Patent application number | Description | Published |
20110070163 | CANCER CELL MIGRATION AND CANCER CELL INVASION INHIBITOR - Provided are an antibody which binds specifically PAR1 (protease activated receptor 1) or a fragment of the antibody which retains similar characteristics thereto; a composition containing the same for inhibiting the migration activity and invasion activity of cancer cells; and a medicinal composition for treating cancer and the like. | 03-24-2011 |
20120107831 | METHOD FOR DETECTING AFFERENT LYMPH VESSEL INFLOW REGIONS AND METHOD FOR IDENTIFYING SPECIFIC CELLS - Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby identifying the location of the sentinel lymph node by means of fluorescence. Subsequently, the sentinel lymph node is extracted. With respect to the sentinel lymph node extracted with quantum dots injected, structural analysis is conducted by means of precision fluorescence measurement which uses a confocal fluorescence microscope for monomolecular observation. Specifically, the fluorescence intensity is measured with respect to each of multiple areas in the sentinel lymph nodes, and out of the multiple areas measured, one or more areas are detected as afferent lymph vessel inflow regions in descending order of fluorescence intensity. | 05-03-2012 |
20130203082 | METHOD FOR DETERMINING CANCER ONSET OR CANCER ONSET RISK - A highly accurate and quantitative method for determining cancer onset or cancer onset risk by a quantitative tissue staining method in biological tissues using an antibody capable of recognizing a cancer growth regulatory factor or cancer metastasis regulatory factor such as PAR1 antibody, which inhibits the cancer cell mobility and infiltration is provided. Cancer onset or cancer onset risk is determined using the tissue staining method comprising the steps of: labeling an antibody which recognizes a cancer growth regulatory factor or cancer metastasis regulatory factor with a fluorescent material, and contacting the fluorescent-labeled antibody with a tissue sample; irradiating a tissue site in contact with the antibody with excitation light to acquire a fluorescence image; acquiring an autofluorescence image in a vicinity region of a short wavelength side or long wavelength side of an acquisition region of fluorescence wavelength emitted by the fluorescent material, in the same field of vision and in the same focal point as those of the fluorescence image; acquiring a corrected fluorescence image by image processing to eliminate a fluorescent brightness of the autofluorescence image from the fluorescent brightness of the fluorescence image; counting the number of cells at the tissue site in contact with the antibody; measuring a mean fluorescent brightness of a single fluorescent particle; and calculating the number of fluorescent particles per cell. | 08-08-2013 |
Patent application number | Description | Published |
20130157287 | BIOLOGICAL SUBSTANCE DETECTION METHOD - A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen, with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label. | 06-20-2013 |
20130157895 | TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD - A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured. | 06-20-2013 |
20130230866 | Method for Determining Effectiveness of Medicine Containing Antibody as Component - Protein recognized by an antibody used as an active ingredient of an antibody medicine such as trastuzumab or an antibody used for targeting a target site of an active ingredient is highly accurately quantitatively determined by employing a quantitative tissue staining method of biological tissues, thereby providing a method for determining therapeutic effectiveness of a medicine containing such an antibody as a component. The effectiveness of a medicine containing an antibody as a component is determined by employing a tissue staining method comprising the steps of: labeling the antibody in the medicine containing an antibody as a component with a fluorescent material and contacting the thus fluorescence-labeled antibody with a tissue sample; obtaining a fluorescence image by irradiating, with excitation light, a tissue site contacted with the antibody; obtaining an autofluorescence image in the same field of view and at the same focus as in the fluorescence image in a close region on a shorter wavelength side or a longer wavelength side of an acquisition wavelength region of fluorescence emitted by the fluorescent material; obtaining a corrected fluorescence image by performing image processing for removing fluorescence brightness of the autofluorescence image from fluorescence brightness of the fluorescence image; counting the number of cells in the tissue site contacted with the antibody; measuring average fluorescence brightness per fluorescent particle; and calculating the number of fluorescent particles per cell. | 09-05-2013 |
20140212889 | METHOD FOR STAINING TISSUE - It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected. | 07-31-2014 |
20140220598 | BIOLOGICAL SUBSTANCE DETECTION METHOD - The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of apart stained for morphological observation when the fluorescent label used for the immunostaining is observed. | 08-07-2014 |
20150049936 | MEDICAL IMAGE PROCESSOR AND STORAGE MEDIUM - A medical image processor and storage medium are shown. According to one implementation, a medical image processor includes an input unit, an operation unit, a cell nucleus extracting unit, a fluorescent bright point extracting unit, a feature amount calculating unit, and an output unit. The input unit is used to input a cell shape image showing a shape of a cell and a fluorescent image showing expression of a specific protein as a fluorescent bright point. The operation unit is used to specify an analysis target region. The cell nucleus extracting unit extracts a region of a cell nucleus. The fluorescent bright point extracting unit extracts a fluorescent bright point. The feature amount calculating unit calculates a feature amount showing an expression amount of the specific protein. The output unit outputs the calculated feature amount. | 02-19-2015 |
20150051101 | DETECTION METHOD FOR BIOLOGICAL SUBSTANCE - It is an object of the present invention to provide a detection method in which background noise is not increased even if a high-luminance fluorescent labeling material is used and which has an improved S/N ratio and high quantitativity and is advantageous for an immunohistological staining method. The present invention provides a detection method which is a method for detecting a specific biological substance using, as a color former, fluorescent substance-encapsulated nanoparticles to whose particle surfaces biological substance-recognizing molecules that specifically recognize a specific biological substance have been bonded, and which has an improved S/N ratio and high quantitativity and is advantageous for an immunohistological staining method because nanoparticles encapsulating no fluorescent substance are used as a blocking agent for preventing the fluorescent substance-encapsulated nanoparticles from being non-specifically adsorbed on a biological substance other than the specific biological substance. | 02-19-2015 |
20150064717 | METHOD FOR STAINING TISSUE - Provided is a method for staining a tissue enabling highly precise staining, by which the expression amount and/or the location of a biological substance in a tissue sample can be detected with a high quantitativity together with detailed information that can be obtained by bright field observation. | 03-05-2015 |
20150079611 | METHOD FOR DETECTING BIOLOGICAL MATERIAL - The present invention provides a staining method in which the fluorescent staining properties in a fluorescently-immunostained specimen are not reduced even when an oil-based mounting medium is used. The present invention also provides a method of preventing deterioration of a fluorescent label caused by irradiation with excitation light and improving the light resistance in a fluorescently-immunostained specimen obtained by the staining method. The biological substance detection method according to the present invention is a biological substance detection method for specifically detecting a biological substance from a pathological specimen, which includes the steps of: immunostaining the specimen with a fluorescent label; immobilizing the thus stained specimen; and mounting the thus immobilized specimen using a mounting medium including an organic solvent not freely miscible with water. In the biological substance detection method, the above-described mounting medium further includes a discoloration inhibitor. | 03-19-2015 |
20150086103 | MEDICAL IMAGE PROCESSOR AND STORAGE MEDIUM - A medical image processor and a storage medium are shown. According to one implementation, the medical image processor includes the following. An input unit is used to input a cell shape image and a fluorescent image showing expression of a specific protein. A cell nucleus extracting unit extracts a cell nucleus. A fluorescent bright point extracting unit extracts a fluorescent bright point. A region estimating unit sets a predetermined region. When the set region does not overlap with another, it is estimated to include one cell. When a plurality of the set regions overlap, it is estimated to include a plurality of cells. A feature amount calculating unit calculates a feature amount. A determining unit determines whether each estimated cell region is cancer and determines an expression status in the region based on the calculated feature amount. An output unit outputs a determination result. | 03-26-2015 |
Patent application number | Description | Published |
20110135063 | RADIOGRAPHIC IMAGING SYSTEM - A radiographic imaging system includes an imaging unit that detects radiation transmitted through a subject, an operation unit that controls the imaging unit, a signal sending and receiving device connects the imaging unit and the operation unit to each other by wired or wireless communication. A signal reception state display unit is disposed in the imaging unit or the signal sending and receiving device so as to display a signal reception state indicative of communication between the imaging unit and the signal sending and receiving device. | 06-09-2011 |
20120104271 | RADIATION IMAGING APPARATUS - A radiation imaging apparatus includes a radiation flat panel detector configured to detect radiation incident thereupon and to generate a radiation image, a control unit configured to control a drive of the radiation flat panel detector, a heat insulation member arranged between the radiation flat panel detector and the control unit, an external housing configured to accommodate therein the flat panel detector and the control unit, a first heat transfer member configured to transfer heat from the radiation flat panel detector to a first surface of the external housing, and a second heat transfer member configured to transfer heat from the control unit to a second surface of the external housing different from the first surface. | 05-03-2012 |
20160025866 | RADIATION DETECTING APPARATUS AND RADIATION IMAGING SYSTEM - Provided is a radiation detecting apparatus, including: a radiation detector arranged to detect radiation; an electrical circuit board configured to control the radiation detector; a cooling unit arranged to cool the radiation detector and the electrical circuit board; and a casing arranged to accommodate the radiation detector, the electrical circuit board, and the cooling unit therein, in which at least an outer surface of the casing has a recessed portion that is recessed across a back surface portion, which is on an opposite side to a side in which the radiation enters, and a lateral surface portion adjacent to the back surface portion, and in which the recessed portion has lead-out portions formed therein, through which a wiring line removably connectable to the electrical circuit board and a piping line arranged to allow a cooling medium to flow to the cooling unit are respectively led out external to the casing. | 01-28-2016 |
Patent application number | Description | Published |
20110176839 | IMAGE FORMING UNIT AND IMAGE FORMING APPARATUS - An image forming unit including a toner supplier that comprises a cylindrical conveying passage member and a toner conveying rotational body that is inserted into the cylindrical conveying passage member, includes first/second spiral blades formed on different areas of a rotational axis in an axis direction, wound in directions opposite to each other and is rotated so that the first/second spiral blades convey toner in convergent directions. The rotational axis is inclined such that the second spiral blade is higher than the first spiral blade, and the cylindrical conveying passage member comprises a fresh toner receiving opening that receives fresh toner, a collected toner receiving opening that receives collected toner, and a toner supplier opening disposed at a position where the fresh toner conveyed by the first spiral blade and the collected toner conveyed by the second spiral blade meet, so as to supply the toner to the developer. | 07-21-2011 |
20110229818 | IMAGE FORMING APPARATUS AND METHOD - An image forming apparatus includes a developing device that uses a developer carrier to advance to an image carrier a developer including a toner and a carrier and supplies the toner to the image carrier by applying a developing bias between the developer carrier and the image carrier. In the image forming apparatus, the following operation is performed before the developer in the developing device is taken out. The toner is supplied to the image carrier by applying the developing bias between the developer carrier and the image carrier, the developing bias increased in a direction to supply the toner to the image carrier. The toner supplied onto the image carrier is not transferred to a transfer receiving material but is advanced into a toner recovery device for recovery. The recovered toner is prevented from being returned to the developing device. | 09-22-2011 |
20120082486 | IMAGE FORMING APPARATUS - An image forming apparatus includes: a developing device that allows a developer to be retained on a developer carrier having a magnet member equipped with a plurality of magnetic poles mounted on an inner periphery thereof and rotates the developer carrier to deliver the developer to an image carrier and that forms a toner image by supplying the toner of the developer to the image carrier by applying a developing bias voltage from a bias voltage source between the developer carrier and the image carrier; a transfer device for transferring the toner image formed on the image carrier to a transfer receiving material; a toner recovery device for recovering the toner remaining on the surface of the image carrier after the transfer of the toner image; and a toner return device for returning to the developing device the toner recovered by the toner recovery device. | 04-05-2012 |
20130342874 | IMAGE FORMING APPARATUS FOR PRINTING ON FRONT AND BACK OF PAPER - An image forming apparatus acquires front and back images to be formed on paper and divides the front and back images of paper into a first image formed a part of the front image, a second image formed of the remaining part of the front image and a part of the back image, and a third image formed of the remaining part of the back image. The image forming apparatus forms the first and second images on the paper folded at the first position, and forms the third image on the paper folded at the second position. The image forming apparatus forms the first to third images such that the part of the front image and the remaining part of the front image constitute the front image and the part of the back image and the remaining part of the back image constitute the back image when the paper is unfolded. | 12-26-2013 |
Patent application number | Description | Published |
20090314411 | ELECTROMAGNETIC NOISE SUPPRESSOR, ARTICLE WITH ELECTROMAGNETIC NOISE SUPPRESSING FUNCTION AND THEIR MANUFACTURING METHODS - An electromagnetic noise suppressor of the present invention includes a base material containing a binding agent and a composite layer formed by integrating the binding agent that is a part of the base material and the magnetic material. This electromagnetic noise suppressor has high electromagnetic noise suppressing effect in the sub-microwave band, and enables it to reduce the space requirement and weight. The electromagnetic noise suppressor can be manufactured by forming the composite layer on the surface of the base material by physical vapor deposition of the magnetic material onto the surface of the base material. The article with an electromagnetic noise suppressing function of the present invention is an electronic component, a printed wiring board, a semiconductor integrated circuit or other article of which at least a part of the surface is covered by the electromagnetic noise suppressor of the present invention. | 12-24-2009 |
20090314539 | ELECTROMAGNETIC NOISE SUPPRESSOR, ARTICLE WITH ELECTROMAGNETIC NOISE SUPPRESSING FUNCTION AND THEIR MANUFACTURING METHODS - An electromagnetic noise suppressor of the present invention includes a base material containing a binding agent and a composite layer formed by integrating the binding agent that is a part of the base material and the magnetic material. This electromagnetic noise suppressor has high electromagnetic noise suppressing effect in the sub-microwave band, and enables it to reduce the space requirement and weight. The electromagnetic noise suppressor can be manufactured by forming the composite layer on the surface of the base material by physical vapor deposition of the magnetic material onto the surface of the base material. The article with an electromagnetic noise suppressing function of the present invention is an electronic component, a printed wiring board, a semiconductor integrated circuit or other article of which at least a part of the surface is covered by the electromagnetic noise suppressor of the present invention. | 12-24-2009 |
20090314634 | ELECTROMAGNETIC NOISE SUPPRESSOR, STRUCTURE WITH ELECTROMAGNETIC NOISE SUPPRESSING FUNCTION AND THEIR MANUFACTURING METHODS - An electromagnetic noise suppressor of the present invention has magnetic resonance frequency of 8 GHz or higher, and the imaginary part of complex magnetic permeability at 8 GHz is higher than the imaginary part of complex magnetic permeability at 5 GHz. Such an electromagnetic noise suppressor is capable of achieving sufficient electromagnetic noise suppressing effect over the entire sub-microwave band. The electromagnetic noise suppressor can be manufactured by forming a composite layer on the surface of a binding agent through physical deposition of a magnetic material on the binding agent. The structure with an electromagnetic noise suppressing function of the present invention is a printed wiring board, a semiconductor integrated circuit or the like that is covered with the electromagnetic noise suppressor on at least a part of the surface of the structure. | 12-24-2009 |
20090316370 | ELECTROMAGNETIC NOISE SUPPRESSOR, STRUCTURE WITH ELECTROMAGNETIC NOISE SUPPRESSING FUNCTION AND THEIR MANUFACTURING METHODS - An electromagnetic noise suppressor of the present invention has magnetic resonance frequency of 8 GHz or higher, and the imaginary part of complex magnetic permeability at 8 GHz is higher than the imaginary part of complex magnetic permeability at 5 GHz. Such an electromagnetic noise suppressor is capable of achieving sufficient electromagnetic noise suppressing effect over the entire sub-microwave band. The electromagnetic noise suppressor can be manufactured by forming a composite layer on the surface of a binding agent through physical deposition of a magnetic material on the binding agent. The structure with an electromagnetic noise suppressing function of the present invention is a printed wiring board, a semiconductor integrated circuit or the like that is covered with the electromagnetic noise suppressor on at least a part of the surface of the structure. | 12-24-2009 |