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Griffioen, NL
Arjan Griffioen, Maastricht NL
| Patent application number | Description | Published |
|---|---|---|
| 20100144836 | Methods for Detecting Epigenetic Modifications - A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, 11112, BNIP3, FOXE1, SYNE1, S0X17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases. The invention also relates to methods for identifying, diagnosing, staging or otherwise characterizing cancers, in particular gastrointestinal cancers such as colorectal cancers, gastric cancers and oesophageal cancers. The methods of the invention relate, inter alia, to isolating and analyzing the human DNA component from faecal samples and blood-based samples. | 06-10-2010 |
Arjan W. Griffioen, Maastricht NL
| Patent application number | Description | Published |
|---|---|---|
| 20080261880 | Synthetic approach to designed chemical structures - This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides. | 10-23-2008 |
Arjan Willem Griffioen, Maastricht NL
| Patent application number | Description | Published |
|---|---|---|
| 20090035312 | TUMOR ANGIOGENESIS ASSOCIATED GENES AND A METHOD FOR THEIR IDENTIFICATION - Methods of identifying specific target molecules for design of anti-angiogenic and vascular targeting approaches are disclosed. Transcriptional profiles of tumor endothelial cells were compared with that of normal resting endothelial cells, normal but angiogenically activated placental endothelial cells, and cultured endothelial cells. Although the majority of transcripts were classified as general angiogenesis markers, 17 genes were identified that show specific overexpression in tumor endothelium. Antibody targeting of four cell-surface expressed or secreted products (vimentin, CD59, HMGB1 and IGFBP7) inhibited angiogenesis in vitro and in vivo. Finally, targeting endothelial vimentin in a mouse tumor model significantly inhibited tumor growth and reduced microvessel density. The results demonstrate the utility of the identification and subsequent targeting of specific tumor endothelial markers for anticancer therapy. | 02-05-2009 |
Gerard Marie Griffioen, Lt Harmelen NL
| Patent application number | Description | Published |
|---|---|---|
| 20100261981 | INFORMATION SYSTEM FOR ANIMALS - There is disclosed an information system ( | 10-14-2010 |
Ingeborg Griffioen, Deventer NL
| Patent application number | Description | Published |
|---|---|---|
| 20110106142 | SUTURING INSTRUMENTS AND SUTURING SYSTEMS - A needle storage and disposal cartridge is loaded with a needle receptor, and or suture and needle. By insertion of a forceps arm into the cartridge the needle receptor can be affixed to an arm of the forceps, and similarly removed after use. The forceps may conveniently be used for gripping and retaining a needle during suturing. A number of alternative suturing forceps and needle receptors are disclosed. | 05-05-2011 |
Jacobus Willem Griffioen, Waalwijk NL
| Patent application number | Description | Published |
|---|---|---|
| 20080317957 | Radiation Curable Composition - A radiation curable composition comprising 15 to 85 wt % of at least one solvent comprising ≦20 wt % of water; 5 to 50 wt % of at least one radiation curable material having a Mn in the range of from 50 to 10,000 g/mol; and 10 to 70 wt % of at least one polyurethane having a Mw in the range of from 4,000 to 70,000 g/mol, the polyurethane having 0 to 5 wt % of isocyanate-reactive component(s) bearing ionic or potentially ionic water-dispersing groups and a free isocyanate group content ≦0.5 wt %. | 12-25-2008 |
Marieke Griffioen, Alphen A/d Rijn NL
| Patent application number | Description | Published |
|---|---|---|
| 20100120683 | Prame derived peptides and immunogenic compositions comprising these - The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer. | 05-13-2010 |
Piet Griffioen, Hengelo NL
| Patent application number | Description | Published |
|---|---|---|
| 20100013697 | METHOD OF AND DEVICE FOR TRACKING AN OBJECT - A method of tracking an object including the steps of: collecting N measurements of range R | 01-21-2010 |
Willem Griffioen, Ter Aar NL
| Patent application number | Description | Published |
|---|---|---|
| 20080199137 | Optical Fiber Cable and Method for Modifying the Same - Disclosed is an optical fiber cable that includes a main tube. A guide tube, which includes at least one optical element, is positioned within the main tube's central space. A compressible element is also positioned within the main tube's central space. To reduce the adverse effects of ice formation within the optical fiber cable, the compressible element more readily deforms than do the guide tube and main tube. Also disclosed is a method for modifying a conventional optical fiber cable with a compressible element according to the present invention. | 08-21-2008 |
| 20080317410 | Modified Pre-Ferrulized Communication Cable Assembly and Installation Method - Disclosed is a modified pre-ferrulized cable assembly that facilitates installation of an optical fiber communication cable through narrow cable guides having sharp bends. The pre-ferrulized cable assembly includes a communication cable having a free, front end, a semi-finished communication connector, and a suction plug. The invention further relates to efficient methods for installing the modified pre-ferrulized cable assembly through a cable guide. | 12-25-2008 |
| 20100067850 | AUTOMATED OPTICAL SWITCH AND METHOD - An automated optical switch for use in a central office to increase coupling density including a frame having a mating plate defining a plurality of precision alignment holes formed therethrough. In one embodiment, the precision alignment holes are sized and configured to receive corresponding pairs of optical fibers with polished end faces disposed within ferrules free of connector housings. In another embodiment, the precision alignment holes are sized and configured to receive optical fibers with polished end faces free of ferrules and connector housings. | 03-18-2010 |
| 20100111479 | Modified Pre-Ferrulized Communication Cable Assembly and Installation Method - Disclosed is a modified pre-ferrulized cable assembly that facilitates installation of an optical fiber communication cable through narrow cable guides having sharp bends. The pre-ferrulized cable assembly includes a communication cable having a free, front end, a semi-finished communication connector, and a suction plug. The invention further relates to efficient methods for installing the modified pre-ferrulized cable assembly through a cable guide. | 05-06-2010 |
| 20100158455 | Cable, And A Use And Method For Constructing A Cable Network - A cable, provided with at least one signal conductor ( | 06-24-2010 |
| 20100158456 | Cable, And A Network And The Use Of Such A Cable - A cable, comprising a cylindrical cable wall ( | 06-24-2010 |
| 20100178020 | Optical Waveguide Assembly, Storage Device, And Method For Installing An Optical Waveguide - An optical waveguide assembly is described that comprises a storage device having a housing ( | 07-15-2010 |