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Green, MA
Alexander A. Green, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120025150 | Separation of single-walled carbon nanotubes by electronic type using block copolymers - The separation of single-walled carbon nanotubes (SWNTs), by electronic type using centrifugation of compositions of SWNTs and surface active block copolymers in density gradient media. | 02-02-2012 |
Allan M. Green, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080317834 | Compounds and methods for modulating cerebral amyloid angiopathy - The invention provides methods of inhibiting cerebral amyloid angiopathy. The invention further provides methods of treating a disease state characterized by cerebral amyloid angiopathy in a subject. | 12-25-2008 |
| 20090016956 | Labeled Macrophages and Methods of Use Thereof - Methods of making and using labeled macrophages are described. | 01-15-2009 |
| 20090252704 | THERAPIES FOR COGNITION AND LEARNING ENHANCEMENT - The invention relates to a combination comprising an amount of an NO donor, such as ISDN, and/or an amount of another pharmaceutical agent that enhances neurotransmission or which acts as neuroprotectants such as memantine, clomethiazole and tacrine. These compositions can be used in producing cognition and learning enhancement, whereby the invention also provides for a new method of treatment of Alzheimer's disease and related neurodegenerative disorders. | 10-08-2009 |
B. David Green, Methuen, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090313967 | POLYOXYMETHYLENE AS STRUCTURAL SUPPORT MEMBER AND PROPELLANT - A vehicle includes at least one polyoxymethylene structural support member. The polyoxymethylene structural support member includes a polyoxymethylene component that is a propellant that provides thrust to the vehicle upon pyrolysis or combustion of the polyoxymethylene component of the product of pyrolysis of the polyoxymethylene component. The vehicle can be a satellite or other type of spacecraft. | 12-24-2009 |
| 20090320974 | Polyoxymethylene as structural support member and propellant - A vehicle includes at least one polyoxymethylene structural support member. The polyoxymethylene structural support member includes a polyoxymethylene component that is a propellant that provides thrust to the vehicle upon pyrolysis or combustion of the polyoxymethylene component of the product of pyrolysis of the polyoxymethylene component. The vehicle can be a satellite or other type of spacecraft. | 12-31-2009 |
| 20100180443 | Method For Fabricating Structural Propellants - A vehicle includes at least one polyoxymethylene structural support member. The polyoxymethylene structural support member includes a polyoxymethylene component that is a propellant that provides thrust to the vehicle upon pyrolysis or combustion of the polyoxymethylene component of the product of pyrolysis of the polyoxymethylene component. The vehicle can be a satellite or other type of spacecraft. | 07-22-2010 |
Brian Green, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110151531 | ETHANOL PRODUCTION BY MICROORGANISMS - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 06-23-2011 |
| 20110281335 | ETHANOL PRODUCTION IN MICROORGANISMS - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 11-17-2011 |
Brian Green, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090203070 | HYPERPHOTOSYNTHETIC ORGANISMS - The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents. | 08-13-2009 |
| 20110124073 | Hyperphotosynthetic Organisms - The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents. | 05-26-2011 |
| 20120015427 | ETHANOL PRODUCTION IN MICROORGANISMS - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 01-19-2012 |
Brian C. Green, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080230450 | Filtration System for Preparation of Fluids for Medical Applications - Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container The latter forms a batch that may be used during treatment. Methods and systems for creating multiple-treatment batches are described. Advantages of creating a multitreatment batch include the fact that the burden of treatment preparation can be reduced and the timing of the preparation of the batch can be independent of the treatment time. As described, there are various trade-offs and concerns with this approach which are addressed by the inventive embodiments. | 09-25-2008 |
| 20090211975 | Batch Filtration System for Preparation of Sterile Fluid for Renal Replacement Therapy - A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration. | 08-27-2009 |
| 20100228177 | BATCH FILTRATION SYSTEM FOR PREPARATION OF STERILE FLUID FOR RENAL REPLACEMENT THERAPY - A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration. | 09-09-2010 |
| 20110186521 | FILTRATION SYSTEM FOR PREPARATION OF FLUIDS FOR MEDICAL APPLICATIONS - Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe. | 08-04-2011 |
| 20110240547 | TUBING SET FOR RENAL REPLACEMENT THERAPY - A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration. | 10-06-2011 |
Brian D. Green, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110008861 | Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest - The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof. | 01-13-2011 |
| 20110262975 | ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST - The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof. | 10-27-2011 |
Brian D. Green, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110020867 | Constructs And Methods For Efficient Transformation Of Micro-Organisms For Production Of Carbon-Based Products Of Interest - Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon-based products of interest are provided. | 01-27-2011 |
David S. Green, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100237265 | REMOTE CONTROL FLUID REGULATION SYSTEM - A fluid regulation system comprising a fluid source and a tube operatively connected to the source configured to deliver the fluid from the source to a site. A valve is configured to control a rate of fluid delivered from the source to the site via the tube, and a remote control unit is configured to enable a user to control the valve to adjust the rate of fluid delivered from the source to the site. | 09-23-2010 |
Donald Green, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100024527 | SYSTEMS AND METHODS FOR HIGH-THROUGHPUT SCREENING OF FLUIDIC SAMPLES - Aspects of the invention provide systems and methods for high-throughput screening of fluidic samples. In some embodiments, two chromatography columns are utilized in series. The first chromatography column can have a high affinity for phosphorylated compounds while the second chromatography column has a high affinity for one or more analytes of interest. | 02-04-2010 |
Donald Green, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110290731 | CARTRIDGE CHANGERS AND METHODS FOR UTILIZING THE SAME - Aspects of the invention provide cartridge changers and methods utilizing the same. One aspect of the invention provides a cartridge changer for a plurality of cartridges. The cartridge changer includes a cartridge holder having a plurality of receptacles each adapted to receive one of the plurality of cartridges and a pair of fittings adapted to releasably engage one of the plurality of cartridges. | 12-01-2011 |
Forrest Green, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100185837 | Reconfigurable Logic Automata - A family of reconfigurable asynchronous logic elements that interact with their nearest neighbors permits reconfigurable implementation of circuits that are asynchronous at the bit level, rather than at the level of functional blocks. These elements pass information by means of tokens. Each cell is self-timed, and cells that are configured as interconnect perform at propagation delay speeds, so no hardware non-local connections are needed. A reconfigurable asynchronous logic element comprises a set of edges for communication with at least one neighboring cell, each edge having an input for receiving tokens from neighboring cells and an output for transferring tokens to at least one neighboring cell, circuitry configured to perform a logic operation utilizing received tokens as inputs and to produce an output token reflecting the result of the logic operation, and circuitry. A reconfigurable lattice of asynchronous logic automata comprises a plurality of reconfigurable logic automata that compute by locally passing state tokens and are reconfigured by the directed shifting of programming instructions through neighboring logic elements. | 07-22-2010 |
Gregory A. Green, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100030618 | System and method for visualizing a marketing strategy - A system and method for visualizing a marketing strategy and its effects on a marketplace are disclosed. Using the system or method, an organization can visualize its marketing strategy in a way that links the original creative intent of the marketing strategy with the marketing strategy's effects upon a marketplace. The method and system enable the organization to evaluate the effectiveness of not only its marketing strategy, but of the creative process that led to the marketing strategy's development. The method and system employ representations of creative aspects of the marketing strategy and representations of effects of the marketing strategy on the marketplace, and present, via a graphical user interface, a user-interactive, creative-aspects-based structure, along with the representations of the effects of the marketing strategy, in a manner enabling interaction with the representations of the creative aspects and the effects on the marketplace. | 02-04-2010 |
Jordan J. Green, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100196492 | ELECTROSTATIC COATING OF PARTICLES FOR DRUG DELIVERY - A system for electrostatically coating particles is provided. The system is particularly well suited for coating charged drug delivery particles (e.g., nanoparticles, microparticles) with a coating of opposite charge. The coating may include a targeting moiety such as a small molecule ligand, peptide, protein, aptamer, etc. The coated particles are biodegradable and/or biocompatible, have a near neutral zeta (ξ) potential, and are stable in serum. The invention also provides pharmaceutical compositions and kits including the inventive coated particles. Methods of preparing and using the inventive particles are also included. | 08-05-2010 |
Kurt Green, Wrentham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100089528 | Urology Catheter - A urology catheter is provided that includes an elongated body extending from a proximal end to a distal end. The body defines at least one lumen. A tip has a proximal end that is disposed in abutting relation with the distal end of the body such that the body is fixed with the tip. The tip defines a lateral opening that is defined by a wall including an external radius disposed in transition with an outer surface of the tip and an internal radius disposed in transition with an inner surface of the tip. The external radius has a non-perpendicular profile with the outer surface of the tip. An expandable member has a proximal portion disposed about the body and a distal portion disposed about the tip. A method of manufacturing the urology catheter is provided. | 04-15-2010 |
Kurt E. Green, Wrentham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090247949 | Single-Use Syringe Assembly - A single-use syringe assembly is disclosed which includes a syringe body defining a fluid reservoir and including an engagement surface, a plunger assembly including a plunger rod and a sealing member supported on a distal end of the plunger rod, and a releasable member having a proximal end releasably positioned within a sealing member throughbore and a distal end configured to engage the engagement surface of the syringe body when the sealing member is moved to the advanced position. The proximal end of the releasable member being configured to seal the sealing member throughbore. The releasable member is configured such that a force required to remove the distal end of the releasable member from engagement with the engagement surface of the syringe body is greater than the force required to disengage the proximal end of the releasable member from the sealing member throughbore. As such, upon movement of the sealing member from the advanced position to the retracted position, the proximal end of the releasable member is disengaged from the sealing member throughbore to unseal the throughbore. | 10-01-2009 |
| 20090326483 | Valve Assembly Including a Dissolvable Valve Member - A valve assembly is provided which includes a housing having an inlet end and an outlet end and defining a fluid channel and a central chamber. A dissolvable valve member is positioned to obstruct flow through the channel within the chamber. The dissolvable valve member is formed of a material which is dissolvable at a predetermined rate upon contact with a preselected fluid. The preselected fluid is selected from the group consisting of blood, urine, saline and antimicrobial solutions. The dissolvable valve member can be formed from a fluid soluble glass or a starch based material. | 12-31-2009 |
| 20100331780 | Catheterization System - The present disclosure relates to catheterization systems and components thereof. In one embodiment of the present disclosure, a catheterization system is disclosed that includes a catheter including a body with proximal and distal ends and defining first and second lumens extending therethrough, and a stylet. The stylet includes first and second stylet portions each having proximal and distal end regions, wherein the distal end regions of the first and second stylet portions together define a tapered penetrating portion. The first and second stylet portions are configured and dimensioned to be slidably positioned within the first and second lumens of the catheter, respectively. The first and second stylet portions extend from the proximal end of the catheter and beyond the distal end of the catheter, and are independently movable in relation to each other to facilitate selective removal of the first stylet portion and/or the second stylet portion from the catheter. | 12-30-2010 |
Martin C. Green, Boxborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090208751 | Mesoporous carbon black and processes for making same - The invention is directed to processes for increasing the surface area of a carbon black starting material and for forming mesoporous carbon black. The process includes the step of contacting a carbon black starting material having a first BET nitrogen surface area with an oxidant in a fluidized bed under conditions effective to form a carbon black product having a second BET nitrogen surface area greater than the first BET nitrogen surface area. The invention is also directed to carbon black product formed by this process. | 08-20-2009 |
| 20110021664 | Elastomer Composite and Method for Producing It - A method of producing an elastomer composite. The method includes A) combining a first fluid comprising elastomer latex with a second fluid comprising particulate filler; B) causing the elastomer latex to coagulate, thereby forming masterbatch crumb; C) bringing the masterbatch crumb to a water content of about 1 weight percent to about 20 weight percent, thereby forming a dewatered coagulum; D) removing water from the dewatered coagulum by subjecting the dewatered coagulum to mechanical energy, thereby causing the dewatered coagulum to heat as a result of friction, while allowing the dewatered coagulum to achieve a temperature of about 130° C. to about 190° C., wherein water content is reduced to about 0.5% to about 3% and wherein substantially all of the decrease in water content is accomplished by evaporation, thereby producing a masticated masterbatch; and E) subjecting the masticated masterbatch to at least an additional 0.3 MJ/kg of mechanical energy while further reducing the water content. | 01-27-2011 |
| 20110313094 | Carbon Blacks Having Low PAH Amounts And Methods Of Making Same - Carbon blacks, such as rubber blacks, having a low PAH concentration are described. Furthermore, elastomeric or rubber compositions containing the carbon black of the present invention are further described, as well as methods of making carbon black having a low PAH concentration. | 12-22-2011 |
Matthew Green, Amherst, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100132203 | Hacksaw with Blade Tensioning Mechanism - A hacksaw with an improved mechanism for applying and adjusting the tension on a blade mounted to a blade mount on a front arm and a blade mount on a rocker arm. The rocker arm is pivotally coupled to a handle and is spring biased to place an initial tension on a blade held by the rocker arm and the front arm. A rotatably mounted lever is positioned on the handle for vertically displacing a nut captured in the rocker arm to pivot the rocker arm and adjust the tension on the rocker arm-held blade. An elongate top frame bar of the hacksaw defines a hollow I-beam cross-section accessible from the face of the front handle and is capable of storing saw blades. A bale screw is positioned in the front member for securing the blades in a position extending past the front handle. | 06-03-2010 |
Matthew C. Green, Amherst, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090064507 | FOUR POINT UTILITY BLADE AND METHOD - A utility blade for use with conventional retractable and fixed blade utility knives comprising a blade body having a generally trapezoidal configuration defined by a cutting edge, an opposite back edge, a pair of opposing side edges and a pair of cutting points defined by the points of intersection between the side edges and the cutting edge. The blade further defines a pair of score lines, each proximate to one of the side edges. The score lines enable the user to remove a dulled or damaged cutting point, which in turn provides the user with two additional cutting points defined by the points of intersection between the score lines and the cutting edge. Further, the blade is configured with one or more notches strategically located on the back edge of the blade, such that each cutting point can extend from the utility knife at approximately the same distance. | 03-12-2009 |
Matthew Christopher Green, Amherst, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110170966 | Hole Cutter with Axially-Elongated Aperture Defining Multiple Fulcrums - A hole cutter has a cylindrical blade body including a cutting edge and one or more axially-elongated apertures formed within a side wall of the blade body. The axially-elongated aperture is configured to receive a lever, such as a screwdriver, therethrough. Each axially-elongated aperture includes a first fulcrum axially spaced adjacent to the cutting edge, a second fulcrum axially spaced further away from the cutting edge than the first fulcrum, and optionally a third fulcrum axially spaced between the first and second fulcrums. A lever, such as a screwdriver, can be inserted into the aperture and placed against each of the fulcrums to lever slugs out of the interior of the blade body. | 07-14-2011 |
| 20110170967 | Hole Cutter with Chip Egress Aperture - A hole cutter has a substantially cylindrical blade body defining a blade body circumference, a cutting edge formed on one end of the blade body, and an axially-elongated slot formed through the substantially cylindrical blade body. The axially-elongated slot is configured to receive chips flowing from the cutting edge within the interior of the blade body and (i) into the slot, and/or (ii) through the slot, to prevent the collection of such chips within the interior of the blade body and/or at an interface between the blade body and work piece. The axially-elongated slot defines a first end adjacent to the cutting edge, a second end axially spaced further from the cutting edge, and a slot area. The hole cutter further defines a total slot area to blade body circumference ratio within the range of about 0.1 to about 0.3 depending on the size of the hole cutter. | 07-14-2011 |
| 20110170969 | Hole Cutter with Axially-Elongated Aperture Defining Multiple Fulcrums - A hole cutter has a cylindrical blade body including a cutting edge and one or more axially-elongated apertures formed within a side wall of the blade body. The axially-elongated aperture is configured to receive a lever, such as a screwdriver, therethrough. Each axially-elongated aperture includes a first fulcrum axially spaced adjacent to the cutting edge, a second fulcrum axially spaced further away from the cutting edge than the first fulcrum, and a third fulcrum axially spaced between the first and second fulcrums. A lever, such as a screwdriver, can be inserted into the aperture and placed against each of the fulcrums to lever slugs out of the interior of the blade body. | 07-14-2011 |
| 20110170971 | Hole Cutter With Chip Egress Aperture - A hole cutter has a substantially cylindrical blade body defining a blade body circumference, a cutting edge formed on one end of the blade body, and an axially-elongated slot formed through the substantially cylindrical blade body. The axially-elongated slot is configured to receive chips flowing from the cutting edge within the interior of the blade body and (i) into the slot, and/or (ii) through the slot, to prevent the collection of such chips within the interior of the blade body and/or at an interface between the blade body and work piece. The axially-elongated slot defines a first end adjacent to the cutting edge, a second end axially spaced further from the cutting edge, and a slot area. The hole cutter further defines a total slot area to blade body circumference ratio within the range of about 0.1 to about 0.3 depending on the size of the hole cutter. | 07-14-2011 |
Maureen Lyden Green, Melrose, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090222119 | MULTIMEDIA SYSTEM FOR DIALYSIS MACHINE - This patent application relates generally to dialysis machines. | 09-03-2009 |
Merlin R. Green, Salem, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110148484 | PHASE-LOCKED LOOP FREQUENCY SYNTHESIZER - Described is a frequency synthesizer having a wide output frequency range and small frequency tuning steps. In-band spurious components are maintained at low levels and phase noise is significantly reduced. The frequency synthesizer can be fabricated as an integrated circuit device having a small area and low power dissipation. The frequency synthesizer can be used in wideband frequency systems to reduce cost and size by replacing multiple frequency synthesizers each devoted to a portion of the overall system frequency range. | 06-23-2011 |
Michael R. Green, Boylston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080249010 | Method Of Inducing Apoptosis In Lymphoid Cells - A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal. | 10-09-2008 |
| 20100137411 | RAS-MEDIATED EPIGENETIC SILENCING EFFECTORS AND USES THEREOF - The invention relates to methods for inhibiting gene silencing, methods for inhibiting cell proliferation, methods for inhibiting Ras mediated tumor growth, methods for screening for regulators of FAS expression, and methods for identifying inhibitors of Ras mediated tumor growth. | 06-03-2010 |
Michael R. Green, Needham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090067398 | Implementing Location Awareness In WLAN Devices - A set of global location signals, an SBAS (Satellite Based Augmentation System), or an ACI (ambient country identifier) signal can be used to automatically provide location awareness for a WLAN device. If one of the set of global location signals, the SBAS signal, or the ACI signal is detected, then the WLAN device can configure itself to comply with channel and power settings for the country/region having the detected signal(s). After configuration, the WLAN device can be “locked” to the country/region having the signal(s), thereby ensuring legal operation of the WLAN device even after subsequent restarts. If one of the signals is not detected, then the WLAN device can be configured in a default mode, e.g. an “open mode” in which end users can configure the WLAN device by entering a country of operation or a “common mode” in which the channel and transmit power settings meet global spectrum usage requirements. | 03-12-2009 |
Oluyinka Green, Waltham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100179150 | ANTIBACTERIAL PIPERDINE DERIVATIVES - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-15-2010 |
Paul Green, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110158553 | PORTABLE DEVICE HAVING VIBRATION REDUCTION FUNCTION AND VIBRATION REDUCTION METHODE THEREOF - A portable device includes a central processing unit, a vibration sensor to sense vibration of the portable device, an image processing unit to process image data, and a memory unit storing a vibration reduction module. The vibration reduction module includes a vibration signal collecting sub-module to collect a vibration signal of the portable device, a filter sub-module to filter noise of the vibration signal, a vibration offset calculating sub-module to calculate a vibration offset of the portable device according to the filtered vibration signal, a vibration compensation calculating sub-module to calculate a compensation value corresponding to the vibration offset of the portable device, and an image controlling sub-module to control images of the portable device to move a distance which is equal to the compensation value via the image processing unit, to make the images of the portable device keep a fixed position. | 06-30-2011 |
Robert L. Green, Haverhill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100315629 | Optical Scanning - Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine infotmation about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector. | 12-16-2010 |
Stephen A. Green, Franklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110010929 | SYSTEMS FOR PRODUCING ASSEMBLIES - This invention relates to methods and systems for attaching components to strips of material to form assemblies, e.g., a system for fastening pre-sharpened razor blades to individual support strips on a continuous band of material, such as a metal, to form discrete blade assemblies. | 01-20-2011 |
Stephen J. Green, Wakefield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090327250 | METHOD AND APPARATUS FOR SEARCHING AND RESOURCE DISCOVERY IN A DISTRIBUTED ENTERPRISE SYSTEM - A method for searching and resource discovery in a distributed enterprise (DE), the method including: generating a first classifier for a first repository in the DE; generating a second classifier for a second repository in the DE, where the second classifier has a vector element identifying a location of the second repository; submitting a copy of the second classifier to a web server of the first repository; obtaining a resource at the first repository after submitting the copy of the second classifier; matching the resource to the copy of a second classifier; sending a copy of the resource to the second repository using the vector element; and storing the copy of the resource in the second repository. | 12-31-2009 |
Stephen J. Green, Burlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090024564 | METHOD AND SYSTEM FOR ACCESSING A FILE SYSTEM - A method for accessing a file system that includes creating a document index for an active document, identifying a similarity score for each of a plurality of stored documents to generate a list of similar documents, wherein the similarity score is computed by comparing the document index for the active document with a search index for the plurality of stored documents, and displaying the list of similar documents in a file system interface. | 01-22-2009 |
| 20100161619 | Method and Apparatus for Generating Recommendations From Descriptive Information - Meaningful words or phrases may be extracted from the information and used as tags. Weights may be determined for the tags, and tag clouds may be generated for the items. The tag clouds may be stored to a data store. Information specifying a tag cloud may be received. Recommended items for which the tag clouds most closely match the specified tag cloud may be identified. Standard vector space distance calculations, for example the cosine distance between the tag clouds, may be used to determine cloud similarity. The results may be filtered to optimize relevance, novelty and familiarity in accordance with preferences of the user. The recommended items may be displayed to a user interface. Users may interact with the user interface to steer the recommendations towards more relevant content. | 06-24-2010 |
| 20100161620 | Method and Apparatus for User-Steerable Recommendations - Method and apparatus for transparent, steerable recommendations. A steerable recommender uses tag clouds including descriptive tags and associated weights to generate recommendations. Users may dynamically interact with the recommender via a user interface to steer the recommendations. A tag cloud for an item is displayed, items for which associated tag clouds are most similar to the displayed tag cloud are identified, and the items are displayed as recommendations. The strength of similarity of the items to the displayed tag cloud may be displayed. The user may modify a tag cloud, for example by changing the weight of a tag or by adding or removing a tag, and the recommendations may be automatically updated to reflect the modification. A recommended item may be selected to display the tag cloud corresponding to the item. A user may select a user interface element to request information on why a particular item was recommended. | 06-24-2010 |
| 20110113042 | METHOD AND SYSTEM FOR ACCESSING A FILE SYSTEM - A method for accessing a file system including computing a first numerical similarity score for a first stored document and a second numerical similarity score for a second stored document by comparing a plurality of weighted active terms with a plurality of weighted indexed terms, determining a document order of the first stored document followed by the second stored document based on the first numerical similarity score exceeding the second numerical similarity score, generating a list of similar documents including the first stored document followed by the second stored document based on the document order, and displaying, in a file system interface and on the computer display, the list of similar documents while an active document is open in an active document interface. | 05-12-2011 |
Stephen Joseph Green, Burlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090157645 | RELATING SIMILAR TERMS FOR INFORMATION RETRIEVAL - A resource analyzer selects a resource (e.g., document) from a grouping of resources. The grouping of resources can be any type of social tagging system used for information retrieval. The selected resource has an assigned uncontrolled tag and an assigned controlled tag. The controlled tag is a term derived from a controlled vocabulary of terms. Having selected the resource for analyzing, the resource analyzer identifies a first set of resources in the grouping of resources having also been assigned a same value as the uncontrolled tag as the selected resource. Similarly, the resource analyzer identifies a second set of resources in the grouping of resources having also been assigned a same value as the controlled tag. With this information, the resource analyzer then produces a comparison result indicative of a similarity between the first set of resources and the second set of resources. | 06-18-2009 |
Zachary I. Green, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110048962 | COMPOSITIONS, ELECTRODES, METHODS, AND SYSTEMS FOR WATER ELECTROLYSIS AND OTHER ELECTROCHEMICAL TECHNIQUES - Compositions, electrodes, systems, and/or methods for water electrolysis and other electrochemical techniques are provided. In some cases, the compositions, electrodes, systems, and/or methods are for electrolysis which can be used for energy storage, particularly in the area of energy conversion, and/or production of oxygen, hydrogen, and/or oxygen and/or hydrogen containing species. In some embodiments, the water for electrolysis comprises at least one impurity and/or at least one additive which has little or no substantially affect on the performance of the electrode. | 03-03-2011 |