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Graham, MA
Alan Karl Graham, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090106004 | Systems and methods for evaluating interventions - A system and method for evaluating one or more interventions having a direct or indirect impact on a disease identification or a disease progression incorporating a causal framework to establish relationships among the disease, complications, and comorbidities. The system and method determines population groups and risk factors for the disease, complications, and comorbidities. The system and method structures and calibrates a simulation model of the relationships, population groups, and risk factors and characterizes interventions. The system and method analyzes the characterized interventions to determine the direct or indirect impact of the interventions on the disease identification or progression using the simulation model. An indication of the impact of the interventions is provided on an electronic display or to a memory device. | 04-23-2009 |
B. Eric Graham, Hamilton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090183514 | Refrigerated Container for Super Frozen Temperatures - A refrigerated container and method capable of maintaining super frozen temperatures of about −50 degrees C. or less, includes container walls insulated to a value of at least about r-20, a cargo compartment configured for receiving cargo, and at least one refrigerant compartment configured for receiving refrigerant in the form of CO | 07-23-2009 |
David C. Graham, Oakham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120034847 | ABRASIVE TOOL AND A METHOD FOR FINISHING COMPLEX SHAPES IN WORKPIECES - An abrasive tool includes a bonded abrasive body having abrasive grains contained within a bonding material, wherein the bonded abrasive body comprises a complex shape having a form depth (FD) of at least about 0.3. The form depth is described by the equation [(Rl−Rs)/Rl], wherein Rs is a smallest radius (Rs) at a point along the longitudinal axis of the bonded abrasive body and Rl is a largest radius (Rl) at a point along the longitudinal axis of the bonded abrasive body. The abrasive tool can be used to finish complex shapes in workpieces. | 02-09-2012 |
Jacob Graham, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110077621 | LOCKING MECHANISM FOR A MEDICAL DEVICE - A locking mechanism for a medical device to selective lock a first elongate member from longitudinal movement relative to a second elongate member of the medical device. The locking mechanism includes a flexible tubular member disposed in a bore of a handle assembly of the medical device, and an actuator, such as a cam member having a cam or eccentric surface. Pivotable movement of the actuator from a first position to a second position compresses or deforms the flexible tubular member against the first elongate member to lock the first elongate member from longitudinal movement relative to the handle assembly. | 03-31-2011 |
James Graham, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090092613 | Novel TNF receptor death domain ligand proteins and inhibitors of ligand binding - Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed. | 04-09-2009 |
| 20090175874 | NOVEL INTERLEUKIN-1 RECEPTOR INTRACELLULAR LIGAND PROTEINS AND INHIBITORS OF LIGAND BINDING - Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed. | 07-09-2009 |
James J. Graham, Westhampton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100229712 | Muzzle attachment system - A muzzle attachment system for a firearm includes a muzzle attachment having a first engagement means, and a muzzle distal portion including a second engagement means, the second engagement means being complementary with the first engagement means. The first and second engagement means cooperate to releasably secure the muzzle attachment to the muzzle distal portion. The first and second engagement means preferably include complementary coarse threaded engagement portions, an annular grooved surface having a plurality of grooves, a grooved surface engagement mechanism, and first and second position stops that abut to form a gas seal. The muzzle distal portion is preferably a flash suppressor, including at least two elongated ports substantially equally skewed from normal relative to a firing axis of the firearm, and substantially evenly distributed around the circumference of the flash suppressor. | 09-16-2010 |
James R. Graham, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090136507 | HBM variants that modulate bone mass and lipid levels - The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis. | 05-28-2009 |
| 20100331200 | POST TRANSLATIONAL MODIFICATION PATTERN ANALYSIS - This invention relates to methods and apparatus for detecting the pattern of post translational modification in a protein or in a plurality of proteins in a sample. One or more target proteins are subjected to predetermined proteolysis to yield plural peptide fragments comprising potential post translational modification sites. The fragments and the state of such sites are analyzed to yield a post translational pattern for the protein or proteins. | 12-30-2010 |
| 20110201513 | PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF - The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured. | 08-18-2011 |
Joseph Graham, Canton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100082016 | Ball-Valve Actuation Mechanism - A valve assembly for use with a catheter assembly is provided. The valve assembly includes a valve housing adapted for fluid engagement with a catheter assembly, the valve housing defining a longitudinal axis and having an internal passageway for flow of fluids relative to the catheter assembly, a valve member at least partially disposed within the valve housing and defining a valve passage, the valve member adapted for movement within the valve housing between an open position wherein the valve passage is in general alignment with the internal passageway of the valve housing to permit flow of fluids through the valve housing, and a closed position to substantially occlude the internal passageway of the valve housing, and an actuation mechanism mounted to the valve housing and operatively connected to the valve member, the actuation mechanism selectively movable in a general longitudinal direction to cause corresponding movement of the valve member between the open position and the closed position. | 04-01-2010 |
Joseph A. Graham, Canton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110009795 | HYBRID COMPRESSION GARMET - A hybrid compression garment comprises a sleeve adapted for placement on a limb of a person for applying static compression to the limb. A connecting device on the sleeve enables releasable connection of the sleeve to a machine. The machine is independent of the sleeve and operable to transmit, through the connecting device, a force to the sleeve that constricts the sleeve without inflating the sleeve to apply active compression to the limb. The connecting device is adapted for connection of the sleeve to the machine such that the sleeve can be used to apply active compression to the limb and adapted for disconnection of the sleeve from the machine such that the sleeve can be used to apply static compression to the limb. A method of applying compression to a limb of a person is also disclosed. | 01-13-2011 |
Kendon Stuart Graham, Millis, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110195513 | Methods And Kits For The Determination Of The Presence And Quantity of Vitamin D Analogs In Samples - Embodiments of the present invention are directed to methods and kits for determining the presence or absence, and the amount if present, of vitamin D analogs in samples. One embodiment of the present method for detecting the presence or absence of vitamin D analogs in a sample comprises the steps of adding an effective amount of a multiple charge cationic agent to the sample to form a cationic treated sample. The effective amount of a multiple charge cationic agent enhances the signal from vitamin D analogs upon analysis by mass spectroscopy. | 08-11-2011 |
Kenneth W. Graham, Plainville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100171508 | In-Circuit Test Assembly - A test assembly that may provide access to signals of a circuit that includes an integrated circuit. The test assembly may include structural members that limit movement of components relative to each other. | 07-08-2010 |
Marc Graham, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090259237 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
| 20090259238 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
| 20090259239 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
| 20090259240 | PYLORIC VALVE - A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient. | 10-15-2009 |
| 20110004228 | Systems and Methods for Treating Obesity and Type 2 Diabetes - The present invention provides systems and methods for treating and/or controlling obesity and type II diabetes. In one aspect of the invention, a device for treating obesity includes a flow restrictor and an anchor coupled to the flow restrictor. The flow restrictor is movable between a first or collapsed configuration sized and shaped for endoscopic advancement through the patient's esophagus and into a distal region of the stomach and a second or operative configuration sized and shaped for inhibiting a flow of chyme from the stomach to the pyloric sphincter. It is believed that this will cause the prolongation of satiety, and result in fewer meals being eaten and/or smaller meals being ingested. The anchor is movable between a first or collapsed configuration sized and shaped for advancement through the esophagus, stomach and pyloric sphincter and into the proximal region of the duodenum and a second or operative configuration sized and shaped to inhibit proximal movement of the anchor through the pyloric sphincter. | 01-06-2011 |
Ohilip B. Graham, Carlisle, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100280050 | Piperidinylamino-Thieno[2,3-D] Pyrimidine Compounds for Treating Fibrosis - The invention provides a method of treating or preventing fibrosis in a subject by administering a 5-HT modulator, e.g., a 5-HT | 11-04-2010 |
Paul Graham, Taunton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090285358 | Battery - A non-invasive multi-step process that includes tomography is applied to determine features of a battery. | 11-19-2009 |
Philip B. Graham, Carlisle, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110257214 | MORPHINAN COMPOUNDS - This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity. | 10-20-2011 |
| 20120029007 | MORPHINAN COMPOUNDS - This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ | 02-02-2012 |
Simon Graham, Maynard, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090037765 | SYSTEMS AND METHODS FOR MAINTAINING LOCK STEP OPERATION - A system is provided for rapidly synchronizing two or more processing elements in a fault-tolerant computing system. Embodiments of this system allow for the rapid synchronization of two processing elements through partial copies of the contents of memory associate with each processing element. | 02-05-2009 |
| 20090138752 | Systems and methods of high availability cluster environment failover protection - A transparent high-availability solution utilizing virtualization technology is presented. A cluster environment and management thereof is implemented through an automated installation and setup procedure resulting in a cluster acting as a single system. The cluster is setup in an isolated virtual machine on each of a number of physical nodes of the system. Customer applications are run within separate application virtual machines on one physical node at a time and are run independently and unaware of their configuration as part of a high-availability cluster. Upon detection of a failure, traffic is rerouted through a redundant node and the application virtual machines are migrated from the failing node to another node using live migration techniques. | 05-28-2009 |
Tim Graham, Newton Center, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100009363 | RBP4 In Insulin sensitivity/resistance, diabetes, and obesity - Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity. | 01-14-2010 |