Patent application number | Description | Published |
20090208923 | System and method for diagnosing diseases - One aspect of the invention provides a method of diagnosing a disease condition, comprising measuring presence or amount of a targeted protein or a degradation product of said protein in a collected biological sample as a marker for the disease condition. The targeted protein or degradation product is selected for measurement based on a prior identification of a measurable half-life at a predetermined time period, including the time at which said method is conducted, and correlating said measuring with the presence or absence of the disease condition. The targeted protein or degradation product may be identified by selecting a protein known or suspected to be a diagnostic marker for the disease condition, analyzing degradation of the protein in the collected biological sample, and selecting a protein or degradation product that exhibits a measurable half-life at a predetermined period of time. The analyzing may include identifying degradation product(s) of the protein as a function of time, and half-life of the protein and the degradation product(s). | 08-20-2009 |
20110311416 | Container Assembly and System for Detection Thereof - A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light. | 12-22-2011 |
20120149004 | BLOOD COLLECTION DEVICES CONTAINING BLOOD STABILIZATION AGENT - Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also provided. | 06-14-2012 |
20130177486 | Label Having an Activatable Bar Code - A label including a label body having an upper surface and a bottom surface and a light-transmissive portion and an opaque portion is disclosed. The label includes an adhesive disposed on at least a portion of the bottom surface for affixing the label body to a portion of a container. An excitation-activatable material arranged to contain machine readable information is disposed on at least a portion of the upper surface of the light-transmissive portion of the label body. The machine readable information is undetected by a detector in ambient light, and detectable by the detector upon application of an excitation wavelength to the excitation-activatable material. | 07-11-2013 |
20140206030 | Dual Barcode Labeling Facilitating Automated Decapping - A specimen collection assembly and method for detecting the same are disclosed. The specimen collection assembly includes a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior adapted to receive a biological specimen. The specimen collection container also includes first indicia containing information. The assembly further includes a cap having thereon second indicia, the cap being removably engagable with the open top end of the container. The second indicia contains the same information as the first indicia. | 07-24-2014 |
20140213934 | Specimen Collection Container Having a Fluid Separation Chamber - A specimen collection container having a separation chamber includes a first chamber, a second chamber, and a valve located between the first chamber and the second chamber. In an open position, the valve permits fluid communication between the first chamber and the second chamber. In a closed position, the valve maintains fluid isolation between the first chamber and the second chamber. A fluid stream passes from the first chamber to the second chamber through the valve permitting a predetermined volume of fluid to pass from the first chamber to the second chamber. When the predetermined volume of fluid passes to the second chamber, the valve transitions from the open position to the closed position so that additional fluid of the fluid stream received by the first chamber is maintained in the first chamber in fluid isolation from the predetermined volume of fluid contained in the second chamber. | 07-31-2014 |
20140305823 | Blood Sampling Transfer Device - A blood sampling transfer device that includes a lancing tape having a flow channel and a transfer cartridge removably connected to the lancing tape is disclosed. The blood sampling transfer device provides a closed system that reduces the exposure of a blood sample to both skin and environment and provides fast mixing of a blood sample with a sample stabilizer. | 10-16-2014 |
20140308167 | Biological Fluid Sampling Transfer Device and Biological Fluid Separation and Testing System - A biological fluid sampling transfer device that is adapted to receive and separate a multi-component blood sample is disclosed. After separation, the biological fluid sampling transfer device is able to transfer a plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device of the present disclosure also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with an anticoagulant. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results. | 10-16-2014 |
20140309096 | Biological Fluid Collection Device and Biological Fluid Separation System - A biological fluid separation system for a blood sample is disclosed. The biological fluid separation system includes a biological fluid collection device adapted to receive a blood sample and a centrifuge. The centrifuge is adapted to receive the biological fluid collection device such that with the biological fluid collection device received within the centrifuge and a rotational force applied to the biological fluid collection device, a plasma portion of the blood sample is separated from a cellular portion of the blood sample. The biological fluid collection device is only receivable within the centrifuge in one orientation. | 10-16-2014 |
20140309555 | Biological Fluid Collection Device and Biological Fluid Separation and Testing System - A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results. | 10-16-2014 |
20140309556 | Biological Fluid Collection Device and Biological Fluid Collection and Testing System - A blood collection device adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the blood collection device separates a plasma portion from a cellular portion. After separation, the blood collection device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The blood collection device of the present disclosure also provides a closed collection and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The blood collection device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the blood collection device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results. | 10-16-2014 |
20140309557 | Biological Fluid Sampling Transfer Device and Biological Fluid Separation and Testing System - A blood separation and testing system for a blood sample is disclosed. The blood separation and testing system includes a blood sampling transfer device adapted to receive a blood sample, a blood separation device, and a blood testing device. The blood separation device is adapted to receive a portion of the blood sampling transfer device such that with the blood sampling transfer device received within the blood separation device and a rotational force applied to the blood sampling transfer device, a plasma portion of the blood sample is separated from a cellular portion of the blood sample. The blood testing device is adapted to receive a portion of the blood sampling transfer device to analyze the plasma portion of the blood sample and obtain test results. | 10-16-2014 |
Patent application number | Description | Published |
20080293071 | Sequencing and Genotyping Using Reversibly Terminating Nucleotides - The invention provides a method of determining the nucleotide sequence of a target nucleic acid using a reversibly terminating nucleotide that is modified at the 2′ position. | 11-27-2008 |
20090148891 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 06-11-2009 |
20090263813 | RIBONUCLEOTIDE TAG NUCLEIC ACID DETECTION - The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides. The ribonucleotides are incorporated into amplification products at regular intervals complementary to the 5′-tail sequence segments. Cleavage of amplification products at the bond immediately 3′ to incorporated ribonucleotides produces detectably distinct fragments indicative of the presence or absence of a target nucleic acid. | 10-22-2009 |
20090280539 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 11-12-2009 |
20110294168 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors. | 12-01-2011 |
20130096027 | RIBONUCLEOTIDE TAG NUCLEIC ACID DETECTION - The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides. The ribonucleotides are incorporated into amplification products at regular intervals complementary to the 5′-tail sequence segments. Cleavage of amplification products at the bond immediately 3′ to incorporated ribonucleotides produces detectably distinct fragments indicative of the presence or absence of a target nucleic acid. | 04-18-2013 |
Patent application number | Description | Published |
20090137000 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 05-28-2009 |
20090142810 | 2'-Terminator Nucleotide-Related Methods and Systems - The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media. | 06-04-2009 |
20090155802 | Mutant DNA Polymerases with Improved Pyrophasphorolysis Activated Polymerization (PAP) Ability - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 06-18-2009 |
20110201002 | 2'-Terminator Nucleotide-Related Methods and Systems - The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media. | 08-18-2011 |
20150218537 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 08-06-2015 |
Patent application number | Description | Published |
20090162427 | VACCINES USING NUCLEIC ACID-LIPID COMPLEXES - This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method. | 06-25-2009 |
20100196376 | METHOD FOR REDUCING ALLERGEN-INDUCED AIRWAY HYPERRESPONSIVENESS - Disclosed is a method to reduce airway hyperresponsiveness, such as allergen-induced airway hyperresponsiveness, in a mammal by administering an agent that increases the biological activity of a CGRP receptor. Also disclosed are methods for identifying compounds useful in the present method. | 08-05-2010 |
20110002980 | VACCINES USING NUCLEIC ACID-LIPID COMPLEXES - This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method. | 01-06-2011 |
20120114663 | METHODS TO TREAT ALLERGIC CONDITIONS - Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are methods to treat allergic conditions in a subject by administering a composition that induces expression of Runx3. | 05-10-2012 |
20140154307 | INHIBITION OF FACTOR B, THE ALTERNATIVE COMPLEMENT PATHWAY AND METHODS RELATED THERETO - Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway. | 06-05-2014 |
20140377310 | METHODS TO TREAT ALLERGIC CONDITIONS - Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are methods to treat allergic conditions in a subject by administering a composition that induces expression of Runx3. | 12-25-2014 |
Patent application number | Description | Published |
20100137866 | Ulna fixation - An improved means for fixation of a fractured coronoid process of the proximal ulna. A substantially rigid plate is secured to the anterior aspect of the proximal ulna relative to a fracture of the coronoid process of the ulna. The plate contains a hook feature at the proximal aspect and is positioned so that it extends over the proximal/anterior aspect of the coronoid process relative to the fracture. The plate has surfaces that define a plurality of openings through which suture and/or screws can pass. The openings may contain a recess at a side of the plate opposite the ulna. At least one hole is formed in the ulna. At least one anchor may be secured to a flexible device, positioned at a side of the plate opposite the ulna, secured to another anchor on the posterior aspect of the ulna and the flexible device tensioned. At least one screw may be inserted through the plate and into the coronoid process or a bone fragment securing it to the plate. | 06-03-2010 |
20100262185 | Method and apparatus for aperture fixation by securing flexible material with a knotless fixation device - A knotless aperture fixation system, and method for use thereof, for securing a flexible material (i.e., suture, cable, fiber tape, or any other suitable flexible material) to a nearby tissue using knotless fixation achieved by a compression fit of the flexible material between two smooth surfaces. The system comprises a cylindrical or spherical flanged sleeve with threaded upper portion and smooth tapered lower portion is used in conjunction with a headless set screw with a bullet-shaped tip to achieve a compression fit of the flexible material between the smooth tapered lower portion of the sleeve and the smooth bullet-shaped tip of the headless set screw. The system may be used in conjunction with an expanded washer with a recessed lip, a flanged washer, or a bone plate with an opening containing a recessed lip. | 10-14-2010 |
20120123416 | METHODS AND DEVICES FOR SOFT TISSUE AND JOINT REPAIR - Disclosed herein are methods and devices for tissue and joint repair. Devices as disclosed herein can be used during surgical procedures, for example, to repair biceps tendons, elbows, shoulders, and knees. Methods disclosed herein relate to methods for repairing the same using the disclosed devices. | 05-17-2012 |
20120123447 | DEVICE FOR TENSIONING FLEXIBLE MATERIAL - The present invention provides a device for impart tension to a flexible material, for example, a suture. The device may be used during surgical procedures to ensure the proper tension is exerted. | 05-17-2012 |
20120290006 | Adjustable Suture Lock Loop - The present disclosure relates to an adjustable suture lock loop for use in soft tissue repair and, more particularly, an adjustable suture lock loop constructed from a suture material having a lumen and one or more anchors. The adjustable suture lock loop can include a strand of braided suture material having a first end and a second end, and a lumen; and one or more anchors, wherein each anchor has two or more holes disposed therethrough that are large enough to permit the suture to pass therethrough; and both ends of the suture material pass through the lumen of a first section of the suture material, and wherein the first end of the suture material is free, while the second end is secured to form a loop. | 11-15-2012 |
20130066378 | Clavicle Fixation - A substantially rigid plate is secured to a medial portion of a clavicle relative to a fracture in the clavicle. The plate is positioned so that it extends at least partially over a distal portion of the clavicle relative to the fracture. The plate has surfaces that define a first opening through which a suture can pass. A hole is formed in the clavicle. A washer may be positioned at a side of the plate opposite the clavicle. Alternatively, the plate may include suture holes or edge features for securing a suture. A suture is secured to the washer, to at least one suture hole or to at least one edge feature, and extends through the first opening, through the hole in the clavicle and is secured to the coracoid process. | 03-14-2013 |
20150182213 | Collapsible Suture Anchor - Described herein are devices and methods for securing sutures to tissue, particularly bone. | 07-02-2015 |
20150209027 | Adjustable Suture Lock Loop - The present disclosure relates to an adjustable suture lock loop for use in soft tissue repair and, more particularly, an adjustable suture lock loop constructed from a suture material having a lumen and one or more anchors. The adjustable suture lock loop can include a strand of braided suture material having a first end and a second end, and a lumen; and one or more anchors, wherein each anchor has two or more holes disposed therethrough that are large enough to permit the suture to pass therethrough; and both ends of the suture material pass through the lumen of a first section of the suture material, and wherein the first end of the suture material is free, while the second end is secured to form a loop. | 07-30-2015 |
Patent application number | Description | Published |
20090068184 | Engineered Antibody-Stress Protein Fusions - Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as | 03-12-2009 |
20100255539 | Engineered Antibody-Stress Protein Fusions - Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as | 10-07-2010 |
20110129484 | IMMUNOTHERAPIES EMPLOYING SELF-ASSEMBLING VACCINES - Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding protein is non-covalently bound to four biotinylated components, and further wherein at least two of the four biotinylated components are not identical. | 06-02-2011 |
20120134992 | MESOTHELIN ANTIBODY PROTEIN FUSIONS AND METHODS OF USE - The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease. | 05-31-2012 |
20150190649 | EMBEDDED PHOTONIC SYSTEMS AND METHODS FOR IRRADIATION OF MEDIUM WITH SAME - System and method for irradiating a region of interest of a medical device, implanted in a biological tissue, and the surrounding tissue. The system includes a translucent wall having an optically diffusing component and, optionally, an associated source of light embedded therein. The optical diffuser is optionally configured to outcouple light with a uniform spatial distribution and may include a network of biocompatible waveguides. The system may include a catheter with a distal end with an embedded diffuser that outcouples light delivered from the external source through a spiral of optical fiber, buried in the wall of the catheter. The system may include a biocompatible layer permanently embedded into the biological tissue and containing quantum dots that are activated wirelessly, through the layer, to irradiate the surrounding tissue from inside. Such a layer does not need to be removed from the tissue after irradiation of the tissue has been accomplished. | 07-09-2015 |