Patent application number | Description | Published |
20090039885 | METHOD AND APPARATUS FOR ACQUISITION OF MAGNETIC RESONANCE DATA - In a magnetic resonance method and apparatus for acquisition of measurement data from a subject, k-space to be scanned into an inner region and an outer region, and the inner region is divided into inner segments that differ in terms of their distance from a k-space center and the outer region is divided into outer segments that differ in terms of their distance from a k-space center. First k-space data are acquired for the inner region, wherein k-space lines of the inner region are divided into first groups such that k-space lines from different inner segments are associated in each of the first groups, and the first groups are successively scanned. Second k-space data are acquired for the outer region, wherein k-space lines of the outer region are divided into second groups such that k-space lines from different outer segments are associated in each of the second groups, and the second groups are successively scanned. | 02-12-2009 |
20100099978 | Breast coil arrangement for magnetic resonance applications - A breast coil arrangement for magnetic resonance applications has a placement web that is designed to allow an examination subject to lie with her sternum on the placement web. Pot-like breast receptacles for each breast of the examination subject are respectively arranged on opposite sides of the placement web. The breast receptacles have limiting elements whose spacing from one another can be adjusted. Multiple array coils are respectively arranged in the limiting elements and are stationary relative to the limiting elements. Each breast receptacle is surrounded by a volume coil that is stationary relative to the placement web. The volume coils are arranged centrally and orthogonally relative to the array coils and surround the array coils. The volume coils are decoupled from the array coils. A spectroscopy phantom can be arranged in proximity to the placement web. The breast receptacles as a structural unit can be detached individually or together from the placement web, and volume-reducing inserts can be inserted into the breast receptacles. Lateral supplementary placement elements carrying axilla coils can be provided and may be separately deactivated depending on an input option of a user. | 04-22-2010 |
20100244830 | MAGNETIC RESONANCE METHOD AND DEVICE TO DIFFERENTIATE AMONG PIXELS REPRESENTING A SILICON-DOMINATED SUBSTANCE, WATER-DOMINATED TISSUE AND FAT-DOMINATED TISSUE - In a magnetic resonance method and device for automatic differentiation of respective pixels as representing either a silicon-dominated substance, or fat-dominated tissue, or water-dominated tissue, a first magnetic resonance signal and a second magnetic resonance signal are acquired per pixel, wherein the first magnetic resonance signal per pixel is acquired at a point in time at which the phase of a magnetic resonance signal originating from water-containing tissue exhibits a phase opposite to the phase of a magnetic resonance signal originating from fat-containing tissue, and the second magnetic resonance signal is acquired per pixel at a point in time at which the phase of the magnetic resonance signal originating from water-containing tissue exhibits a phase identical to the phase of the magnetic resonance signal originating from fat-containing tissue, and the phase of a magnetic resonance signal originating from a silicon-containing substance exhibits a phase opposite to the phase of the magnetic resonance signal originating from water-containing or fat-containing tissue. A first intermediate result is determined that indicates whether the pixel represents water-dominated tissue or fat-dominated tissue on the basis of first magnetic resonance signals. A second intermediate result is determined that indicates whether the pixel represents the silicon-dominated substance on the basis of second magnetic resonance signals. The pixel is designated as representing water-dominated tissue, fat-dominated tissue or the silicon-dominated substance on the basis of the first intermediate result and the second intermediate result. | 09-30-2010 |
20110150758 | TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING - At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method. | 06-23-2011 |
20110229414 | Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients - A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method. | 09-22-2011 |
Patent application number | Description | Published |
20100126540 | Tube Lancing Machine - A pair of parallel metal lances is driven by a transversal drive into and out of heat exchanger tubes. The lances are supported by a plurality of spaced apart, retractable door supports so that the transversal drive mechanism can approach the tube sheet of the heat exchanger tubes as closely as possible. A pair of rotational drive motors rotates the lances at a user controllable speed. As the lances are moved into the tubes, the interlocked support doors retract one at a time, sequentially. Similarly, as the lances are withdrawn from the tubes, the support doors close one at a time in an interlocked fashion. | 05-27-2010 |
20120090651 | Tube Lancing Machine - A pair of parallel metal lances is driven by a transversal drive into and out of heat exchanger tubes. The lances are supported by a plurality of spaced apart, retractable door supports so that the transversal drive mechanism can approach the tube sheet of the heat exchanger tubes as closely as possible. A pair of rotational drive motors rotates the lances at a user controllable speed. As the lances are moved into the tubes, the interlocked support doors retract one at a time, sequentially. Similarly, as the lances are withdrawn from the tubes, the support doors close one at a time in an interlocked fashion. | 04-19-2012 |
20150013725 | Tube Lancing Machine - A pair of parallel metal lances is driven by a transversal drive into and out of heat exchanger tubes. The lances are supported by a plurality of spaced apart, retractable door supports so that the transversal drive mechanism can approach the tube sheet of the heat exchanger tubes as closely as possible. A pair of rotational drive motors rotates the lances at a user controllable speed. As the lances are moved into the tubes, the interlocked support doors retract one at a time, sequentially. Similarly, as the lances are withdrawn from the tubes, the support doors close one at a time in an interlocked fashion. | 01-15-2015 |
Patent application number | Description | Published |
20090169547 | MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER - The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder. | 07-02-2009 |
20120164160 | MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER - The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder. | 06-28-2012 |
20120195830 | Monoclonal Antibodies Against Claudin-18 For Treatment of Cancer - The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder. | 08-02-2012 |
20150252103 | MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER - The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder. | 09-10-2015 |
20150252104 | MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER - The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder. | 09-10-2015 |
Patent application number | Description | Published |
20140044546 | BLADED ROTOR FOR A TURBOMACHINE - A bladed rotor for a turbomachine, in particular a gas turbine, having a plurality of blades distributed around the circumference thereof; the blade distribution being made up of a natural-number sector count of first angular sectors and second angular sectors; a first blade count of first blades being arranged in the first angular sectors, and a second blade count of second blades being arranged in the second angular sectors, said second blade count being different from said first blade count; and the sector count being odd (Z=2n+1, n=1, 2, 3, . . . ) and/or greater than two (Z>2). | 02-13-2014 |
20140044553 | BLADE FOR A CONTINUOUS-FLOW MACHINE AND A CONTINUOUS-FLOW MACHINE - A blade for a continuous-flow machine is disclosed, especially an aircraft engine, whereby, starting from the middle section, the cross section of the blade tip is reduced with respect to the middle section, at least over a front partial section in the direction of the leading edge and over at least a rear section in the direction of the trailing edge, and a continuous-flow machine having at least one row of blades including such blades is also disclosed. | 02-13-2014 |
Patent application number | Description | Published |
20100302085 | Field Device Having an Analog Output - A field device having an analog output, i.e., a measuring transducer, for process instrumentation having a 4-20 mA interface as the analog output. For digital-to-analog conversion, a digital value is split into a digital coarse portion and a digital fine portion. Depending on the digital coarse portion, a first analog signal is generated using a pulse width modulator having a downstream mounted low path filter and a signal above the analog output signal, and a second output signal using a pulse width modulator also having a downstream mounted low path filter with a signal below the analog output signal. The analog signals are supplied to a third pulse width modulator controlled with the digital fine portion, where a low-pass filter (TP | 12-02-2010 |
20100305896 | Field Device for Process Instrumentation - A field device for process instrumentation, in particular a measuring transducer, comprising an analogue output to which a two-wire line is connectable for transmitting an analogue output signal. The output circuit contains a controller with an actuator connected downstream for the analogue output signal. A monitoring unit monitors whether an actuating signal remains within a predeterminable value range to monitor the output circuit for correctly setting the loop current. If the actuating signal is outside the value range, an indicator signal is output to a computing unit so that suitable measures can be introduced in response to an error state that has thus been identified. | 12-02-2010 |
20110043189 | Method for the Secure Acquisition of Multiple Analog Input Signals, Analog Input Circuit, and Measuring Sensor and Measuring Transducer Having an Analog Input Circuit of This Type - A method for securely acquiring multiple analog input signals that are converted using a plurality of A/D converters into corresponding digital single measured values. A first measurement averaging cycle having a predetermined total number of measuring intervals is predetermined by a higher-order control unit. First and second input signals are acquired by first and second A/D converters in a first and second number of measuring intervals, the second number being smaller than the first number. The first and second input signals are averaged to form first and second measured values, respectively. The first input signal is acquired by the second A/D converter in a third number of measuring intervals as at least one further single measured value. A message is output if a deviation of the at least one further single measured value from a single measured value of the first input signals measured by the first A/D converter or from the first measured values averaged up to that point exceeds a maximum permissible absolute value of the deviation. | 02-24-2011 |
20120188005 | Field Device for Process Instrumentation - A field device for process instrumentation having an interface for connecting a two-wire cable and for outputting measurement values, wherein the interface comprises a series circuit having a transistor circuit by which the loop current is adjustable as a function of a control signal, a power supply, and a device by which the loop current can be captured as an actual value that is fed by a first feedback coupling to a regulator having integrated behavior. The regulator compares the actual value to a target value, and generates a control signal for the transistor circuit. The actual value is fed by a second feedback coupling to a summation point as a compensation signal for generating an input signal for the transistor circuit as a function of the control signal and the compensation signal to suppress interference coupled into the two-conductor line. | 07-26-2012 |
20150035684 | Field Device for Process Instrumentation - A field device for process instrumentation comprises a measuring and comparison device and a readable storage element. The measuring and comparison device is configured for monitoring an operating characteristic variable for compliance with a predefined range The readable storage element maintains a state. The storage element state is permanently changed if a value held by the operating characteristic variable goes out of said predefined range. The predefined range is determined in such a manner that, as a result of a changed state of the storage element, a loss of suitability of the field device for special operation with an operating characteristic variable with restricted specifications, but not a loss of suitability for normal operation with an operating characteristic variable with less restricted specifications, is indicated. | 02-05-2015 |