Gotlib
Elena Gotlib, Kazan RU
Patent application number | Description | Published |
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20130264737 | METHOD OF MANUFACTURING A TRACK MEMBRANE - Method of manufacturing track membranes by penetration of working substances into and through the membrane matrix of polymer material is disclosed. The matrix is placed into holder that is inserted into one end of a tubular shell, the other end of which contains a cartridge with an explosive material and a working substance in the form of a supersaturated solution of a water-soluble salt. When the explosive material is detonated, the particles of the water-soluble salt interact with the matrix in the form of a high-speed jet with the velocity of particles in the range of 3800 to 4200 m/sec. As a result of penetrating of the particles into and through the material of the matrix, a plurality of holes is formed in the matrix. The track membranes are produced by slicing the membrane matrix after removal of the residue of the particles by washing the pierced membrane with water. | 10-10-2013 |
Jason Gotlib, Stanford, CA US
Patent application number | Description | Published |
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20100287631 | WNT PATHWAY MUTATIONS IN CANCER STEM CELLS - Cancer specific splicing events in the Wnt/β-catenin signaling pathway are associated with progression of myelogenous leukemia. Misspliced genes of interest include GSK3β. In some embodiments of the invention, polynucleotides are provided that correspond to misspliced GSK3β transcripts associated with cancer. Such transcripts are characterized by a deletion of exon (8), and particularly in exon (8) and (9). Detection of such transcripts in cells is indicative of the presence of leukemia, and particularly of the presence of leukemia stem cells. In other embodiments, polypeptides are provided that are encoded by misspliced GSK3β transcripts associated with cancer. Such polypeptides are useful as diagnostic markers for cancer, and as a target for screening of therapeutic agents. Animal models comprising a human LSC having a misspliced GSK3b transcript provide a useful model for leukemia, for drug/gene screening in the prevention and treatment of leukemia in humans, etc. | 11-11-2010 |
Mihail Vladilenovich Gotlib, Moscow RU
Patent application number | Description | Published |
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20130017075 | Electrical Submersible Pump - An electrical submersible pump can include a housing with a head and a base; a shaft arranged for rotation within the housing; an impeller stack that includes ceramic impellers mounted along the shaft; a diffuser stack that includes diffusers disposed within the housing; and a spring sleeve that includes axially spaced and overlapping tangential slots, the spring sleeve mounted along the shaft to apply a compressive force between the shaft and the impeller stack. Various other devices, systems, methods, etc., are also disclosed. | 01-17-2013 |