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Gomes, MA
Bruce Charles Gomes, Ashburnham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100068199 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 03-18-2010 |
Gerard Gomes, West Boylston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110138639 | PHOTOLUMINESCENT OPTICAL SIGHTS AND DEVICES AND METHODS THEREFROM - The present invention provides for photoluminescent optical fibers that are used to illuminate sighting reticles. The fibers are activated by electromagnetic radiation and emit electromagnetic radiation of various wavelengths at high intensity and for long periods of time. The emission from the photoluminescent fiber can only be seen coming from one terminal end of the fiber, which is designed to be positioned inside the sighting device to illuminate a reticle. The photoluminescent fiber contains a base optical fiber which is covered at least in part by a photoluminescent composition which itself is fully covered by a second composition that allows the activating electromagnetic radiation to pass through to activate the photoluminescent layer while preventing the emissive electromagnetic radiation of the photoluminescent layer from passing back through. | 06-16-2011 |
Jen Gomes, Norton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100170902 | DRINKING CONTAINER WITH STRAW - A drinking container including a main body and a removable lid. The lid includes an opening configured to receive a straw. The lid includes a removable cover having an opening configured to receive an upper portion of the straw. The cover includes a slide mechanism adapted to move and bend the straw to close the opening. The straw is bent at an angle to prevent closing or kinking of the straw. | 07-08-2010 |
Jose Manuel Gomes, Chelmsford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080269132 | USE OF LOW TEMPERATURE AND/OR LOW PH IN CELL CULTURE - The present invention provides a novel method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present invention facilitates improvements in the efficacy of therapeutic proteins produced in cell culture. | 10-30-2008 |
| 20080274507 | METHODS OF PROTEIN PRODUCTION USING ANTI-SENESCENCE COMPOUNDS - Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of an anti-senescence compound exhibit decreased levels of high molecular weight aggregates in the cell culture medium. | 11-06-2008 |
| 20090317867 | METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS - Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media. | 12-24-2009 |
Paul Gomes, Haverhill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100240624 | Ophthalmic Formulations of Ketotifen and Methods of Use - The present invention provides topical formulations of ketotifen that provide a comfortable formulation when instilled in the eye and are effective in the treatment and prevention of ocular allergy, particularly allergic conjunctivitis. The invention further provides methods of treating and preventing ocular allergy by in a subject in need of such treatment by topical application of the ketotifen formulations of the invention to the eye of a subject in need thereof. | 09-23-2010 |
| 20100240625 | Ophthalmic Formulations of Cetirizine and Methods of Use - The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye. | 09-23-2010 |
| 20110105450 | OPHTHALMIC FORMULATIONS OF FLUTICASONE AND METHODS OF USE - The present invention provides ophthalmic formulations of fluticasone that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic conjunctivitis in a subject in need of such treatment by topical application of the fluticasone formulations of the invention directly to the eye. | 05-05-2011 |
Rodrigo S. Gomes, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100097336 | TOUCH SYSTEMS AND METHODS UTILIZING CUSTOMIZED SENSORS AND GENERICIZED CONTROLLERS - Touch sensing circuit arrangements include a touch sensor and a controller board. The touch sensor includes one or more sensing elements to generate touch-related signals responsive to a touch input to the sensor, and a memory device storing computer-executable firmware instructions for determining touch positions based on the touch-related signals. The controller board includes query logic executable by the controller board to cause the controller board to query for the computer-executable firmware instructions stored on the memory device of the touch sensor, and a processor circuit to determine touch positions by executing the firmware instructions loaded onto the generic controller board in response to the query. | 04-22-2010 |