Patent application number | Description | Published |
20110308945 | GENETIC ANALYSIS LOC DEVICE WITH THICK ELECTRODES FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the photosensor has a planar active surface area for receiving the light from the ECL luminophore and the electrodes are between 0.25 micron and 2 microns thick in a direction normal to the planar active surface area of the photodiodes. | 12-22-2011 |
20110312070 | MICROFLUIDIC DEVICE WITH PCR CHAMBER FOR HIGH RATE OF TEMPERATURE CHANGE - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein during use, the heater element heats the nucleic acid sequences at a rate more than 80 K per second. | 12-22-2011 |
20110312075 | LOC DEVICE WITH PARALLEL INCUBATION AND PARALLEL DNA AND RNA AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first incubation section, the first incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a second incubation section, the second incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material in parallel with the first incubation section, a first nucleic acid amplification section downstream of the first incubation section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section downstream of the second incubation section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section, wherein, the first incubation section, the second incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312078 | MICROFLUIDIC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES IN MITOCHONDRIAL DNA - A microfluidic device for detecting mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 12-22-2011 |
20110312545 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, CHEMICAL LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312546 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH CHEMICAL LYSIS, INCUBATION AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a lysis section for lysing pathogens and leukocytes in the sample to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the pathogens and leukocytes in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a first nucleic acid amplification section downstream of the incubation section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the lysis section, the incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312550 | LOC DEVICE FOR GENETIC ANALYSIS WHICH PERFORMS NUCLEIC ACID AMPLIFICATION AFTER SAMPLE PREPARATION IN A DIALYSIS SECTION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating small constituents from larger constituents in the sample, a plurality of reagent reservoirs, a nucleic acid amplification section downstream of the dialysis section for amplifying nucleic acid sequences in the sample, wherein, the dialysis section and the nucleic acid amplification section are both supported on the supporting substrate. | 12-22-2011 |
20110312551 | LOC DEVICE FOR GENETIC ANALYSIS WHICH PERFORMS NUCLEIC ACID AMPLIFICATION BEFORE REMOVING NON-NUCLEIC ACID CONSTITUENTS IN A DIALYSIS SECTION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the sample, and, a dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the dialysis section being configured to remove cell debris from the amplicon, wherein, the nucleic acid amplification section and the dialysis section are both supported on the supporting substrate. | 12-22-2011 |
20110312557 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, LYSIS AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a first portion of the sample flow from the lysis section, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a second portion of the sample flow from the lysis section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312558 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312559 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a first portion of the sample flow from the lysis section, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a second portion of the sample flow from the lysis section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312560 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312562 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, CHEMICAL LYSIS AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a first portion of the sample flow from the lysis section, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in a second portion of the sample flow from the lysis section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312564 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312566 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a first nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312568 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a first nucleic acid amplification section downstream of the incubation section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312569 | MICROFLUIDIC DEVICE WITH SMALL CROSS SECTIONAL AREA MICROCHANNEL - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling the sample to amplify the nucleic acid sequences, the PCR microchannel defining a flow-path for the sample such that flow of the sample along the PCR microchannel is driven by capillary action, and, the PCR microchannel has a cross sectional area transverse to the flow less than 100,000 square microns. | 12-22-2011 |
20110312571 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312572 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH CHEMICAL LYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a lysis section for lysing pathogens and leukocytes in the sample to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the pathogens and leukocytes in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312573 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH CHEMICAL LYSIS, INCUBATION AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a lysis section for lysing pathogens and leukocytes in the sample to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the pathogens and leukocytes in the lysis section, an incubation section downstream of the lysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a first nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material in a first portion of the sample flow from the incubation section, and, a second nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material in a second portion of the sample flow from the incubation section, wherein, the lysis section, the incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312574 | LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND PARALLEL NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, using a leukocyte dialysis section for separating out a leukocyte stream, a pathogen dialysis section for separating out a pathogen stream. A leukocyte lysis section lyses the leukocytes and a leukocyte incubation section allows enzymatic reaction of the genetic material with enzymes. A pathogen lysis section lyses the pathogens and, a pathogen incubation section allows enzymatic reaction of the genetic material with enzymes. An erythrocyte lysis section lyses the erythrocytes. First and second leukocyte nucleic acid amplification sections amplify nucleic acid sequences in parallel. First and second pathogen nucleic acid amplification sections amplify nucleic acid sequences in parallel. | 12-22-2011 |
20110312575 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING A NICKING ENZYME AND A DNA POLYMERASE - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, nicking enzymes, buffer solution and DNA polymerase for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences. | 12-22-2011 |
20110312576 | GENETIC ANALYSIS LOC DEVICE FOR MULTI-STAGE AMPLIFICATION OF NUCLEIC ACID SEQUENCES - A lab-on-a-chip (LOC) device for genetic analysis of nucleic acid sequences in a sample, the LOC device having a sample inlet for receiving the sample, a first polymerase chain reaction (PCR) section for thermal cycling a first PCR mixture of dNTP's, primers, and buffer solution together with the sample and polymerase, to amplify the nucleic acid sequences, and, a second PCR section downstream of the first PCR section for thermally cycling a second PCR mixture of dNTPs, primers, and buffer solution together with polymerase, and at least some of the amplicon from the first PCR section. | 12-22-2011 |
20110312578 | GENETIC ANALYSIS LOC FOR NON-SPECIFIC NUCLEIC ACID AMPLIFICATION PRIOR TO SPECIFIC AMPLIFICATION OF PARTICULAR SEQUENCES - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTP's, primers, polymerase and buffer solution for addition to the sample, and, a nucleic acid amplification section for thermal control of the sample to perform a first stage amplification of the target nucleic acid sequences and subsequent thermal control of amplicon from the first stage amplification, to perform a second stage amplification for further amplifying the target nucleic acid sequences. | 12-22-2011 |
20110312579 | LOC DEVICE WITH PARALLEL INCUBATION AND PARALLEL NUCLEIC ACID AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, a first incubation section, the first incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a second incubation section, the second incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material in parallel with the first incubation section, a first nucleic acid amplification section downstream of the first incubation section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the second incubation section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the first incubation section, the second incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312580 | LOC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION AND THERMAL INSULATION TRENCH - A lab-on-a-chip (LOC) device for amplifying nucleic acid sequences in a sample, the LOC device having a supporting substrate, a plurality of functional sections for processing the sample, one of the functional sections being a nucleic acid amplification section for amplifying nucleic acid sequences in the sample, wherein, the nucleic acid amplification section is supported on the supporting substrate and the supporting substrate defines a trench for thermally insulating the nucleic acid amplification section from one or more of the other functional sections. | 12-22-2011 |
20110312581 | MICROFLUIDIC DEVICE WITH NUCLEIC ACID AMPLIFICATION CHAMBER HEATER BONDED TO CHAMBER INTERIOR - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, and, a nucleic acid amplification section for amplifying the nucleic acid sequences, the nucleic acid amplification section having an amplification chamber and a heater element, wherein, the heater element is bonded to an interior surface of the amplification chamber. | 12-22-2011 |
20110312582 | TEST MODULE WITH NUCLEIC ACID AMPLIFICATION SECTION - A test module for amplifying nucleic acid sequences, the test module having an outer casing with receptacle for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material. | 12-22-2011 |
20110312583 | TEST MODULE WITH PARALLEL NUCLEIC ACID AMPLIFICATION SECTIONS - A test module for amplifying nucleic acid sequences, the test module having an outer casing with receptacle for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312585 | MICROFLUIDIC DEVICE WITH PARALLEL DNA AND RNA AMPLIFICATION SECTION - A microfluidic device for amplifying DNA and RNA, the microfluidic device having an inlet for receiving a sample containing genetic material including DNA and RNA, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312586 | MICROFLUIDIC DEVICE FOR CHEMICALLY AND THERMALLY LYSING CELLS - A microfluidic device for lysing cells in a fluid, the microfluidic device having a supporting substrate, an inlet for receiving fluid containing cells, a lysis section in fluid communication with the inlet, the lysis section having at least one heater for heating the fluid, a reservoir containing a lysis reagent, and, CMOS circuitry between the supporting substrate and the lysis section, the CMOS circuitry being configured for selectively lysing the cells using thermal lysis in the lysis section, chemically lysing the cells using the lysis reagent, or both chemically and thermally lysing the cells using the lysis section and the lysis reagent. | 12-22-2011 |
20110312588 | LOC DEVICE WITH ON-CHIP SEMICONDUCTOR CONTROLLED INCUBATION SECTION - A lab-on-a-chip (LOC) device having a supporting substrate, a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater, and, CMOS circuitry between the supporting substrate and the incubation section, wherein, the CMOS circuitry is connected to the at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period. | 12-22-2011 |
20110312590 | MICROFLUIDIC DEVICE WITH ELONGATE INCUBATION CHAMBER - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section having an elongate incubation chamber with a longitudinal extent much greater than the lateral dimensions, and at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period, wherein, the at least one heater is also elongated with a lateral extent parallel to that of the elongate incubation chamber. | 12-22-2011 |
20110312592 | MICROFLUIDIC DEVICE WITH INCUBATION CHAMBER BETWEEN SUPPORTING SUBSTRATE AND HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a fluid sample, an incubation section having an incubation chamber, and at least one heater for maintaining the fluid sample at an incubation temperature for a period, wherein, the incubation chamber is between the at least one heater element and the supporting substrate. | 12-22-2011 |
20110312593 | MICROFLUIDIC DEVICE WITH INCUBATOR HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX - A microfluidic device having an inlet for receiving a fluid, an incubation section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a plurality of elongate heaters positioned end to end along each of the channel sections, wherein, each of the heaters are independently operable for two-dimensional control of heat flux density to the incubation section. | 12-22-2011 |
20110312599 | MICROFLUIDIC DEVICE WITH A PCR SECTION WITH SINGLE ACTIVATION, OUTLET VALVE - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having a polymerase chain reaction (PCR) section for thermally cycling the nucleic acid sequences and a PCR mix of reagents through a denaturation temperature, an annealing temperature and a primer extension temperature, and, a PCR outlet valve to retain the nucleic acid sequences and a PCR mix of reagents in the PCR section during the thermal cycling, wherein, the PCR outlet valve is configured to open in response to an activation signal such that amplicon can flow from the PCR section and once open, the PCR outlet valve is unable to close. | 12-22-2011 |
20110312612 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH PROBES BETWEEN A WORKING ELECTRODE AND A PHOTOSENSOR - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being positioned such that the probes are between the photosensor and the working electrode. | 12-22-2011 |
20110312615 | MICROFLUIDIC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312616 | TEST MODULE WITH PARALLEL DNA AND RNA AMPLIFICATION SECTIONS - A test module for amplifying DNA and RNA, the test module having an outer casing with receptacle for receiving a sample containing genetic material including DNA and RNA, a plurality of reagent reservoirs containing reagents for addition to the sample, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section. | 12-22-2011 |
20110312623 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a first dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, and, a second dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the second dialysis section being configured to remove cell debris from the amplicon, wherein, the first dialysis section, the lysis section, the nucleic acid amplification section and the second dialysis section are all supported on the supporting substrate. | 12-22-2011 |
20110312625 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, a first nucleic acid amplification section downstream of the lysis section for amplifying first nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section downstream of the first nucleic acid amplification section for amplifying second nucleic acid sequences in the amplicon from the first nucleic acid amplification section, wherein, the dialysis section, the lysis section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312630 | LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND TANDEM NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, a first leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a second leukocyte nucleic acid amplification section downstream of the first leukocyte nucleic acid amplification section for amplifying nucleic acid sequences, a first pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, and, a second pathogen nucleic acid amplification section downstream of the first pathogen nucleic acid amplification for amplifying nucleic acid sequences, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the leukocyte incubation section, the pathogen incubation section, the first and second leukocyte nucleic acid amplification sections and the first and second pathogen nucleic acid amplification sections are all supported on the supporting substrate. | 12-22-2011 |
20110312631 | GENETIC ANALYSIS LOC WITH NON-SPECIFIC NUCLEIC ACID AMPLIFICATION SECTION AND SUBSEQUENT SPECIFIC AMPLIFICATION OF PARTICULAR SEQUENCES IN A SEPARATE SECTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTP's, primers, polymerase and buffer solution for addition to the sample, a first nucleic acid amplification section for thermal control of the sample to amplify the target nucleic acid sequences, and, a second nucleic acid amplification section for thermal control of amplicon from the first nucleic acid amplification section to further amplify the target nucleic acid sequences. | 12-22-2011 |
20110312632 | MICROFLUIDIC DEVICE WITH PCR SECTION AND DIFFUSION MIXER - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, a reagent reservoir containing a reagent, and, a diffusion mixing section for mixing the nucleic acid sequences with the reagent, the diffusion mixing section having a microchannel defining a tortuous flow-path having a length sufficient for diffusive mixing of the reagent and the sample, wherein during use, the sample flows from the sample inlet to the PCR section via the diffusion mixing section. | 12-22-2011 |
20110312638 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating pathogens and cells larger than a predetermined threshold in the sample from smaller constituents, whereby the pathogens and cells larger than the predetermined threshold contain genetic material for analysis, a nucleic acid amplification section downstream of the dialysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312655 | MICROFLUIDIC DEVICE FOR PCR, PROBE HYBRIDIZATION AND ELECTROCHEMILUMINESCENT DETECTION OF PROBE-TARGET HYBRIDS - A microfluidic device for amplifying and detecting target nucleic acid sequences in a sample, the microfluidic device having a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and, a hybridization section that has an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and a plurality of electrodes for receiving an electrical pulse such that the probe-target hybrids emit a photon of light. | 12-22-2011 |
20110312656 | MICROFLUIDIC DEVICE FOR PCR AND PROBE HYBRIDIZATION - A microfluidic device having a sample inlet for receiving a sample of biological material containing target nucleic acid sequences, and, a microsystems technologies (MST) layer with a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, and an array of probes for hybridization with the target nucleic acid sequences. | 12-22-2011 |
20110312658 | LOC DEVICE WITH DIALYSIS SECTION FOR CONCENTRATING NUCLEATED CELLS IN A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for concentrating nucleated cells in a biological sample, the LOC device having an inlet for receiving a sample of biological material including nucleated cells and other constituents, the nucleated cells all being larger than a predetermined threshold, a dialysis section for concentrating the nucleated cells into a portion of the sample such that the remainder of the sample contains the other constituents smaller than the predetermined threshold, and, a microsystems technology (MST) layer for processing the nucleated cells. | 12-22-2011 |
20110312662 | LOC DEVICE WITH DIALYSIS SECTION FOR REMOVING CELL DEBRIS FROM A BIOLOGICAL SAMPLE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target molecules, the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for reaction with the target molecules to form probe-target complexes, wherein, the apertures are sized to allow the target molecules to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 12-22-2011 |
20110312665 | LOC WITH DIALYSIS SECTION FOR REMOVING INSOLUBLE SAMPLE CONSTITUENTS FROM A NUCLEIC ACID MIXTURE - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel having an upstream end for receiving the biological sample, the biological sample being a liquid carrying a mixture of cell debris and target nucleic acid sequences, and the small constituent channel having a downstream end for connection to a hybridization section with an array of probes for hybridization with the target nucleic acid sequences to form probe-target complexes, wherein, the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel but retain the cell debris larger than a threshold size in the large constituent channel. | 12-22-2011 |
20110312668 | LOC WITH DIALYSIS SECTION FOR RETAINING INSOLUBLE SAMPLE CONSTITUENTS AFTER AMPLIFICATION AND PASSING SOLUBLE CONSTITUENTS TO A DETECTION SECTION - A lab-on-a-chip (LOC) device for removing cell debris from a biological sample containing target nucleic acid sequences, the LOC device having an amplification section for amplifying the nucleic acid sequences, a dialysis section with a large constituent channel, a small constituent channel and a plurality of apertures for fluid communication between the large constituent channel and the small constituent channel, the large constituent channel configured to receive the biological sample after nucleic acid amplification in the amplification section, the biological sample being a liquid mixture of the cell debris and the target nucleic acid sequences and the apertures are sized to allow the target nucleic acid sequences to flow into the small constituent channel while the cell debris larger than a threshold size is retained in the large constituent channel, and, an array of probes in fluid communication with the small constituent channel for hybridization with the target nucleic acid sequences to form probe-target hybrids. | 12-22-2011 |
20110312684 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312686 | MICROFLUIDIC DEVICE WITH ELONGATE PCR CHAMBERS - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one elongate PCR chamber having a longitudinal extent much greater than its lateral dimensions, and, at least one elongate heater element for heating the nucleic acid sequences within the elongate PCR chamber, wherein, the elongate heater element extends parallel with the longitudinal extent of the PCR chamber. | 12-22-2011 |
20110312688 | MICROFLUIDIC DEVICE WITH PCR CHAMBER BETWEEN SUPPORTING SUBSTRATE AND HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein, the PCR chamber is between the heater element and the supporting substrate. | 12-22-2011 |
20110312690 | MICROFLUIDIC DEVICE WITH PCR SECTION HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX DENSITY - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a plurality of elongate heaters positioned end to end along each of the channel sections, wherein, each of the heaters are independently operable for two-dimensional control of heat flux density to the PCR section. | 12-22-2011 |
20110312692 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section having a lysis chamber and a heater for lysing the pathogens while the sample is in the lysis chamber, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312693 | MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater. | 12-22-2011 |
20110312696 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating pathogens from larger constituents in the sample, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the pathogens to release genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312697 | MICROFLUIDIC DEVICE WITH TEMPERATURE FEEDBACK CONTROLLED PCR SECTION - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater, and, at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater. | 12-22-2011 |
20110312698 | MICROFLUIDIC DEVICE WITH PCR SECTION HAVING SHORT THERMAL CYCLE TIMES - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, wherein during use, the PCR section has a thermal cycle time of less than 30 seconds. | 12-22-2011 |
20110312699 | MICROFLUIDIC DEVICE WITH ON-CHIP SEMICONDUCTOR CONTROLLED PCR SECTION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturation phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater during the thermal cycling. | 12-22-2011 |
20110312700 | MICROFLUIDIC DEVICE WITH PWM CONTROLLED PCR HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturing phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry configured to energize the at least one heater with a pulse width modulated (PWM) signal during the thermal cycling. | 12-22-2011 |
20110312702 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312703 | MICROFLUIDIC DEVICE FOR RAPID PCR AMPLIFICATION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein during use, the PCR section generates sufficient amplicon for hybridization with an array of probes in less than 10 minutes. | 12-22-2011 |
20110312704 | MICROFLUIDIC DEVICE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample, polymerase, dNTP's and buffer solution to amplify the nucleic acid sequences, the PCR microchannel defining a flow-path for the sample such that flow of the sample along the PCR microchannel is driven by capillary action, wherein, the PCR mixture has a volume less than 400 nanoliters. | 12-22-2011 |
20110312705 | TEST MODULE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A test module for amplifying nucleic acid sequences in a sample fluid, the test module having an outer casing with receptacle for receiving the sample fluid, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample fluid, polymerase, dNTP's, primers, and buffer solution to amplify the nucleic acid sequences, wherein, the PCR mixture has a volume less than 400 nanoliters. | 12-22-2011 |
20110312707 | GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample, and, a polymerase chain reaction (PCR) section for thermal cycling the sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences. | 12-22-2011 |
20110312708 | GENETIC ANALYSIS LOC FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample to form an amplification mix, and, a nucleic acid amplification section for controlling the temperature of the amplification mix during isothermal amplification of the target nucleic acid sequences. | 12-22-2011 |
20110312710 | LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the erythrocyte lysis section, the leukocyte incubation section, the pathogen incubation section, the leukocyte nucleic acid amplification section and the pathogen nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312712 | GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS FROM WHOLE BLOOD - A lab-on-a-chip (LOC) device for genetic analysis of a whole blood sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the whole blood sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the whole blood sample, and, a polymerase chain reaction (PCR) section for thermal cycling the whole blood sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences. | 12-22-2011 |
20110312714 | GENETIC ANALYSIS LOC FOR AMPLIFICATION OF NUCLEIC ACIDS USING DNA POLYMERASES OF THERMOPHILES - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase derived from a thermophilic bacterium for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for controlling the temperature of the amplification mixture during amplification of the target nucleic acid sequences. | 12-22-2011 |
20110312716 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING AN ISOTHERMAL REACTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer solution, dNTPs, primers, and polymerase for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences. | 12-22-2011 |
20110312717 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a pathogen dialysis section for separating pathogens from constituents smaller than a predetermined threshold, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material therein, an incubation section downstream of the pathogen dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the pathogen dialysis section, the pathogen lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312718 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING RECOMBINASE POLYMERASE AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, recombinase, DNA polymerase and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during recombinase polymerase amplification (RPA) of the target nucleic acid sequences. | 12-22-2011 |
20110312720 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating smaller constituents from larger constituents, the smaller constituents being smaller than a predetermined size threshold, and the larger constituents being larger than the predetermined size threshold, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section and the nucleic acid amplification section are both supported on the supporting substrate. | 12-22-2011 |
20110312721 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, INCUBATION, AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, an incubation section downstream of the dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 12-22-2011 |
20110312723 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING NUCLEIC ACID SEQUENCE BASED AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, reverse transcriptase, RNA polymerase, and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences. | 12-22-2011 |
20110312724 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH INCUBATION, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, an incubation section downstream of the inlet, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material, and, a dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the dialysis section being configured to remove cell debris from the amplicon, wherein, the incubation section, the nucleic acid amplification section and the dialysis section are all supported on the supporting substrate. | 12-22-2011 |
20110312727 | LOC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate. | 12-22-2011 |
20110312730 | LOC DEVICE WITH PARALLEL DNA AND RNA AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate. | 12-22-2011 |
20110312733 | LOC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A lab-on-a-chip (LOC) device for amplifying nucleic acid sequences, the LOC device having an inlet for receiving a sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the nucleic acid amplification section is supported on the supporting substrate. | 12-22-2011 |
20110312735 | MICROFLUIDIC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material. | 12-22-2011 |
20110312739 | SINGLE-USE TEST MODULE FOR PCR AMPLIFICATION OF TARGETS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for amplifying and detecting target nucleic acid sequences in a fluid, the test module having an outer casing with a receptacle for receiving a fluid containing the target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, electrodes positioned for receiving an electrical pulse, the probe-target hybrids being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes. | 12-22-2011 |
20110312741 | MICROFLUIDIC DEVICE FOR ANALYSIS OF MITOCHONDRIAL DNA - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids. | 12-22-2011 |
20110312744 | MICROFLUIDIC DEVICE FOR AMPLIFYING MITOCHONDRIAL DNA IN A BIOLOGICAL SAMPLE - A microfluidic device for amplifying mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, a nucleic acid amplification section configured for amplifying target nucleic acid sequences in the mitochondrial DNA. | 12-22-2011 |
20110312746 | MICROFLUIDIC DEVICE WITH CHEMICAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the inlet for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 12-22-2011 |
20110312749 | MICROFLUIDIC DEVICE WITH THERMAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet channel for receiving a fluid containing cells, a lysis section in fluid communication with the inlet channel for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section such that the cells lyse, wherein, the inlet channel is configured for filling the lysis section by capillary action. | 12-22-2011 |
20110312751 | MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA FLUORESCENCE MODULATED BY HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, fluorescence resonance energy transfer (FRET) probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 12-22-2011 |
20110312754 | MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA ELECTROCHEMILUMINESCENCE MODULATED HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, electrochemiluminescent (ECL) resonance energy transfer probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 12-22-2011 |
20110312755 | TEST MODULE WITH CHEMICAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 12-22-2011 |
20110312758 | TEST MODULE WITH THERMAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a sample that is a fluid containing cells, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section to lyse cells, wherein, the test module is configured for drawing the fluid from the receptacle to the lysis section by capillary action. | 12-22-2011 |
20110312761 | TEST MODULE FOR CHEMICALLY AND THERMALLY LYSING CELLS - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having a valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, the lysis section having a lysis heater for heating the fluid in the lysis section, wherein, the valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 12-22-2011 |
20110312764 | MICROFLUIDIC DEVICE WITH INCUBATOR - A microfluidic device having a supporting substrate, an inlet for receiving a fluid, a microsystems technology (MST) layer for processing the fluid, the MST layer incorporating an incubation section, the incubation section having at least one heater for maintaining the fluid at a predetermined incubation temperature, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater. | 12-22-2011 |
20110312766 | MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater. | 12-22-2011 |
20110312767 | MICROFLUIDIC DEVICE WITH INCUBATION SECTION HAVING TEMPERATURE FEEDBACK - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater and at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater. | 12-22-2011 |
20110312771 | MICROFLUIDIC DEVICE WITH PWM CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period, and, CMOS circuitry to energize the at least one heater with a pulse width modulated (PWM) signal. | 12-22-2011 |
20110312811 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH ELECTRODES PROFILED FOR GREATER PERIPHERAL EDGE LENGTH - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having edge profiles configured such that the length of peripheral edge of each of the plates is greater than 128 microns. | 12-22-2011 |
20110312813 | SINGLE-USE GENETIC TEST MODULE - A single-use test module for detecting hybridization of probes with nucleic acid sequences, the test module having a sample input for receiving a biological sample with target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences in the biological sample, an array of probes for hybridization with target nucleic acid sequences in the biological sample, and, circuitry having a photosensor for sensing hybridization between the probes and target nucleic acid sequences in the biological sample, wherein, the circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized. | 12-22-2011 |
20110312819 | LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENCE OF A LUMINOPHORE IN THE PRESENCE OF AN ELECTROCHEMICAL COREACTANT - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an electrochemical coreactant that is present with the luminophore during electrochemiluminescence. | 12-22-2011 |
20110312822 | GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 12-22-2011 |
20110312825 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION WITH ELECTRODE PAIRS HAVING COMPLEMENTARY AND MUTUALLY INTERDIGITATED FINGER FORMATIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes have an anode and a cathode, each having fingers configured for mutual interdigitation. | 12-22-2011 |
20110312827 | GENETIC ANALYSIS LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT LUMINOPHORE AND FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 12-22-2011 |
20110312828 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING ELECTRODE PAIRS OPTICALLY COUPLED TO PHOTODIODE - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrode pairs in which one electrode in each of the electrode pairs is a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, and, photodiodes corresponding to each of the electrode pairs respectively, wherein, the photodiodes have a planar active surface area for receiving the light from the luminophore, and the working electrode has a surface area optically coupled to the active surface area of the photodiode, the working electrode being configured such that the optically coupled surface area is greater than 50% of the active surface area of the photodiode. | 12-22-2011 |
20110312829 | LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light. | 12-22-2011 |
20110312830 | GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES HAVING A FUNCTIONAL MOIETY FOR QUENCHING PHOTON EMISSIONS CONFIGURED TO CHANGE PROXIMITY TO A LUMINOPHORE UPON FORMING A PROBE-TARGET HYBRID - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, an electrochemiluminescent (ECL) luminophore, and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein during use, the functional moiety changes proximity to the luminophore upon formation of a probe-target hybrid. | 12-22-2011 |
20110312831 | LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCE WITH ELECTROCHEMILUMINESCENT METALORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) metalorganic complex, and, electrodes for generating an excited state in the metalorganic complex in which the metalorganic complex emits photons of light, and, CMOS circuitry between the supporting substrate and the probes for applying a voltage across the electrodes. | 12-22-2011 |
20110312832 | LOC DEVICE FOR DETECTION OF TARGET SEQUENCES WITH ELECTROCHEMILUMINESCENT PROBES IN HYBRIDIZATION CHAMBERS - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, an array of hybridization chambers, each of the hybridization chambers having a pair of the electrodes respectively and containing a plurality of the probes, the nucleic acid sequence in the probes in each of the hybridization chambers being different to the nucleic acid sequence in at least one other hybridization chamber in the array such that a plurality of target nucleic acid sequences are detectable. | 12-22-2011 |
20110312833 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES USING TRANSPARENT ELECTRODES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, and, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, wherein, the electrodes are arranged in pairs, one of the electrodes in each electrode pair being a working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits a photon, the working electrode being transparent to light at the wavelength of the photons emitted by the ECL luminophores. | 12-22-2011 |
20110312834 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING A RUTHENIUM ORGANIC COMPLEX - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and a ruthenium organic complex, electrodes for generating an excited state in the ruthenium organic complex in which the ruthenium organic complex emits photons of light, and, CMOS circuitry for applying a voltage across the electrodes. | 12-22-2011 |
20110312835 | GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore. | 12-22-2011 |
20110312837 | LOC DEVICE FOR GENETIC ANALYSIS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes are plates of conductive material, the plates having peripheral edges optically coupled to the photosensor. | 12-22-2011 |
20110312839 | GENETIC ANALYSIS LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES WITH WORKING ELECTRODE IN CONTACT WITH PHOTOSENSOR - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the electrodes have at least one working electrode which causes oxidation or reduction of the luminophore to generate an excited species that emits the photons, the working electrode being positioned immediately adjacent the photosensor. | 12-22-2011 |