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Glenn, CA
Bradley J. Glenn, Danville, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090093765 | Enhanced stability implantable medical device - An implantable medical device is provided which has a housing of an elongate form to minimize a size of an incision required for implantation. A stabilizing element is associated with the elongated form housing for the medical device. The stabilizing element transitions from a low profile initial form to a higher width final form to provide the medical device with a stabilized footprint after implantation. The stabilizing element is in the form of a rotating wing in one embodiment. In another embodiment, the stabilizing element is in the form of an expanding loop that can bend to extend out of side openings of a cavity within the housing, to provide such stabilization at the implantation site. The medical device can be in the form of a pacemaker, infusion pump, vascular access port or other subcutaneously implanted medical device. | 04-09-2009 |
Bradley J. Glenn, Davis, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100076491 | Intervertebral space implant for use in spinal fusion procedures - An implant assembly is provided for surgical implantation into an intervertebral space, such as for stabilization of vertebrae adjacent the intervertebral space during a spinal fusion procedure. The implant assembly includes a primary segment separate from a secondary segment. These segments are elongate and of sufficiently small cross-section that they can be implanted posteriorly in a minimally invasive manner. The primary segment preferably includes a tunnel and the secondary segment preferably includes a neck with the tunnel and neck sized complementally so that the segments stabilize each other where they intersect with the neck within the tunnel. The entire implant assembly is thus provided which both widens and supports the intervertebral space and is sufficiently rigid to provide adequate support for the intervertebral space as the vertebrae are fusing together. | 03-25-2010 |
Brian Glenn, Plymouth, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110020126 | MODULAR ROTOR BLADE FOR A POWER-GENERATING TURBINE AND A METHOD FOR ASSEMBLING A POWER-GENERATING TURBINE WITH MODULAR ROTOR BLADES - A modular rotor blade for a power generating turbine allows simple replacement of individual rotor blade sections in case of damage to or malfunction of a section. The modular rotor blade includes at least two rotor blade sections, wherein each rotor blade section includes at least one connecting part having at least one conical opening. The connecting parts of adjacent rotor blade sections rest against each other such that the conical openings of the connecting parts are aligned with each other and form a continuous conical connecting opening. Receiving elements for receiving tensioning elements are arranged at the smaller diameter end of the conical connecting opening. A conical bolt corresponding to the continuous conical connecting opening is arranged therein, and at least one tensioning element passes through the conical bolt and tensions the conical bolt against the receiving element. | 01-27-2011 |
Jeffrey Glenn, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080261906 | METHODS AND COMPOSITIONS FOR IDENTIFYING ANTI-HCV AGENTS - The invention features methods and compositions for screening for agents that modulate replication of a virus, particularly Flaviviridae virus (particularly hepatitis C virus (HCV)), where the methods provide for detection of agents that modulate the binding of TBC and NS5A, the inhibition of TBC activity, inhibition of Rab1 activity, and/or the expression of the TBC protein and/or Rab1 protein. The invention also features methods of controlling viral replication, and agents useful in such methods. | 10-23-2008 |
| 20090105151 | AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS - The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner. | 04-23-2009 |
Jeffrey S. Glenn, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080214471 | Method for inhibition of viral infection - The invention is directed to inhibiting viral morphogenesis and viral infection. In particular, it concerns effecting such inhibition by inhibiting the prenylation or post prenylation reactions of a viral or host protein. | 09-04-2008 |
| 20090083869 | METHODS AND COMPOSITIONS FOR IDENTIFYING AGENTS THAT INHIBIT AN NS4B-MEDIATED NEOPLASTIC CELLULAR PHENOTYPE OF HCV INFECTED CELLS - The disclosure provides methods and compositions for identifying agents that inhibit a neoplastic cellular phenotype mediated by the NS4B protein nucleotide binding motif (NBM) of hepatitis C virus (HCV). In general, the methods involve contacting a candidate agent with a mammalian cell expressing an NS4B NBM polypeptide of an HCV virus, wherein expression of the NS4B NBM polypeptide in the absence of candidate agent promotes a neoplastic cellular phenotype, and detecting the presence or absence of an effect of said candidate agent on NS4B-mediated promotion of a neoplastic cellular phenotype. The disclosed methods and compositions find use in a variety of therapeutic and screening applications. | 03-26-2009 |
| 20100015093 | Methods and compositions of treating a flaviviridae family viral infection - Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like. | 01-21-2010 |
| 20100028299 | Methods and compositions of treating a flaviviridae family viral infection - Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like. | 02-04-2010 |
| 20100203498 | METHODS AND COMPOSITIONS FOR IDENTIFYING ANTI-HCV AGENTS - The invention provides methods and compositions for identifying agents for treating infection by viruses that encode a nucleotide-binding NS4B protein, or functional equivalent thereof, e.g., hepatitis C virus (HCV) or other members of the family Flaviviridae. In general, the methods involve contacting an NS4B nucleotide binding motif (NBM)-containing polypeptide with a candidate agent, and determining the effect of the candidate agent on nucleotide binding activity, a nucleotide hydrolyzing activity, or a nucleotide-dependent RNA binding activity of the polypeptide. A candidate agent that inhibits NS4B polypeptide binding to a nucleotide is an anti-viral agent, e.g., an anti-HCV agent. The invention also features a polynucleotide encoding a NS4B polypeptide having a modified NBM (e.g., which is impaired in NTP binding). The subject methods and compositions find use in a variety of therapeutic and screening applications. | 08-12-2010 |
| 20100260717 | METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION - Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of identifying a candidate agent for the treatment of hepatitis C virus (HCV) infection, and the like. | 10-14-2010 |
| 20110052536 | METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION - Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like. | 03-03-2011 |
| 20110217265 | Screening for Inhibitors of HCV Amphipathic Helix (AH) Function - Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent. | 09-08-2011 |
| 20110256183 | Hydrogels with network defects enhanced by nanoparticle incorporation - Compositions and methods are provided for the manufacture and use of hydrogels with increased permeability to macromolecules with minimum loss of matrix mechanical strength and prepolymer viscosity for patternability. The hydrogels of the invention are formed from a prepolymer, which is polymerized in the presence of hydrophobic nanoparticles. In some embodiments of the invention cells are present during polymerization, and are encapsulated by the hydrogel. A high interfacial energy between the hydrophobic substrate and the aqueous polymerizing solution disrupts the hydrogel network structure, leading to network defects that increase permeability without loss of patternability. | 10-20-2011 |
| 20110262565 | PIP-2 Inhibition-Based Antiviral and Anti-Hyperlipidemic Therapies - Interaction of a specific viral domain with phosphatidylinositol 4,5-bisphosphate (PIP 2) is shown to mediate viral replication. Basic Amino Acid PIP-2 Pincer (BAAPP) domains are described herein, including, without limitation, NS5A protein of HCV, NS4B protein of HCV, poliovirus, and rhinovirus. | 10-27-2011 |
Jonathan P. Glenn, Los Angeles, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090211860 | WIRE AND CABLE ORGANIZING SYSTEM - A simple and effective wire and cable management device includes a housing generally in the form of a rectangular cuboid having opposing front and back walls, opposing top and bottom walls and opposing first and second side walls. A reel is disposed within the housing and is rotatable on an axis perpendicular to the front and back walls. A peripheral portion of the reel extends through an opening in the side wall of the housing. At least two of the opposing walls have cooperating mechanical couplings for securing the device to another identical device so that a plurality of devices may be easily connected together to manage and organize an array of wires, cables and cords. | 08-27-2009 |
Matthew Glenn, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090119762 | WLAN Access Integration with Physical Access Control System - A network access system. In particular implementations, a method includes monitoring, responsive to a network access request of a client, an authentication session between an authentication server and the client, and determining user credential information associated with a user of the client based on one or more messages of the authentication session. The method also includes accessing, using the user credential information, physical entry information indicating a physical location of the user relative to a defined perimeter, and conditionally allowing the client access to a network based on the physical entry information and a successful authentication of the client. | 05-07-2009 |
Richard Glenn, Santa Rosa, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110112548 | METHODS AND SYSTEMS FOR REMOVAL OF IMPLANTABLE INTRAVASCULAR DEVICES - Improved methods, systems and apparatuses for extracting devices implanted within the vasculature of a patient are provided, including a method of extracting an intravascular device anchored in a vasculature of a patient, the device including a device body and a lead coupled to the device body, the lead having a distal end including an electrode, the distal end being fixed in a heart of the patient, the method comprising forming an incision in the vasculature, disconnecting the lead from the device body, removing the distal end of the lead from the heart, withdrawing the lead from the patient, disconnecting the device body from an anchor, and withdrawing the device body from the patient via the incision. | 05-12-2011 |
Tracey Glenn, Altadena, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110259775 | LABELS, RELATED PADS THEREOF, AND RELATED METHODS - A label is provided that includes a body portion having an area, a front surface, and a back surface. The label also includes a tab portion having an area and a back surface, and the tab portion is integrally coupled to the body portion and extending from an end of the body portion. A line of weakness divides the tab portion and the body portion, and the line of weakness is formed such that the tab portion is selectively separable form the body portion along the line of weakness. A layer of adhesive is provided on the back surface of the body portion of the label, and a majority of the back surface of the tab portion is free of adhesive. The area of the tab portion is less than the area of the body portion. | 10-27-2011 |
Walter B. Glenn, Pacifica, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090214786 | MULTI-STATION DEPOSITION APPARATUS AND METHOD - A multi-station deposition apparatus capable of simultaneous processing multiple substrates using a plurality of stations, where a gas curtain separates the stations. The apparatus further comprises a multi-station platen that supports a plurality of wafers and rotates the wafers into specific deposition positions at which deposition gases are supplied to the wafers. The deposition gases may be supplied to the wafer through single zone or multi-zone gas dispensing nozzles. | 08-27-2009 |
| 20100316800 | MULTI-STATION DEPOSITION APPARATUS AND METHOD - A multi-station deposition apparatus capable of simultaneous processing multiple substrates using a plurality of stations, where a gas curtain separates the stations. The apparatus further comprises a multi-station platen that supports a plurality of wafers and rotates the wafers into specific deposition positions at which deposition gases are supplied to the wafers. The deposition gases may be supplied to the wafer through single zone or multi-zone gas dispensing nozzles. | 12-16-2010 |
Walter Benjamin Glenn, Pacifica, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090056626 | APPARATUS FOR CYCLICAL DEPOSITING OF THIN FILMS - An apparatus for cyclical depositing of thin films on semiconductor substrates, comprising a process chamber having a gas distribution system with separate paths for process gases and an exhaust system synchronized with operation of valves dosing the process gases into a reaction region of the chamber. | 03-05-2009 |