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Grimaldi
Christopher Grimaldi, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090291097 | IL-17 homologous polypeptides and therapeutic uses thereof - The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases. | 11-26-2009 |
| 20090318340 | IL-17 homologous polypeptides and therapeutic uses thereof - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 12-24-2009 |
| 20100041138 | IL-17 homologous polypeptides and therapeutic uses thereof - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 02-18-2010 |
J. Chistopher Grimaldi, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090197301 | Secreted and transmembrane polypeptides and nucleic acids encoding the same - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 08-06-2009 |
John Grimaldi, Lawrenceville, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20120065459 | ANGLED SURGICAL INTRODUCER - The invention describes a surgical introducer comprising a proximal tip portion and a distal tip portion, wherein each tip portion comprises a notch, a base portion comprising an angle, wherein the base portion is between the proximal tip portion and the distal tip portion and wherein the base portion is wider than the remainder of the introducer. The introducer can be used for insertion of arms of a urethral sling into a patient. | 03-15-2012 |
Keith Grimaldi, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20080275912 | Computer-Assisted Means for Providing Personalised Healthcare Products - The present invention relates to a computer assisted method of providing a personalized assessment of supplement requirements for a human subject in which an individual's genotype is analysed for the presence of alleles at one or more genetic loci which may be associated with risk factors, and the alleles present compared to a first dataset comprising information correlating the presence of individual alleles at genetic loci with a lifestyle risk factor to provide a risk factor associated with the presence of particular alleles in order to generate a personalized assessment of nutritional and therapeutic supplement requirements, which may include a personalized supplementation formula. | 11-06-2008 |
Kevin S. Grimaldi, Roslindale, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120078847 | System and method for managing integrity in a distributed database - Cluster recovery time is reduced by an incremental refresh technique that is described herein. The goal of the technique is to salvage the portion of the redundant distributed database lost (e.g., during a fault) by performing an incremental refresh of only the updates occurring to that portion of the database since the time of loss. | 03-29-2012 |
| 20120078849 | System and method for enhancing availability of a distributed object storage system during a partial database outage - An “operate with missing region” feature of this disclosure allows the cluster to continue servicing reads for available regions even when some regions are missing. In particular, upon a given node failure condition, the cluster is placed in an effective read-only mode for all regions. The node failure condition typically is one where there has been a failure of an authoritative region copy and no backup copy is then available. As used herein, “read-only” means that no client write or update requests will succeed while the cluster is in this state. In particular, those requests should fail with an error message (or the like) that indicates failure because of the read-only status. Preferably, such requests are then re-tried. In this mode, all regions are only allowed to perform read operations. During the read-only state, the cluster continues to operate with missing regions, and missing regions are entered on the region map. The cluster then automatically recovers returning missing region(s), after which is leaves the read-only state. | 03-29-2012 |
| 20120078850 | System and method for managing scalability in a distributed database - This disclosure enables a user to incrementally increase or decrease the size of the cluster and, in particular, to incrementally increase or decrease the number of map regions implemented in a metadata manager associated with the cluster while maintaining availability of the cluster. In a representative embodiment, a configurable target map size is identified, either manually (e.g., by the user) or programmatically. If the target map size is found to be within an acceptable value (given the available node configuration), a procedure to create a new map is triggered. The new map preferably is generated as follows. Initially, one or more new temporary region(s) are created either to split or join the existing regions (depending on whether the map is being increased or decreased). For each temporary region, the process also generates MDPL backup regions. Metadata from an original region (or regions) is then migrated to the temporary region(s). Once the migrations have been completed, the old region or regions (from which the metadata is migrated) are removed and what were the temporary regions are, in effect, promoted. The result is the new map. | 03-29-2012 |
Maurizio Grimaldi, Birmingham, AL US
| Patent application number | Description | Published |
|---|---|---|
| 20110060000 | ACRIDINE ANALOGS IN THE TREATMENT OF GLIOMAS - Disclosed are methods and compositions for treating gliomas that involve quinacrine and other acridine analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 03-10-2011 |
Nancy Grimaldi, Ellington, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20080256523 | Computerized Data Warehousing - A system and method for transforming data from a first format to a second format. A pre-existing set of software instructions may be used to transform the data from the first format to the second format. A user may document a set of format parameters for the first format of data, which can be used to determine which portion of the pre-existing software instructions are used to transform the data from the first format to the second format. | 10-16-2008 |