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Giuliano, US
Armando E. Giuliano, Los Angeles, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100068743 | Method for predicting response of cancer patient to anticancer drug treatment - A method predicts a response of a cancer patient to anticancer drug based on a cell cycle profile score obtained by analyzing a malignant tumor of the cancer patient, wherein the method can predict a disease outcome including a complete response, a partial response, stable disease, no response, and time to progression of disease as patient's response to anticancer drug therapy. | 03-18-2010 |
Concetta Giuliano, Winter Springs, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20080199403 | Composition and Method for Direct Visualization of the Human Appendix - A positive contrast agent composition containing meglumine diatrizoate, sodium diatrizoate, simethicone, famotidine and aspartame in predetermined amounts that is orally administered to a patient for clinical evaluations of appendicitis wherein a positive contrast effect is achieved. Methods of use include orally administering individual doses of the composition approximately 50 minutes prior to appendix visualization using computerized axial tomography. | 08-21-2008 |
David M. Giuliano, Rochester, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090278520 | Power Converter with Capacitive Energy Transfer and Fast Dynamic Response - A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices. | 11-12-2009 |
John P. Giuliano, Ledgewood, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110073017 | THREE-DIMENSIONAL TELESCOPING ADJUSTABLE EQUIPMENT MOUNTING FIXTURE - An adjustable equipment curb has upper and lower frames, each having opposed first and second length-adjustable sides and opposed length-adjustable first and second ends interconnectable to form a rigid frame and height-adjustable mounting legs. The lower frame may be used alone, or may support the upper frame through a shock mount system having mounts affixed to both the upper and lower frames and shock absorbing springs between the mounts. The frames may be formed of interconnecting channel members, and the lower frame channel members may be of a perforated construction that, in conjunction with applied sheathing, provides acoustic damping. Seismic brackets may be affixed to the either of the frames to provide resist seismic shock and developed moment resistance. | 03-31-2011 |
Kenneth Giuliano, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090170091 | Method For Predicting Biological Systems Responses - The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles. | 07-02-2009 |
Kenneth A. Giuliano, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090131270 | METHODS FOR THE DETECTION OF MOLECULAR INTERACTIONS WITHIN CELLS - The invention provides a method of detecting the effect of an agent of interest on the interaction between two or more polypeptides introduced into a cell. The invention also provides a method for quantifying the interaction between at least two molecules of interest, which are introduced into a cell. A method for quantifying the effects of an agent of interest or the interaction between two molecules of interest on cellular constituents or functions in the same cells is also provided. The above inventive methods can be automatically quantified by a device, such as a HCS device, and utilized in the construction of a database. | 05-21-2009 |
| 20100009352 | Method for Modeling a Disease - The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided. | 01-14-2010 |
| 20100112602 | Protein-Protein Interaction Biosensors and Methods of Use Thereof - The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of two or more polypeptides, the method comprising: introducing into a cell at least a first polypeptide, each comprising a binding domain, wherein the first polypeptide comprises a localization domain of the second polypeptide; and detecting the cellular location of the first polypeptide, the second polypeptide or a combination thereof, wherein a change in the cellular location of the first polypeptide, the second polypeptide or a combination thereof indicates that the agent modulates the interaction of the two or more polypeptides. The invention also provides methods and reagents for identifying the binding domains of one or more polypeptides. | 05-06-2010 |
Michael Giuliano, Madison, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20110118440 | GAMMA AMINO ACID BUILDING BLOCKS - The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained α-substituted-γ-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.). | 05-19-2011 |
Vincent Giuliano, Winter Springs, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090214680 | Weight Loss Composition - The present invention comprises a purposefully formulated weight loss composition and a method for causing a meaningful weight loss in a living human subject. The formulated weight loss composition, in its most preferred embodiments comprises: at least one amino acid that is a pharmacologically active precursor in the catecholamine biosynthesis pathway; one or more sympathomimetic agents; a lipolytic agent; a high-Dalton macromolecular protein, and a plurality of micronutrients. The preferred composition is formulated as a dry particulate admixture initially; and then is made into a fluid beverage, which is able to achieve multiple physiologic functions in-vivo. These in-vivo functions include: causing a meaningful weight loss, with a preference for lipolysis and fat metabolism; providing for a low glycemic index; offering lean muscle maintenance and replenishment; and concomitantly initiating dopaminergic (D2-receptor) brain stimulation, resulting in improved cognitive function and affective augmentation. | 08-27-2009 |