Patent application number | Description | Published |
20090202512 | PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS - The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO: | 08-13-2009 |
20090304673 | Method of Treatment of Inflammatory Diseases - The present invention relates to a method of treatment of an inflammatory disease, in particular sepsis, in particular sepsis caused by gram-positive bacteria, wherein the method comprises the step of administering to a subject in need thereof a sufficient amount of bacterial cell wall degrading enzymes. The present invention relates further to pharmaceutical compositions comprising bacterial cell wall degrading enzymes. | 12-10-2009 |
20100216711 | Protease-Stable, Cell Wall-Lysing Enzymes - The present invention relates to a modified polypeptide with a biological activity to lyse cell walls of bacteria, wherein the polypeptide has no caspase, clostripain, enterokinase, factor Xa, granzyme B, | 08-26-2010 |
20110306068 | Method For Detecting And Removing Endotoxin - The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca | 12-15-2011 |
20120164126 | PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYOCOCCUS INFECTIONS - The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci. | 06-28-2012 |
20130183689 | METHOD FOR DETECTING AND REMOVING ENDOTOXIN - The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca | 07-18-2013 |
20140065104 | PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS - The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci. | 03-06-2014 |
20140377775 | METHOD FOR DETECTING AND REMOVING ENDOTOXIN - The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca | 12-25-2014 |
Patent application number | Description | Published |
20110243916 | MODIFIED ENDOLYSIN PLY511 - The present invention relates to polypeptides with a changed amino acid sequence on at least one amino acid position compared to the amino acid sequence according to SEQ ID NO: 1. The present invention further relates to the nucleotide sequences encoding the polypeptide, vectors, comprising the nucleotide sequences and host cells for expression of the polypeptide. The present invention further relates to the use of the polypeptides as a human, veterinary medical or diagnostic substance, in food, in cosmetics, as disinfectant or in the environmental field. | 10-06-2011 |
20120171188 | Artificial Peptidoglycan Lysing Enzymes and Peptidoglycan Binding Proteins - The present invention relates to recombinant polypeptides having the activity of binding and lysing of bacteria, comprising at least one enzymatically active domain and at least two bacterial cell binding domains. The present invention further relates to recombinant polypeptide having the activity of binding bacteria, comprising at least two bacterial cell binding domain. Further the present inventions relates to nucleic acid molecules comprising a nucleotide sequence encoding the recombinant polypeptides, vectors and host cells. | 07-05-2012 |
20120244595 | ARTIFICIAL PEPTIDOGLYCAN LYSING ENZYMES AND PEPTIDOGLYCAN BINDING PROTEINS - The present invention relates to recombinant polypeptides having the activity of binding and lysing of bacteria, comprising at least one enzymatically active domain and at least two bacterial cell binding domains. The present invention further relates to recombinant polypeptide having the activity of binding bacteria, comprising at least two bacterial cell binding domain. Further the present inventions relates to nucleic acid molecules comprising a nucleotide sequence encoding the recombinant polypeptides, vectors and host cells. | 09-27-2012 |
20130004476 | Chimeric Polypeptides and Their Use in Bacterial Decolonization - The present invention relates to chimeric polypeptides comprising a first portion, which comprises a bacteriocin cell wall-binding domain (CBD) and a second portion, which comprises an enzymatic active domain (EAD) selected from the lytic domain of a bacteriophage lysin, a bacteriocin and a bacterial autolysin. Provided are such chimeric polypeptides and variants and fragments thereof, nucleic acids encoding the same, vectors carrying such nucleic acids and host cells transformed or transfected with such vectors. The chimeric polypeptides of the present invention are useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, chimeric polypeptides of the present invention have been shown to effectively kill various bacteria, including methicillin-resistant | 01-03-2013 |
20130295070 | PROTEASE STABLE CELL WALL LYSING ENZYMES - The present invention relates to a modified polypeptide with a biological activity to lyse cell walls of bacteria, wherein the polypeptide has no caspase, clostripain, enterokinase, factor Xa, granzyme B, | 11-07-2013 |
20140302495 | NOVEL LISTERIA BACTERIOPHAGE TAILSPIKE PROTEIN AND USES THEREOF - The present invention relates to a novel tail spike protein (TSP) encoded by the novel | 10-09-2014 |
20150037284 | NOVEL LISTERIA BACTERIOPHAGE P825 AND USES THEREOF - The present invention relates to a novel | 02-05-2015 |
20150238577 | Chimeric Polypeptides and Their Use in Bacterial Decolonization - The present invention relates to chimeric polypeptides comprising a first portion, which comprises a bacteriocin cell wall-binding domain (CBD) and a second portion, which comprises an enzymatic active domain (EAD) selected from the lytic domain of a bacteriophage lysin, a bacteriocin and a bacterial autolysin. Provided are such chimeric polypeptides and variants and fragments thereof, nucleic acids encoding the same, vectors carrying such nucleic acids and host cells transformed or transfected with such vectors. The chimeric polypeptides of the present invention are useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, chimeric polypeptides of the present invention have been shown to effectively kill various bacteria, including methicillin-resistant | 08-27-2015 |