| Patent application number | Description | Published |
|---|
| 20090176659 | TRANSCRIPTIONAL ENGINEERING OF LACTOBACILLUS - The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes and methods for evaluating phenotypic diversity. | 07-09-2009 |
| 20090258045 | STRUCTURES INCLUDING ANTIMICROBIAL PEPTIDES - A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a polyelectrolyte having a charge opposite the charge of the first layer. At least a portion of the structure is capable of degrading by sequential removal of the first layer and the second layer, and releasing the antimicrobial peptide from the structure. | 10-15-2009 |
| 20100076173 | SYSTEMS AND METHODS FOR GENERATING PEPTIDES - Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods may treat the amino acid sequences of these peptides as a formal language and build a set of right-linear grammars that describe this language. These grammars may allow for rationally designed novel antimicrobial peptides in silico. These peptides conform to the syntax of natural antimicrobial peptides lack significant homology to any natural sequences, thus populating a previously unexplored region of protein sequence space. Synthesis of these peptides, leads to de novo AmPs. | 03-25-2010 |
| 20100124759 | MICROFLUIDIC DROPLETS FOR METABOLIC ENGINEERING AND OTHER APPLICATIONS - The present invention relates generally to the use of droplets to culture and/or assay cells or other species. In some cases, the cells or other species may be sorted based upon the results of the culture and/or assay. In some embodiments, cells other species can be encapsulated in droplets and exposed to one or more agents (e.g., a sugar, an indicator dye, etc.). For instance, in some cases, exposure of cells to the agents may result in the production of metabolites or other compounds (e.g., amino acids, proteins, organic acids, etc.) which may be, for example, assayed or otherwise determined. In some embodiments, the reaction of an agent with cells and/or other species within a droplet may reveal a property of the cells or other species (e.g., sugar consumption, growth rate, ability to withstand exposure to the agent, etc.). As an example, cells that produce desired metabolites or exhibit certain properties may be separated from the other cells via sorting techniques. Other aspects of the invention relate to devices or kits for implementing such sorts, methods of promoting such techniques, or the like. | 05-20-2010 |
| 20100184693 | METHODS AND SYSTEMS FOR GENERATING AND EVALUATING PEPTIDES - A method has been developed to create databases of peptides having a desirable property, such as antimicrobial activity, based on analyzing a database of known peptides for a pattern statistically associated with an activity. One can determine a set of patterns that may be representative of a peptide having a desired characteristic or property, and evaluate a set of sequences against the set of patterns (grammars) to determine if the peptide sequence being evaluated has similar patterns to those of a peptide having the desired characteristic or property. The set of sequences being evaluated may include peptide sequences of a desired length comprising all or substantially all combinations of amino acids that conform to at least one of the set of patterns. Once the database is identified, the database may be processed in a pattern recognition procedure that identifies a set of patterns that could be understood as representative of a peptide having the characteristic of interest. A set of newly generated peptides sequences may then be processed to score these new sequences against the identified patterns to correlate the patterns to the sequences and determine a degree of association or a similarity between a respective one of the new sequences and the set of identified patterns. The method is used to provide a database of sequences that are expected to have one or more desired activities, specific sequences within the database proven to have the desired activity, and the patterns or grammars used to create the database of sequences. Although described with reference to antimicrobial peptides, a database of peptides may be identified that contains peptides that have antiviral properties, wound response properties, or some other property of interest. | 07-22-2010 |
| 20100291648 | Global transcription machinery engineering - The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. | 11-18-2010 |
| 20100330614 | GLOBAL TRANSCRIPTION MACHINERY ENGINEERING TARGETING THE RNAP ALPHA SUBUNIT (RPOA) - The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes. | 12-30-2010 |
| 20110111457 | METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDS - The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids. | 05-12-2011 |
| 20110151496 | METHODS FOR IDENTIFYING BACTERIAL STRAINS THAT PRODUCE L-TYROSINE - The invention relates to high-throughput screens for identifying bacterial strains capable of L-tyrosine production. | 06-23-2011 |
