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| 20080245953 | MULTI-AXIS INTEGRATION SYSTEM AND METHOD - An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence. | 10-09-2008 |
| 20090026386 | SYSTEM AND METHOD EMPLOYING PHOTOKINETIC TECHNIQUES IN CELL BIOLOGY IMAGING APPLICATIONS - A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components. | 01-29-2009 |
| 20090028413 | SYSTEM AND METHOD EMPLOYING PHOTOKINETIC TECHNIQUES IN CELL BIOLOGY IMAGING APPLICATIONS - A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components. | 01-29-2009 |
| 20090097110 | POLARIZED PHASE MICROSCOPY - A system and method of generating and acquiring phase contrast microscope images while minimizing interference with the intensity and optical quality of other microscopy modalities employing polarization and attenuation strategies for phase microscopy applications. A plane polarizing objective phase ring may be used in conjunction with a phase microscopy apparatus. Attenuated light may be controlled such that transparency may be selectively provided with respect to light in a predetermined plane. Illumination outside of the predetermined plane may be selected for phase microscopy applications. Accordingly, a polarizing objective phase ring effective for enabling polarized phase microscopy may reduce interfere with normal usage of the microscope for other applications such as, for example, fluorescence microscopy. | 04-16-2009 |
| 20090109416 | DISPERSING IMMERSION LIQUID FOR HIGH RESOLUTION IMAGING AND LITHOGRAPHY - Methods and apparatus are described for delivering index-matching immersion liquid in high numerical-aperture optical microscopy and lithography. An array of immersion liquid droplets is delivered to a specimen substrate or specimen substrate cover by an immersion liquid printing apparatus. An immersion liquid reservoir provides immersion liquid to the printer by a precision pump. The printer delivers immersion liquid to the substrate or substrate cover in arrays of immersion liquid droplets of defined volumes and array patterns. The volumes and patterns of array droplets delivered to the substrate or substrate cover are optimized to maintain adequate immersion liquid between the substrate or substrate cover and an immersion objective while avoiding the formation of air bubbles in the immersion liquid and the accumulation of excess volumes of immersion liquid. | 04-30-2009 |
| 20110149097 | SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING - Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images. | 06-23-2011 |
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| 20090081700 | Methods of use of the TACI/TACI-L interaction - The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed. | 03-26-2009 |
| 20090118186 | Use of TRAIL Polypeptides to Treat Cancer - A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well. | 05-07-2009 |
| 20090264349 | CD30 Ligand - There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplastic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor. | 10-22-2009 |
| 20090270592 | Purified TNFR preparations - Purified protein preparations comprising tumor necrosis factor are disclosed. | 10-29-2009 |
| 20100196404 | METHODS OF USE OF THE TACI/TACI-L INTERACTION - The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to inhibit graft vs. host rejections is further disclosed. | 08-05-2010 |
| 20100323399 | Use of Trail Polypeptides to Treat Cancer - A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well. | 12-23-2010 |
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| 20120108368 | BALL BAT INCLUDING A BARREL PORTION HAVING SEPARATE PROXIMAL AND DISTAL MEMBERS - A ball bat extending about a longitudinal axis. The bat includes a handle and a barrel portion. The barrel portion has an outer surface and includes a proximal member and a distal member. The proximal member has first and second end regions and the distal member has third and fourth end regions. The first end region is coupled to the handle portion, the second end region of the proximal member is coupled to the third end region of the distal member, and the fourth end region of the distal member is coupled to an end cap. At least a portion of each of the proximal and distal members defines the outer surface of the barrel portion. One of the second and third end regions overlaps the other of the second and third end regions. | 05-03-2012 |
| 20120108369 | BALL BAT INCLUDING A BARREL PORTION HAVING SEPARATE PROXIMAL AND DISTAL MEMBERS - A ball bat extending about a longitudinal axis. The bat includes a handle and a barrel portion having an outer surface and including a proximal member and a distal member. The proximal member has first and second end regions and the distal member has third and fourth end regions. The first end region is coupled to the handle portion, the second end region of the proximal member is coupled to the third end region of the distal member, and the fourth end region of the distal member is coupled to an end cap. The proximal and distal members are formed of first and second materials, respectively. The second material is a fiber composite material, the second fiber composite material of the distal member is co-molded to the outer surface of the second end region of the proximal member. | 05-03-2012 |
| 20120108371 | BALL BAT INCLUDING A BARREL PORTION HAVING SEPARATE PROXIMAL AND DISTAL MEMBERS - A ball bat extending about a longitudinal axis. A bat includes a tubular bat frame. The bat frame includes first and second frame pieces. The first frame piece has a gripping portion integrally formed to a transition portion, and the transition portion has a distal end region. The second frame piece has a proximal end region. The distal end region of the first piece is coupled to the proximal end region of the second piece. One of the distal and proximal end regions overlaps the other of the distal and proximal end regions. The bat has a center of percussion, and the mid-length of the overlap of the distal and proximal end regions is positioned within plus or minus three inches of the center of percussion of the bat. | 05-03-2012 |
