Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Gelfand, US
Boris Gelfand, Chanhassen, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110016159 | DATA CELLS AND DATA CELL GENERATIONS - Data cells are described containing an entity identifier (“O”), an entity type (“E”) an attribute type (“A”), and an attribute value (“V”). Cells with identical O and E values constitute a cell set. Pairs of synapse cells relate cell sets, each synapse cell having O and E values of one cell set and A and V values equal to the E and O values of the other cell set. Cell generations store information about attributes, entities, relationships, constraints, and default data formats in the same cell listing as the cells containing the actual real-world data. As a result, the data in a data cell can be considered self-identifying. The present invention also provides a way to normalize data using data pool cell sets. The data cells themselves can be stored in multiple, co-existing storage trees that are specialized for increased data query efficiency. | 01-20-2011 |
Craig A. Gelfand, Jackson, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090208923 | System and method for diagnosing diseases - One aspect of the invention provides a method of diagnosing a disease condition, comprising measuring presence or amount of a targeted protein or a degradation product of said protein in a collected biological sample as a marker for the disease condition. The targeted protein or degradation product is selected for measurement based on a prior identification of a measurable half-life at a predetermined time period, including the time at which said method is conducted, and correlating said measuring with the presence or absence of the disease condition. The targeted protein or degradation product may be identified by selecting a protein known or suspected to be a diagnostic marker for the disease condition, analyzing degradation of the protein in the collected biological sample, and selecting a protein or degradation product that exhibits a measurable half-life at a predetermined period of time. The analyzing may include identifying degradation product(s) of the protein as a function of time, and half-life of the protein and the degradation product(s). | 08-20-2009 |
David H. Gelfand, Oakland, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293071 | Sequencing and Genotyping Using Reversibly Terminating Nucleotides - The invention provides a method of determining the nucleotide sequence of a target nucleic acid using a reversibly terminating nucleotide that is modified at the 2′ position. | 11-27-2008 |
| 20090148891 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 06-11-2009 |
| 20090263813 | RIBONUCLEOTIDE TAG NUCLEIC ACID DETECTION - The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides. The ribonucleotides are incorporated into amplification products at regular intervals complementary to the 5′-tail sequence segments. Cleavage of amplification products at the bond immediately 3′ to incorporated ribonucleotides produces detectably distinct fragments indicative of the presence or absence of a target nucleic acid. | 10-22-2009 |
| 20090280539 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 11-12-2009 |
David Harrow Gelfand, Oakland, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090137000 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 05-28-2009 |
| 20090142810 | 2'-Terminator Nucleotide-Related Methods and Systems - The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media. | 06-04-2009 |
| 20090155802 | Mutant DNA Polymerases with Improved Pyrophasphorolysis Activated Polymerization (PAP) Ability - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 06-18-2009 |
Erwin Gelfand, Englewood, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100272739 | Modulation of Gamma-Delta T Cells to Regulate Airway Hyperresponsiveness - Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of γδ T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway hyperresponsiveness by modulating γδ T cell action. | 10-28-2010 |
Erwin W. Gelfand, Englewood, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20090162427 | VACCINES USING NUCLEIC ACID-LIPID COMPLEXES - This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method. | 06-25-2009 |
| 20100196376 | METHOD FOR REDUCING ALLERGEN-INDUCED AIRWAY HYPERRESPONSIVENESS - Disclosed is a method to reduce airway hyperresponsiveness, such as allergen-induced airway hyperresponsiveness, in a mammal by administering an agent that increases the biological activity of a CGRP receptor. Also disclosed are methods for identifying compounds useful in the present method. | 08-05-2010 |
| 20110002980 | VACCINES USING NUCLEIC ACID-LIPID COMPLEXES - This invention relates to a vaccine and a method for immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, an infectious disease, or a condition associated with a deleterious activity of a self-antigen. Also disclosed are therapeutic compositions useful in such a method. | 01-06-2011 |
Jeffrey Gelfand, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080260650 | Methods of Detection and Therapy of Inflamed Tissues Using Immune Modulation - The present invention relates to methods for the detection and therapy of inflamed tissue, whereby immune modulators are used to increase the uptake of diagnostic or therapeutic compositions by inflammatory cells. | 10-23-2008 |
Jeffrey Gelfand, Severna Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100137866 | Ulna fixation - An improved means for fixation of a fractured coronoid process of the proximal ulna. A substantially rigid plate is secured to the anterior aspect of the proximal ulna relative to a fracture of the coronoid process of the ulna. The plate contains a hook feature at the proximal aspect and is positioned so that it extends over the proximal/anterior aspect of the coronoid process relative to the fracture. The plate has surfaces that define a plurality of openings through which suture and/or screws can pass. The openings may contain a recess at a side of the plate opposite the ulna. At least one hole is formed in the ulna. At least one anchor may be secured to a flexible device, positioned at a side of the plate opposite the ulna, secured to another anchor on the posterior aspect of the ulna and the flexible device tensioned. At least one screw may be inserted through the plate and into the coronoid process or a bone fragment securing it to the plate. | 06-03-2010 |
| 20100262185 | Method and apparatus for aperture fixation by securing flexible material with a knotless fixation device - A knotless aperture fixation system, and method for use thereof, for securing a flexible material (i.e., suture, cable, fiber tape, or any other suitable flexible material) to a nearby tissue using knotless fixation achieved by a compression fit of the flexible material between two smooth surfaces. The system comprises a cylindrical or spherical flanged sleeve with threaded upper portion and smooth tapered lower portion is used in conjunction with a headless set screw with a bullet-shaped tip to achieve a compression fit of the flexible material between the smooth tapered lower portion of the sleeve and the smooth bullet-shaped tip of the headless set screw. The system may be used in conjunction with an expanded washer with a recessed lip, a flanged washer, or a bone plate with an opening containing a recessed lip. | 10-14-2010 |
Jeffrey Gelfand, Sevema Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100016899 | CLAVICLE FIXATION - A substantially rigid plate is secured to a medial portion of a clavicle relative to a fracture in the clavicle. The plate is positioned so that it extends at least partially over a distal portion of the clavicle relative to the fracture. The plate has surfaces that define a first opening through which a suture can pass. A hole is formed in the clavicle. A washer may be positioned at a side of the plate opposite the clavicle. Alternatively, the plate may include suture holes or edge features for securing a suture. A suture is secured to the washer, to at least one suture hole or to at least one edge feature, and extends through the first opening, through the hole in the clavicle and is secured to the coracoid process. | 01-21-2010 |
Jeffrey A. Gelfand, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090155269 | Mesothelin antibody protein fusions and methods of use - The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease. | 06-18-2009 |
Jeffrey A. Gelfand, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090068184 | Engineered Antibody-Stress Protein Fusions - Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as | 03-12-2009 |
| 20100255539 | Engineered Antibody-Stress Protein Fusions - Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as | 10-07-2010 |
| 20110129484 | IMMUNOTHERAPIES EMPLOYING SELF-ASSEMBLING VACCINES - Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding protein is non-covalently bound to four biotinylated components, and further wherein at least two of the four biotinylated components are not identical. | 06-02-2011 |
Matthew Gelfand, Rockville Centre, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090175680 | Energy absorbing system with support - An energy absorbing system. The system includes an energy absorber mechanically coupled to a net, a joint mechanically coupled to an anchor, and a support mechanically coupled to the net via a frangible connector. The frangible connector may uncouple the support from the net upon application of at least a threshold force to the frangible connector. The joint may pivot on a horizontal axis and support the energy absorber at a predetermined angle relative to ground level. | 07-09-2009 |
Matthew A. Gelfand, Rockville Centre, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090116904 | Energy absorbing bollard system - An energy absorbing system. The energy absorbing system includes a supporting member, a barrier pivotable between a first angular position and a second angular position, where the barrier becomes mechanically coupled to the supporting member when arranged at a predetermined angular position, and an energy absorber mechanically coupled to the supporting member, where the energy absorber absorbs energy when the supporting member travels from a first position to a second position. | 05-07-2009 |
| 20090185857 | Retractable Energy Absorbing System - An energy absorbing system. The energy absorbing system includes a supporting member, a barrier mechanically coupled to the supporting member, the barrier pivotable between a first angular position and a second angular position, an energy absorber, at least a portion of which is immovably fixed, that is mechanically coupled to the supporting member, wherein the energy absorber absorbs energy when the supporting member travels from a first lateral position to a second lateral position, and a first rotation limiter mechanically coupled to one of the barrier and the supporting member that limits the barrier from pivoting beyond the second angular position. | 07-23-2009 |
Matthew A. Gelfand, Brentwood, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20100133411 | Energy Absorbing System with Anchor Net - An anchor for use with a vehicle restraining system. In one aspect, the anchor may include a matrix of members, where the matrix is of sufficient size to accommodate a vehicle on top thereof, and one or more connection members, where each of the one or more connection members is joined at one end to the matrix and each of the one or more connection members is joined at another end to a connector. | 06-03-2010 |
| 20100202829 | Vehicle Barrier with Release Mechanism - A barrier for arresting a vehicle. The barrier includes a net spanning an area through which the vehicle may pass, an anchor coupled to the net, a support arm arranged on one side of the area through which the vehicle may pass, a raising/lowering mechanism for raising and lowering the support arm, and a release mechanism arranged on the support arm, the release mechanism having an upper and a lower protrusion forming an interior space to accommodate a member coupled to the net, and the member and the release mechanism become uncoupled upon application to the net of at least a predetermined threshold force. | 08-12-2010 |
Matthew A. Gelfand, Franklin, TN US
| Patent application number | Description | Published |
|---|---|---|
| 20100275515 | ENERGY ABSORBING SYSTEM - An energy absorbing system having a stanchion, a linearly extendable energy absorber coupled to the stanchion, a net coupled to the energy absorber, wherein the net transfers force to the energy absorber, and a securing mechanism that maintains tension between the net and the energy absorber until acted upon by tensile forces of at least a minimum threshold force, wherein at least a portion of the system is retractable into the ground. | 11-04-2010 |
Mikhail Gelfand, Milford, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20100025159 | LUBRICATION SYSTEM WITH PROLONGED LOSS OF LUBRICANT OPERATION - A lubrication system includes an external pump system which pumps air out of the housing and develop negative pressure therein in response to a loss of lubrication condition. The negative pressure operates as an air lock to minimize or prevent lubricating oil loss from the housing while an internal lubrication system continues to distribute lubricating oil—which although now increasing in temperature—still operates to lubricate the gearbox components. For further ballistic tolerance, the housing is a compound housing that reduces or closes the penetration and further minimizes lubricating oil and negative pressure loss. The housing may be still further hardened by an armor layer. | 02-04-2010 |