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Gerber, US
Allen Gerber, High Falls, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090040032 | Hybrid drive mode indicator - A motorized vehicle that is capable of operating in a mode in which motive power is being supplied wholly or partially from electric power is provided with an exterior indicator showing this mode of operation to other vehicle operators. In this way other drivers are alerted to the fact that the vehicle is under electric power and is not likely to be accelerated, particularly uphill. | 02-12-2009 |
| 20110015611 | Aspiration prevention mechanism - A patient angle sensor is employed in conjunction with gastric feeding devices to shut off or to reverse the flow of fluid in the tube when the angle of a bed ridden patient becomes sufficient to allow gastric juices to percolate up through the esophagus and into the patient's lungs. In this way incidents of aspirational pneumonia in hospitalized patients is significantly reduced or eliminated. | 01-20-2011 |
| 20110140880 | Power delivery with power source identification - A system and method is described in which energy source identification information is impressed upon electrical conductors employed in an electrical energy distribution network. The present invention negates the concept that electrical energy in a power distribution system is or should be treated as a fungible quantity. The present invention provides a mechanism by which end-users are rendered capable of determining and requesting that the electrical energy being provided to them is derived from renewable resources in general or from specific renewable resources. The present invention also enhances the capabilities for monitoring and controlling the production of greenhouse gases, particularly carbon dioxide. | 06-16-2011 |
| 20110223896 | Meeting mode for cell phones - A cellular telephone or other portable communication device is provided with program instructions which cause the device to be set into a “meeting mode” by a user. When in this mode, callers are provided with a message indicating the meeting status. The called party is preferably then provided with the option of responding to questions from the caller by selectably activating button icons on a user interface which cause an audio transmission to the called party which is not also transmitted to the device's external speaker. The icons are labeled with such short responses such as: NO, YES, MAYBE, OKAY, MORE, LESS, TODAY, TOMORROW, and NEVER. | 09-15-2011 |
Anthony Gerber, Denver, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20120094945 | Discovery of Selective Glucocorticoid Receptor Modulators by Multiplexed Reporter Screening - The invention relates to assays to detect selective gene regulation by ligand dependent transcription factors. The invention also relates to selective modulators of the glucocortocoid receptor for treatment of inflammation and allergic and immune-mediated diseases. | 04-19-2012 |
Clifford Gerber, West Linn, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20100083541 | ARTICLES WITH RETRACTABLE TRACTION ELEMENTS - Articles of manufacture and articles of wear may include one or more traction elements. Portions of the traction elements may be extendable and/or retractable. The traction elements have at least a two-plate construction that is designed to moderate a force that is applied to one of the plates. This construction may be used in articles of footwear having cleats or other traction elements. force applied by a wearer's foot may be moderated by the two-plate construction. | 04-08-2010 |
David Gerber, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110274666 | METHOD OF ENGRAFTING CELLS FROM SOLID TISSUES - A method of repairing diseased or dysfunctional organs or of establishing a model system of a disease state is provided. For repairing diseased organs, the method involves engraftment of cells from healthy tissue of the diseased or dysfunctional organ admixed with gel-forming biomaterials and nutrient medium, signaling molecules and extracellular matrix components that can be made insoluble rapidly upon transplantation to form a graft. In this way, the graft mimics the complexity of the native microenvironment with a minimum number of components that allow transplantation of cells to successfully engraft, expand and then rebuild part or the entirety of the diseased or dysfunctional organ. In the case of using grafting methods for establishing a disease model, diseased cells may be transplanted in the biomaterials and into experimental hosts. | 11-10-2011 |
David Gerber, West Chester, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090270992 | ARTIFICIAL INTERVERTEBRAL DISC IMPLANT - The invention relates to an artificial intervertebral disc for placement between adjacent vertebrae. The artificial intervertebral disc is preferably designed to restore disc height and natural disc curvature, allow for a natural range of motion, absorb shock and provide resistance to motion and axial compression. Furthermore, the intervertebral disc may be used in the cervical, the thoracic, or the lumbar regions of the spine. The artificial intervertebral disc may include either singularly or in combination: an interior including at least one spring member preferably incorporating an arcuate surface member, a flexible core, the flexible core preferably being a slotted core, a ring spring, a winged leaf spring, a leaf spring, or the articulating member preferably being attached to one of the endplate by an intermediate shock absorbing element. Moreover, the interior may include a fluid; a valve for injecting fluid into the interior of the disk; a central region having a stiffness that is preferably greater than the stiffness of the outer regions thus enabling the disc to pivot about the central region. The central pivot may be formed by a center opening, a central chamber, an inner core or a central cable. | 10-29-2009 |
| 20100076443 | DRILLING/MILLING GUIDE AND KEEL CUT PREPARATION SYSTEM - An instrument system, associated milling or drilling guide and method include use of a trial implant of a size corresponding to an actual implant for the intervertebral space, with a milling guide mounted on the trial implant. The milling guide includes a longitudinal guide chamber which is tapered from a forward end to a rearward end. The system also includes a cutting tool which is received in the guide chamber in order to form a cutout in an adjacent vertebra. This cutting tool includes a bearing member which pivotally engages the rearward end to form a pivot axis for the cutting tool in the tapered guide chamber. Either the milling guide can be inverted to form the cutout in the other vertebra; or the milling guide can be provided with two guide chambers, to be used with one cutting tool moved between them or two respective cutting tools. | 03-25-2010 |
| 20100131016 | LESS INVASIVE SURGICAL SYSTEM AND METHODS - A system for performing a less invasive surgical procedure and, in particular, devices and methods for spinal fixation. The system comprises dilation tool(s), at least one working/insertion cannula, a plurality of screws, at least one fixation rod for connecting the screws, and a rod inserter. The dilation tool(s) may be used to dilate an incision made in a patient to form an opening. Thereafter, a drill may be used to form holes in the vertebrae. An insertion cannula may be attached to a screw and inserted into the opening. The screws may be polyaxial screws and may be inserted into the vertebrae using a screwdriver. An operator may then move the insertion cannula to manipulate a head portions of the screws such that the head portions may be aligned to receive a fixation rod. A rod inserter may be used to insert a fixation rod into the head portions. After the fixation rod is in place, it may be locked to the screws, thereby fixing the system in place on the spine. | 05-27-2010 |
| 20100217395 | INTERVERTEBRAL IMPLANT WITH KEEL - An intervertebral implant component of an intervertebral implant includes an outer surface for engaging an adjacent vertebra and an inner surface. A keel extends from the outer surface and is designed to be disposed in a slot provided in the adjacent vertebra. This keel extends in a plane which is non-perpendicular to the outer surface; and preferably there are two of the keels extending from the outer surface which are preferably offset laterally from one another. In another embodiment, an anterior shelf is provided at an anterior end of the outer surface, and this anterior shelf extends vertically away from the inner surface in order to help prevent bone growth from the adjacent vertebra towards the inner surface. Further in accordance with disclosed embodiments, various materials, shapes and forms of construction of the component and/or keel provide various benefits. | 08-26-2010 |
| 20120016480 | ARTIFICIAL INTERVERTEBRAL DISC IMPLANT - An intervertebral disc for placement between adjacent vertebrae comprising: an anterior side; a posterior side; a first lateral side; a second lateral side; an upper endplate having an inner surface and an outer surface, wherein the outer surface of the upper endplate is adapted for contacting a first vertebra; a lower endplate having an inner surface and an outer surface, wherein the outer surface of the lower endplate is adapted for contacting a second vertebra; and an elastic membrane extending from the inner surface of the upper endplate to the inner surface of the lower endplate and defining an inner volume that is at least partially filled with a fluid, wherein the elastic membrane is affixed to the inner surface of the upper endplate and to the inner surface of the lower endplate. | 01-19-2012 |
David Gerber, Exton, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110160864 | INTERVERTEBRAL IMPLANT FOR TRANSFORAMINAL POSTERIOR LUMBAR INTERBODY FUSION PROCEDURE - An intervertebral implant for fusing vertebrae is disclosed. The implant may have a body with curved, posterior and anterior faces separated by two narrow implant ends, superior and inferior faces having a plurality of undulating surfaces for contacting vertebral endplates, and at least one depression in the anterior or posterior face for engagement by an insertion tool. The implant may also have one or more vertical through-channels extending through the implant from the superior face to the inferior face, a chamfer on the superior and inferior surfaces at one of the narrow implant ends, and/or a beveled edge along a perimeter of the superior and inferior faces. The implant configuration facilitates transforaminal insertion of the implant into a symmetric position about the midline of the spine so that a single implant provides balanced support to the spinal column. The implant may be formed of a plurality of interconnecting bodies assembled to form a single unit. An implantation kit and method are also disclosed. | 06-30-2011 |
David J. Gerber, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110172158 | TARGETS, METHODS, AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA - The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens. | 07-14-2011 |
| 20110288027 | TARGETS, METHODS, AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA - The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms, mutations, variations, alterations in expression, etc., in calcineurin genes or calcineurin interacting genes, or polymorphisms linked to such genes. The invention provides oligonucleotides, arrays, and antibodies for detection of polymorphisms and variants. The invention provides transgenic mice having alterations in such genes. The invention also provides methods of treating schizophrenia by administering compounds that target these genes. The invention further provides screening methods for identifying such compounds and compounds obtained by performing the screens. | 11-24-2011 |
David M. Gerber, East Syracuse, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100040421 | System for Pneumatically Conveying Particulate Material - An apparatus for pneumatically conveying particulate material from a container to an application site includes a mill that is operative to reduce the particle size of the material. The apparatus further includes a blower. Pneumatic lines are configured to connect the blower pneumatically with the application site through the container to convey material-laden air from the container to the application site. The pneumatic lines are configured for connection in alternative milling and non-milling arrangements. | 02-18-2010 |
David W. Gerber, Birmingham, AL US
| Patent application number | Description | Published |
|---|---|---|
| 20100286025 | SYNTHETIC APOLIPOPROTEIN E MIMICKING POLYPEPTIDES AND METHODS OF USE - The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties. | 11-11-2010 |
Donald S. Gerber, Scottsdale, AZ US
| Patent application number | Description | Published |
|---|---|---|
| 20090122618 | Method for Programming and Erasing an Array of NMOS EEPROM Cells that Minimizes Bit Disturbances and Voltage Withstand Requirements for the Memory Array and Supporting Circuits - A method for programming and erasing an array of NMOS electrically erasable programmable read only memory (EEPROM) cells that minimizes bit disturbances and high voltage requirements for the memory array cells and supporting circuits. In addition, the array of N-channel memory cells may be separated into independently programmable memory segments by creating multiple, electrically isolated P-wells upon which the memory segments are fabricated. The multiple, electrically isolated P-wells may be created, for example, by p-n junction isolation or dielectric isolation. | 05-14-2009 |
| 20100302857 | METHOD OF PROGRAMMING AN ARRAY OF NMOS EEPROM CELLS THAT MINIMIZES BIT DISTURBANCES AND VOLTAGE WITHSTAND REQUIREMENTS FOR THE MEMORY ARRAY AND SUPPORTING CIRCUITS - A method for programming and erasing an array of NMOS electrically erasable programmable read only memory (EEPROM) cells that minimizes bit disturbances and high voltage requirements for the memory array cells and supporting circuits. In addition, the array of N-channel memory cells may be separated into independently programmable memory segments by creating multiple, electrically isolated P-wells upon which the memory segments are fabricated. The multiple, electrically isolated P-wells may be created, for example, by p-n junction isolation or dielectric isolation. | 12-02-2010 |
Donna E. Gerber, Mason, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20110083705 | ENGINE WASH SYSTEM - A system for washing a gas turbine engine, the gas turbine engine having an inlet and an exhaust, the exhaust having an inner surface and an outer surface. The system comprises: a containment structure for capturing gaseous, liquid, and solid material emerging from the engine; a filtration system for separating the gaseous, liquid, and solid material; and a retaining ring for securing the containment structure to said exhaust; wherein the retaining ring is adjustable in at least one of size and shape so as to sealingly engage the inner surface of the exhaust. | 04-14-2011 |
| 20110108062 | METHOD OF WASHING A GAS TURBINE ENGINE - A method of washing a gas turbine engine, the method comprising the steps of: providing a gas turbine engine, the engine having an intake and an exhaust, the exhaust having an inner surface and an outer surface; providing a system for washing gas turbine engines, the system including a containment structure; releasably securing the containment structure to the inner surface via a retaining ring; introducing a wash liquid into the intake; and collecting the wash liquid in the containment structure. | 05-12-2011 |
Douglas E. Gerber, North Canton, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100005613 | WET/DRY FLOOR CLEANING UNIT AND METHOD OF CLEANING - A floor cleaning device comprises a base portion for movement along a surface and a handle portion pivotally connected to the base. The base portion further includes a suction nozzle and a brush assembly for agitating the surface, wherein the brush assembly and the nozzle assembly are in a first position raised off of the surface for vacuuming saw the surface, and the nozzle assembly is lowered to a second position contacting the surface for collecting and picking up liquid and dirt from the surface. A method of cleaning a surface by first dry vacuuming the surface using a cleaning unit in which the nozzle assembly is raised to pick up particles and then wet vacuuming the floor with the nozzle assembly lowered to collect and pick up dirt from the floor mixed with cleaning solution distributed on the floor. | 01-14-2010 |
| 20110302731 | WET/DRY FLOOR CLEANING UNIT - A floor cleaning device including a base assembly for movement along a surface, a handle, a nozzle, a nozzle lifting mechanism, a brush, a brush lifting mechanism, a recovery tank, and a liquid distribution system. The nozzle lifting mechanism moving the nozzle relative to the base assembly and the surface and the brush lifting mechanism moving the brush relative to the base assembly and the surface. | 12-15-2011 |
Gary A. Gerber, West Milton, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20100000582 | DRIVE SYSTEMS FOR CONVEYOR-TYPE WAREWASHERS - A conveyor-type warewash machine includes a housing through which racks of wares are passed along a conveyance path for cleaning. A rack drive system includes a rack engaging structure that moves back and forth in first and second directions. When moving in the first direction, the rack engaging structure moves an adjacent rack forward along the conveyance path. When moving in the second direction, the rack engaging structure leaves the adjacent rack substantially stationary. The drive system is configured to move the rack engaging structure in the first direction at a first average speed and to move the rack engaging structure in the second direction at a second average speed. The second average speed is faster than the first average speed so that the adjacent rack spends more time moving forward than being stationary. A seal assembly may be provided about a drive shaft of the drive system. | 01-07-2010 |
Jack Gerber, Elizabeth, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100089245 | Conic funnel integrally connected to a supporting planar platform - Avionic funnel integrally connected to a supporting planar platform in combination with an essentially flat disposable filter that is transformed into a three-dimensional conic configuration disposed to be inserted into the conic funnel. The apex of the conic funnel is truncated and projected through a first circular orifice at the approximate center of the supporting planar platform such that an effluent is focused into a receiving vessel upon which the supporting planar platform is placed. A second orifice vents air displaced by the effluent. A tab-like member and/or handle are used to hold or hang the apparatus. The apparatus has special applications for brewing beverages such as coffee by using nonproprietary nonpreformed low-cost generic circular paper filters such as those used in consumer coffeemakers as well as eliminating auxiliary laboratory equipment needed to vertically hold Buchner type funnels. | 04-15-2010 |
James G.c.t. Gerber, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100100502 | SYSTEM AND METHODS TO PROVIDE FOR AND COMMUNICATE ABOUT SAFER AND BETTER RETURNING ASSET-LIABILITY INVESTMENT PROGRAMS - A data processing system compiles information about account holders, holdings, and other investment-related information. A hypothetical portfolio is generated to provide for a specified payout stream over a defined period of time, statistically evaluated, and compared by means of scaling to determine the best fit scale of the portfolio to the defined criteria. The composition of this scaled portfolio in comparison with the composition of the available assets defines a series of trades. The composition of the level of payout that can be expected to be supported by the new composition of available assets defines a series of insurance trades. Insurance providers can impose limitations and requirements on the assets managed by limiting or stipulating certain settings that a given account can be allowed to have. | 04-22-2010 |
James S. Gerber, St. Paul, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20100126164 | Float for wave energy converter (WEC) - A float structure for a WEC is designed to have a tapered underside to reduce the impact due to wave slam and bending moments while providing little reduction in the surface area responding to the wave surface in order to maintain the beneficial power generating capability of a “flat” float. The underside of the float presents an inverted wedge section to decrease loads associated with wave slamming. The float may have a generally toroidal or elliptical configuration at and about the “still” water line with the generally submerged underside of the float having a cross section shaped to have one or more inverted triangular sections extending between the outer perimeter of the float and its center to reduce impact loading due to wave slamming while maintaining power producing capability. | 05-27-2010 |
| 20100148504 | Advanced wave energy converter control - A wave energy converter (WEC) system includes first and second bodies which can move relative to each other in response to waves and a power-take-off (PTO) device coupled between the two bodies to convert their relative motion into energy. A sensor is used to sense selected characteristics of an incoming wave and produce signals which are applied to a control computer for predicting the impact of the incoming waves on the WEC. Simultaneously, signals indicative of the actual conditions (e.g. the velocity) of the WEC are also supplied to the control computer which is programmed to process the predicted and actual information in order to generate appropriate signals (forces) to the components of the WEC such that the average wave power captured by the PTO is maximized. | 06-17-2010 |
Jay D. Gerber, Lincoln, NE US
| Patent application number | Description | Published |
|---|---|---|
| 20080292663 | ADJUVANT COMPOSITIONS AND METHODS FOR DELIVERING VACCINES - An adjuvant composition is provided that is comprised of a calcium compound, lecithin, and an acrylic polymer. Pharmaceutical compositions are provided which include an antigen and the adjuvant. Methods are provided for stimulating an immune response in a human or animal subject by administering a composition comprising an antigen and the adjuvant composition to human or animal subjects. | 11-27-2008 |
| 20120070453 | Methods for Preparing and Delivering Adjuvant Compositions - Methods are provided for preparing and delivering an adjuvant for vaccines including lecithin and a polymer. The polymer is preferably polyacrylic acid-based and the delivery method involves administering a vaccine, including an antigen and the adjuvant, to a mucosal surface. | 03-22-2012 |
Jesse I. Gerber, West Keansburg, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100061916 | High Temperature Support Apparatus and Method of Use for Casting Materials - This invention relates to a system and a method of use for large ceramic member support and manipulation at elevated temperatures in non-oxidizing atmospheres, such as using carbon-carbon composite materials for producing high purity silicon in the manufacture of solar modules. The high temperature apparatus of this invention includes one or more support ribs, one or more cross braces in combination with the one or more support ribs, and a shaped support liner positionable upon the one or more support ribs and the one or more cross braces. | 03-11-2010 |
Linda M. Gerber, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090157328 | METHOD OF DETERMING EXCRETION OF SODIUM AND OTHER ANALYTES - Methods and kits of the invention are useful for calculating 24-hour excretion of sodium without the need to collect urine for 24 hours. | 06-18-2009 |
Marni L. Gerber, West Linn, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20080216353 | Article of Footwear for Use with a Left Foot and a Right Foot - An article of footwear intended for use with a left foot and a right foot is disclosed. The article of footwear includes an interior space configured to fit a left for and a right foot. Additionally, the article of footwear may be associated with an insert that deforms during use. | 09-11-2008 |
| 20100212185 | ARTICLE OF FOOTWEAR WITH A MIDSOLE STRUCTURE - An article of footwear is disclosed that includes at least one of an upper and a segmented sole structure. The sole structure may include an insole portion and a plurality of discrete sole elements disposed within an outsole unit. The insole is positioned adjacent the upper and may extend along a longitudinal length of the upper. The sole elements extend from the connecting portion, and the sole elements are separated by a plurality of flexible regions. | 08-26-2010 |
Martin Gerber, Brick, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090267564 | Charging cabinet assembly for hand held devices - A charging cabinet for hand held devices comprising a cavity defined by a rear wall, top and bottom parallel walls, and opposing side walls, and a front wall hingeably secured to one of the side walls to form a closure door, there being positioned within the cavity of the cabinet, a plurality of shelves for support of a hand held devices, the cabinet having a plurality of 110 volt or 220 volt outlets secured thereto, each of the 110 volt or 220 volt charging outlets having an on/off switch associated therewith to activate and deactivate a particular outlet, there also being a plurality of securing means associated with each shelf for securing excess wire associated with each charger in a compact manner, the charging cabinet being wall mounted or recessed in a wall and connected to a power source. | 10-29-2009 |
Martin Gerber, Carmel, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20100025270 | BIOSENSOR CONTAINER - A biosensor container comprising a housing defining an internal glucose test strip compartment. The housing has an engagement portion for retaining a detachable means for storing data, and the means for storing data has data stored thereon specific to a batch of glucose test strips. At least one of the housing and the means for storing data includes at least one data reading element that is externally accessible when the means for storing data is retained by the engagement portion of the housing. The container includes various fail safe features to prevent mishandling and insure the user obtains the correct results. The housing includes means for connecting to the bG meter only when the means for storing data is retained by the housing. The housing further includes means for dispensing glucose test strips only when the housing is in either of an attached-to meter mode or a stand-alone mode. In the attached-to-meter mode the means for storing data is retained by the housing and the housing is connected to a bG meter. In the stand-alone mode the means for storing data is detached from the housing and the housing is not connected to the bG meter. | 02-04-2010 |
Merle Ray Gerber, Moline, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100285854 | Grain Tank Seal - 1. A covered grain tank ( | 11-11-2010 |
Michael J. Gerber, Denver, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090054473 | THERAPY FOR COMPLICATIONS OF DIABETES - A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective endothelin A (ET | 02-26-2009 |
| 20090221549 | ANTIHYPERTENSIVE THERAPY - A new use of darusentan is provided in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy with one or more drugs. The composition comprises darusentan in an amount providing a therapeutically effective daily dose; wherein (a) the composition is orally deliverable and/or (b) the daily dose of darusentan is effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, trough sitting diastolic, 24-hour ambulatory systolic, 24-hour ambulatory diastolic, maximum diurnal systolic and maximum diurnal diastolic blood pressures. Further provided is a new use of darusentan in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy, wherein the composition is administered adjunctively with at least one diuretic and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers. | 09-03-2009 |
| 20100152217 | METHOD FOR TREATING A PULMONARY HYPERTENSION CONDITION - A method for treating a pulmonary hypertension condition such as pulmonary arterial hypertension (PAH) in a subject comprises administering to the subject a therapeutically effective amount of ambrisentan, wherein, at baseline, time from first diagnosis of the condition in the subject is not greater than about 2 years. | 06-17-2010 |
| 20100222668 | GUIDANCE AND IMPLANTATION OF CATHETERS - A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum. | 09-02-2010 |
| 20100233081 | METHODS FOR ADMINISTRATION OF RADIOTHERAPEUTIC AGENTS - A method is provided for treatment of disorders involving hyperproliferative cells, such as malignancies, advanced stage solid tumors like glioblastoma multiforme, and non-malignant hyperproliferative pathological conditions such as adult macular degeneration. A short range, unselective cell killing radiotherapeutic substance is administered, optionally in a spatially defined volume of tissue, optionally in combination with a mitogenic agent that stimulates or induces DNA biosynthesis. In this way, the percentage of hyperproliferative that are susceptible to killing by the radiotherapeutic agent is increased. Cancer stem cells can be induced to enter S phase with the mitogenic agent, then killed with the radiotherapeutic agent. Thus, not only does the combination effectively kill the transit amplifying cell population, the most rapidly replicating type of cell in a tumor, but it also effectively kills the tumor stem cells, which give rise to the transit amplifying cells, for a longer lasting anticancer effect. | 09-16-2010 |
| 20110135569 | METHOD FOR THERAPEUTIC ADMINISTRATION OF RADIONUCLEOSIDES - Methods are provided for the local radiotherapy of cancers such as locally invasive, advanced stage solid tumors, and normal tissues penetrated by processes of cancerous tissue, through administration of Auger-electron emitting radionucleoside analogs using high-flow microinfusion techniques (“convection-enhanced delivery”). Direct infusion under pressure, at flow rates in excess of at least about 0.5 microliters/min of the radionucleosides provides for their mass transport through tissue to a much higher degree than could be achieved by passive, unpressurized diffusion. The unique properties of these radionucleoside analogs that provide for surprisingly effacacious delivery by high-flow microinfusion include rapid clearance from tissues following local injection without the benefit of sustained high-flow microinfusion, rapid and complete clearance via the blood stream, poor permeation of barriers such as the blood-brain barrier, and a highly potent, non-selective, but very short range killing effect on cells that are undergoing DNA replication that incorporate radionucleosides into their chromosomes. | 06-09-2011 |
| 20110245253 | METHOD FOR TREATING A PULMONARY HYPERTENSION CONDITION - A method for treating a pulmonary hypertension condition such as pulmonary arterial hypertension (PAH) in a subject comprises administering to the subject a therapeutically effective amount of ambrisentan, wherein, at baseline, time from first diagnosis of the condition in the subject is not greater than about 2 years. | 10-06-2011 |
Naomi Lynn Gerber, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100134408 | Fine-motor execution using repetitive force-feedback - An individual's fine-motor skills can be assessed using a force-feedback haptic unit that includes an end-effecter and programmable settings. To assess these skills, a tangible computer readable medium initializes the programmable settings with a set of initial settings. It then presents a 3-D representation of a character or characters to a user. The user in turn is prompted to mimic the character(s) on a work space. While the user is attempting to mimic the character(s) using the end-effecter on the work space, timed stroke data are collected from the force-feedback haptic unit. Using the timed stroke data, an analysis is then generated to determine the user's precision and accuracy of mimicking the character. | 06-03-2010 |
Neal R. Gerber, Park City, KY US
| Patent application number | Description | Published |
|---|---|---|
| 20090101104 | AIR VALVE AND METHOD OF USE - An air valve and its method of use including an air valve housing; a throttle plate disposed on a throttle shaft; a driven gear attached on the throttle shaft; a brushless direct current motor assembly in connection via a pinion with the driven gear; an integrated electronic valve controller including digital signal processing on a circuit board; and a throttle position sensor on the circuit board, wherein the throttle position sensor includes at least one non-contact type sensor. In a preferred embodiment, the air valve includes an inlet port and an outlet port connected to an engine via an air intake manifold, such that re-circulated exhaust gas is introduced into the air intake manifold. | 04-23-2009 |
Raymond Gerber, Duluth, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20090060165 | Method and System for Customer Transaction Request Routing | 03-05-2009 |
| 20090063320 | Electronic Lending System Method and Apparatus for Loan Completion - A method and system for completing on-line electronic installment loan application ( | 03-05-2009 |
| 20090063329 | Method and System for Loan Application Non-Acceptance Follow-Up - Methods and systems for facilitating post offer communication with a prospective borrower using an on-line lending system ( | 03-05-2009 |
Rickey Gerber, Roanoke, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20080264657 | Rigid Standard Bearing Shield Disk Scraper System - A bearing shield and disk scraper system to remove and deflect dirt, debris, and soil from a bearing assembly, rigid bearing hanger or standard, and/or disk blade, is provided; the system also provides a protective barrier structure for the bearing assembly. The bearing shield and disk scraper system includes a shield member and a scraper blade connected thereto. The bearing shield at least partially encases and protects a bearing assembly that rotatably supports a common axle which carries multiple disk blades of the disk gang. The scraper blade is attached to the shield member by way of a mounting flange that extends therefrom. An edge of the scraper blade is positioned in close proximity to a concave surface of an adjacent disk blade, whereby the entire assemblage of bearing shield and disk scraper system protects the bearing assembly and prevents non-desired accumulation of dirt and debris on the disk blade. | 10-30-2008 |
| 20080264659 | Cushion Standard Shield System - A cushion standard shield system to remove and deflect residue, dirt, debris, and soil from a cushion bearing hanger, or cushion standard, portion of a disk gang type agricultural implement is provided. The cushion standard shield system includes a mounting bracket supported by a common axle which carries multiple disk blades of the disk gang. A blade assembly is mounted to an upright portion of the mounting bracket, and is positioned generally behind and above the axle, behind the cushion standard. The blade assembly includes one or more plate member with arcuate lateral edges. The radii of the arcuate lateral edges correspond closely in magnitude to the radii of the concave and convex surfaces of the disk blades. The plate members are laterally adjustable with respect to each other, whereby the width dimension of blade assembly is variable to accommodate different axial spacing widths of adjacent disk blades. | 10-30-2008 |
| 20090000796 | ADJUSTABLE SCRAPER BLADE SYSTEM FOR DISK HARROWS - An adjustable scraper blade system for use with disk harrow implements is provided. The adjustable scraper blade system includes a mounting bracket secured at one end to the harrow implement, a scraper blade, and fasteners for selectively fixing the scraper blade in position. The scraper blade includes an arcuate scraping edge and an anchoring aperture defining an axis of pivotation of the scraper blade. It further includes an elongate adjustment slot that defines a range of arcuate adjustment of the scraper blade. The adjustability features of the adjustable scraper blade system facilitate alignment of the scraper blade so its scraping edge can be fixed in aligned face-to-face registration with the disk blade concave surface defining a clearance or gap therebetween of generally constant width. | 01-01-2009 |
Rickey L. Gerber, Roanoke, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100084148 | TANDEM DISK WITH FINISHING REEL - Embodiments of the present invention provide a novel configuration for agricultural tandem disk systems that feature soil finishing systems. This configuration of the finishing system features finishing reels that provide a robust assembly that will require less frequent repair and maintenance. The finishing system also features support arms that allow the user to adjust the position of finishing reels and the downward force applied to the reels. In an exemplary embodiment, the soil finishing reels are located behind two rows of ground breaking disk blades. After the soil is opened by the disks, the finishing reel may be used to break up or split large soil clods created by the disks. The soil finishing system allows the user to have the soil in an optimized state for germination after one pass of the agricultural system, reducing the number of passes needed to prepare the field. | 04-08-2010 |
Ricky Gerber, Roanoke, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20110030979 | Apparatus For Providing Support Of A Cantilevered Component Mounted To A Rigid Frame - An apparatus for reducing the stresses placed on a cantilevered component mounted to a rigid frame includes cushioned bushings coupling the cantilevered component to a rigid frame. As the cantilevered component is loaded due to bending moments, the cushioned bushings flex and cushion the cantilevered component. The cantilevered component is retained within the bushing using hardware that allows the cantilevered component to float as needed to further reduce stresses and strains thereon. | 02-10-2011 |
Ronald E. Gerber, Richfield, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110141594 | REFLECTIVE OBJECTIVE - A reflective objective is disclosed, in which essentially all the optical power is in a single, off-axis, concave mirror, which is oriented generally perpendicular to the central axis of the objective. An incident beam is directed to and from the concave mirror by a pair of flat mirrors, so that a central on-axis ray in the incident beam is collinear with the corresponding thrice-reflected ray at the object. The object is one focal length away from the concave mirror. The aperture stop is also one focal length away from the concave mirror, leading to a condition of telecentricity at the object. Different focal lengths for the objectives are realized by using mirrors with different curvatures, located at different distances away from the central axis of the objective. The reflective objective can optionally be retrofitted into a turret typically used for microscope objectives, and can optionally have refractive elements, making the objective catadioptric. | 06-16-2011 |
Scott Anthony Gerber, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090053742 | Capture and release based isotope tagged peptides and methods for using the same - The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association with the peptide (e.g., a covalent bond) and an anchoring site (AS) group for reversibly or removably anchoring the tag to a solid phase such as a resin support. Anchoring may be direct or indirect (e.g., through a linker molecule). Preferably, the anchoring site comprises a biotin compound. Preferably, the tag comprises a mass-altering label, such as a stable isotope, such that association of the tag with the peptide can be monitored by mass spectrometry. The reagents can be used for rapid and quantitative analysis of proteins or protein function in mixtures of proteins. | 02-26-2009 |
Steven A. Gerber, South Hill, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20110011544 | WET PULPING SYSTEM AND METHOD FOR PRODUCING CELLULOSIC INSULATION WITH LOW ASH CONTENT - Apparatus and method for recovering organic cellulosic fibers from landfill materials (such as post consumer, municipal and industrial waste materials). The apparatus and method selectively introduces waste materials containing organic cellulosic fibers into a size reduction machine. The pre-cleaned waste materials are conveyed to a tank, drum, or tunnel type fiber recovery apparatus. The waste materials are subjected to mechanical and fluid fiberization for a selected period of time to produce useful products, such as cellulosic insulation with a total ash content equal to or less than 10%, as well animal and fowl bedding products that is substantially devoid of moisture content, among other products. | 01-20-2011 |
Terry L. Gerber, Lisbon, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090139290 | METHOD AND PLANT FOR INTEGRATED MONITORING AND CONTROL OF STRIP FLATNESS AND STRIP PROFILE - Apparatus and method of controlling strip geometry in casting strip having a rolling mill. A target thickness profile is calculated as a function of the measured entry thickness profile of the strip while satisfying profile and flatness parameters. A differential strain feedback from longitudinal strain in the strip is calculated by a control system by comparing the exit thickness profile with the target thickness profile, and a control signal is generated to control a device capable of affecting the geometry of the strip processed by the hot rolling mill. A feed-forward control reference and/or sensitivity vector may also be calculated as a function of the target thickness profile, and used in generating the control signal sent to the control device. The control device may be selected from one or more of the group consisting of a bending controller, gap controller and coolant controller. | 06-04-2009 |
Thomas E. Gerber, Williamsville, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090294717 | COMPRESSOR THROTTLING VALVE ASSEMBLY - A throttling valve assembly has an outer housing that is sealed. An actuator is connected to a pressure balanced shaft that extends into the housing to operate a plurality of linkages that can rotate blades in tandem. With the surrounding housing sealed, the shaft penetrations of the blade support shafts no longer need seals or a purge system to supply process gas during times of reduced pressure in situations with the blades nearly closed. A pressure equalization system has balance passages internal to the housing to allow flow from higher pressure zones to lower pressure zone of the process gas so as to avoid creation of a condition that can draw air into any zones of reduced pressure in the housing. | 12-03-2009 |
| 20100096577 | COMPRESSOR THROTTLING VALVE ASSEMBLY - A throttling valve assembly has an outer housing that is sealed. An actuator is connected to a pressure balanced shaft that extends into the housing to operate a plurality of linkages that can rotate blades in tandem. With the surrounding housing sealed, the shaft penetrations of the blade support shafts no longer need seals or a purge system to supply process gas during times of reduced pressure in situations with the blades nearly closed. A pressure equalization system has balance passages internal to the housing to allow flow from higher pressure zones to lower pressure zone of the process gas so as to avoid creation of a condition that can draw air into any zones of reduced pressure in the housing. | 04-22-2010 |
| 20110209767 | COMPRESSOR THROTTLING VALVE ASSEMBLY - A throttling valve assembly has an outer housing that is sealed. An actuator is connected to a pressure balanced shaft that extends into the housing to operate a plurality of linkages that can rotate blades in tandem. With the surrounding housing sealed, the shaft penetrations of the blade support shafts no longer need seals or a purge system to supply process gas during times of reduced pressure in situations with the blades nearly closed. A pressure equalization system has balance passages internal to the housing to allow flow from higher pressure zones to lower pressure zone of the process gas so as to avoid creation of a condition that can draw air into any zones of reduced pressure in the housing. | 09-01-2011 |
Timothy James Gerber, Rochester, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20080201001 | INVENTORY MECHANISM THAT GENERATES LOGICAL INVENTORY FROM ASSEMBLIES IN INVENTORY - A logical inventory mechanism takes components in assemblies into account when determining purchase requirements. The inventory control system determines assemblies that are available, determines their components and whether or not each component may be reused, then adjusts physical inventory to generate therefrom logical inventory based on physical inventory plus parts in the assemblies that may be reused if the assemblies are disassembled. By computing logical inventory that would be available by disassembling assemblies, inventory levels may be reduced, thereby enhancing the efficiency of an inventory control system that includes the logical inventory mechanism. Assemblies in inventory thus may be used in two very different matters, as the starting point for a higher-level assembly, or to be disassembled to use one or more reusable components in the assembly in a different assembly. | 08-21-2008 |
| 20080288373 | Method for Assisting Selection of a Build Ahead Configuration For Use in Supplying an Ordered Product - A method is provided for use in connection with build ahead configurations (BAC's), for enabling a manufacturer to quickly identify the available BAC that is most suitable for use in completing a product order. In one embodiment, directed to a method for increasing efficiency in constructing individual products of a particular product type, each individual product has an associated specification set. A number of BAC's are initially constructed, wherein each BAC comprises an at least partially complete product of the particular type, and likewise has an associated specification set. An order is received for an individual product of the particular type, wherein the order defines each specification in the specification set for the ordered product. Respective specifications for the ordered product are compared with the specifications of each BAC, in order to calculate a metric for each BAC, wherein the metric for a given BAC represents the effort required to modify the given BAC to conform to all specifications set of the ordered product. | 11-20-2008 |