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Gennaro
Gennaro Amelio, Napoli IT
| Patent application number | Description | Published |
|---|---|---|
| 20090125995 | Method and System For Accounting Access by Users to Data Networks, Related Computer Program Product - A system for the time-based accounting of access by users to services provided by a data network includes a primary access node to provide access by users by establishing via the primary access node a steady connectivity between the users and the network. A secondary access node is associated with the primary access node, such secondary access node being configured for acting as a backup node to maintain connectivity in the case of failure involving the primary access node. The primary access node is configured for issuing a request for credentials for any user requesting access to said data network and, as a result of receiving valid credentials from the user, starts time-based accounting for the user. An authentication node cooperative with the primary access node and the secondary access node stores the secondary access node information items concerning the time-based accounting started for the user. The time-based accounting is thus maintained in the case of failure involving the primary access node as connectivity is maintained by the secondary access node. | 05-14-2009 |
Gennaro Calabritto, Milanese-Milano IT
| Patent application number | Description | Published |
|---|---|---|
| 20080202734 | Heat Exchanger - A heat exchanger for cooling a high temperature gas leaving a reaction unit/device, including a coupling element to the reaction unit/device, a gas transportation and cooling pipe, and a covering shell. | 08-28-2008 |
Gennaro Ciliberto, Rome IT
| Patent application number | Description | Published |
|---|---|---|
| 20110182926 | MINIGENE - The present invention provides minigenes suitable as a prophylactic or therapeutic vaccine against conditions such as cancer, infectious diseases or autoimmune diseases, and pharmaceutical compositions comprising the minigene. The minigenes of the present invention comprise (a) a human tissue plasminogen signal peptide; (b) at least one T-cell epitope; and (c) an | 07-28-2011 |
Gennaro Ciliberto, Roma IT
| Patent application number | Description | Published |
|---|---|---|
| 20080311137 | Carcinoembryonic Antigen Fusions and Uses Thereof - Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins are provided, the CEA fusion proteins comprising a CEA protein, or functional variant thereof, fused to a substantial portion of an immunoenhancing element. The polynucleotides of the present invention can elicit an immune response in a mammal, which, in preferred embodiments, is stronger than the immune response elicited by a wild-type CEA. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying polynucleotides encoding CEA fusion proteins and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer. | 12-18-2008 |
| 20090155298 | Matrix Metalloproteinase 11 Vaccine - Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid en->coding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. | 06-18-2009 |
Gennaro Citro, Rome IT
| Patent application number | Description | Published |
|---|---|---|
| 20080317771 | Anti-Clusterin Oligoclonal Antibodies for Diagnosis and Prediction of the Aggressiveness of Tumours, Diagnostic Method and Related Kits - The invention concerns anti-clusterin oligoclonal antibodies able to recognize and bind in a selective and specific way antigenic epitopes of clusterin isoforms to be used in tumours diagnosis and in the prediction of their malignancy grade, diagnostic method and related kits. | 12-25-2008 |
Gennaro Citro, Roma IT
| Patent application number | Description | Published |
|---|---|---|
| 20090181418 | PEPTIDE ABLE TO BREAK THE M-P53/P63, M-P53/P73 AND M-P53/RESPECTIVE ISOFORM PROTEINS COMPLEX FORMED IN THE TUMOR CELLS AND USES THEREOF IN THE PHARMACOLOGICAL FIELD - The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors. | 07-16-2009 |
Gennaro De Libero, Bottmingen CH
| Patent application number | Description | Published |
|---|---|---|
| 20100255015 | PHARMACEUTICALS COMPOSITIONS COMPRISING ACTINOMYCETE GLYCEROL ACYL DERIVATIVES ANTIGENS, THEIR PROCESS OF EXTRACTION, AND THEIR USE AGAINST TUBERCULOSIS - The present invention relates to the therapeutic use of actinomycete glycerol monomycolate derivatives as antigens, their process of extraction, and their use in the treatment or the prophylaxis of tuberculosis. | 10-07-2010 |
Gennaro De Libero, Bale CH
| Patent application number | Description | Published |
|---|---|---|
| 20100166801 | SULFOGLYCOLIPID ANTIGENS, THEIR PROCESS OF PREPARATION, AND THEIR USE AGAINST TUBERCULOSIS - The present invention relates to compounds of the following general formula (I) their process of preparation and their use in the treatment or the prophylaxis of tuberculosis. | 07-01-2010 |
Gennaro Melino, Leicester GB
| Patent application number | Description | Published |
|---|---|---|
| 20090306187 | Modulators of Itch Ubiquitinase Activity - The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including cancer treatment and modulation of skin differentiation. | 12-10-2009 |
Gennaro Venoso, Pozzuoli IT
| Patent application number | Description | Published |
|---|---|---|
| 20110178722 | Method and apparatus for detection of the remote origin fraction of radon present in a measuring site - A method and an apparatus for detecting the remote origin fraction of | 07-21-2011 |