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Graziani
Davide Graziani, Milan IT
| Patent application number | Description | Published |
|---|---|---|
| 20090042841 | NOVEL HETEROCYCLIC DERIVATIVES AS M-GLU5 ANTAGONISTS - This invention relates to novel heterocyclic compounds having selective affinity for the mGlu5 subtype of metabotropic receptors, pharmaceutical compositions thereof and uses for such compounds and compositions in the treatment of lower urinary tract disorders, such as neuromuscular dysfunction of the lower urinary tract, and in the treatment of migraine and gastroesophagael reflux disease (GERD). | 02-12-2009 |
| 20100317630 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS - The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed. | 12-16-2010 |
Dominic Graziani, Emeryville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110068793 | SOLVATED HYPERPOLARIZED XeNMR AND MRI SIGNAL AMPLIFICATION BY GAS EXTRACTION - The present invention provides a method and apparatus of amplifying the signal of at least one NMR spectrum and of at least one MRI of hyperpolarized xenon. In an embodiment, the invention includes dissolving the hyperpolarized xenon in a liquid via an input membrane, thereby resulting in xenon in liquid phase, encoding information in the longitudinal magnetization of the nuclear spins of the xenon in liquid phase via an encoding coil surrounding an encoding phantom coupled to an output of the input membrane and via an encoding magnet, thereby resulting in encoded xenon, extracting the encoded xenon into the gas phase from the liquid phase via an extraction membrane coupled to an output of the encoding phantom, thereby resulting in encoded xenon in the gas phase, and decoding the encoded information from the encoded xenon in gas phase via a detection coil coupled to an output of the extraction membrane. | 03-24-2011 |
Edmund I. Graziani, Ridgewood, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100022593 | Process for Producing Anticancer Agent LL-D45042 - The disclosure describes the production of anticancer agent LL-D45042, having the structure: | 01-28-2010 |
Edmund Idris Graziani, Chestnut Ridge, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090088448 | Rapamycin Derivatives and the Uses Thereof in the Treatment of Neurological Disorders - Provided is a method of treating neurodegenerative disorders comprising administering to a subject in need thereof a compound of formula I: | 04-02-2009 |
| 20090105294 | Biosynthetic Gene Cluster for the Production of a Complex Polyketide - A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel | 04-23-2009 |
| 20090203682 | Rapamycin Analogues and the Uses Thereof in the Treatment of Neurological Disorders - Method of treatment of neurological disorders or complications due to stroke or head injury through the administration of a pharmaceutical composition including a pharmaceutically acceptable excipient or carrier and a compound of formula I are provided: | 08-13-2009 |
| 20090239855 | Rapamycin Analogues and the Uses Thereof in the Treatment of Neurological, Proliferative, and Inflammatory Disorders - The present invention provides for methods of treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders using compounds of the following structure: | 09-24-2009 |
| 20100196355 | Immunophilin Ligands and Methods for Modulating Immunophilin and Calcium Channel Activity - Immunophilin ligands and their uses as modulators of calcium channel activity are disclosed. Screening, therapeutic and prophylactic methods for conditions associated with calcium channel dysfunction, e.g., neurodegenerative and cardiovascular disorders, are also disclosed. | 08-05-2010 |
| 20110144176 | MACROLIDES AND METHODS FOR PRODUCING SAME - This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them. | 06-16-2011 |
Franco Graziani, Firenze IT
| Patent application number | Description | Published |
|---|---|---|
| 20080276737 | Crank Gear for a Reciprocating Compressor - Crank gear ( | 11-13-2008 |
Giordano Graziani, Corridonia IT
| Patent application number | Description | Published |
|---|---|---|
| 20110167679 | SHOE WITH VENTILATION SYSTEM OBTAINED BY DIRECT INJECTION METHOD ON UPPER AND MOULD THEREFOR | 07-14-2011 |
Giorgio Graziani, Milano IT
| Patent application number | Description | Published |
|---|---|---|
| 20080312575 | Haemofilters for Blood Detoxification - The present invention regards the use of hemofilters for the removal of bacterial toxins (lipopolysaccharides) from the blood, said hemofilters comprising a solid support to which cyclodextrins are covalently bonded. The solid support can be a fabric or non-woven fabric or a polymeric resin obtained by means of cross-linking of the cyclodextrins with appropriate cross-linking agents, for example epichlorohydrin. | 12-18-2008 |
Giulio Graziani, Ottawa CA
| Patent application number | Description | Published |
|---|---|---|
| 20090119742 | Methods for authenticating and authorizing a mobile device using tunneled extensible authentication protocol - Methods for authenticating and authorizing a mobile device using tunneled extensible authentication protocol are provided. The methods include evaluating an inner user identifier against a policy engine to determine a home AAA server to route an access request for inner user authentication. Instead of having a static route configured based on an outer identifier/roaming identity, the policy engine can have multiple rules and actions for routing the request. The evaluation can be based on the conditions of the inner user identifier and or other AAA attributes received in the request. The request is transmitted within a secure communication tunnel. There are several embodiments of evaluating an inner user identifier against a policy engine. | 05-07-2009 |
| 20090249452 | Systems and Methods for Flexible Service Delivery Network Services - A system and method are described that use a subscriber-centric approach to scalably support the delivery of network services across numerous access protocols and across a multitude of access devices. By allowing the use of a service engine that can range in complexity from a simple macro to a rules engine, this approach is suitable for bundled services, as well as single services. | 10-01-2009 |
Paul Leonard Graziani, Wayne, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090021516 | METHOD FOR VISUALIZING DATA CLOUDS USING COLOR AND OPACITY BLENDING - In order to address the challenge associated with the analysis and visualization of large datasets, a method and apparatus provides for visualizing data clouds using color and opacity blending. The information stored within the data cloud is represented using a data container object. The colors and opacities associated with the container object's data point or points is blended to develop two-dimensional computer generated imagery that is unique to the virtual reference point chosen, typically within an OpenGL environment. The result is the ability to understand the sample density of large interactively rendered datasets from different reference points and as the datasets change over time. | 01-22-2009 |
Salvatore Graziani, Nicolosi IT
| Patent application number | Description | Published |
|---|---|---|
| 20100148164 | ALL-ORGANIC SENSOR/ACTUATOR SYSTEM - A sensor and/or actuator system in which functional circuitry is embedded in an all organic electromechanical transducer device is disclosed. The electromechanical transducer device exploits the behavior of a flexible sensible ionomeric material sheet as effective sensing or actuating member sandwiched between flexible organic electrodes when undergoing a deformation or being polarized at a certain drive voltage applied to the, electrodes, respectively. The completely embedded all organic system is realized with a process exploiting relatively low cost deposition and patterning techniques. The enhanced flexibility makes the all organic device suitable for new applications in fields ranging from biomedical to aerospace industry. | 06-17-2010 |
Valerio Graziani, Roma IT
| Patent application number | Description | Published |
|---|---|---|
| 20100218002 | SECURING COMPUTER LOG FILES - A log file is secured. One implementation involves maintaining a log file including one or more log entries in a storage device connected to a computer, and entering a new log entry by generating a new message authentication code based on a preceding log entry including a preceding message authentication code, and applying the message authentication code to the new log entry. | 08-26-2010 |
| 20110131188 | METHOD AND SYSTEM FOR REAL TIME SYSTEM LOG INTEGRITY PROTECTION - A method and system for managing integrity of system log file data. The system comprises a first component which, using a hook in a kernel of an operating system, allows interception of a write operation by a file system on at least one log file; then the first component detects a change in the security context in which the record is written in the log file. At each change detected, the first component adds information in the log file including the context information. The system further comprises a second component which reads the log file and, using the information added by the first component, detects if the change of context is due to a malicious writing operation in the log file for instance done by an unauthorized user or process. | 06-02-2011 |