| Patent application number | Description | Published |
| 20100021920 | MUTATED ABL KINASE DOMAINS - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 01-28-2010 |
| Patent application number | Description | Published |
| 20090117641 | Mutated Abl Kinase Domains - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 05-07-2009 |
| 20100021920 | MUTATED ABL KINASE DOMAINS - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 01-28-2010 |
| 20100021921 | MUTATED ABL KINASE DOMAINS - The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides. | 01-28-2010 |
| Patent application number | Description | Published |
| 20100224206 | Portable Apparatus for the Steam Treatment of Hair - A portable apparatus for the steam treatment of hair, comprising a housing including a liquid tank, and a means for supplying a steam generator with liquid having a vaporisation chamber in thermal contact with an electric heating member, the vaporisation chamber communicating with one or more openings for dispensing steam towards a lock of hair. The generator is supplied with liquid by an electric pump, and the flow rate of the steam thus generated is higher than 5 g/min, and preferably of between 10 g/min and 60 g/min. | 09-09-2010 |
| 20100242986 | Apparatus for the Steam Treatment of Hair - An apparatus for the steam treatment of hair, comprising a housing including a liquid tank, a means for supplying a steam generator with liquid, one or more openings for dispensing the steam thus generated towards a lock of hair, and a hair shaping device that comprises at least one treatment surface provided with heating means and brought into contact with a lock of hair. The steam generator includes a heating member that is thermally independent from said treatment surface. | 09-30-2010 |
| 20100288298 | Portable Apparatus for the Steam Treatment of Hair - A portable apparatus for the steam treatment of hair, comprising a housing including a liquid tank, a means for supplying a steam generator with liquid, one or more openings for dispensing the steam thus generated towards a lock of hair, and a hair shaping device that comprises at least one treatment surface brought into contact with said lock of hair. The generator is supplied with liquid by an electric pump. | 11-18-2010 |
| Patent application number | Description | Published |
| 20100224206 | Portable Apparatus for the Steam Treatment of Hair - A portable apparatus for the steam treatment of hair, comprising a housing including a liquid tank, and a means for supplying a steam generator with liquid having a vaporisation chamber in thermal contact with an electric heating member, the vaporisation chamber communicating with one or more openings for dispensing steam towards a lock of hair. The generator is supplied with liquid by an electric pump, and the flow rate of the steam thus generated is higher than 5 g/min, and preferably of between 10 g/min and 60 g/min. | 09-09-2010 |
| 20100242986 | Apparatus for the Steam Treatment of Hair - An apparatus for the steam treatment of hair, comprising a housing including a liquid tank, a means for supplying a steam generator with liquid, one or more openings for dispensing the steam thus generated towards a lock of hair, and a hair shaping device that comprises at least one treatment surface provided with heating means and brought into contact with a lock of hair. The steam generator includes a heating member that is thermally independent from said treatment surface. | 09-30-2010 |
| 20100288298 | Portable Apparatus for the Steam Treatment of Hair - A portable apparatus for the steam treatment of hair, comprising a housing including a liquid tank, a means for supplying a steam generator with liquid, one or more openings for dispensing the steam thus generated towards a lock of hair, and a hair shaping device that comprises at least one treatment surface brought into contact with said lock of hair. The generator is supplied with liquid by an electric pump. | 11-18-2010 |