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George N.

George N. Eichbauer, Bishop, GA US

Patent application numberDescriptionPublished
20090269566PRE-STRETCHED MULTI-LAYER STRETCH FILM - A multi-layer stretch film includes multiple layers of polyolefins. A multi-layer stretch film may include two or more layers including a cling layer, a non-cling layer, or a core layer. A multi-layer stretch film includes a pre-stretched multi-layer stretch film having two or more layers.10-29-2009
20100129632MULTI-LAYER STRETCH FILM - A multi-layer stretch film having several polyolefin layers.05-27-2010

George N. Foutrakis, Oxford, PA US

Patent application numberDescriptionPublished
20090198219Catheter Assembly - Novel catheter constructions comprising thin covering or wrapping materials such as polymer films. A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. Moreover, polymer film can be used in combination with one or more elements to produce novel catheter constructions.08-06-2009

George N. Glavee, San Ramon, CA US

Patent application numberDescriptionPublished
20110082422Fluid dispenser with non-electric fluid heating component - A novel dispensing system for dispensing medicaments to a patient that includes means for controllably heating fluid medicaments within the dispensing system by converting a chemical component, such as calcium chloride or the like, into a solution or solvent by adding a suitable solution or solvent to create an exothermic process causing an increase in temperature of the mixed solution.04-07-2011
20110082423Non-electric fluid heating component for use with fluid dispenser - A non-electric heater apparatus for controllably heating and cooling fluid medicaments flowing from a medicament dispenser through the fluid delivery member of the apparatus by adding a suitable solution or solvent to a chemical component, such as magnesium chloride, or the like, to create an exothermic process that can be used to heat the fluid delivery member and the fluid flowing there through.04-07-2011

George N. Glavee, Burlingame, CA US

Patent application numberDescriptionPublished
20080243077Fluid dispenser with uniformly collapsible reservoir - A compact, easy-to-use dispensing device that includes a uniquely configured unitary fluid container formed by a blow-fill-seal process. The container has a collapsible, tapered sidewall of progressively varying wall thickness that, upon being acted upon by an elastic member, will deliver an injectable parenteral fluid contained within the fluid reservoir to the patient at a substantially constant flow rate.10-02-2008

George N. Hackleman, Adair Village, OR US

Patent application numberDescriptionPublished
20110056983BAG-IN-BOX CONTAINER INCLUDING A PRE-POSITIONED, SECURED DISPENSING SPOUT - In one embodiment, a bag-in-box container includes a fluid containment bag including a pliable body and a dispensing spout that extends from the body, the spout including a neck and a collar that extends outward from the neck, a carton in which the bag is positioned, the spout of the bag being recessed within an interior space of the carton, and a locking member placed in contact with the neck that secures the spout in a predetermined position within the carton interior space.03-10-2011

George N. Katselis, Redmond, WA US

Patent application numberDescriptionPublished
20120110129WEBSITE REDEVELOPMENT WRAPPER - Existing network-based services can be reused by a new network service providing an updated interface to the existing services. A client request directed to the new network service triggers a back-end request from the new network service to the existing network service. The back-end request comprises aspects of the client's request and additional formatting rules and other information to override specific aspects of the existing network service. The existing network service generates a back-end response with its existing functionality that is being reused, and applies the specified overrides. Additional information to be utilized by the new network service in responding to the client can be added to the back-end response. The new network service can then form and transmit a response to the client by utilizing the central portion of the back-end response and appending additional information to it, including the information specified by the existing network-service.05-03-2012

George N. Kfoury, Carol Stream, IL US

Patent application numberDescriptionPublished
20090117924SYSTEM AND METHOD FOR ADAPTIVE MESSAGE RETRANSMISSION - A method and network controller (05-07-2009

George N. Maracas, Phoenix, AZ US

Patent application numberDescriptionPublished
20080240025SYSTEM AND METHOD FOR CONTROLLING THE TRANSMISSION POWER OF A NODE10-02-2008
20100062178Apparatus and method for fabricating one-dimensional nanostructures on flexible substrates - An apparatus and method are provided for forming one dimensional nanostructures. The method comprises ink jet printing (03-11-2010

Patent applications by George N. Maracas, Phoenix, AZ US

George N. Pavlakis, Rockville, MD US

Patent application numberDescriptionPublished
20090082299CODON OPTIMIZED IL-15 AND IL-15R-ALPHA GENES FOR EXPRESSION IN MAMMALIAN CELLS - The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence comprising a codon optimized IL-15 sequence. The present invention further provides expression vectors, and IL-15 and IL 15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human).03-26-2009
20090137005IL-12 for Expression in Mammalian Cell - The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence.05-28-2009
20090169503DNA-BASED VACCINATION OF RETROVIRAL-INFECTED INDIVIDUALS UNDERGOING TREATMENT - This invention provides DNA vaccines for the treatment of patients undergoing retroviral therapy. The vaccines are surprisingly effective at controlling viremia.07-02-2009
20100285061DNA VACCINATION PROTOCOLS - This invention provides DNA vaccines for the treatment of patients undergoing anti-retroviral therapy. The vaccines are surprisingly effective at controlling viremia.11-11-2010
20110081311COMPLEXES OF IL-15 AND IL-15RALPHA AND USES THEREOF - The present invention relates to agents that modulate interleukin-15 (“IL-15”) signal transduction or function (“Therapeutic Agents”) and the use ol″ those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers, such as poly-β-1-♦4-N-acetylglucosamine. for administration to a human subject to modulate IL-15-mediated immune function.04-07-2011
20110166210IMPROVED EXPRESSION OF IL-12 FAMILY HETERODIMERS - The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio.07-07-2011
20120027792EXPRESSION VECTORS ABLE TO ELICIT IMPROVED IMMUNE RESPONSE AND METHODS OF USING SAME - The invention relates to nucleic acids (such as DNA immunization plasmids), encoding fusion proteins containing a destabilizing amino acid sequence attached to an amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased by the presence of the destabilizing amino acid sequence. The invention also relates to nucleic acids encoding secreted fusion proteins, such as those containing chemokines or cytokines, and an attached amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased as a result of being attached to the secretory sequence. The invention also relates methods of increasing the immunogenicity of the encoded proteins for use as vaccines or in gene therapy.02-02-2012

Patent applications by George N. Pavlakis, Rockville, MD US

George N. Peroulakis, West Suffield, CT US

Patent application numberDescriptionPublished
20090053041GAS TURBINE ENGINE CASE FOR CLEARANCE CONTROL - A gas turbine engine includes an active clearance control (ACC) system within the engine casing. The case includes a wall structure with a cast-in cooling configuration through Refractory Metal Core technology which is tailored to address traditional hot spots and improve discrete control of case growth.02-26-2009

George N. Philllips, Jr., Madison, WI US

Patent application numberDescriptionPublished
20120009173CYTOTOXIC RIBONUCLEASE VARIANTS - This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.01-12-2012

George N. Popa, Iii, Poway, CA US

Patent application numberDescriptionPublished
20110221187INKJET REFILLING STATION - Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.09-15-2011

George N. Serbedzija US

Patent application numberDescriptionPublished
20110219463METHODS OF SCREENING AGENTS FOR ACTIVITY USING TELEOSTS - The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity in teleosts are provided. Methods of screening an agent for an activity in the brain or central nervous system in zebrafish are provided. The invention further provides high throughput methods of screening agents in multi-well plates.09-08-2011

George N. Serbedzija, Woburn, MA US

Patent application numberDescriptionPublished
20110286973METHODS FOR INTRODUCING HETEROLOGOUS CELLS INTO FISH - The invention provides methods of introducing heterologous cells into fish. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are useful for screening potential drugs for toxicity toward introduced cells or for capacity to stimulate differentiation and/or proliferation of introduced cells. Such methods are also useful for diagnosing the presence of small quantities of cancerous cells or pathogens in patient tissue samples. Such methods are also useful for culturing cells for subsequent use in cell or tissue engineering.11-24-2011