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Goodwin, NC
Bryan James Goodwin, Morrisville, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090288181 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation - The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. | 11-19-2009 |
| 20090307785 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation - The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. | 12-10-2009 |
Bryan James Goodwin, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080227864 | Lhr1 Activators as Medicaments - Methods or prevention or treatment of diseases or conditions caused by low plasma apoA-1 levels, the use of LRH1 activators in such methods and methods for identification of compounds useful in such treatment. | 09-18-2008 |
Bryan James Goodwin, Carrborro, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100146652 | XENOBIOTIC RELATED INDUCTION OF GENE EXPRESSION - An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals. | 06-10-2010 |
Christopher J. Goodwin, Greenville, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090222167 | MULTI-DIRECTION VEHICLE CONTROL SENSING - A vehicle includes a first control configured to operate the vehicle from a first operator position facing a front of the vehicle and a second control configured to operate the vehicle from a second operator position facing a rear of the vehicle. The vehicle further includes a processor configured to monitor for an operator presence in the first operator position or the second operator position and receive a vehicle operating request, wherein the operator presence is monitored independent of receiving the vehicle operating request. The processor is further configured to enable either the first control or the second control and select a vehicle operating parameter associated with the vehicle operating request, wherein the vehicle operating parameter varies according to which control is enabled. | 09-03-2009 |
Edward C. Goodwin, Edenton, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100280755 | METHOD, APPARATUS, AND SYSTEM FOR RAPID ASSESSMENT - Systems and devices for assessment of an impact by an event on an environment are disclosed. Processes for automated impact assessment are also disclosed. An impact assessment can be performed in computer-generated environments which include data regarding the environment impacted and data regarding the event impacting the environment. Environment data may be represented as a geospatial layer. | 11-04-2010 |
Frank Goodwin, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090101522 | High Temperature Electrochemical Characterization of Molten Metal Corrosion - A system and method for the high temperature in-situ determination of corrosion characteristics of a molten metal on an alloy under study is provided which takes place within an insulated furnace. A graphite crucible provided in the furnace contains an electrolyte formed from a molten salt of a metal halide. A reference electrode formed from the same metal as the electrolyte is immersed in the electrolyte solution in the graphite crucible. A beta-alumina crucible containing a molten metal is also provided within the furnace and preferably within the graphite crucible. A measuring electrode formed from the alloy under study is immersed in the molten metal. Standard electrochemical techniques are used to measure and analyze the electrochemical effects of corrosion of the molten metal on the alloy. | 04-23-2009 |
Jodi Maglich Goodwin, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100105749 | CHEMICAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS - The present invention provides compounds of the formulae (I) and (II), and derivatives thereof, for the treatment of cardiovascular conditions | 04-29-2010 |
Linda Goodwin, Concord, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110022420 | SYSTEMS AND METHODS FOR INSURANCE UNDERWRITING - The systems and methods described herein may automate insurance underwriting by integrating information from multiple online databases and creating decision making advice useful to insurance underwriters. One system includes a client, database, and server. The client allows an underwriter to enter applicant information, enter customized risk modifiers, and receive an underwriting decision. The database provides additional applicant information. This information can include one or more of prescription drug history, credit history, motor vehicle records, and geocentric mortality risk. The server obtains the applicant information, calculates the applicant's risk, and makes an underwriting decision. Another system calculates a prescription drug risk for an applicant from pharmacy benefits management data, drug risk category data, and application data. Another system calculates a geocentric mortality risk for an applicant from census data, mortality data, credit information, and application data. Preset external modifiers are added to systems and methods of calculating risk in order to allow the underwriter to customize the risk results. | 01-27-2011 |
Michael Goodwin, Raleigh, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090313587 | METHOD AND APPARATUS FOR PROVIDING MOTION ACTIVATED UPDATING OF WEATHER INFORMATION - An approach provides updating of weather information on a mobile device. Motion of a mobile device is detected, wherein the mobile device is configured to execute a weather application for presenting weather information to a user. Update of the weather information is retrieved in response to the detected motion. | 12-17-2009 |
Scott Goodwin, Hillsborough, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100183302 | OPTICAL SWITCH - An optical device for switching an optical signal between a first optical path and a second optical path, including a substrate, a first guide forming at least a portion of the first optical path, formed on the substrate, and having a movable portion separated from the substrate, a second guide forming at least a portion of the second optical path and disposed adjacent to the first guide, and means for electro statically bending the movable portion so as to optically couple the first guide to the second guide. | 07-22-2010 |
Scott H. Goodwin, Hillsborough, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100236644 | Methods of Operating Microvalve Assemblies and Related Structures and Related Devices - A valve assembly may include a main housing and first and second electro-statically actuated valves. The main housing may define at least three chambers, with a first chamber configured to be coupled to a high pressure supply port, a second chamber configured to be coupled to an output port, and a third chamber configured to be coupled to a low pressure exhaust port. The first electro-statically actuated valve may be provided between the first and second chambers, and the first electro-statically actuated valve may allow or substantially block fluid communication between the first chamber and the second chamber responsive to a first electrical signal. The second electro-statically actuated valve may be provided between the second and third chambers, and the second electro-statically actuated valve may allow or substantially block fluid communication between the second chamber and the third chamber responsive to a second electrical signal. Related methods are also discussed. | 09-23-2010 |
Steven J. Goodwin, Fuquay Varina, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110132837 | Method and System for Treating Wastewater - Methods and systems for utilizing biological wastewater treatment processes to remove nutrients from wastewater containing reduced sulfide compounds may include treating the wastewater in an anaerobic zone, an anoxic zone, and an aerobic zone. The wastewater is first treated in the anaerobic zone to uptake residual biodegradable organic material using specialized bacteria known as phosphorus accumulating organisms (“PAOs”) and glycogen accumulating organisms (“GAOs”). After treatment in the anaerobic zone, the wastewater is treated in an anoxic zone to convert nitrates to nitrogen gas and sulfur to sulfates. Following treatment in the anoxic zone, the wastewater is treated in the aerobic zone to oxidize ammonia to nitrate and to complete removal of phosphorus. After treatment in the aerobic zone, the wastewater may be treated in other zones, or may be delivered to a liquid-solids treatment stage. | 06-09-2011 |