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Graham, MD

Barney S. Graham, Rockville, MD US

Patent application numberDescriptionPublished
20100247621CODON MODIFIED IMMUNOGENIC COMPOSITIONS AND METHODS OF USE - The present invention features immunogenic compositions comprising codon modified genes that encode viral proteins and/or glycoproteins or fragments. The immunogenic compositions of the invention are useful in various methods of treatment, such as preventing or treating viral infection. Also provided in the present invention are kits and instructions for use.09-30-2010
20110091496METHODS AND COMPOSITIONS FOR THE DELIVERY OF VACCINES TO DISRUPTED EPITHELIUM - The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The methods are useful in preventing or treating a subject having a disease or an infection. In particular examples, the methods are useful for preventing or treating a viral infection.04-21-2011

Patent applications by Barney S. Graham, Rockville, MD US

Barry Michael Graham, Silver Spring, MD US

Patent application numberDescriptionPublished
20080291022AUTOMATIC LOCATING SYSTEM - In accordance with the present invention, radio frequency identification (RFID) and short message service center (SMS), or follow-on technology, e.g., Mobile Multimedia Services (MMS) technology is implemented to support an identification and messaging system. A social services server tracks a user's location with a RFID or GPS or similar system and also acquires locations for user-selected contacts which are made available to the system. When a system user is near a user-selected contact or individual within a selected group that the user wants to meet, a message or other alert, such as an SMS message, is automatically sent to the user's cellular telephone or other communications device, telling the user that the selected contact is nearby.11-27-2008
20080294337TRAVEL-RELATED INFORMATION PROCESSING SYSTEM - A method and implementing computer system are provided in which users are enabled to provide spontaneous routing and driving condition information to a data base which is made available to other drivers on a real-time basis. Users are also enabled to define new routes between travel points and upload new route information for access by other users of the system. In an exemplary embodiment, wireless communication techniques are implemented to transfer data from a GPS device in an automobile to a data base on a central server to provide other users of the system who have access to the data base with the current status of dynamic driving conditions.11-27-2008
20080316053Dynamic Vehicle Grid Infrastructure to Allow Vehicles to Sense and Respond to Traffic Conditions - A dynamic ‘vehicle grid’ system provides the ability for drivers to be automatically warned to the conditions of other vehicles in the vicinity. In this grid system, a motor vehicle would be equipped with a transmitter, receiver, computer and a selection of sensors. Other adjacent vehicles are also contain the same of equipment for transmitting and receiving signals. When the sensors in a vehicle detect a change such as hard braking (rapid deceleration) or very slow speed (blockages), it automatically sends this information via the transmitter over a wireless communication channel to any other receivers in the vicinity.12-25-2008

Christopher J. Graham, Bethesda, MD US

Patent application numberDescriptionPublished
20100070124Unmanned Vehicle Route Management System - According to one embodiment, a route management system for an unmanned vehicle includes a network node in communication with an unmanned vehicle control system and an unmanned vehicle. The network node is operable to transmit a number of initial waypoints to the unmanned vehicle, transmit one or more in-flight waypoints to the unmanned vehicle after the unmanned vehicle has arrived at a corresponding one or more of the initial waypoints, and replace the one or more of the initial waypoints with the one or more in-flight waypoints in the unmanned vehicle such that the total quantity waypoints stored in the unmanned vehicle does not exceed a specified quantity.03-18-2010
20110245996Vehicle Control Station with Back-Up VSM for Remotely Controlling an Unmanned Vehicle, and Method - According to one embodiment, a control station having a station processing system, a control system, a data link computing unit, a second data link and a back-up VSM (a second vehicle computing unit) is operable to communicate via an RF link with an unmanned vehicle having a first data link, a vehicle processing system, a first vehicle computing unit and a route control system. The control station being operable to communicate with the unmanned vehicle using a first protocol for messaging under normal operating conditions as well as through the use of a second protocol for messaging, initiated via the second vehicle computing unit, when either the vehicle processing system is inoperable, the vehicle computing unit is inoperable or when the second vehicle computing unit in the control station is directed to use the second protocol for messaging.10-06-2011

David Raymond Graham, Baltimore, MD US

Patent application numberDescriptionPublished
20100047812PEPTIDE ANTIBODY DEPLETION AND ITS APPLICATION TO MASS SPECTROMETRY SAMPLE PREPARATION - The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other methods: analytic (diagnostic) methods using antibodies against highly ionizable peptides from a protein target of interest; and compositions kits and devices comprising antibodies of the invention.02-25-2010
20110143379DETECTION AND QUANTITATION OF FULL-LENGTH THIOREDOXIN (TRX) AND TRUNCATED THIOREDOXIN (TRX 80) IN COMPLEX SAMPLES - The present invention relates, e.g., to a method for detecting a full-length protein and a truncated form (e.g., a naturally occurring cleavage product) thereof, in a sample, comprising 06-16-2011

Eliza Graham, Monkton, MD US

Patent application numberDescriptionPublished
20120103015Reconfigurable Jewelry and System and Method Thereof - Reconfigurable jewelry, including rings, necklaces, pendants, bracelets, earrings, cufflinks, tie clips, berets, belt buckles, body piercing jewelry other than earrings, and watches. The jewelry includes an enclosed globe portion that contains a liquid. The jewelry may be reconfigurable in the sense that different globe portions may be interchanged. The jewelry also may include a receptacle for receiving an insert element. The jewelry is therefore also reconfigurable in the sense that different insert elements may be used.05-03-2012

John S. Graham, Bel Air, MD US

Patent application numberDescriptionPublished
20090286263SKIN TAPE STRIPPING: A NON-INVASIVE DIAGNOSTIC STRATEGY FOR DERMAL EXPOSURE TO CYTOTOXIC COMPOUNDS - A non-invasive method for determining a subject's dermal exposure to an agent employing an immunohistochemical procedure on a skin strip applied to an exposed area on the subject's person and detecting agent adduct thereon.11-19-2009

Nicholas Simon Graham, Potomac, MD US

Patent application numberDescriptionPublished
20080276400Quick release paint roller - A quick-release paint roller having a roller cover that can be removed from a handle assembly without requiring the user to apply a force directly to the roller cover. The paint roller includes a tube-shaped roller cover having an outer surface of paint absorbing material and a rotatably mounted roller core. When the actuator is in the release position, the roller mounting device is free of the latching mechanism, thus permitting the roller core and roller cover to be removed from the handle assembly.11-13-2008
20090166975SEALING ASSEMBLY FOR USE WITH A PRESSURIZED VESSEL AND METHODS OF ASSEMBLING THE SAME - A method for assembling a seal assembly is provided. The method includes coupling a first ring within a vessel, coupling a second ring within the vessel, and coupling a first seal layer between the first ring and the second ring such that the first seal layer contacts at least the first ring.07-02-2009

Stephanie M. Graham, Crofton, MD US

Patent application numberDescriptionPublished
20100177959COLOR FORM DROPOUT USING DYNAMIC GEOMETRIC SOLID THRESHOLDING - Dropping out of color form backgrounds from images of completed forms to obtain color form dropout images retaining only the respondent information. In one embodiment, a color form image processing method (07-15-2010

Thomas J. Graham, Baltimore, MD US

Patent application numberDescriptionPublished
20100082068Intramedullary Tubular Bone Fixation - An intramedullary bone fixation device suitable for treatment of fractures of the tubular bones of the hand or feet. The implantable device can be used singly or introduced through both the radial and ulnar aspects. The device includes a stem having a tip portion at one end and a base member at the opposite end of the stem. The stem and tip portions are configured with a unique configuration and cross section to facilitate insertion into and through the canal and provide the necessary forces on the stem portion within the canal. The base is sized and configured to minimize tissue damage while as the same time providing a strong point of fixation.04-01-2010

Thomas J. Graham, Cockeysville, MD US

Patent application numberDescriptionPublished
20090204224Method And Apparatus For Wrist Arthroplasty - A wrist prosthesis system to replace at least a portion of a bone of a wrist of a patient. The system includes a carpal implant to replace at least a portion of a carpal bone of a carpal complex of the patient. The carpal implant includes a base and an augment that replaces at least a portion of the carpal bone. The augment is removably coupled to the base.08-13-2009
20100030339METHOD AND APPARATUS FOR ADJUSTING HEIGHT AND ANGLE FOR A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a radius. The prosthesis system includes a head component having a first connection portion that connects to a second connection portion and a collar component having the second connection portion and a third connection portion. The system also includes a stem component including a fourth connection portion that connects with the third connection portion, the stem component having a stem anchoring portion that connects to the radius. The collar component provides the modular geometry to the prosthesis without having to have an increased number of head components and stem components with variable lengths and angles.02-04-2010
20100087928Elbow Prosthesis - An elbow prosthesis constructed in accordance to one example of the present teachings can include a capitellar implant having an articulating head and a stem. The articulating head can have a first articulating surface positioned generally between a lateral side and a medial side. A passage can extend through the articulating head from the lateral side to the medial side. The articulating head can define a counterbore formed at the lateral side and that is concentric with the passage. According to other features, the elbow prosthesis can include a coronoid implant that has a body and a stem. The body can have a superior articulating surface that includes a central ridge and an anterior buttress. The central ridge can be configured to accommodate articulation with a trochlea in an implanted position.04-08-2010
20100179661ELBOW PROSTHESIS - A method and apparatus for replacing a selected portion of the anatomy is described. In particular, a prosthesis can be provided to replace a portion of an articulating joint, such as an elbow. The apparatus can be modular for various reasons and each of the modular portions can include a different dimension to achieve a selected result. For example, the prosthesis can achieve a different size condylar replacement, a selected offset, a selected articulation, or combinations thereof.07-15-2010
20100262252MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided.10-14-2010
20110125276MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided.05-26-2011
20110144759MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided.06-16-2011

Patent applications by Thomas J. Graham, Cockeysville, MD US