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Gladwin, US
Christopher S. Gladwin, Chicago, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20110106909 | DISTRIBUTED STORAGE NETWORK AND METHOD FOR COMMUNICATING DATA ACROSS A PLURALITY OF PARALLEL WIRELESS DATA STREAMS - A distributed storage network receives data that is to be transmitted. The data is processed via one or more error-coding dispersed storage functions and sliced into data slices. A certain number of the data slices are selected for wireless communication via a plurality of wireless modules wherein a first wireless module sends a first portion of the data slices, and a second wireless module sends a second portion of the data slices, and so on until the data slices are fully communicated. The wireless modules may be of different hardware, software, protocols, throughputs, bandwidth, speeds, encoding schemes, algorithms, etc. The transmission over several different wireless modules that potentially have different (and potentially changing over time) characteristics may increase both performance and security. | 05-05-2011 |
Elizabeth Gladwin, Christiansburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199685 | SPRAY SELF ASSEMBLY - An apparatus (and a method of making an apparatus) that includes a flexible functional material. The flexible functional material includes nano-particle layer(s) and linking agent layer(s). The nano-particle layer(s) are bonded to the linking agent layer(s). The nano-particle layer(s) and/or linking agent layer(s) are deposited by being sprayed. Since nano-particle layer(s) and/or linking agent layer(s) may be deposited by being sprayed, a flexible functional material may be easily formed on structures (e.g. such as external aircraft parts) to create a conductive surface. Through spraying, deposition may be efficient and effective and allow for implementations which are impractical and/or not possible with bulk metal materials. | 08-21-2008 |
| 20090104437 | SCALABLE SILVER NANO-PARTICLE COLLOID - A method for synthesizing silver nano-particle colloid includes initiating formation of silver colloid nano-particles by combining a reduction solution and a silver nitrate solution in a container; and then stabilizing the silver colloid nano-particles by combining a stabilizing solution to the container. Thus a colloid can be produced using such a method and an electrostatic self assembly may be constructed using such a colloid. | 04-23-2009 |
Mark T. Gladwin, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100247682 | USE OF NITRITE SALTS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS - It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm. | 09-30-2010 |
| 20100323029 | FIVE-COORDINATE NEUROGLOBIN AND USE THEREOF AS A BLOOD SUBSTITUTE - Described herein is the finding that a mutant form of human neuroglobin (H64L) with a stable five-coordinate geometry reduces nitrite to nitric oxide approximately 2000-times faster than the wild type neuroglobin. Five-coordinate neuroglobin is also capable of binding and releasing oxygen. Based on these findings, the use of five-coordinate neuroglobin as a blood substitute is described herein. Particularly provided is a method of replacing blood and/or increasing oxygen delivery to tissues in a subject by administering to the subject a therapeutically effective amount of neuroglobin with a stable five-coordinate geometry. In some cases, five-coordinate neuroglobin is administered in combination with another therapeutic agent or composition, such as a second blood replacement product (for example, a hemoglobin-based oxygen carrier), a blood product (such as red blood cells, serum or plasma) or whole blood. | 12-23-2010 |
Mark T. Gladwin, Pittsburg, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100247681 | NITRITE AND NITRITE-METHEME THERAPY TO DETOXIFY STROMA-FREE HEMOGLOBIN BASED BLOOD SUBSTITUTES - This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject. | 09-30-2010 |
Mark T. Gladwin, Garrett Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100239692 | METHODS OF TREATMENT FOR HEMOLYSIS - Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds preferentially react with cell-free OxyHb, as compared to OxyHb encapsulated in a red blood cell, and reacts with MetHb to form iron-nitrosyl Hb or nitrite bound MetHb. It has also been found that such compounds reduce cell-free Hb and hemolysis. Active compounds are also contemplated for use in combination therapies, for example, in combination with the administration of red blood cells and/or an agent that promotes hematopoiesis, or in combination with the administration of a nitric oxide donor. | 09-23-2010 |
Stephen Christopher Gladwin, Chicago, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100173579 | PROXIMITY SYNCHRONIZATION OF AUDIO CONTENT AMONG MULTIPLE PLAYBACK AND STORAGE DEVICES - A wireless communication system and in particular to a wireless communication system for digital audio players that provides for increased functionality, such as communication, interaction and synchronization between a computing platform and various mobile, portable or fixed digital audio players, as well as providing a communication link between the various digital audio players themselves. The computing platform may act, for example, through a wireless network or wireless communication platform, to control the digital audio players; to act as a cache of digital audio data for the digital audio players; as well as provide a gateway to the Internet to enable the digital audio players to access additional digital audio content and other information. The computing platform may also be used to automatically update digital audio content on the digital audio players; synchronize digital audio content and playlists between digital audio players; and automatically continue a particular playlist as the user moves from one digital audio player to another. | 07-08-2010 |
| 20100262269 | STRUCTURE AND METHOD FOR SELECTING, CONTROLLING AND SENDING INTERNET-BASED OR LOCAL DIGITAL AUDIO TO AN AM/FM RADIO OR ANALOG AMPLIFIER - A system and method that allows digital audio files, either streaming or stored to be controlled and selected and provides an analog audio signal for broadcast by a radio or amplifier without interfering with the operation of the host PC. A remote device is provided which facilitates control of the system. | 10-14-2010 |