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| 20090246772 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES - The present invention concerns novel dibenzo[c,h][1,5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same. | 10-01-2009 |
| 20110003843 | NOVEL COMPOUNDS DERIVED FROM INDOLE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - The present invention relates to a compound derived from indole corresponding to the following formula II: | 01-06-2011 |
| 20110053975 | CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES - The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly. | 03-03-2011 |
| 20110201648 | POLY-HETEROARYL DERIVATIVES FOR THE TREATMENT OF CANCER - The present invention relates to Penta-hexa-, hepta-, octa-, nona- and, deca-heteroaryl derivatives, comprising a combination of heterocycle 1 (Het-1) | 08-18-2011 |
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| 20080242704 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors - The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Fit-3 inhibitors. | 10-02-2008 |
| 20100113471 | 2-Aminoaryloxazole compounds as tyrosine kinase inhibitors - The present invention relates to novel compounds selected from 2-aminoaryloxazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors. | 05-06-2010 |
| 20100329992 | SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3 EXPRESSING TUMORS - The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb | 12-30-2010 |
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| 20090048670 | METHOD AND APPARATUS FOR UNIVERSAL IMPROVEMENT OF VISION - “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea. | 02-19-2009 |
| 20090303441 | DIAGNOSIS AND TREATMENT OF DISORDERS OF THE EYE - Certain disorders of the cornea exhibit unique characteristics in a surface model of the cornea. Through various manipulations of the characteristics of the surface model of a patient's cornea, certain “markers” that are associated with disorders of the eye may be revealed. | 12-10-2009 |
| 20100114078 | METHOD AND APPARATUS FOR UNIVERSAL IMPROVEMENT OF VISION - “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea. | 05-06-2010 |
| 20110037942 | UNIVERSAL CONTACT LENS POSTERIOR SURFACE CONSTRUCTION - The carrier region extending beyond the optical portion of a contact lens overlying the cornea of an eye can be modeled in one universal shape that will fit all eyes. That shape is characterized by a curve of radius of curvature versus distance from the High point which is substantially linear with a first slope below a 10 mm diameter of the eye as projected onto a plane perpendicular to the optical axis, is substantially linear above 10 mm with a second slope which is substantially greater than the first slope, and which has an inflection point in the vicinity of approximately 10 mm. Preferably the first linear portion has a radius of curvature of approximately 7.6 mm at a diameter of about 7 mm, with a slope of about 0.13 (the first slope) and a radius of curvature of about 9 mm at a diameter of 12 mm, with a slope of about 0.45 (the second slope). | 02-17-2011 |
| 20110077734 | Method and Apparatus for Universal Improvement of Vision - “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea. | 03-31-2011 |
| 20110087200 | Method and Apparatus for Universal Improvement of Vision - “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea. | 04-14-2011 |
| 20110112805 | METHOD AND APPARATUS FOR IMPROVING VISION - Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis. | 05-12-2011 |
