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Geschwind
Dan Geschwind, Santa Monica, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110311512 | Genetic Variants Underlying Human Cognition and Methods of Use Thereof as Diagnostic and Therapeutic Targets - Compositions and methods for the detection and treatment of neurological disorders, including ASD, are provided. | 12-22-2011 |
Daniel H. Geschwind, Santa Monica, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090163406 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING BRAIN CANCER AND IDENTIFYING NEURAL STEM CELLS - In one aspect, the invention provides composition and methods for the diagnosis, prognosis and treatment of tumors and cancers, e.g., brain cancers. In one aspect, the invention provides compositions and methods for inhibiting the growth, proliferation, differentiation and/or survival of a neural stem cell or a cancer cell, or progenitor stem cell thereof. In one aspect, the invention provides compositions and methods for identifying the genetic profile of a brain cancer cell or a self-renewing neural cancer stem cell. In one aspect, the invention provides methods employing these profiles to identify compounds that inhibit tumor growth. | 06-25-2009 |
| 20100125042 | PERIPHERAL GENE EXPRESSION BIOMARKERS FOR AUTISM - The disclosed invention comprises methods and materials for screening cells for genetic profiles associated with autism spectrum disorders. The methods typically involve isolating a cell from an individual and then observing the expression profile of one or more genes in the cell, wherein certain expression patterns of the genes observed are associated with autism spectrum disorders. | 05-20-2010 |
| 20100267020 | GENETIC RISK FACTOR FOR NEURODEGENERATIVE DISEASE - The present invention relates to single base polymorphisms in the glycogen synthase kinase 3 beta and risk for developing neurodegenerative disease. | 10-21-2010 |
Jean-Francois Geschwind, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100137434 | Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer - The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds. | 06-03-2010 |
| 20100203110 | Therapeutics for Cancer Using 3-Bromopyruvate and Other Selective Inhibitors of ATP Production - The present invention relates to methods of treating a cancerous tumor in a subject comprising administering to the subject an effective amount of 3-bromopyruvate. The 3-bromopyruvate may be administered intraarterially directly to a tumor as a continuous intraarterial infusion. The present invention also relates to methods for identifying agents that inhibit type II hexokinase activity. | 08-12-2010 |
Jean-Francois H. Geschwind, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090326068 | Therapeutics for Cancer using 3-Bromopyruvate and other Selective Inhibitors of ATP Production - The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising such inhibitors and methods for administering them intraarterially directly to a tumor, as well as methods for identifying compositions that selectively inhibitor ATP production for use in the invention. | 12-31-2009 |
Jeffrey Geschwind, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110104052 | METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES - The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent. | 05-05-2011 |