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Griesinger
Christian Griesinger, Gottingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110293520 | NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES - The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from —C(R | 12-01-2011 |
Christian Griesinger, Goettingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20110296539 | Mutant Alpha-Synuclein, and Methods Using Same - The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (A56), at the alanine at position 76 (A76), at the methionine at position 127 (M127) and/or at the valine at position 118 (V118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims. Also, a non-human animal comprising the cell of the invention is provided, as defined in the claims. Finally, the invention provides methods for identifying a substance that prevents or reduces toxicity of alpha-synuclein, as defined in the claims. | 12-01-2011 |
David H. Griesinger, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090028360 | Multichannel Downmixing Device - A downmixer provides a listener of an output signal with a substantially accurate rendition of the apparent direction and relative loudness of an input signal. Downmixing certain channels of the input signal independently may substantially preserve the energy and intended direction of the input signal. The downmixer may include a test downmixer that operates over a limited frequency range to more accurately reflect the loudness of the input signal at the output, as perceived by a listener. The downmixer may demand fewer resources, freeing up resources for use in other operations. | 01-29-2009 |
Eberhard Griesinger, Munsingen DE
| Patent application number | Description | Published |
|---|---|---|
| 20090072495 | Sealing system, in particular for attachment connections on flow paths for hot gases - A sealing system, in particular for attachment connections on flow paths for hot gases, such as exhaust gas flows from internal combustion engines, with a sealing support ( | 03-19-2009 |
Manfred Griesinger, Leonberg DE
| Patent application number | Description | Published |
|---|---|---|
| 20080239739 | Lighting Device For The Interior Of Motor Vehicles - In a lighting device with low intensity light-emitting light sources for incident lighting of areas in a motor vehicle interior, the light sources are distributed in a mount above a converging lens, and aligned via the converging lens onto at least one area to be illuminated in the interior. | 10-02-2008 |
Siegbert Griesinger, Oetisheim DE
| Patent application number | Description | Published |
|---|---|---|
| 20100146952 | METERING MODULE WITH IMPROVED ACOUSTIC PROPERTIES - The invention relates to a device for metering a liquid reducing agent into an exhaust gas system for the reduction of pollutants in the exhaust gas. The device comprises a metering valve and an adapter to be mounted on an exhaust gas pipe. The metering valve is connected to the adapter by a connector element, which has at least one metal sound absorber. | 06-17-2010 |
| 20100326547 | RETAINER DEVICE FOR A REDUCING AGENT METERING VALVE - The invention relates to a retainer device for retaining a reducing agent metering valve. The retainer device at least partially surrounds an interior space which is provided for holding the reducing agent metering valve. According to the invention, the retainer device has a sound dampening device which dampens sound vibrations emerging from the interior space. | 12-30-2010 |
William K. Griesinger, Ringoes, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090270354 | Method of removing ticks from the skin and reducing the risk of bites - Compositions and method of using the same for the removal of ticks embedded in the skin or tissue of a human or animal host and for preventing ticks from attaching themselves to and biting humans or other animals. | 10-29-2009 |