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Goldstein, TX
Joseph L. Goldstein, Dallas, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090093426 | RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 04-09-2009 |
| 20090170141 | GHRELIN O-ACYLTRANSFERASE (GOAT) BIOCHEMICAL ASSAY - Ghrelin is acylated ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase. | 07-02-2009 |
| 20100086955 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase - Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition. | 04-08-2010 |
| 20100184829 | RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. | 07-22-2010 |
Lawrence N. Goldstein, Dallas, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100262454 | System and method for sentiment-based text classification and relevancy ranking - The sentimental significance of a group of historical documents related to a topic is assessed with respect to change in an extrinsic metric for the topic. A unique sentiment binding label is included to the content of actions documents that are determined to have sentimental significance and the group of documents is inserted into a historical document sentiment vector space for the topic. Action areas in the vector space are defined from the locations of action documents and singular sentiment vector may be created that describes the cumulative action area. Newly published documents are sentiment-scored by semantically comparing them to documents in the space and/or to the singular sentiment vector. The sentiment scores for the newly published documents are supplemented by human sentiment assessment of the documents and a sentiment time decay factor is applied to the supplemented sentiment score of each newly published documents. User queries are received and a set of sentiment-ranked documents is returned with the highest age-adjusted sentiment scores. | 10-14-2010 |
Mona A. Goldstein, Corinth, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100073453 | METHODS AND SYSTEMS FOR VISUAL VOICE CALLS - In an exemplary method, at least one telephony attribute associated with a voice call directed from a client communication subsystem to a voice network identifier is detected. Visual content that has been predefined as being associated with the at least one telephony attribute is identified. A request for the visual content is initiated in response to the detecting step. The visual content is received, in response to the initiating step, for display at the client communication subsystem. | 03-25-2010 |
Seymour Goldstein, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090040509 | OPTICAL TOPOLOGY FOR MULTIMODE AND SINGLEMODE OTDR - A network test instrument for singlemode and multimode OTDR testing employs an optical topology providing for combined singlemode and multimode use of a detector for reduced cost and instrument size. | 02-12-2009 |
| 20100225901 | PON TESTER - A high resolution optical fiber length meter, live fiber detector, and reflectance tester (instrument) for single mode applications using a low power, long wavelength laser for generating wide and narrow optical pulses that are launched into a single mode fiber under test. The laser output fiber pigtail is fusion spliced to a singlemode coupler whose output is coupled to the instrument bulkhead connector. A PIN photodiode is fusion spliced to the singlemode coupler to receive the reflected light from the fiber under test. The high resolution hand-held instrument is useful in examining singlemode passive optical networks (PON). | 09-09-2010 |