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Grimm, US

Aimee Grimm, St. Louis Park, MN US

Patent application numberDescriptionPublished
20110117245DOUGH COMPOSITIONS FOR EXTENDED SHELF LIFE BAKED ARTICLES - Dough compositions that can be baked to form baked articles having a desirable shelf life, for example about 3 days or greater, or about 7 days or greater, or about 14 days or greater are described. The dough compositions comprise: hard wheat flour; a leavening agent; sucrose; about 2% weight or greater of a pre-hydrated monoglyceride; about 4% weight or greater of a fat having a solid fat index (SFI) of: 0 to about 21 at 50° F.; 0 to about 16 at 70° F.; and 0 to about 12 at 92° F.; less than about 3% weight dextrose; less than about 10% weight corn syrup; less than about 3% weight glycerin; and less than about 10% weight soft wheat flour.05-19-2011

Alfred E. Grimm, Virginia Beach, VA US

Patent application numberDescriptionPublished
20090017707Reconfigurable Buoyant Apparatus - In one embodiment, a buoyant device includes multiple buoyant members with each buoyant member defining a first aperture and a second aperture. Each buoyant member is coupled to an elongate member such that the elongate member extends from that first aperture to that second aperture.01-15-2009

Andrew A. Grimm, St. Louis, MO US

Patent application numberDescriptionPublished
20090246803NAD BIOSYNTHESIS SYSTEMS - The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical activators and inhibitors for mammalian NAD biosynthesis. Another aspect of the invention provides a method of identifying a compound that effects in vivo activity of NAD metabolic enzymes. Further aspects of the invention include nucleic acid sequences, vectors, and transformed cells that can be used in the methods described herein.10-01-2009

Ann K. Grimm, Cedar Rapids, IA US

Patent application numberDescriptionPublished
20100063656Train Control Method and System - A train control system for controlling trains traveling in a track network including tracks with signals associated therewith. The system includes an on-board track database, a positioning system and an on-board control system. The on-board control system receives position data and automatically brakes the train prior to encountering an upcoming signal based upon specified data points. The train is not automatically braked if certain conditions are met. A method for controlling a train traveling in a track network is also disclosed.03-11-2010

Charles M. Grimm, Carmel, IN US

Patent application numberDescriptionPublished
20080210291Solar collector and photovoltaic converter - This invention relates generally to a solar collector and photovoltaic converter with a concentrating reflective inner surface with a static fluid filter attached to the bottom half of a enclosure with a photovoltaic converter cell mounted to the under side of the hemi-spherical transparent top half of the enclosure.09-04-2008

Daniel S. Grimm, Chicago, IL US

Patent application numberDescriptionPublished
20110040651SYSTEMS AND METHODS FOR MANAGING ORDERS MADE VIA A COMPUTER NETWORK - A system and method for allowing a user to schedule pickup of an ordered item provides a user interface having user interface elements for allowing a user to specify a frequency with which an order is it to be picked up, for informing a user as to availability of the item for pickup, and/or for allowing a user to request that an item be held in reserve for pickup within a given period of time, such as 24 hours. Frequency options provided to the user for selection when scheduling an order for pickup may include a one-time frequency, a daily frequency, a weekly frequency, a monthly frequency, and user specified dates. The information as to availability of the item for pickup is determined considering a time of order and real-time stocking information for the item.02-17-2011
20110320309SYSTEMS AND METHODS FOR MANAGING ORDERS MADE VIA A COMPUTER NETWORK - A system and method for allowing a user to schedule pickup of an ordered item provides a user interface having user interface elements for allowing a user to specify a frequency with which an order is it to be picked up, for informing a user as to availability of the item for pickup, and/or for allowing a user to request that an item be held in reserve for pickup within a given period of time, such as 24 hours. Frequency options provided to the user for selection when scheduling an order for pickup may include a one-time frequency, a daily frequency, a weekly frequency, a monthly frequency, and user specified dates. The information as to availability of the item for pickup is determined considering a time of order and real-time stocking information for the item.12-29-2011

Dan S. Grimm, Chicago, IL US

Patent application numberDescriptionPublished
20110006114SYSTEM AND METHOD FOR USING A MOBILE DEVICE TO FOLLOW A PRICE FOR AN ITEM - A mobile device, such as a cellular telephone, is used to obtain information that is indicative of an item, such as a photograph of the item or a scan of an information carrying indicia associated with the item. The information obtained is then used to present on the mobile device a page by which a user can establish parameters for following the price of the item.01-13-2011
20110191207SYSTEM AND METHOD FOR USING A MOBILE DEVICE TO LOCATE A FOLLOWED ITEM IN A RETAIL STORE - A computing device receives information that is representative of a location of a mobile device and uses the information representative of the location of the mobile device to select one or more maps corresponding to a retail establishment. The computing device also receives information that is representative of a customer and uses the information representative of the customer to place on the one or more selected maps indicia indicative of one or more locations within the retail establishment at which one or more items determined to be of interest to the customer are located. The one or more selected maps with the indicia are then provided to the mobile device for display.08-04-2011
20110196732SYSTEM AND METHOD FOR HANDLING AN OFFER TO PURCHASE A FOLLOWED ITEM - A system receives from a customer having an associated rewards points account a price offer for an item. The system determines if the price offer for the item is below an established threshold price, e.g., a price a retailer would accept for the item. When the price offer for the item is below the established threshold price, the system determines an amount of rewards points to be redeemed by the customer to thereby allow the customer to purchase the item at the price offer for the item as received from the customer. The system then allows the item to be purchased by the customer at the price offer for the item as received from the customer in the event that the customer indicates a willingness to redeem the determined amount of rewards points from their associated rewards points account.08-11-2011

David M. Grimm, Verona, WI US

Patent application numberDescriptionPublished
20090260351Exhaust Assembly with Universal Multi-Position Water Trap - An exhaust assembly includes a water trap blocking upstream water flow at a plurality of angular positions enabling universal application and flexibility of orientation.10-22-2009

Donald K. Grimm, Utica, MI US

Patent application numberDescriptionPublished
20080275618Slow or stopped vehicle ahead advisor with digital map integration - A driver assistance or collision avoidance system is adapted for use with trailing and preceding host vehicles, and in a preferred embodiment includes a preceding vehicle speed sensor for determining the current speed of the preceding vehicle at a point; a vehicle-to-vehicle communication sub-system; a normal speed determining sub-system operable to determine the normally expected speed of the preceding vehicle at the point, and including an exterior remote vehicle sensor or digital map-indicia database; and a controller configured to compare the current and normally expected speeds, and the discrepancy there-between to a threshold, and cause an alert to be generated only when the discrepancy exceeds the threshold or an otherwise stalled condition is determined.11-06-2008
20100245124E85 GAS STATION LOCATOR APPLICATIONS USING V2X PEER-TO-PEER SOCIAL NETWORKING - A system and method for wirelessly exchanging information concerning the location of E85 gas stations between E85 vehicles. The method includes transmitting messages from an E85 gas station that identifies the location of the E85 gas station, the time of the transmission and the price of the E85 gas, and receiving the messages by E85 vehicles that pass within a certain distance of the E85 gas station. The method also includes identifying that two E85 vehicles pass close to each other, where the vehicles periodically broadcast an E85 beacon identifying them as E85 vehicles. When two E85 vehicles are identified, the vehicles exchange information concerning a list of the E85 gas stations that they have stored from messages received from E85 gas stations and/or other E85 vehicles. The two vehicles update their lists to include those E85 gas stations that one vehicle may have that the other does not.09-30-2010
20100248618USING V2X IN-NETWORK SESSION MAINTENANCE PROTOCOLS TO ENABLE INSTANT CHATTING APPLICATIONS - A system and method for allowing vehicle occupants to wirelessly chat with each other over a DSRC channel. A vehicle occupant may initiate a chatting session by wirelessly transmitting a request to speak with an occupant of another vehicle in its vicinity on a certain topic in a multi-hop manner. If the request is accepted by the occupant of another vehicle to enter into a chatting session on that topic, a wireless communications link is established between the two vehicles, where messages may be transmitted through other intermediate vehicles. The chatting session is maintained by monitoring the signal strength of the links between the vehicles in the chain of vehicles and new links are re-established if any of the existing links fail.09-30-2010
20100250106USING V2X-BASED IN-NETWORK MESSAGE GENERATION, AGGREGATION, DISTRIBUTION AND PROCESSING PROTOCOLS TO ENABLE ROAD HAZARD CONDITION WARNING APPLICATIONS - A method for providing messages indicating potential hazardous road conditions using a wireless communications network. Vehicles using the network include sensors that are able to detect various potentially hazardous road conditions, such as rain, fog, icy road conditions, traffic congestion, etc. A plurality of vehicles that detect a specific road condition provide a confidence value that the condition exists. The confidence value is then aggregated by the vehicles with the confidence value of the detected condition from the other vehicles to provide an aggregated result that identifies the probability that the detected road condition is occurring. The aggregated result is then transmitted to other vehicles approaching the road condition, possibly in a multi-hop manner. Alternately, the confidence value from all of the vehicles that detect the condition can be transmitted to approaching vehicles who will provide the aggregated result identifying the potential that the condition exists.09-30-2010
20100250346USING V2X IN-NETWORK MESSAGE DISTRIBUTION AND PROCESSING PROTOCOLS TO ENABLE GEO-SERVICE ADVERTISEMENT APPLICATIONS - A system and method for providing geo-service advertising messages using a wireless vehicle-to-infrastructure (V2X) communications network. Messages are transmitted from a business that identify the type of business, the name of the business and the location of the business, which are received by vehicles traveling within a certain distance of the business. The messages can be rebroadcast by the vehicles receiving the messages from the business to other vehicles either in a multi-hop information routing manner or in a delay-tolerant network information dissemination fashion so that the messages are sent to a wider area, but within a predetermined geographic area and with a predetermined time. If a particular user of the system wishes to learn about a particular business or type of business, he can activate the system so that the messages being sent between the vehicles and from the businesses can be displayed to the user for his use.09-30-2010
20110090093Vehicle to Entity Communication - A vehicle to pedestrian communication system includes a vehicle-based device having a transmitter and receiver for communicating global positioning of the vehicle. The transmitter broadcasts a global position of the vehicle as part of a vehicle periodic beacon message. A pedestrian-based device is carried by a pedestrian. The pedestrian-based device has a transmitter and receiver for communicating a global position of the pedestrian as part of a pedestrian periodic beacon message. A positional awareness of the vehicle in relation to the pedestrian is assessed by at least one of the vehicle-based device or the pedestrian-based device based on the positioning of the vehicle in relation to the pedestrian. An alert is provided to at least one of the vehicle or the pedestrian indicating a presence of the vehicle or pedestrian based on the respective global positions of the pedestrian and the vehicle.04-21-2011
20110109475Travel Lane Advisor - A traffic flow advisory system includes a locating device for identifying a position of a driven vehicle. A communication device exchanges vehicle position data, speed data, and heading data with remote vehicles. A processor constructs a traffic flow rate in a plurality of road lanes based on the position data and speed data. A human machine interface indicates to a driver of the driven vehicle the traffic flow rate of each of the road lanes.05-12-2011
20110136429VEHICULAR WIRELESS PAYMENT AUTHORIZATION METHOD - A method and system for making payments from a vehicle using onboard wireless communication systems. A Near Field Communication (NFC) reader is placed a vehicle, such that a customer can pass an NFC-enabled phone or credit card near the reader to provide a source of funding for a purchase. A Dedicated Short Range Communications (DSRC) radio onboard the vehicle communicates with a seller of products or services, such as a fast food restaurant, a parking garage, or a toll booth. The seller communicates to the vehicle the amount of a pending payment, the customer approves the payment within the vehicle, and the vehicle sends the authorization to the seller. The entire transaction is handled wirelessly, without the customer having to leave the vehicle or roll down a window. Pre-approval accounts can also be established for certain types of payments, thus making those payment transactions automatic.06-09-2011
20110205943OPPORTUNISTIC DATA TRANSFER BETWEEN VEHICLES - A system and method for optimizing wireless vehicle to vehicle communications is configured to maximize the amount of data that can be transferred from one vehicle to another during a transient encounter by adaptively adjusting the message packet size and data modulation rate during an inter-vehicle communication session.08-25-2011
20120065858VEHICLE SAFETY SYSTEMS AND METHODS - A safety system is provided for use in a first vehicle at a first location. The safety system includes a position unit configured to determine the first location; a sensor group configured to detect an opening of the enclosure; a controller coupled to the position unit and the sensor group, the controller configured to generate a warning message including the first location when the opening of the enclosure is detected; and a transmitter coupled to the controller and configured to transmit the warning message.03-15-2012
20120087292Adaptive Multi-Channel Access for Vehicular Networks - A system and method is provided for dynamically self-allocating channel access for communication between communicating entities in an inter-vehicle ad hoc network. A respective entity observes communication activity over each inter-vehicle ad hoc network communication channel. Available time slots are identified within each communication channel for the respective entity to broadcast a data packet in response to the observed communication activity on a respective channel. An available communication channel and timeslot are selected to broadcast the data packet. A message is broadcast within the inter-vehicle ad hoc network that provides a schedule identifying the communication channel and time slot selected for broadcasting the data packet by the respective entity. The data packet is broadcast over the selected communication channel at the respective timeslot.04-12-2012
20120108163Intelligent Telematics Information Dissemination Using Delegation, Fetch, and Share Algorithms - A system for intelligent dissemination of messages via long-range communications to select delegate vehicles, and short-range communications from the delegate vehicles. The system includes a processor and a memory storing a delegation and dissemination algorithm that, when executed by the processor, causes the processor to define a dissemination area and define multiple delegation zones within the dissemination area. The algorithm also causes the processor to identify at least one delegate vehicle, of a network of vehicles, for each delegation zone and seed a message into the network of vehicles by transmitting the message to each delegate vehicle via long-range communications so that the delegate vehicles can transmit the message throughout the network of vehicles via short-range communications.05-03-2012

Patent applications by Donald K. Grimm, Utica, MI US

Erik D. Grimm, Parkersburg, WV US

Patent application numberDescriptionPublished
20120031237TILTING ROTARY FURNACE SYSTEM AND METHODS OF ALUMINUM RECOVERY - A tilting rotary furnace with a door assembly that seals against a furnace vessel. The seal between the door and the furnace vessel allows for regulation of the internal environment of the furnace and control over thermitting of the aluminum. As a result, aluminum recovery may be carried out without the use of salt. A portion of the door may rotate with the furnace vessel and a portion of the door may remain rotationally stationary with respect to the furnace vessel and the rotating portion of the door.02-09-2012

Frank Grimm, Shippensburg, PA US

Patent application numberDescriptionPublished
20100209190PAVING SCREED - In a paving screed E for a road paver F, the paving screed E comprises a base screed G and extension screeds A at the front side of the base screed, the extension screeds A being extendable and retractable and pivotable relative to the base screed G, a base guiding structure 08-19-2010

Ivan Jerome Grimm, Wayzata, MN US

Patent application numberDescriptionPublished
20120082305ILEXORE (Imaginary Length Enhanced XOR Encoding), is a data transformation process characterized by a series of steps which use a Carried Collateral Damage device which transforms the Vernam Cipher from a "two dimensional" cipher into a "three dimensional" cipher capable of possibly infinite levels of reversible data transformation using the same key - ILEXORE (Imaginary Length Enhanced XOR Encoding), is a data transformation process characterized by the use of a Carried Collateral Damage device which transforms the Vernam Cipher from a “two dimensional” cipher into a “three dimensional” cipher capable of possibly infinite levels of reversible data transformation using the same key, by dynamically biasing the state of a key so as to allow the selective creation of perfect, or imperfect, or randomized, or non-randomized universes of transformed data results and carried collateral states from which optimum results and states with desirable characteristics may be selected, possibly dynamically, for purposes of data encryption and data compression,04-05-2012

Jeff Grimm, Hiawatha, KS US

Patent application numberDescriptionPublished
20100032492Method and System to Control Flow From Individual Nozzles While Controlling Overall System Flow And Pressure - A method and system has been developed to individually control the flow of liquid products from any nozzle within a plurality of nozzles using pulse width modulated solenoid actuated valves residing on a CAN communication network. The CAN communication network has been further developed to manage the high current requirements of the solenoid actuated valves, the large physical length and high number of nozzles used on modern agricultural application equipment and integration and retrofit requirements when used in conjunction with commercially available application rate control devices. The method and system simultaneously controls multiple flow and shutoff related inputs including but not limited to turn radius, nozzle overlap, swath reduction, nozzle spacing, fence row rates, wheel track rates, etc. The method and system will also simultaneously accept one or more external inputs from commercially available application rate control devices where other rate and shutoff inputs may be used, for example, variable rates per boom section based on GIS maps or multiple in-field sensors along the boom. The method and system further incorporates the artificial manipulation of commercial rate controller inputs and outputs to facilitate these individual nozzle control features and benefits without compromising the overall system flow control performed by the commercial rate controller.02-11-2010

Jeffrey Grimm, Chicago, IL US

Patent application numberDescriptionPublished
20090175408COMPRESSION PADDLE AND METHODS FOR USING THE SAME IN VARIOUS MEDICAL PROCEDURES - A compression paddle includes a frame defining a hollow cavity. The cavity has two opposed ends. A plurality of filaments is attached to at least one of the two opposed ends of the cavity such that the plurality of filaments extends across the cavity in a predetermined manner.07-09-2009

Jeffrey S. Grimm, Somerville, NJ US

Patent application numberDescriptionPublished
20100004450Process for the preparation of substituted pyrimidine derivatives - The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H01-07-2010
20100029942Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives - The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H02-04-2010
20110105752PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES - The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.05-05-2011

Patent applications by Jeffrey S. Grimm, Somerville, NJ US

Jimm Grimm, Huntingdon Valley, PA US

Patent application numberDescriptionPublished
20110285716Evaluation of Radiation Dose Tolerance Limits - A software device that aids the user to evaluate the dose distribution and dose tolerance limits for radiation therapy treatment plans. Radiation therapy treats a desired tumor volume as well as undesired volumes of critical anatomical structures within the patient. The dose volume histogram (DVH) is commonly used to assess the volume of tumor and the volumes of critical structures receiving certain doses. The disclosed invention overlays historical dose statistical information on the dose volume histogram to conveniently enable the user to evaluate the quality of the radiation treatment plan.11-24-2011

Jimm Grimm, Huntington Valley, PA US

Patent application numberDescriptionPublished
20110273472Dose Volume Histogram Evaluator - A software device that aids the user to evaluate the dose distribution for radiation therapy treatment plans. Radiation therapy treats a desired tumor volume as well as undesired volumes of critical anatomical structures within the patient. The dose volume histogram (DVH) is commonly used to assess the volume of tumor and the volumes of critical structures receiving certain doses. The disclosed invention overlays dose tolerance limits onto the DVH to conveniently and comprehensively enable the user to evaluate the quality of the radiation treatment plan.11-10-2011

Jonathan Grimm US

Patent application numberDescriptionPublished
20110245205AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.10-06-2011

Jonathan Grimm, Newton, MA US

Patent application numberDescriptionPublished
20090062297Hydroxyalkylarylamide Derivatives - The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.03-05-2009
20090270351PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the phosphorus derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the phosphorus derivatives in vivo.10-29-2009
20100160327Modified Malonate Derivatives - The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.06-24-2010
20110130361SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS - The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the Silicon derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the Silicon derivatives in vivo.06-02-2011

Patent applications by Jonathan Grimm, Newton, MA US

Jonathan B. Grimm, Newton, MA US

Patent application numberDescriptionPublished
20090069250Inhibitors of Histone Deacetylase - The present invention relates to a novel class of compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and sale dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.03-12-2009
20110082136INHIBITORS OF JANUS KINASES - The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.04-07-2011

Jonathon L. Grimm, Moreland Hills, OH US

Patent application numberDescriptionPublished
20090028183Platform for communicating across multiple communication channels - Systems, methods, and other embodiments associated with communications through a software platform are described herein. In an embodiment, a method for communicating with users across multiple communication channels from a single platform includes gathering data related to a first user; storing the gathered data; accessing the stored data to determine whether a message should be sent to the first user; accessing the stored data to determine what communication channel should be used to send the message to the first user; formatting the message for the determined communication channel; and sending the message to the first user through the determined communication channel.01-29-2009

Karen M. Grimm, Duryea, PA US

Patent application numberDescriptionPublished
20100143396Method for Preparing a Covalently Cross Linked Oligomer of Amyloid Beta Peptides - The invention relates to a method for the preparation of a stabilized cross-linked oligomer of amyloid beta using a near-zero length bifunctional cross-linking agent for use as an immunogen for the generation of antibodies for the treatment of Alzheimer's Disease and other conditions related to abnormal amyloid beta aggregation. A preferred bifunctional cross-linking agent is 1,5-difluoro-2,4-dinitrobenzene (DFDNB).06-10-2010

Kevin Grimm, Danville, PA US

Patent application numberDescriptionPublished
20110046602DEVICES AND METHODS FOR FLUID ADMINISTRATION - Improved fluid delivery devices and systems are disclosed, including drug delivery devices and systems, and methods that permit, inter alia, the rapid sequential delivery of two or more fluids to a single external fluid flow or intravenous line.02-24-2011

Mark Grimm, Stanley, NC US

Patent application numberDescriptionPublished
20120103547METHOD OF USING ALDEHYDE-FUNCTIONALIZED POLYMERS TO INCREASE PAPERMACHINE PERFORMANCE AND ENHANCE SIZING - Novel sizing mixtures to achieve improved sizing along with other benefits is disclosed and claimed. The invention is a composition comprising a sizing mixture having a stabilizing amount of one or more aldehyde-functionalized polymers and a sizing amount of a sizing composition. The invention is also a method of improving paper and paperboard production and enhancing sizing through adding an effective amount of the disclosed sizing mixture to the paper machine and a method of producing a medium having cellulosic fibers, wherein the method includes adding the disclosed sizing mixture to the medium at any point in a papermaking process.05-03-2012

Mark T. Grimm, Dunlap, IL US

Patent application numberDescriptionPublished
20090000471Filter service system and method - According to an exemplary embodiment of the present disclosure, a system for removing matter from a filtering device of a work machine includes a gas pressurization assembly. An element of the gas pressurization assembly is removably attachable to a first orifice of the filtering device without removing the filtering device from a work machine to which the filtering device is connected. The system also includes a heat source fluidly connected to the gas pressurization assembly.01-01-2009

Patent applications by Mark T. Grimm, Dunlap, IL US

Michael Grimm, Altoona, PA US

Patent application numberDescriptionPublished
20110185803BICYCLE FITTING APPARATUS AND METHOD - A bicycle fitting system includes a wind tunnel, a platform, a load cell, a bicycle rig, a plurality of actuators, and a processor. The platform is disposed within the wind tunnel and includes a rear roller, a front strut, and a rear strut. The load cell is coupled to the platform. The bicycle rig is coupled to the front and rear struts and includes a plurality of adjustment points, a rear wheel, a handle bar, and a seat, with the rear wheel friction coupled to the rear roller. Each adjustment point is associated with one of the actuators, and each actuator is operable to alter a configuration of the bicycle rig. The processor receives an output from the load cell and operates the actuators while a rider is riding the bicycle rig.08-04-2011

Michael B. Grimm, Evanston, IL US

Patent application numberDescriptionPublished
20090155015MAT FASTENING SYSTEM - A system for securing a floor mat with respect to a carpet within a vehicle that may include a carpet grommet configured to secure to the carpet, a mat grommet configured to secure to the floor mat, and a locking ring secured to or within one of the carpet grommet or the mat grommet. The locking ring includes first ramped shelves configured to securely abut reciprocal ramped surfaces formed on the other of the carpet grommet or the mat grommet. The first ramped shelves are angled in a non-perpendicular and non-parallel manner with respect to a central longitudinal axis of the system, wherein the locking ring secures the carpet grommet to the mat grommet. The carpet grommet may also include an auger configured to pierce and secure into the carpet.06-18-2009

Michael J. Grimm, Sylvania, OH US

Patent application numberDescriptionPublished
20090035500Container of sustainable materials and having high moisture barrier properties - A prescription vial includes a generally cylindrical body of molded polylactic acid construction and a wrap-around label of polyolefin construction on an exterior surface of the cylindrical body. The cylindrical body with wrap-around label has a moisture vapor transmission rate of not more than 100 mg/day/liter, meeting USP standards for prescription vials. The wrap-around label preferably is of high density polyethylene or polypropylene construction.02-05-2009
20090036862Multilayer plastic container and method of storing lyophilized products - A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.—day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture.02-05-2009
20100236090Multilayer Plastic Container and Method of Storing Lyophilized Products - A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.-day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture.09-23-2010

Phillip H. Grimm, Scottsdale, AZ US

Patent application numberDescriptionPublished
20110148627TRACKING UNIT - A tracking unit for assisting in the recovery of stolen monies or other property includes a housing containing a GPS receiver for receiving GPS signals from overhead satellites, a cellular phone transceiver, a microprocessor, and a battery. Following a theft, the microprocessor activates the cellular phone transceiver to dial the telephone number of a central monitoring station. The microprocessor obtains location data from the GPS receiver and transmits the location data, along with identification information, to the central monitoring station. The tracking unit also includes a separate, conventional RF beacon transmitter for allowing authorities to home-in on the tracking unit within a large building or other structure, either after the GPS signals are lost, or after the location of the tracking unit is localized to a specific building or area.06-23-2011

Randall Lane Grimm, Rochester, MN US

Patent application numberDescriptionPublished
20080228644PROVIDING METERED CAPACITY OF COMPUTER RESOURCES - An apparatus and method provides the capability of metering temporary capacity on demand in a computer system. A resource-time is specified, such as processor-days. The actual usage of the resource is monitored, and the customer is charged for only the actual usage of the resource. In this manner a customer may purchase a specified resource-time, and is only charged for the time that the resource is actually used. The preferred embodiments extend to metering temporary capacity on demand in a logically partitioned computer system. If a resource is shared, the actual usage of the resource is monitored, and the customer is only billed for actual usage that exceeds a predetermined non-zero threshold.09-18-2008
20080306847PROVIDING METERED ACCOUNTING OF COMPUTER RESOURCES - An apparatus and method provide the capability of metering temporary capacity on demand in a computer system in a way that allows one resource to benefit from unused billed capacity of a different resource. The actual use of a selected resource is monitored. When the selected resource is actually used, before charging the customer for the resource, a check is made to see if there is unused billed capacity of another resource that may be used by the selected resource. If so, the unused billed capacity of the other resource is “stolen” and used by the selected resource. If there is no unused billed capacity of another resource, a resource-time increment is billed for the use of the selected resource.12-11-2008
20090043877SYSTEM FOR TRANSFERRING STANDBY RESOURCE ENTITLEMENT - An apparatus and program product for transferring entitlement to standby resources between respective computers. Standby resources are made available at a destination computer by rendering unavailable corresponding resources at a source computer. As such, the aggregate number of available standby resources may remain unchanged, but the distribution of the availability may be reapportioned according to operational requirements. Where desired, this transfer of entitlement may be accomplished automatically, dynamically and/or in a secure manner.02-12-2009

Patent applications by Randall Lane Grimm, Rochester, MN US

Randy L. Grimm, Rochester, MN US

Patent application numberDescriptionPublished
20090319635CENTRALLY MANAGED INVENTORY AND ENTITLEMENT DATA - A method, apparatus and program product manages application entitlement data by storing entitlement data received from a plurality of application providers. Inventory data associated with a networked computing device or an application executable on the networked computing device is monitored. Delivery of the entitlement data to the networked computing device is enabled according to the inventory data.12-24-2009

Richard A. Grimm, Chagrin Falls, OH US

Patent application numberDescriptionPublished
20100280355SYSTEM AND METHOD TO CHARACTERIZE CARDIAC FUNCTION - Systems and methods can quantify cardiac function. In one embodiment, a method (11-04-2010

Robert Grimm, New York, NY US

Patent application numberDescriptionPublished
20110219362Virtual Execution Environment for Streaming Languages - A virtual execution environment (VEE) for a streaming Intermediate Language (IL), wherein the streaming IL represents a streaming program, communicates streaming data in queues, stores data-at-rest in variables, and determines data by functions, where inputs are read from the queues and the variables, and outputs are written to the queues and the variables.09-08-2011

Robert M. Grimm, Raymond, ME US

Patent application numberDescriptionPublished
20120127298SYSTEM AND METHOD FOR MONITORING BIREFRINGENT PARTICLES IN A FLUID - An imaging system with an imaging mechanism which includes polarization analyzers, which may be crossed polarization analyzers, positioned to provide birefringence images of particles in the fluid passing through the flow chamber. Captured images are of high resolution and may be used in comparison to known images of a library of images. The system and related method enhance the accuracy and sensitivity of particle monitoring by utilizing birefringence imaging combined with particle analysis and the detection of each particle's characteristic features, such as crystalline features. The system includes a scatter detector used to trigger backlighting of the flow chamber and capture images of particles therein.05-24-2012

Scott W. Grimm, Wilmington, DE US

Patent application numberDescriptionPublished
20090093460Compositions - Pharmaceutical compositions, oral pharmaceutical compositions, and solid dosage forms comprising up to about 750 mg of 11-piperazin-1-yldibenzo[b,f] [1,4]thiazepine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent are provided.04-09-2009
20090093461Methods of Treating Anxiety and Mood Disorders - Methods of treating at least one symptom or condition associated with Anxiety Disorders and/or Mood Disorders comprising administering an effective amount of a compound of Formula I04-09-2009
20100093700Methods of Treating Mood Disorders - A method of treating at least one symptom or condition associated with but not limited to: Mood Disorders including but not limited to a) Depressive Disorders, including but not limited to, Major Depressive Disorder and Dysthymic Disorder and b) Bipolar Depression and/or Bipolar mania including but not limited to Bipolar I Disorder, including but not limited to those with manic, depressive or mixed episodes, and Bipolar II Disorder, c) Cyclothymic Disorder, and d) Mood Disorder Due to a General Medical Condition, comprising administering an effective amount of formula (I) or its pharmaceutically acceptable salt. In another aspect of the invention a pharmaceutical composition is provided comprising an effective amount of formula (I) or its pharmaceutically acceptable salt and at least one pharmaceutically acceptable carrier or diluent.04-15-2010
20110136784Method of Treating Anxiety Disorders - A method of treating at least one symptom or condition associated with but not limited to: Anxiety Disorders including but not limited to Panic Disorder Without Agoraphobia, Panic Disorder With Agoraphobia, Agoraphobia Without History of Panic Disorder, Specific Phobia, Social Phobia, Obsessive-Compulsive Disorder, Postaumatic Stress Disorder, Acute Stress Disorder, Generalized Anxiety Disorder and Generalized Anxiety Disorder Due to a General Medical Condition comprising administering an effective amount of Formula I06-09-2011
20110136785METHOD OF TREATMENT - A method of treating at least one symptom or condition associated with but not limited to: 1) Substance-Related Disorders including but not limited to Substance Dependence, Substance Abuse, Substance Intoxication, Substance Withdrawal, Alcohol-Related Disorders, Amphetamine (or Amphetamine-Like)-Related Disorders, Caffeine-Related Disorders, Cannabis-Related Disorders, Cocaine-Related Disorders, Hallucinogen-Related Disorders, Inhalant-Related Disorders, Nicotine-Related Disorders, Opioid-Related Disorders, Phencyclidine (or Phencyclidine-Like)-Related Disorders, and Sedative-, Hypnotic- or Anxiolytic-Related Disorders. 2) Attention-Deficit and Disruptive Behavior Disorders. 3) Eating Disorders. 4) Personality Disorders including but not limited to Obsessive-Compulsive Personality Disorder. 5) Impulse-Control Disorders, comprising administering an effective amount of Formula I06-09-2011
20110136786METHOD OF TREATING MOOD DISORDERS - Methods of treating mood disorders comprising administering an effective amount of 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine or a pharmaceutically acceptable salt thereof and pharmaceutical compositions therefor.06-09-2011
20110144088METHOD OF TREATING SLEEP DISORDERS - A method of treating at least one symptom or condition associated with but not limited to: Sleep Disorders including but not limited to 1) Dyssomnia Disorders including but not limited to: a) Primary inomnia, b) Primary Hypersomnia, and c) narcolepsy; and 2) Parasomnias Disorders including but not limited to a) Nightmare Disorder, Sleep Terror Disorder and Sleepwalking Disorder, comprising administering an effective amount of Formula I06-16-2011
20110144089METHOD OF TREATING SCHIZOPHRENIA AND OTHER DISORDERS - A method of treating at least one symptom or condition associated with but not limited to: 1) Schizophrenia and other Psychotic Disorders including but not limited to Psychotic Disorder, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder, Brief Psychotic Disorder, Shared Psychotic Disorder, and Psychotic Disorder Due to a General Medical Condition and 2) Dementia and other Cognitive Disorders comprising administering an effective amount of Formula I06-16-2011
20110237568CRYSTALLINE FORMS - 11-piperazin-09-29-2011

Patent applications by Scott W. Grimm, Wilmington, DE US