are provided that can include at least one polyhydric alcohol; at least one acrylic compound; and at least one polyhydric ester. Compositions are provided that can include a particle at least partially coated with a mixture can include at least one polyhydric alcohol and a carbonyl compound. Methods for limiting particulate distribution during road use are provided that can include providing a mixture to the surface of the road, the mixture including at least one polyhydric alcohol and a carbonyl compound. Methods for limiting particulate distribution are provided that can include providing a mixture comprising at least one polyhydric alcohol and a carbonyl compound to a surface prior to agitating the surface. | 10-29-2009 |
Thomas Grogan, Folsom, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080259269 | Decorative magnetic attachments to enhance eyewear - Decorative elements magnetically attachable to, removable from and/or interchangeable with eyewear frames comprise decorative element mounting means having a recess for receiving a magnet and cooperating with a recess on the eyewear frame which receives the mounting means. The two recesses are generally opposed in direction such that the recess on the mounting means and the magnet therein are both received internally by the recess on the eyewear frame with the magnet being sufficiently close to the internal metal or wire reinforcement of the frame to be attracted thereto. | 10-23-2008 |
Thomas Grogan, Tucson, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20110136130 | METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE - The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule. | 06-09-2011 |
Thomas M. Grogan, Tucson, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20080286386 | Na+, K+-Atpase Expression in Cervical Dysplasia and Cancer - The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na | 11-20-2008 |
| 20080299555 | Multicolor chromogenic detection of biomarkers - The present invention provides compositions, kits, assembles of articles and methodology for detecting multiple target molecules in a sample, such as in a tissue sample. In particular, site-specific deposition of elemental metal is used in conjunction with other means of detection, such as other chromogenic, radioactive, chemiluminescent and fluorescent labeling, to simultaneously detect multiple targets, such a gene, a protein, and a chromosome, in a biological sample. More particularly the multiple targets may be labeled with the specifically deposited metal and other chromogenic labels to allow chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope. | 12-04-2008 |
Timothy W. Grogan, Rochester Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20080224524 | MOTOR VEHICLE SEAT ASSEMBLY - According to one embodiment of a seat assembly for a motor vehicle a seat back pivots about a hip axis, a seat bottom pivots about a knee axis, and at least one seat bottom leg is pivots about an ankle axis, so that the seat back folds down against the seat bottom and the seat bottom kneels on the floor to at least partially define a seating load floor. According to another embodiment; a seat bottom and a seat back are articulatable in a forward direction to fold the seat bottom and back down toward a floor of the vehicle to at least partially define a seating load floor. | 09-18-2008 |
| 20110148163 | MOTOR VEHICLE SEAT ASSEMBLY - According to one embodiment of a seat assembly for a motor vehicle a seat back pivots about a hip axis, a seat bottom pivots about a knee axis, and at least one seat bottom leg is pivots about an ankle axis, so that the seat back folds down against the seat bottom and the seat bottom kneels on the floor to at least partially define a seating load floor. According to another embodiment, a seat bottom and a seat back are articulatable in a forward direction to fold the seat bottom and back down toward a floor of the vehicle to at least partially define a seating load floor. | 06-23-2011 |